Incidental Mutation 'R1906:Zfp112'
ID 214372
Institutional Source Beutler Lab
Gene Symbol Zfp112
Ensembl Gene ENSMUSG00000052675
Gene Name zinc finger protein 112
Synonyms
MMRRC Submission 039925-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.144) question?
Stock # R1906 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 23811739-23827377 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 23821720 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 20 (D20G)
Ref Sequence ENSEMBL: ENSMUSP00000113031 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000005413] [ENSMUST00000120006] [ENSMUST00000215113]
AlphaFold Q0VAW7
Predicted Effect probably benign
Transcript: ENSMUST00000005413
AA Change: D26G

PolyPhen 2 Score 0.335 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000005413
Gene: ENSMUSG00000052675
AA Change: D26G

DomainStartEndE-ValueType
KRAB 8 68 7.93e-27 SMART
low complexity region 385 397 N/A INTRINSIC
ZnF_C2H2 523 545 4.11e-2 SMART
ZnF_C2H2 551 573 3.44e-4 SMART
ZnF_C2H2 579 601 1.6e-4 SMART
ZnF_C2H2 607 629 1.5e-4 SMART
ZnF_C2H2 635 657 3.89e-3 SMART
ZnF_C2H2 663 685 1.58e-3 SMART
ZnF_C2H2 691 713 6.42e-4 SMART
ZnF_C2H2 719 741 5.99e-4 SMART
ZnF_C2H2 747 769 7.78e-3 SMART
ZnF_C2H2 775 797 3.95e-4 SMART
ZnF_C2H2 803 825 2.01e-5 SMART
ZnF_C2H2 831 853 1.36e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000120006
AA Change: D20G

PolyPhen 2 Score 0.335 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000113031
Gene: ENSMUSG00000052675
AA Change: D20G

DomainStartEndE-ValueType
KRAB 2 62 7.93e-27 SMART
low complexity region 379 391 N/A INTRINSIC
ZnF_C2H2 517 539 4.11e-2 SMART
ZnF_C2H2 545 567 3.44e-4 SMART
ZnF_C2H2 573 595 1.6e-4 SMART
ZnF_C2H2 601 623 1.5e-4 SMART
ZnF_C2H2 629 651 3.89e-3 SMART
ZnF_C2H2 657 679 1.58e-3 SMART
ZnF_C2H2 685 707 6.42e-4 SMART
ZnF_C2H2 713 735 5.99e-4 SMART
ZnF_C2H2 741 763 7.78e-3 SMART
ZnF_C2H2 769 791 3.95e-4 SMART
ZnF_C2H2 797 819 2.01e-5 SMART
ZnF_C2H2 825 847 1.36e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000215113
AA Change: D26G

PolyPhen 2 Score 0.287 (Sensitivity: 0.91; Specificity: 0.88)
Coding Region Coverage
  • 1x: 97.3%
  • 3x: 96.7%
  • 10x: 94.9%
  • 20x: 91.5%
Validation Efficiency
Allele List at MGI

All alleles(1) : Gene trapped(1)

Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aass G A 6: 23,072,984 (GRCm39) T923I probably benign Het
Abhd13 T A 8: 10,038,170 (GRCm39) C256S probably benign Het
Adamts5 C T 16: 85,665,573 (GRCm39) W576* probably null Het
Adnp A T 2: 168,024,287 (GRCm39) S1003T probably benign Het
AI987944 C T 7: 41,024,550 (GRCm39) R146Q probably benign Het
Apol6 G T 15: 76,935,060 (GRCm39) V110F probably damaging Het
Arhgap27 A G 11: 103,223,751 (GRCm39) F651L probably damaging Het
Atm T C 9: 53,417,868 (GRCm39) D813G probably damaging Het
Casd1 T A 6: 4,641,979 (GRCm39) I752N probably damaging Het
Cdr2 A G 7: 120,581,224 (GRCm39) Y18H probably damaging Het
Cntn4 T C 6: 106,330,607 (GRCm39) F75S probably benign Het
Col20a1 G A 2: 180,640,490 (GRCm39) R549H probably benign Het
Col28a1 A T 6: 7,999,644 (GRCm39) N1024K probably benign Het
Dnah10 T A 5: 124,878,048 (GRCm39) V2654D probably damaging Het
Dnph1 A T 17: 46,807,787 (GRCm39) I18F probably damaging Het
Dsn1 G A 2: 156,838,163 (GRCm39) R334W probably damaging Het
Egf T A 3: 129,518,873 (GRCm39) K325N probably benign Het
Eps15 T G 4: 109,181,398 (GRCm39) S311A possibly damaging Het
Fmo3 G T 1: 162,794,475 (GRCm39) D198E probably damaging Het
Folh1 C G 7: 86,391,374 (GRCm39) probably null Het
Foxn1 A G 11: 78,262,636 (GRCm39) probably null Het
Gm10604 T G 4: 11,979,989 (GRCm39) D105A unknown Het
Gpx8 A G 13: 113,182,110 (GRCm39) C108R probably damaging Het
Herc2 A T 7: 55,764,612 (GRCm39) I1013L probably benign Het
Hyal4 T G 6: 24,756,110 (GRCm39) N109K probably damaging Het
Il22ra1 T G 4: 135,478,544 (GRCm39) C538W probably damaging Het
Ints13 A T 6: 146,453,868 (GRCm39) probably null Het
Krt75 T A 15: 101,481,801 (GRCm39) T156S possibly damaging Het
Lama2 A C 10: 26,932,523 (GRCm39) probably null Het
Lifr G T 15: 7,217,612 (GRCm39) V847L probably damaging Het
Lmf1 T A 17: 25,831,309 (GRCm39) I185N probably damaging Het
Mast1 G A 8: 85,642,895 (GRCm39) R967C probably damaging Het
Ms4a15 T C 19: 10,960,644 (GRCm39) I94V probably benign Het
Mycbpap A T 11: 94,396,447 (GRCm39) M131K probably benign Het
Ncor1 A T 11: 62,240,211 (GRCm39) M920K possibly damaging Het
Neb A G 2: 52,198,538 (GRCm39) Y437H probably damaging Het
Npy5r A T 8: 67,134,125 (GRCm39) W223R probably damaging Het
Or10ak11 G A 4: 118,687,467 (GRCm39) H56Y probably damaging Het
Or10x4 C A 1: 174,218,730 (GRCm39) L32M probably damaging Het
Or4c114 A G 2: 88,905,414 (GRCm39) V7A possibly damaging Het
Or6c6c T G 10: 129,541,365 (GRCm39) V206G probably benign Het
Polg T C 7: 79,110,070 (GRCm39) K353E probably damaging Het
Proz C G 8: 13,123,686 (GRCm39) probably null Het
Pus7 T C 5: 23,983,209 (GRCm39) D86G probably damaging Het
Rhpn1 T C 15: 75,583,673 (GRCm39) V386A probably benign Het
Rigi T C 4: 40,206,054 (GRCm39) K846R probably benign Het
Sptbn4 A G 7: 27,090,856 (GRCm39) probably null Het
Srp68 A T 11: 116,141,587 (GRCm39) I424N probably damaging Het
Stard9 A G 2: 120,526,908 (GRCm39) E1055G probably benign Het
Taf4b A G 18: 14,955,159 (GRCm39) I571V probably benign Het
Tas2r107 T C 6: 131,636,951 (GRCm39) M33V probably benign Het
Thap12 T C 7: 98,365,947 (GRCm39) L705P probably damaging Het
Tom1 T C 8: 75,778,218 (GRCm39) V100A probably damaging Het
Tox3 A G 8: 90,975,057 (GRCm39) probably benign Het
Vmn2r82 A G 10: 79,232,344 (GRCm39) N781S probably damaging Het
Vwa5b1 A T 4: 138,327,547 (GRCm39) V343E possibly damaging Het
Zbbx A G 3: 74,979,047 (GRCm39) Y467H probably damaging Het
Zbtb46 G A 2: 181,065,632 (GRCm39) R173W probably damaging Het
Zfp777 A C 6: 48,018,995 (GRCm39) M313R probably damaging Het
Other mutations in Zfp112
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00094:Zfp112 APN 7 23,821,668 (GRCm39) missense probably damaging 1.00
IGL00575:Zfp112 APN 7 23,825,757 (GRCm39) missense probably damaging 1.00
IGL00944:Zfp112 APN 7 23,825,021 (GRCm39) missense probably benign 0.02
IGL01662:Zfp112 APN 7 23,825,379 (GRCm39) missense probably benign 0.44
IGL03383:Zfp112 APN 7 23,825,103 (GRCm39) missense probably damaging 1.00
2107:Zfp112 UTSW 7 23,826,266 (GRCm39) missense probably damaging 1.00
FR4737:Zfp112 UTSW 7 23,824,832 (GRCm39) small insertion probably benign
R0566:Zfp112 UTSW 7 23,825,102 (GRCm39) missense probably benign 0.09
R0581:Zfp112 UTSW 7 23,825,288 (GRCm39) missense probably damaging 0.97
R0613:Zfp112 UTSW 7 23,826,453 (GRCm39) missense probably benign 0.33
R1521:Zfp112 UTSW 7 23,825,210 (GRCm39) missense probably damaging 0.97
R1614:Zfp112 UTSW 7 23,826,024 (GRCm39) missense probably damaging 1.00
R1827:Zfp112 UTSW 7 23,824,385 (GRCm39) missense probably damaging 1.00
R1920:Zfp112 UTSW 7 23,824,662 (GRCm39) missense probably benign 0.01
R2008:Zfp112 UTSW 7 23,826,176 (GRCm39) missense probably damaging 1.00
R2012:Zfp112 UTSW 7 23,824,725 (GRCm39) missense possibly damaging 0.69
R2192:Zfp112 UTSW 7 23,824,863 (GRCm39) missense probably damaging 0.98
R2985:Zfp112 UTSW 7 23,821,720 (GRCm39) missense probably benign 0.34
R4191:Zfp112 UTSW 7 23,825,568 (GRCm39) missense probably benign 0.19
R4373:Zfp112 UTSW 7 23,824,473 (GRCm39) missense probably damaging 0.99
R4374:Zfp112 UTSW 7 23,825,798 (GRCm39) missense probably damaging 1.00
R4674:Zfp112 UTSW 7 23,826,399 (GRCm39) missense probably damaging 1.00
R4676:Zfp112 UTSW 7 23,825,685 (GRCm39) missense probably damaging 0.97
R5023:Zfp112 UTSW 7 23,825,909 (GRCm39) missense probably damaging 0.99
R5198:Zfp112 UTSW 7 23,824,281 (GRCm39) missense possibly damaging 0.49
R6559:Zfp112 UTSW 7 23,825,888 (GRCm39) nonsense probably null
R6835:Zfp112 UTSW 7 23,825,231 (GRCm39) missense probably damaging 1.00
R6946:Zfp112 UTSW 7 23,824,766 (GRCm39) missense probably damaging 0.98
R7263:Zfp112 UTSW 7 23,824,952 (GRCm39) missense probably benign 0.04
R7512:Zfp112 UTSW 7 23,824,604 (GRCm39) missense possibly damaging 0.73
R7533:Zfp112 UTSW 7 23,824,752 (GRCm39) missense possibly damaging 0.58
R7535:Zfp112 UTSW 7 23,826,135 (GRCm39) missense probably damaging 1.00
R8179:Zfp112 UTSW 7 23,825,063 (GRCm39) missense probably benign 0.10
R8516:Zfp112 UTSW 7 23,823,389 (GRCm39) missense probably benign
R8525:Zfp112 UTSW 7 23,825,322 (GRCm39) missense probably benign 0.38
R8701:Zfp112 UTSW 7 23,825,165 (GRCm39) missense probably damaging 1.00
R8756:Zfp112 UTSW 7 23,824,997 (GRCm39) missense probably benign 0.03
R8853:Zfp112 UTSW 7 23,823,390 (GRCm39) synonymous silent
R8994:Zfp112 UTSW 7 23,825,490 (GRCm39) missense probably benign 0.06
R9295:Zfp112 UTSW 7 23,824,805 (GRCm39) missense probably benign
R9530:Zfp112 UTSW 7 23,824,665 (GRCm39) missense probably benign 0.01
R9537:Zfp112 UTSW 7 23,826,512 (GRCm39) missense probably damaging 1.00
R9559:Zfp112 UTSW 7 23,826,108 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATGCACATGGATTTCCTTTGC -3'
(R):5'- CAGAGTTTGCCTGGAAGGAG -3'

Sequencing Primer
(F):5'- CCCTTATAGTGGATGGATCTAGC -3'
(R):5'- AGCCATGAGAACCTTCCGTG -3'
Posted On 2014-07-14