Incidental Mutation 'R1906:Or4c114'
ID 214345
Institutional Source Beutler Lab
Gene Symbol Or4c114
Ensembl Gene ENSMUSG00000075104
Gene Name olfactory receptor family 4 subfamily C member 114
Synonyms GA_x6K02T2Q125-50555603-50554668, MOR233-6, Olfr1219
MMRRC Submission 039925-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.084) question?
Stock # R1906 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 88904498-88905433 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 88905414 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 7 (V7A)
Ref Sequence ENSEMBL: ENSMUSP00000150043 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099797] [ENSMUST00000213724] [ENSMUST00000214442] [ENSMUST00000215225] [ENSMUST00000217421]
AlphaFold Q7TR04
Predicted Effect possibly damaging
Transcript: ENSMUST00000099797
AA Change: V7A

PolyPhen 2 Score 0.926 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000097385
Gene: ENSMUSG00000075104
AA Change: V7A

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 3e-46 PFAM
Pfam:7tm_1 39 286 1.5e-16 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213724
AA Change: V7A

PolyPhen 2 Score 0.926 (Sensitivity: 0.81; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000214442
AA Change: V7A

PolyPhen 2 Score 0.926 (Sensitivity: 0.81; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000215225
AA Change: V7A

PolyPhen 2 Score 0.926 (Sensitivity: 0.81; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000217421
AA Change: V7A

PolyPhen 2 Score 0.926 (Sensitivity: 0.81; Specificity: 0.94)
Coding Region Coverage
  • 1x: 97.3%
  • 3x: 96.7%
  • 10x: 94.9%
  • 20x: 91.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aass G A 6: 23,072,984 (GRCm39) T923I probably benign Het
Abhd13 T A 8: 10,038,170 (GRCm39) C256S probably benign Het
Adamts5 C T 16: 85,665,573 (GRCm39) W576* probably null Het
Adnp A T 2: 168,024,287 (GRCm39) S1003T probably benign Het
AI987944 C T 7: 41,024,550 (GRCm39) R146Q probably benign Het
Apol6 G T 15: 76,935,060 (GRCm39) V110F probably damaging Het
Arhgap27 A G 11: 103,223,751 (GRCm39) F651L probably damaging Het
Atm T C 9: 53,417,868 (GRCm39) D813G probably damaging Het
Casd1 T A 6: 4,641,979 (GRCm39) I752N probably damaging Het
Cdr2 A G 7: 120,581,224 (GRCm39) Y18H probably damaging Het
Cntn4 T C 6: 106,330,607 (GRCm39) F75S probably benign Het
Col20a1 G A 2: 180,640,490 (GRCm39) R549H probably benign Het
Col28a1 A T 6: 7,999,644 (GRCm39) N1024K probably benign Het
Dnah10 T A 5: 124,878,048 (GRCm39) V2654D probably damaging Het
Dnph1 A T 17: 46,807,787 (GRCm39) I18F probably damaging Het
Dsn1 G A 2: 156,838,163 (GRCm39) R334W probably damaging Het
Egf T A 3: 129,518,873 (GRCm39) K325N probably benign Het
Eps15 T G 4: 109,181,398 (GRCm39) S311A possibly damaging Het
Fmo3 G T 1: 162,794,475 (GRCm39) D198E probably damaging Het
Folh1 C G 7: 86,391,374 (GRCm39) probably null Het
Foxn1 A G 11: 78,262,636 (GRCm39) probably null Het
Gm10604 T G 4: 11,979,989 (GRCm39) D105A unknown Het
Gpx8 A G 13: 113,182,110 (GRCm39) C108R probably damaging Het
Herc2 A T 7: 55,764,612 (GRCm39) I1013L probably benign Het
Hyal4 T G 6: 24,756,110 (GRCm39) N109K probably damaging Het
Il22ra1 T G 4: 135,478,544 (GRCm39) C538W probably damaging Het
Ints13 A T 6: 146,453,868 (GRCm39) probably null Het
Krt75 T A 15: 101,481,801 (GRCm39) T156S possibly damaging Het
Lama2 A C 10: 26,932,523 (GRCm39) probably null Het
Lifr G T 15: 7,217,612 (GRCm39) V847L probably damaging Het
Lmf1 T A 17: 25,831,309 (GRCm39) I185N probably damaging Het
Mast1 G A 8: 85,642,895 (GRCm39) R967C probably damaging Het
Ms4a15 T C 19: 10,960,644 (GRCm39) I94V probably benign Het
Mycbpap A T 11: 94,396,447 (GRCm39) M131K probably benign Het
Ncor1 A T 11: 62,240,211 (GRCm39) M920K possibly damaging Het
Neb A G 2: 52,198,538 (GRCm39) Y437H probably damaging Het
Npy5r A T 8: 67,134,125 (GRCm39) W223R probably damaging Het
Or10ak11 G A 4: 118,687,467 (GRCm39) H56Y probably damaging Het
Or10x4 C A 1: 174,218,730 (GRCm39) L32M probably damaging Het
Or6c6c T G 10: 129,541,365 (GRCm39) V206G probably benign Het
Polg T C 7: 79,110,070 (GRCm39) K353E probably damaging Het
Proz C G 8: 13,123,686 (GRCm39) probably null Het
Pus7 T C 5: 23,983,209 (GRCm39) D86G probably damaging Het
Rhpn1 T C 15: 75,583,673 (GRCm39) V386A probably benign Het
Rigi T C 4: 40,206,054 (GRCm39) K846R probably benign Het
Sptbn4 A G 7: 27,090,856 (GRCm39) probably null Het
Srp68 A T 11: 116,141,587 (GRCm39) I424N probably damaging Het
Stard9 A G 2: 120,526,908 (GRCm39) E1055G probably benign Het
Taf4b A G 18: 14,955,159 (GRCm39) I571V probably benign Het
Tas2r107 T C 6: 131,636,951 (GRCm39) M33V probably benign Het
Thap12 T C 7: 98,365,947 (GRCm39) L705P probably damaging Het
Tom1 T C 8: 75,778,218 (GRCm39) V100A probably damaging Het
Tox3 A G 8: 90,975,057 (GRCm39) probably benign Het
Vmn2r82 A G 10: 79,232,344 (GRCm39) N781S probably damaging Het
Vwa5b1 A T 4: 138,327,547 (GRCm39) V343E possibly damaging Het
Zbbx A G 3: 74,979,047 (GRCm39) Y467H probably damaging Het
Zbtb46 G A 2: 181,065,632 (GRCm39) R173W probably damaging Het
Zfp112 A G 7: 23,821,720 (GRCm39) D20G probably benign Het
Zfp777 A C 6: 48,018,995 (GRCm39) M313R probably damaging Het
Other mutations in Or4c114
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01432:Or4c114 APN 2 88,904,545 (GRCm39) missense probably benign 0.04
R0437:Or4c114 UTSW 2 88,904,956 (GRCm39) missense probably benign 0.00
R0653:Or4c114 UTSW 2 88,904,808 (GRCm39) missense possibly damaging 0.90
R1637:Or4c114 UTSW 2 88,905,396 (GRCm39) missense probably damaging 1.00
R1837:Or4c114 UTSW 2 88,905,176 (GRCm39) nonsense probably null
R2234:Or4c114 UTSW 2 88,904,592 (GRCm39) missense probably damaging 1.00
R2351:Or4c114 UTSW 2 88,904,743 (GRCm39) missense possibly damaging 0.74
R2420:Or4c114 UTSW 2 88,905,336 (GRCm39) missense possibly damaging 0.78
R2421:Or4c114 UTSW 2 88,905,336 (GRCm39) missense possibly damaging 0.78
R3438:Or4c114 UTSW 2 88,904,707 (GRCm39) missense probably benign 0.08
R4470:Or4c114 UTSW 2 88,905,382 (GRCm39) missense probably benign 0.01
R4607:Or4c114 UTSW 2 88,904,656 (GRCm39) missense probably benign 0.08
R4608:Or4c114 UTSW 2 88,904,656 (GRCm39) missense probably benign 0.08
R4693:Or4c114 UTSW 2 88,905,412 (GRCm39) missense possibly damaging 0.69
R5382:Or4c114 UTSW 2 88,905,079 (GRCm39) missense probably damaging 1.00
R5460:Or4c114 UTSW 2 88,905,208 (GRCm39) missense probably benign 0.00
R5504:Or4c114 UTSW 2 88,905,024 (GRCm39) missense probably benign 0.00
R6053:Or4c114 UTSW 2 88,904,898 (GRCm39) missense probably damaging 1.00
R7057:Or4c114 UTSW 2 88,904,808 (GRCm39) missense possibly damaging 0.56
R7323:Or4c114 UTSW 2 88,904,811 (GRCm39) missense probably damaging 0.99
R7606:Or4c114 UTSW 2 88,905,641 (GRCm39) start gained probably benign
R8229:Or4c114 UTSW 2 88,905,382 (GRCm39) missense possibly damaging 0.88
T0722:Or4c114 UTSW 2 88,905,303 (GRCm39) missense probably benign 0.07
Z1176:Or4c114 UTSW 2 88,904,782 (GRCm39) missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- GTGACAGTAGAAGAAGTTAATGCATCC -3'
(R):5'- CAGGTTGCACAACTATTGCC -3'

Sequencing Primer
(F):5'- TAGAAGAAGTTAATGCATCCAGTAAG -3'
(R):5'- TGCACAACTATTGCCTTCAAAAATC -3'
Posted On 2014-07-14