Incidental Mutation 'R1905:Cyp2c68'
ID 214339
Institutional Source Beutler Lab
Gene Symbol Cyp2c68
Ensembl Gene ENSMUSG00000074882
Gene Name cytochrome P450, family 2, subfamily c, polypeptide 68
Synonyms 9030012A22Rik
MMRRC Submission 039924-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1905 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 39677278-39729498 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 39724026 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Serine at position 213 (C213S)
Ref Sequence ENSEMBL: ENSMUSP00000097071 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099472]
AlphaFold K7N6C2
Predicted Effect probably benign
Transcript: ENSMUST00000099472
AA Change: C213S

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000097071
Gene: ENSMUSG00000074882
AA Change: C213S

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
Pfam:p450 30 487 2.1e-150 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 97.5%
  • 3x: 97.0%
  • 10x: 95.5%
  • 20x: 93.1%
Validation Efficiency 99% (90/91)
Allele List at MGI
Other mutations in this stock
Total: 89 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4833420G17Rik G T 13: 119,606,216 (GRCm39) V153L possibly damaging Het
Adamts17 T A 7: 66,697,220 (GRCm39) C631* probably null Het
Adamts19 A G 18: 59,166,017 (GRCm39) R1070G possibly damaging Het
Aldh1a1 A G 19: 20,595,362 (GRCm39) E97G probably damaging Het
Bola2 T A 7: 126,295,410 (GRCm39) V40E probably damaging Het
Ccar1 A G 10: 62,612,437 (GRCm39) S243P possibly damaging Het
Cd80 A T 16: 38,294,539 (GRCm39) I141F probably damaging Het
Ceacam23 T A 7: 17,607,477 (GRCm39) noncoding transcript Het
Chn2 T C 6: 54,263,106 (GRCm39) C92R probably damaging Het
Ciao2a A G 9: 66,039,929 (GRCm39) K82R probably benign Het
Clk1 A T 1: 58,461,101 (GRCm39) probably benign Het
Clock T C 5: 76,414,735 (GRCm39) probably benign Het
Cntnap3 A G 13: 65,051,578 (GRCm39) V26A probably benign Het
Csf3r A T 4: 125,936,538 (GRCm39) K651N probably benign Het
Cul4a T C 8: 13,183,171 (GRCm39) M322T probably benign Het
Cx3cl1 A G 8: 95,506,687 (GRCm39) T231A probably benign Het
Dhx16 T G 17: 36,199,247 (GRCm39) S814A probably benign Het
Dnah1 T C 14: 30,986,587 (GRCm39) I3659V probably benign Het
Dock6 A T 9: 21,740,870 (GRCm39) V906D probably benign Het
Ep400 G A 5: 110,818,814 (GRCm39) T2738I probably damaging Het
Erbb4 A T 1: 68,114,569 (GRCm39) probably benign Het
Fam135b C T 15: 71,404,836 (GRCm39) R70H probably damaging Het
Fam13a T C 6: 58,930,475 (GRCm39) Q479R probably damaging Het
Fcgr4 A T 1: 170,856,874 (GRCm39) Q247L probably damaging Het
Flnc T A 6: 29,459,459 (GRCm39) C2520S probably damaging Het
Foxn1 A G 11: 78,262,636 (GRCm39) probably null Het
Fsip2 C T 2: 82,813,772 (GRCm39) P3364S possibly damaging Het
Fzd8 C T 18: 9,213,803 (GRCm39) T295I probably damaging Het
Gm4744 G A 6: 40,928,736 (GRCm39) probably benign Het
Gm4871 G T 5: 144,966,859 (GRCm39) A208D probably damaging Het
Gm527 A G 12: 64,967,797 (GRCm39) N73S possibly damaging Het
Gm5414 T C 15: 101,533,075 (GRCm39) I451V probably damaging Het
Golm1 A T 13: 59,790,065 (GRCm39) V245E probably benign Het
Grik1 A T 16: 87,693,754 (GRCm39) Y879* probably null Het
Grn C A 11: 102,327,276 (GRCm39) P241Q probably damaging Het
H2-T7 T C 17: 36,453,833 (GRCm39) noncoding transcript Het
Hjurp T C 1: 88,194,338 (GRCm39) E190G probably benign Het
Hmcn1 A C 1: 150,868,606 (GRCm39) I66S probably damaging Het
Hykk T A 9: 54,853,667 (GRCm39) Y330N probably benign Het
Khdc1c A G 1: 21,439,281 (GRCm39) N89S probably benign Het
Lcor A G 19: 41,572,013 (GRCm39) D256G possibly damaging Het
Lrrc72 T A 12: 36,258,661 (GRCm39) probably null Het
Lyst T G 13: 13,808,719 (GRCm39) S130A probably benign Het
Mast1 G A 8: 85,642,895 (GRCm39) R967C probably damaging Het
Mfng T C 15: 78,657,286 (GRCm39) T63A probably damaging Het
Mre11a G A 9: 14,710,923 (GRCm39) D206N probably benign Het
Myh10 A G 11: 68,662,694 (GRCm39) probably benign Het
Myt1 A G 2: 181,439,549 (GRCm39) D357G probably damaging Het
Nacad T A 11: 6,552,540 (GRCm39) H217L probably benign Het
Ncoa1 A G 12: 4,345,433 (GRCm39) V638A probably damaging Het
Nlrp3 T G 11: 59,439,862 (GRCm39) F480V probably damaging Het
Nos1ap A G 1: 170,146,127 (GRCm39) W476R possibly damaging Het
Nr1h4 T A 10: 89,316,421 (GRCm39) T220S possibly damaging Het
Ntf5 G T 7: 45,065,176 (GRCm39) V103L probably damaging Het
Ntm C A 9: 29,090,393 (GRCm39) D109Y probably damaging Het
Or7e178 C T 9: 20,226,142 (GRCm39) E17K probably benign Het
P2rx7 G A 5: 122,819,015 (GRCm39) C479Y probably damaging Het
Pappa2 T A 1: 158,631,073 (GRCm39) probably null Het
Pgap1 A C 1: 54,551,120 (GRCm39) I520R probably benign Het
Pikfyve G A 1: 65,231,454 (GRCm39) probably null Het
Plekhg3 T C 12: 76,622,991 (GRCm39) S744P probably benign Het
Pramel6 A G 2: 87,339,526 (GRCm39) R97G probably damaging Het
Pramel6 G T 2: 87,339,527 (GRCm39) R97M probably damaging Het
Psme4 T C 11: 30,760,922 (GRCm39) V397A probably damaging Het
Ptk2b T C 14: 66,396,119 (GRCm39) D783G probably damaging Het
Ptma-ps1 T A 7: 23,763,306 (GRCm39) L17* probably null Het
Ralgapa2 C A 2: 146,229,621 (GRCm39) R1053L probably damaging Het
Sap130 C T 18: 31,813,620 (GRCm39) P559L possibly damaging Het
Sap30 T C 8: 57,940,345 (GRCm39) S86G probably damaging Het
Sdk2 C T 11: 113,729,472 (GRCm39) silent Het
Sema3f G T 9: 107,561,575 (GRCm39) Q500K probably damaging Het
Serpinb3d T C 1: 107,007,014 (GRCm39) I231M possibly damaging Het
Sf3a1 T A 11: 4,126,678 (GRCm39) N563K probably benign Het
Sipa1l3 A G 7: 29,038,592 (GRCm39) S352P possibly damaging Het
Slc6a12 G T 6: 121,324,402 (GRCm39) E9* probably null Het
Srebf1 T C 11: 60,095,319 (GRCm39) D400G probably damaging Het
Swsap1 T C 9: 21,867,988 (GRCm39) Y87H probably damaging Het
Tanc2 G A 11: 105,813,689 (GRCm39) G1711D possibly damaging Het
Tas2r107 T C 6: 131,636,951 (GRCm39) M33V probably benign Het
Tdrd9 T A 12: 112,030,061 (GRCm39) probably benign Het
Tdrp T C 8: 14,004,079 (GRCm39) D86G probably damaging Het
Tmem92 A T 11: 94,669,501 (GRCm39) M106K probably benign Het
Tmf1 A T 6: 97,138,440 (GRCm39) C764S possibly damaging Het
Ttc21a G T 9: 119,795,823 (GRCm39) R1219L possibly damaging Het
Ttn C T 2: 76,593,792 (GRCm39) G18870D probably damaging Het
Tubgcp6 T C 15: 88,984,811 (GRCm39) Y1732C probably damaging Het
Vmn1r28 A G 6: 58,242,912 (GRCm39) T252A probably benign Het
Xirp2 A G 2: 67,346,700 (GRCm39) I2980M probably damaging Het
Zc2hc1c A G 12: 85,337,288 (GRCm39) D315G probably benign Het
Other mutations in Cyp2c68
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00514:Cyp2c68 APN 19 39,700,939 (GRCm39) missense probably damaging 0.98
IGL00826:Cyp2c68 APN 19 39,727,949 (GRCm39) missense possibly damaging 0.87
IGL01363:Cyp2c68 APN 19 39,691,871 (GRCm39) missense probably benign 0.01
IGL01892:Cyp2c68 APN 19 39,722,788 (GRCm39) missense probably benign 0.00
IGL02088:Cyp2c68 APN 19 39,691,965 (GRCm39) splice site probably benign
IGL02422:Cyp2c68 APN 19 39,722,896 (GRCm39) missense probably damaging 1.00
IGL03047:Cyp2c68 UTSW 19 39,722,904 (GRCm39) missense probably benign 0.00
R0523:Cyp2c68 UTSW 19 39,727,873 (GRCm39) missense probably benign 0.08
R0729:Cyp2c68 UTSW 19 39,727,994 (GRCm39) splice site probably benign
R0975:Cyp2c68 UTSW 19 39,691,802 (GRCm39) missense possibly damaging 0.85
R1117:Cyp2c68 UTSW 19 39,700,903 (GRCm39) missense probably damaging 1.00
R1355:Cyp2c68 UTSW 19 39,729,400 (GRCm39) missense probably damaging 1.00
R1370:Cyp2c68 UTSW 19 39,729,400 (GRCm39) missense probably damaging 1.00
R1436:Cyp2c68 UTSW 19 39,729,484 (GRCm39) start codon destroyed probably null 1.00
R1564:Cyp2c68 UTSW 19 39,724,024 (GRCm39) nonsense probably null
R1730:Cyp2c68 UTSW 19 39,687,719 (GRCm39) missense possibly damaging 0.87
R1865:Cyp2c68 UTSW 19 39,722,733 (GRCm39) missense probably benign 0.04
R1951:Cyp2c68 UTSW 19 39,700,972 (GRCm39) missense probably benign 0.22
R1952:Cyp2c68 UTSW 19 39,700,972 (GRCm39) missense probably benign 0.22
R2224:Cyp2c68 UTSW 19 39,724,026 (GRCm39) missense probably benign 0.34
R2230:Cyp2c68 UTSW 19 39,687,804 (GRCm39) missense probably benign 0.07
R2231:Cyp2c68 UTSW 19 39,687,804 (GRCm39) missense probably benign 0.07
R2866:Cyp2c68 UTSW 19 39,677,589 (GRCm39) missense probably damaging 1.00
R3104:Cyp2c68 UTSW 19 39,722,757 (GRCm39) missense probably benign
R4409:Cyp2c68 UTSW 19 39,727,896 (GRCm39) missense probably damaging 0.98
R4575:Cyp2c68 UTSW 19 39,722,805 (GRCm39) missense probably benign 0.21
R4620:Cyp2c68 UTSW 19 39,701,006 (GRCm39) splice site probably null
R4684:Cyp2c68 UTSW 19 39,687,779 (GRCm39) missense possibly damaging 0.48
R5023:Cyp2c68 UTSW 19 39,700,951 (GRCm39) missense probably benign 0.01
R5410:Cyp2c68 UTSW 19 39,687,728 (GRCm39) missense possibly damaging 0.65
R5513:Cyp2c68 UTSW 19 39,691,850 (GRCm39) missense probably damaging 1.00
R5568:Cyp2c68 UTSW 19 39,677,526 (GRCm39) missense probably benign 0.19
R5706:Cyp2c68 UTSW 19 39,722,762 (GRCm39) missense possibly damaging 0.95
R5890:Cyp2c68 UTSW 19 39,700,936 (GRCm39) missense probably damaging 1.00
R5897:Cyp2c68 UTSW 19 39,700,975 (GRCm39) missense probably benign 0.01
R6007:Cyp2c68 UTSW 19 39,722,780 (GRCm39) missense probably damaging 1.00
R6132:Cyp2c68 UTSW 19 39,691,858 (GRCm39) missense possibly damaging 0.90
R6187:Cyp2c68 UTSW 19 39,729,452 (GRCm39) missense probably benign 0.32
R6229:Cyp2c68 UTSW 19 39,727,622 (GRCm39) missense probably benign 0.02
R6341:Cyp2c68 UTSW 19 39,700,933 (GRCm39) missense possibly damaging 0.54
R7209:Cyp2c68 UTSW 19 39,677,649 (GRCm39) missense probably damaging 1.00
R7330:Cyp2c68 UTSW 19 39,677,634 (GRCm39) missense probably damaging 1.00
R7374:Cyp2c68 UTSW 19 39,727,648 (GRCm39) critical splice acceptor site probably null
R7402:Cyp2c68 UTSW 19 39,729,318 (GRCm39) missense probably benign 0.02
R7483:Cyp2c68 UTSW 19 39,677,581 (GRCm39) missense probably benign 0.02
R9103:Cyp2c68 UTSW 19 39,727,625 (GRCm39) missense possibly damaging 0.95
R9204:Cyp2c68 UTSW 19 39,727,571 (GRCm39) missense probably damaging 1.00
R9452:Cyp2c68 UTSW 19 39,687,833 (GRCm39) missense possibly damaging 0.75
Z1088:Cyp2c68 UTSW 19 39,727,907 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- TGACTACCCACACTTGTAGAAG -3'
(R):5'- GTTTCCAAACTTCAGGCTCAC -3'

Sequencing Primer
(F):5'- TTCATGGATAAGCAGCTAACAGGC -3'
(R):5'- AGGCTCACCCTGTGATCC -3'
Posted On 2014-07-14