Incidental Mutation 'R1905:Ralgapa2'
| ID |
214265 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ralgapa2
|
| Ensembl Gene |
ENSMUSG00000037110 |
| Gene Name |
Ral GTPase activating protein, alpha subunit 2 (catalytic) |
| Synonyms |
AS250, A230067G21Rik, RGC2 |
| MMRRC Submission |
039924-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.209)
|
| Stock # |
R1905 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
146081799-146354264 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 146229621 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Leucine
at position 1053
(R1053L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153734
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000109986]
[ENSMUST00000131824]
[ENSMUST00000228797]
|
| AlphaFold |
A3KGS3 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000109986
AA Change: R1006L
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000105613
Gene: ENSMUSG00000037110
AA Change: R1006L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
469 |
480 |
N/A |
INTRINSIC |
|
low complexity region
|
1017 |
1028 |
N/A |
INTRINSIC |
|
low complexity region
|
1296 |
1301 |
N/A |
INTRINSIC |
|
Pfam:Rap_GAP
|
1701 |
1877 |
6.8e-48 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000131824
AA Change: R968L
PolyPhen 2
Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000122039
Gene: ENSMUSG00000037110
AA Change: R968L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
469 |
480 |
N/A |
INTRINSIC |
|
low complexity region
|
979 |
990 |
N/A |
INTRINSIC |
|
low complexity region
|
1258 |
1263 |
N/A |
INTRINSIC |
|
Pfam:Rap_GAP
|
1663 |
1842 |
1.3e-66 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000146307
|
| SMART Domains |
Protein: ENSMUSP00000114547
Gene: ENSMUSG00000037110
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
6 |
17 |
N/A |
INTRINSIC |
|
low complexity region
|
285 |
290 |
N/A |
INTRINSIC |
|
Pfam:Rap_GAP
|
690 |
830 |
4.9e-39 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000148784
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000149499
AA Change: R638L
|
| SMART Domains |
Protein: ENSMUSP00000122017
Gene: ENSMUSG00000037110
AA Change: R638L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
140 |
151 |
N/A |
INTRINSIC |
|
low complexity region
|
650 |
661 |
N/A |
INTRINSIC |
|
low complexity region
|
929 |
934 |
N/A |
INTRINSIC |
|
Pfam:Rap_GAP
|
1334 |
1511 |
2.4e-48 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000228797
AA Change: R1053L
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Meta Mutation Damage Score |
0.7391 |
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 97.0%
- 10x: 95.5%
- 20x: 93.1%
|
| Validation Efficiency |
99% (90/91) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased incidence and severity of induced urothelial bladder tumors. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 89 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4833420G17Rik |
G |
T |
13: 119,606,216 (GRCm39) |
V153L |
possibly damaging |
Het |
| Adamts17 |
T |
A |
7: 66,697,220 (GRCm39) |
C631* |
probably null |
Het |
| Adamts19 |
A |
G |
18: 59,166,017 (GRCm39) |
R1070G |
possibly damaging |
Het |
| Aldh1a1 |
A |
G |
19: 20,595,362 (GRCm39) |
E97G |
probably damaging |
Het |
| Bola2 |
T |
A |
7: 126,295,410 (GRCm39) |
V40E |
probably damaging |
Het |
| Ccar1 |
A |
G |
10: 62,612,437 (GRCm39) |
S243P |
possibly damaging |
Het |
| Cd80 |
A |
T |
16: 38,294,539 (GRCm39) |
I141F |
probably damaging |
Het |
| Ceacam23 |
T |
A |
7: 17,607,477 (GRCm39) |
|
noncoding transcript |
Het |
| Chn2 |
T |
C |
6: 54,263,106 (GRCm39) |
C92R |
probably damaging |
Het |
| Ciao2a |
A |
G |
9: 66,039,929 (GRCm39) |
K82R |
probably benign |
Het |
| Clk1 |
A |
T |
1: 58,461,101 (GRCm39) |
|
probably benign |
Het |
| Clock |
T |
C |
5: 76,414,735 (GRCm39) |
|
probably benign |
Het |
| Cntnap3 |
A |
G |
13: 65,051,578 (GRCm39) |
V26A |
probably benign |
Het |
| Csf3r |
A |
T |
4: 125,936,538 (GRCm39) |
K651N |
probably benign |
Het |
| Cul4a |
T |
C |
8: 13,183,171 (GRCm39) |
M322T |
probably benign |
Het |
| Cx3cl1 |
A |
G |
8: 95,506,687 (GRCm39) |
T231A |
probably benign |
Het |
| Cyp2c68 |
A |
T |
19: 39,724,026 (GRCm39) |
C213S |
probably benign |
Het |
| Dhx16 |
T |
G |
17: 36,199,247 (GRCm39) |
S814A |
probably benign |
Het |
| Dnah1 |
T |
C |
14: 30,986,587 (GRCm39) |
I3659V |
probably benign |
Het |
| Dock6 |
A |
T |
9: 21,740,870 (GRCm39) |
V906D |
probably benign |
Het |
| Ep400 |
G |
A |
5: 110,818,814 (GRCm39) |
T2738I |
probably damaging |
Het |
| Erbb4 |
A |
T |
1: 68,114,569 (GRCm39) |
|
probably benign |
Het |
| Fam135b |
C |
T |
15: 71,404,836 (GRCm39) |
R70H |
probably damaging |
Het |
| Fam13a |
T |
C |
6: 58,930,475 (GRCm39) |
Q479R |
probably damaging |
Het |
| Fcgr4 |
A |
T |
1: 170,856,874 (GRCm39) |
Q247L |
probably damaging |
Het |
| Flnc |
T |
A |
6: 29,459,459 (GRCm39) |
C2520S |
probably damaging |
Het |
| Foxn1 |
A |
G |
11: 78,262,636 (GRCm39) |
|
probably null |
Het |
| Fsip2 |
C |
T |
2: 82,813,772 (GRCm39) |
P3364S |
possibly damaging |
Het |
| Fzd8 |
C |
T |
18: 9,213,803 (GRCm39) |
T295I |
probably damaging |
Het |
| Gm4744 |
G |
A |
6: 40,928,736 (GRCm39) |
|
probably benign |
Het |
| Gm4871 |
G |
T |
5: 144,966,859 (GRCm39) |
A208D |
probably damaging |
Het |
| Gm527 |
A |
G |
12: 64,967,797 (GRCm39) |
N73S |
possibly damaging |
Het |
| Gm5414 |
T |
C |
15: 101,533,075 (GRCm39) |
I451V |
probably damaging |
Het |
| Golm1 |
A |
T |
13: 59,790,065 (GRCm39) |
V245E |
probably benign |
Het |
| Grik1 |
A |
T |
16: 87,693,754 (GRCm39) |
Y879* |
probably null |
Het |
| Grn |
C |
A |
11: 102,327,276 (GRCm39) |
P241Q |
probably damaging |
Het |
| H2-T7 |
T |
C |
17: 36,453,833 (GRCm39) |
|
noncoding transcript |
Het |
| Hjurp |
T |
C |
1: 88,194,338 (GRCm39) |
E190G |
probably benign |
Het |
| Hmcn1 |
A |
C |
1: 150,868,606 (GRCm39) |
I66S |
probably damaging |
Het |
| Hykk |
T |
A |
9: 54,853,667 (GRCm39) |
Y330N |
probably benign |
Het |
| Khdc1c |
A |
G |
1: 21,439,281 (GRCm39) |
N89S |
probably benign |
Het |
| Lcor |
A |
G |
19: 41,572,013 (GRCm39) |
D256G |
possibly damaging |
Het |
| Lrrc72 |
T |
A |
12: 36,258,661 (GRCm39) |
|
probably null |
Het |
| Lyst |
T |
G |
13: 13,808,719 (GRCm39) |
S130A |
probably benign |
Het |
| Mast1 |
G |
A |
8: 85,642,895 (GRCm39) |
R967C |
probably damaging |
Het |
| Mfng |
T |
C |
15: 78,657,286 (GRCm39) |
T63A |
probably damaging |
Het |
| Mre11a |
G |
A |
9: 14,710,923 (GRCm39) |
D206N |
probably benign |
Het |
| Myh10 |
A |
G |
11: 68,662,694 (GRCm39) |
|
probably benign |
Het |
| Myt1 |
A |
G |
2: 181,439,549 (GRCm39) |
D357G |
probably damaging |
Het |
| Nacad |
T |
A |
11: 6,552,540 (GRCm39) |
H217L |
probably benign |
Het |
| Ncoa1 |
A |
G |
12: 4,345,433 (GRCm39) |
V638A |
probably damaging |
Het |
| Nlrp3 |
T |
G |
11: 59,439,862 (GRCm39) |
F480V |
probably damaging |
Het |
| Nos1ap |
A |
G |
1: 170,146,127 (GRCm39) |
W476R |
possibly damaging |
Het |
| Nr1h4 |
T |
A |
10: 89,316,421 (GRCm39) |
T220S |
possibly damaging |
Het |
| Ntf5 |
G |
T |
7: 45,065,176 (GRCm39) |
V103L |
probably damaging |
Het |
| Ntm |
C |
A |
9: 29,090,393 (GRCm39) |
D109Y |
probably damaging |
Het |
| Or7e178 |
C |
T |
9: 20,226,142 (GRCm39) |
E17K |
probably benign |
Het |
| P2rx7 |
G |
A |
5: 122,819,015 (GRCm39) |
C479Y |
probably damaging |
Het |
| Pappa2 |
T |
A |
1: 158,631,073 (GRCm39) |
|
probably null |
Het |
| Pgap1 |
A |
C |
1: 54,551,120 (GRCm39) |
I520R |
probably benign |
Het |
| Pikfyve |
G |
A |
1: 65,231,454 (GRCm39) |
|
probably null |
Het |
| Plekhg3 |
T |
C |
12: 76,622,991 (GRCm39) |
S744P |
probably benign |
Het |
| Pramel6 |
A |
G |
2: 87,339,526 (GRCm39) |
R97G |
probably damaging |
Het |
| Pramel6 |
G |
T |
2: 87,339,527 (GRCm39) |
R97M |
probably damaging |
Het |
| Psme4 |
T |
C |
11: 30,760,922 (GRCm39) |
V397A |
probably damaging |
Het |
| Ptk2b |
T |
C |
14: 66,396,119 (GRCm39) |
D783G |
probably damaging |
Het |
| Ptma-ps1 |
T |
A |
7: 23,763,306 (GRCm39) |
L17* |
probably null |
Het |
| Sap130 |
C |
T |
18: 31,813,620 (GRCm39) |
P559L |
possibly damaging |
Het |
| Sap30 |
T |
C |
8: 57,940,345 (GRCm39) |
S86G |
probably damaging |
Het |
| Sdk2 |
C |
T |
11: 113,729,472 (GRCm39) |
|
silent |
Het |
| Sema3f |
G |
T |
9: 107,561,575 (GRCm39) |
Q500K |
probably damaging |
Het |
| Serpinb3d |
T |
C |
1: 107,007,014 (GRCm39) |
I231M |
possibly damaging |
Het |
| Sf3a1 |
T |
A |
11: 4,126,678 (GRCm39) |
N563K |
probably benign |
Het |
| Sipa1l3 |
A |
G |
7: 29,038,592 (GRCm39) |
S352P |
possibly damaging |
Het |
| Slc6a12 |
G |
T |
6: 121,324,402 (GRCm39) |
E9* |
probably null |
Het |
| Srebf1 |
T |
C |
11: 60,095,319 (GRCm39) |
D400G |
probably damaging |
Het |
| Swsap1 |
T |
C |
9: 21,867,988 (GRCm39) |
Y87H |
probably damaging |
Het |
| Tanc2 |
G |
A |
11: 105,813,689 (GRCm39) |
G1711D |
possibly damaging |
Het |
| Tas2r107 |
T |
C |
6: 131,636,951 (GRCm39) |
M33V |
probably benign |
Het |
| Tdrd9 |
T |
A |
12: 112,030,061 (GRCm39) |
|
probably benign |
Het |
| Tdrp |
T |
C |
8: 14,004,079 (GRCm39) |
D86G |
probably damaging |
Het |
| Tmem92 |
A |
T |
11: 94,669,501 (GRCm39) |
M106K |
probably benign |
Het |
| Tmf1 |
A |
T |
6: 97,138,440 (GRCm39) |
C764S |
possibly damaging |
Het |
| Ttc21a |
G |
T |
9: 119,795,823 (GRCm39) |
R1219L |
possibly damaging |
Het |
| Ttn |
C |
T |
2: 76,593,792 (GRCm39) |
G18870D |
probably damaging |
Het |
| Tubgcp6 |
T |
C |
15: 88,984,811 (GRCm39) |
Y1732C |
probably damaging |
Het |
| Vmn1r28 |
A |
G |
6: 58,242,912 (GRCm39) |
T252A |
probably benign |
Het |
| Xirp2 |
A |
G |
2: 67,346,700 (GRCm39) |
I2980M |
probably damaging |
Het |
| Zc2hc1c |
A |
G |
12: 85,337,288 (GRCm39) |
D315G |
probably benign |
Het |
|
| Other mutations in Ralgapa2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00666:Ralgapa2
|
APN |
2 |
146,327,056 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
IGL00915:Ralgapa2
|
APN |
2 |
146,184,442 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01012:Ralgapa2
|
APN |
2 |
146,263,659 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL01018:Ralgapa2
|
APN |
2 |
146,252,112 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01018:Ralgapa2
|
APN |
2 |
146,252,113 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01902:Ralgapa2
|
APN |
2 |
146,156,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02160:Ralgapa2
|
APN |
2 |
146,190,360 (GRCm39) |
splice site |
probably benign |
|
|
IGL02321:Ralgapa2
|
APN |
2 |
146,254,736 (GRCm39) |
nonsense |
probably null |
|
|
IGL02412:Ralgapa2
|
APN |
2 |
146,254,052 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL03026:Ralgapa2
|
APN |
2 |
146,302,695 (GRCm39) |
splice site |
probably benign |
|
|
IGL03115:Ralgapa2
|
APN |
2 |
146,266,734 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03256:Ralgapa2
|
APN |
2 |
146,302,632 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03379:Ralgapa2
|
APN |
2 |
146,199,907 (GRCm39) |
missense |
probably benign |
0.01 |
|
Chow
|
UTSW |
2 |
146,188,638 (GRCm39) |
nonsense |
probably null |
|
|
purina
|
UTSW |
2 |
146,175,406 (GRCm39) |
missense |
probably damaging |
1.00 |
|
P4748:Ralgapa2
|
UTSW |
2 |
146,188,731 (GRCm39) |
nonsense |
probably null |
|
|
R0012:Ralgapa2
|
UTSW |
2 |
146,254,672 (GRCm39) |
missense |
probably benign |
|
|
R0012:Ralgapa2
|
UTSW |
2 |
146,254,672 (GRCm39) |
missense |
probably benign |
|
|
R0165:Ralgapa2
|
UTSW |
2 |
146,230,407 (GRCm39) |
splice site |
probably benign |
|
|
R0344:Ralgapa2
|
UTSW |
2 |
146,188,714 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R0402:Ralgapa2
|
UTSW |
2 |
146,276,729 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0419:Ralgapa2
|
UTSW |
2 |
146,270,592 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R0638:Ralgapa2
|
UTSW |
2 |
146,184,112 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0704:Ralgapa2
|
UTSW |
2 |
146,293,704 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0722:Ralgapa2
|
UTSW |
2 |
146,230,451 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0866:Ralgapa2
|
UTSW |
2 |
146,277,923 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1065:Ralgapa2
|
UTSW |
2 |
146,292,478 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1212:Ralgapa2
|
UTSW |
2 |
146,199,902 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1395:Ralgapa2
|
UTSW |
2 |
146,230,420 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1614:Ralgapa2
|
UTSW |
2 |
146,230,532 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1686:Ralgapa2
|
UTSW |
2 |
146,199,920 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1799:Ralgapa2
|
UTSW |
2 |
146,184,648 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1956:Ralgapa2
|
UTSW |
2 |
146,302,679 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2144:Ralgapa2
|
UTSW |
2 |
146,230,524 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2148:Ralgapa2
|
UTSW |
2 |
146,273,807 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2219:Ralgapa2
|
UTSW |
2 |
146,263,599 (GRCm39) |
missense |
probably benign |
0.09 |
|
R2220:Ralgapa2
|
UTSW |
2 |
146,263,599 (GRCm39) |
missense |
probably benign |
0.09 |
|
R2261:Ralgapa2
|
UTSW |
2 |
146,184,603 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2402:Ralgapa2
|
UTSW |
2 |
146,195,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2495:Ralgapa2
|
UTSW |
2 |
146,203,320 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R3752:Ralgapa2
|
UTSW |
2 |
146,263,551 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3953:Ralgapa2
|
UTSW |
2 |
146,277,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3956:Ralgapa2
|
UTSW |
2 |
146,277,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4177:Ralgapa2
|
UTSW |
2 |
146,327,083 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4182:Ralgapa2
|
UTSW |
2 |
146,277,914 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4193:Ralgapa2
|
UTSW |
2 |
146,184,493 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4332:Ralgapa2
|
UTSW |
2 |
146,102,288 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4507:Ralgapa2
|
UTSW |
2 |
146,195,168 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4574:Ralgapa2
|
UTSW |
2 |
146,277,919 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4585:Ralgapa2
|
UTSW |
2 |
146,156,944 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4627:Ralgapa2
|
UTSW |
2 |
146,203,373 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4647:Ralgapa2
|
UTSW |
2 |
146,229,549 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R4677:Ralgapa2
|
UTSW |
2 |
146,187,387 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4724:Ralgapa2
|
UTSW |
2 |
146,187,453 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4760:Ralgapa2
|
UTSW |
2 |
146,188,669 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4831:Ralgapa2
|
UTSW |
2 |
146,246,987 (GRCm39) |
intron |
probably benign |
|
|
R4962:Ralgapa2
|
UTSW |
2 |
146,276,754 (GRCm39) |
nonsense |
probably null |
|
|
R4993:Ralgapa2
|
UTSW |
2 |
146,289,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5041:Ralgapa2
|
UTSW |
2 |
146,327,071 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5120:Ralgapa2
|
UTSW |
2 |
146,254,004 (GRCm39) |
missense |
probably benign |
0.26 |
|
R5185:Ralgapa2
|
UTSW |
2 |
146,230,406 (GRCm39) |
splice site |
probably null |
|
|
R5393:Ralgapa2
|
UTSW |
2 |
146,187,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5428:Ralgapa2
|
UTSW |
2 |
146,176,414 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5439:Ralgapa2
|
UTSW |
2 |
146,184,430 (GRCm39) |
missense |
probably benign |
0.08 |
|
R5476:Ralgapa2
|
UTSW |
2 |
146,289,356 (GRCm39) |
missense |
probably benign |
|
|
R5695:Ralgapa2
|
UTSW |
2 |
146,175,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5705:Ralgapa2
|
UTSW |
2 |
146,291,193 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5718:Ralgapa2
|
UTSW |
2 |
146,295,326 (GRCm39) |
splice site |
probably null |
|
|
R5817:Ralgapa2
|
UTSW |
2 |
146,175,406 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5877:Ralgapa2
|
UTSW |
2 |
146,230,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5994:Ralgapa2
|
UTSW |
2 |
146,203,373 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6048:Ralgapa2
|
UTSW |
2 |
146,276,765 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6158:Ralgapa2
|
UTSW |
2 |
146,266,596 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6169:Ralgapa2
|
UTSW |
2 |
146,292,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6280:Ralgapa2
|
UTSW |
2 |
146,184,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6301:Ralgapa2
|
UTSW |
2 |
146,169,331 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6650:Ralgapa2
|
UTSW |
2 |
146,230,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6959:Ralgapa2
|
UTSW |
2 |
146,184,621 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7020:Ralgapa2
|
UTSW |
2 |
146,188,638 (GRCm39) |
nonsense |
probably null |
|
|
R7035:Ralgapa2
|
UTSW |
2 |
146,353,777 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7167:Ralgapa2
|
UTSW |
2 |
146,190,374 (GRCm39) |
missense |
probably benign |
|
|
R7186:Ralgapa2
|
UTSW |
2 |
146,230,406 (GRCm39) |
splice site |
probably null |
|
|
R7252:Ralgapa2
|
UTSW |
2 |
146,184,671 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7266:Ralgapa2
|
UTSW |
2 |
146,176,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7371:Ralgapa2
|
UTSW |
2 |
146,189,046 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7432:Ralgapa2
|
UTSW |
2 |
146,276,776 (GRCm39) |
missense |
probably benign |
0.41 |
|
R7470:Ralgapa2
|
UTSW |
2 |
146,266,587 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7663:Ralgapa2
|
UTSW |
2 |
146,260,335 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7780:Ralgapa2
|
UTSW |
2 |
146,184,334 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7973:Ralgapa2
|
UTSW |
2 |
146,230,481 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8018:Ralgapa2
|
UTSW |
2 |
146,182,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8063:Ralgapa2
|
UTSW |
2 |
146,285,775 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8070:Ralgapa2
|
UTSW |
2 |
146,195,199 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8264:Ralgapa2
|
UTSW |
2 |
146,175,370 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8309:Ralgapa2
|
UTSW |
2 |
146,246,786 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8409:Ralgapa2
|
UTSW |
2 |
146,086,897 (GRCm39) |
missense |
|
|
|
R8474:Ralgapa2
|
UTSW |
2 |
146,266,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8487:Ralgapa2
|
UTSW |
2 |
146,230,463 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8492:Ralgapa2
|
UTSW |
2 |
146,184,524 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R8733:Ralgapa2
|
UTSW |
2 |
146,266,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8856:Ralgapa2
|
UTSW |
2 |
146,184,139 (GRCm39) |
missense |
probably benign |
0.30 |
|
R8858:Ralgapa2
|
UTSW |
2 |
146,102,285 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8862:Ralgapa2
|
UTSW |
2 |
146,266,731 (GRCm39) |
missense |
probably benign |
0.41 |
|
R9146:Ralgapa2
|
UTSW |
2 |
146,184,252 (GRCm39) |
missense |
probably benign |
|
|
R9324:Ralgapa2
|
UTSW |
2 |
146,302,645 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9439:Ralgapa2
|
UTSW |
2 |
146,254,058 (GRCm39) |
missense |
probably benign |
|
|
R9457:Ralgapa2
|
UTSW |
2 |
146,176,474 (GRCm39) |
missense |
probably damaging |
0.99 |
|
RF019:Ralgapa2
|
UTSW |
2 |
146,203,423 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
X0019:Ralgapa2
|
UTSW |
2 |
146,230,572 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
Z1088:Ralgapa2
|
UTSW |
2 |
146,276,825 (GRCm39) |
missense |
probably benign |
0.20 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCAGTCTTGGGCAATTAGAG -3'
(R):5'- CCGGGGTTCAGAATCTCTCTAG -3'
Sequencing Primer
(F):5'- GTCTTGGGCAATTAGAGTTTTTAAAC -3'
(R):5'- AGAATCTCTCTAGGTGTTCACAC -3'
|
| Posted On |
2014-07-14 |
Incidental Mutation