Mutagenetix > Incidental Mutations

Incidental Mutation 'R1906:Tas2r107'

214370

Institutional Source

Beutler Lab

Gene Symbol

Tas2r107

Ensembl Gene

ENSMUSG00000053389

Gene Name

taste receptor, type 2, member 107

Synonyms

T2R4, Tas2r7, mGR06, STC 5-1, mt2r43, T2R07

MMRRC Submission

039925-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.051) question?

Stock #

R1906 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

131659118-131660149 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 131659988 bp

Zygosity

Heterozygous

Amino Acid Change

Methionine to Valine at position 33 (M33V)

Ref Sequence

ENSEMBL: ENSMUSP00000067082 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000065781]

Predicted Effect

probably benign
Transcript: ENSMUST00000065781
AA Change: M33V

PolyPhen 2 Score 0.198 (Sensitivity: 0.92; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000067082
Gene: ENSMUSG00000053389
AA Change: M33V

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	297	4e-106	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 97.3%
3x: 96.7%
10x: 94.9%
20x: 91.5%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aass	G	A	6: 23,072,985	T923I	probably benign	Het
Abhd13	T	A	8: 9,988,170	C256S	probably benign	Het
Adamts5	C	T	16: 85,868,685	W576*	probably null	Het
Adnp	A	T	2: 168,182,367	S1003T	probably benign	Het
AI987944	C	T	7: 41,375,126	R146Q	probably benign	Het
Apol6	G	T	15: 77,050,860	V110F	probably damaging	Het
Arhgap27	A	G	11: 103,332,925	F651L	probably damaging	Het
Atm	T	C	9: 53,506,568	D813G	probably damaging	Het
Casd1	T	A	6: 4,641,979	I752N	probably damaging	Het
Cdr2	A	G	7: 120,982,001	Y18H	probably damaging	Het
Cntn4	T	C	6: 106,353,646	F75S	probably benign	Het
Col20a1	G	A	2: 180,998,697	R549H	probably benign	Het
Col28a1	A	T	6: 7,999,644	N1024K	probably benign	Het
Ddx58	T	C	4: 40,206,054	K846R	probably benign	Het
Dnah10	T	A	5: 124,800,984	V2654D	probably damaging	Het
Dnph1	A	T	17: 46,496,861	I18F	probably damaging	Het
Dsn1	G	A	2: 156,996,243	R334W	probably damaging	Het
Egf	T	A	3: 129,725,224	K325N	probably benign	Het
Eps15	T	G	4: 109,324,201	S311A	possibly damaging	Het
Fmo3	G	T	1: 162,966,906	D198E	probably damaging	Het
Folh1	C	G	7: 86,742,166		probably null	Het
Foxn1	A	G	11: 78,371,810		probably null	Het
Gm10604	T	G	4: 11,979,989	D105A	unknown	Het
Gpx8	A	G	13: 113,045,576	C108R	probably damaging	Het
Herc2	A	T	7: 56,114,864	I1013L	probably benign	Het
Hyal4	T	G	6: 24,756,111	N109K	probably damaging	Het
Il22ra1	T	G	4: 135,751,233	C538W	probably damaging	Het
Ints13	A	T	6: 146,552,370		probably null	Het
Krt75	T	A	15: 101,573,366	T156S	possibly damaging	Het
Lama2	A	C	10: 27,056,527		probably null	Het
Lifr	G	T	15: 7,188,131	V847L	probably damaging	Het
Lmf1	T	A	17: 25,612,335	I185N	probably damaging	Het
Mast1	G	A	8: 84,916,266	R967C	probably damaging	Het
Ms4a15	T	C	19: 10,983,280	I94V	probably benign	Het
Mycbpap	A	T	11: 94,505,621	M131K	probably benign	Het
Ncor1	A	T	11: 62,349,385	M920K	possibly damaging	Het
Neb	A	G	2: 52,308,526	Y437H	probably damaging	Het
Npy5r	A	T	8: 66,681,473	W223R	probably damaging	Het
Olfr1219	A	G	2: 89,075,070	V7A	possibly damaging	Het
Olfr1333	G	A	4: 118,830,270	H56Y	probably damaging	Het
Olfr248	C	A	1: 174,391,164	L32M	probably damaging	Het
Olfr804	T	G	10: 129,705,496	V206G	probably benign	Het
Polg	T	C	7: 79,460,322	K353E	probably damaging	Het
Proz	C	G	8: 13,073,686		probably null	Het
Pus7	T	C	5: 23,778,211	D86G	probably damaging	Het
Rhpn1	T	C	15: 75,711,824	V386A	probably benign	Het
Sptbn4	A	G	7: 27,391,431		probably null	Het
Srp68	A	T	11: 116,250,761	I424N	probably damaging	Het
Stard9	A	G	2: 120,696,427	E1055G	probably benign	Het
Taf4b	A	G	18: 14,822,102	I571V	probably benign	Het
Thap12	T	C	7: 98,716,740	L705P	probably damaging	Het
Tom1	T	C	8: 75,051,590	V100A	probably damaging	Het
Tox3	A	G	8: 90,248,429		probably benign	Het
Vmn2r82	A	G	10: 79,396,510	N781S	probably damaging	Het
Vwa5b1	A	T	4: 138,600,236	V343E	possibly damaging	Het
Zbbx	A	G	3: 75,071,740	Y467H	probably damaging	Het
Zbtb46	G	A	2: 181,423,839	R173W	probably damaging	Het
Zfp112	A	G	7: 24,122,295	D20G	probably benign	Het
Zfp777	A	C	6: 48,042,061	M313R	probably damaging	Het

Other mutations in Tas2r107

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02749:Tas2r107	APN	6	131659954	missense	probably damaging	1.00
IGL02751:Tas2r107	APN	6	131659484	missense	probably damaging	1.00
IGL02868:Tas2r107	APN	6	131659286	missense	probably benign	0.11
IGL02943:Tas2r107	APN	6	131659406	missense	probably damaging	0.99
R1564:Tas2r107	UTSW	6	131659822	missense	probably damaging	0.96
R1905:Tas2r107	UTSW	6	131659988	missense	probably benign	0.20
R1907:Tas2r107	UTSW	6	131659988	missense	probably benign	0.20
R2185:Tas2r107	UTSW	6	131659603	missense	probably damaging	0.98
R3014:Tas2r107	UTSW	6	131660009	missense	probably benign	0.30
R3824:Tas2r107	UTSW	6	131659330	missense	probably benign	0.00
R4465:Tas2r107	UTSW	6	131660009	missense	probably benign	0.30
R5058:Tas2r107	UTSW	6	131659742	missense	probably damaging	1.00
R5646:Tas2r107	UTSW	6	131659708	missense	probably benign	0.02
R5975:Tas2r107	UTSW	6	131659780	missense	probably benign	0.02
R6008:Tas2r107	UTSW	6	131659912	missense	possibly damaging	0.82
R6144:Tas2r107	UTSW	6	131660003	missense	possibly damaging	0.87
R6451:Tas2r107	UTSW	6	131660014	missense	possibly damaging	0.81
R6662:Tas2r107	UTSW	6	131659489	missense	possibly damaging	0.82
R6702:Tas2r107	UTSW	6	131659384	missense	probably benign	0.12
R7032:Tas2r107	UTSW	6	131659190	missense	possibly damaging	0.62
R7635:Tas2r107	UTSW	6	131659600	missense	possibly damaging	0.92
R8303:Tas2r107	UTSW	6	131659622	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- GACTCTCCTTTTCAGCCAGAG -3'
(R):5'- TTCTCCATCAAGAAGCCAGTATATGG -3'

Sequencing Primer
(F):5'- TCCTTTTCAGCCAGAGAAATACAGAG -3'
(R):5'- GGGACATTCTCCAGCAGATAATTTAC -3'

Posted On

2014-07-14