Mutagenetix > Incidental Mutation

Incidental Mutation 'R1916:Mycbp2'

214899

Institutional Source

Beutler Lab

Gene Symbol

Mycbp2

Ensembl Gene

ENSMUSG00000033004

Gene Name

MYC binding protein 2

Synonyms

C130061D10Rik, Phr1, Pam

MMRRC Submission

039934-MU

Accession Numbers

Genbank: NM_207215; MGI: 2179432

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R1916 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

103113411-103346814 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 103184883 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Arginine at position 2451 (S2451R)

Ref Sequence

ENSEMBL: ENSMUSP00000124601 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000159855] [ENSMUST00000160758]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000159855
AA Change: S2484R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000124710
Gene: ENSMUSG00000033004
AA Change: S2484R

Domain	Start	End	E-Value	Type
low complexity region	5	27	N/A	INTRINSIC
low complexity region	47	55	N/A	INTRINSIC
low complexity region	100	127	N/A	INTRINSIC
low complexity region	178	191	N/A	INTRINSIC
Pfam:RCC1_2	683	712	1.4e-10	PFAM
low complexity region	737	750	N/A	INTRINSIC
low complexity region	793	815	N/A	INTRINSIC
Pfam:RCC1_2	942	971	5.5e-10	PFAM
Pfam:RCC1	958	1006	4.8e-15	PFAM
Pfam:PHR	1235	1385	8.2e-44	PFAM
Pfam:PHR	1723	1880	1.4e-43	PFAM
low complexity region	1935	1948	N/A	INTRINSIC
low complexity region	2182	2195	N/A	INTRINSIC
Pfam:Filamin	2261	2431	7.5e-9	PFAM
Pfam:SH3_3	2472	2539	4.1e-9	PFAM
internal_repeat_3	2612	2679	1.69e-7	PROSPERO
low complexity region	2701	2710	N/A	INTRINSIC
low complexity region	2884	2917	N/A	INTRINSIC
low complexity region	2970	2984	N/A	INTRINSIC
coiled coil region	3263	3290	N/A	INTRINSIC
low complexity region	3352	3365	N/A	INTRINSIC
low complexity region	3418	3433	N/A	INTRINSIC
low complexity region	3678	3695	N/A	INTRINSIC
APC10	3810	3968	1.11e-18	SMART
low complexity region	4103	4115	N/A	INTRINSIC
low complexity region	4190	4212	N/A	INTRINSIC
Blast:BBOX	4327	4370	7e-7	BLAST
RING	4496	4546	5.35e-5	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000160758
AA Change: S2451R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000124601
Gene: ENSMUSG00000033004
AA Change: S2451R

Domain	Start	End	E-Value	Type
low complexity region	14	22	N/A	INTRINSIC
low complexity region	67	94	N/A	INTRINSIC
low complexity region	145	158	N/A	INTRINSIC
Pfam:RCC1_2	650	679	1e-10	PFAM
low complexity region	704	717	N/A	INTRINSIC
low complexity region	760	782	N/A	INTRINSIC
Pfam:RCC1_2	909	938	1.5e-9	PFAM
Pfam:RCC1	925	973	1.3e-15	PFAM
Pfam:PHR	1202	1353	1.6e-50	PFAM
Pfam:PHR	1690	1848	3.1e-58	PFAM
low complexity region	1902	1915	N/A	INTRINSIC
low complexity region	2149	2162	N/A	INTRINSIC
Pfam:Filamin	2228	2398	7.6e-9	PFAM
Pfam:SH3_3	2439	2507	2.3e-10	PFAM
internal_repeat_3	2554	2621	2e-7	PROSPERO
low complexity region	2643	2652	N/A	INTRINSIC
low complexity region	2774	2807	N/A	INTRINSIC
low complexity region	2860	2874	N/A	INTRINSIC
coiled coil region	3153	3180	N/A	INTRINSIC
low complexity region	3242	3255	N/A	INTRINSIC
low complexity region	3308	3323	N/A	INTRINSIC
low complexity region	3568	3585	N/A	INTRINSIC
APC10	3700	3858	1.11e-18	SMART
low complexity region	3993	4005	N/A	INTRINSIC
low complexity region	4080	4102	N/A	INTRINSIC
Blast:BBOX	4217	4260	7e-7	BLAST
RING	4386	4436	5.35e-5	SMART

Predicted Effect

unknown
Transcript: ENSMUST00000161278
AA Change: S109R

SMART Domains

Protein: ENSMUSP00000125189
Gene: ENSMUSG00000033004
AA Change: S109R

Domain	Start	End	E-Value	Type
Blast:IG_FLMN	2	66	1e-37	BLAST
SCOP:d1qfha1	14	64	2e-7	SMART
Pfam:SH3_3	98	165	5.8e-10	PFAM
internal_repeat_1	213	280	8.77e-8	PROSPERO
low complexity region	302	311	N/A	INTRINSIC
low complexity region	485	518	N/A	INTRINSIC
low complexity region	571	585	N/A	INTRINSIC

Meta Mutation Damage Score

0.6393

Coding Region Coverage

1x: 97.3%
3x: 96.7%
10x: 94.9%
20x: 91.5%

Validation Efficiency

99% (97/98)

MGI Phenotype

PHENOTYPE: Mice homozygous for a targeted allele exhibit neonatal lethality, defective diaphragm innervation, abnormal brain morphology and defective axonal guidance. [provided by MGI curators]

Allele List at MGI

All alleles(10) : Targeted, knock-out(1) Targeted, other(1) Gene trapped(5) Chemically induced(3)

Other mutations in this stock

Total: 88 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3632451O06Rik	T	C	14: 49,768,475 (GRCm38)	T588A	probably damaging	Het
Abca13	G	T	11: 9,534,456 (GRCm38)	W4342L	probably damaging	Het
Abcg8	A	T	17: 84,688,530 (GRCm38)		probably null	Het
Acaa1b	A	G	9: 119,156,662 (GRCm38)	L65P	probably damaging	Het
Adam6a	G	T	12: 113,545,936 (GRCm38)	R643L	probably benign	Het
Agbl2	A	T	2: 90,815,441 (GRCm38)	R839S	possibly damaging	Het
Ambra1	A	T	2: 91,911,461 (GRCm38)	N967I	probably damaging	Het
Ankrd17	T	A	5: 90,260,141 (GRCm38)	N1406Y	probably damaging	Het
Bbx	G	T	16: 50,266,245 (GRCm38)	S96Y	probably damaging	Het
Casc1	A	C	6: 145,176,200 (GRCm38)	V631G	probably benign	Het
Cdh12	T	A	15: 21,520,250 (GRCm38)		probably null	Het
Cdh9	A	C	15: 16,823,275 (GRCm38)	R114S	probably benign	Het
Cenpo	T	G	12: 4,216,683 (GRCm38)	I142L	probably benign	Het
Cfap69	T	C	5: 5,663,970 (GRCm38)	K21E	probably damaging	Het
Chmp4c	A	T	3: 10,389,936 (GRCm38)	D221V	probably benign	Het
Cstf3	T	A	2: 104,655,756 (GRCm38)	V447D	possibly damaging	Het
Cwc22	A	T	2: 77,905,475 (GRCm38)	C566S	probably benign	Het
Dgkh	A	G	14: 78,595,223 (GRCm38)	M798T	probably damaging	Het
Dnaic2	T	C	11: 114,732,923 (GRCm38)	V4A	possibly damaging	Het
Dnmbp	T	G	19: 43,901,568 (GRCm38)	I587L	possibly damaging	Het
Dock6	A	T	9: 21,813,091 (GRCm38)	M301K	probably damaging	Het
Dock8	T	C	19: 25,061,157 (GRCm38)	M69T	probably benign	Het
Ears2	T	C	7: 122,044,578 (GRCm38)	S386G	probably benign	Het
Ecsit	T	C	9: 22,072,521 (GRCm38)	I371V	probably benign	Het
Eif4a3	T	C	11: 119,293,911 (GRCm38)	I216V	probably benign	Het
Emp1	A	G	6: 135,380,130 (GRCm38)	I69V	probably damaging	Het
Epg5	A	G	18: 77,965,021 (GRCm38)	D788G	probably benign	Het
Eps15	A	G	4: 109,368,974 (GRCm38)	K324E	probably damaging	Het
Extl3	A	G	14: 65,077,622 (GRCm38)	F37S	probably benign	Het
Fam83g	A	G	11: 61,695,168 (GRCm38)	D194G	probably damaging	Het
Gcc2	A	G	10: 58,276,663 (GRCm38)	D1005G	probably damaging	Het
Gm10226	T	A	17: 21,692,009 (GRCm38)	H50Q	possibly damaging	Het
Gm1110	A	T	9: 26,889,638 (GRCm38)	V420E	probably damaging	Het
Gm16503	A	G	4: 147,541,210 (GRCm38)	R54G	unknown	Het
Gm5538	A	G	3: 59,745,503 (GRCm38)	K121R	possibly damaging	Het
Grasp	T	C	15: 101,226,969 (GRCm38)		probably benign	Het
Grin3b	T	C	10: 79,974,598 (GRCm38)	M646T	probably damaging	Het
Grm8	T	C	6: 27,363,584 (GRCm38)	D644G	probably benign	Het
Gtf2i	C	A	5: 134,246,848 (GRCm38)	V660F	probably damaging	Het
Heatr4	G	T	12: 83,955,817 (GRCm38)	Q808K	probably benign	Het
Hif3a	T	C	7: 17,039,656 (GRCm38)	S573G	possibly damaging	Het
Htr2b	C	T	1: 86,099,801 (GRCm38)	V328M	probably damaging	Het
Jph1	T	C	1: 17,092,055 (GRCm38)	T128A	probably damaging	Het
Kcnt1	T	C	2: 25,900,469 (GRCm38)	V481A	probably damaging	Het
Khk	A	G	5: 30,930,618 (GRCm38)	Y212C	probably damaging	Het
Lgi2	T	A	5: 52,546,632 (GRCm38)	Q219L	probably benign	Het
Lipf	T	A	19: 33,965,675 (GRCm38)	Y128N	probably benign	Het
Lipg	A	G	18: 74,960,937 (GRCm38)	V13A	probably benign	Het
Lrrc8e	T	C	8: 4,235,202 (GRCm38)	S476P	probably benign	Het
Map2k7	T	G	8: 4,245,795 (GRCm38)	V425G	probably benign	Het
Mylk3	A	G	8: 85,327,192 (GRCm38)	S629P	probably damaging	Het
Nrp2	A	T	1: 62,762,747 (GRCm38)	I450F	probably damaging	Het
Olfr1261	T	C	2: 89,993,804 (GRCm38)	V137A	probably benign	Het
Olfr150	A	G	9: 39,737,622 (GRCm38)	D269G	probably benign	Het
Osbpl11	T	C	16: 33,185,843 (GRCm38)	S14P	probably benign	Het
Osbpl11	T	A	16: 33,210,095 (GRCm38)	V231D	possibly damaging	Het
Parg	T	A	14: 32,208,227 (GRCm38)		probably benign	Het
Pax9	G	T	12: 56,697,138 (GRCm38)	R190L	possibly damaging	Het
Prss12	G	A	3: 123,506,495 (GRCm38)	V752I	probably benign	Het
Pstpip2	A	G	18: 77,835,192 (GRCm38)	N34S	probably damaging	Het
Rarg	T	C	15: 102,252,445 (GRCm38)	D53G	probably benign	Het
Rbak	T	C	5: 143,176,116 (GRCm38)	K53R	probably damaging	Het
Scgn	A	T	13: 23,978,825 (GRCm38)	S107R	probably damaging	Het
Sema3c	A	G	5: 17,727,401 (GRCm38)	Q634R	probably benign	Het
Serpinh1	A	G	7: 99,349,081 (GRCm38)	L114P	probably damaging	Het
Slc35f4	T	C	14: 49,303,923 (GRCm38)		probably benign	Het
Sned1	A	T	1: 93,274,162 (GRCm38)	I617F	probably null	Het
Spata31	C	T	13: 64,922,545 (GRCm38)	R836*	probably null	Het
Spen	A	G	4: 141,472,598 (GRCm38)	L2883P	probably damaging	Het
Stmn3	A	T	2: 181,307,280 (GRCm38)	M140K	possibly damaging	Het
Syn3	A	G	10: 86,354,344 (GRCm38)		probably null	Het
Tor4a	A	G	2: 25,195,402 (GRCm38)	V163A	possibly damaging	Het
Ttc12	A	G	9: 49,460,398 (GRCm38)	Y189H	probably damaging	Het
Ubxn7	T	G	16: 32,381,759 (GRCm38)		probably benign	Het
Unc5b	G	A	10: 60,778,248 (GRCm38)	T274I	probably damaging	Het
Upk1b	C	A	16: 38,776,186 (GRCm38)		probably null	Het
Usp18	A	G	6: 121,268,554 (GRCm38)	I296M	probably benign	Het
Usp42	A	G	5: 143,715,056 (GRCm38)	Y1071H	probably damaging	Het
Vil1	A	G	1: 74,418,525 (GRCm38)	T106A	probably benign	Het
Vmn1r42	T	A	6: 89,844,967 (GRCm38)	I207F	probably benign	Het
Vmn1r63	A	G	7: 5,803,226 (GRCm38)	F136L	probably damaging	Het
Vopp1	C	T	6: 57,754,587 (GRCm38)	V140I	probably benign	Het
Wdhd1	T	C	14: 47,258,577 (GRCm38)	D610G	possibly damaging	Het
Wdr48	T	A	9: 119,912,417 (GRCm38)	D142E	probably benign	Het
Whrn	A	G	4: 63,494,732 (GRCm38)	Y10H	probably damaging	Het
Zmat3	A	G	3: 32,343,348 (GRCm38)	V216A	probably benign	Het
Zmym2	C	T	14: 56,959,842 (GRCm38)	R1356W	probably damaging	Het
Zyg11b	A	T	4: 108,272,283 (GRCm38)	L44Q	probably damaging	Het

Other mutations in Mycbp2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00094:Mycbp2	APN	14	103,223,050 (GRCm38)	missense	probably damaging	1.00
IGL00518:Mycbp2	APN	14	103,155,808 (GRCm38)	missense	probably damaging	1.00
IGL00650:Mycbp2	APN	14	103,143,228 (GRCm38)	missense	probably damaging	0.97
IGL00653:Mycbp2	APN	14	103,143,228 (GRCm38)	missense	probably damaging	0.97
IGL00742:Mycbp2	APN	14	103,201,352 (GRCm38)	missense	probably damaging	1.00
IGL00755:Mycbp2	APN	14	103,194,621 (GRCm38)	missense	possibly damaging	0.72
IGL00793:Mycbp2	APN	14	103,126,753 (GRCm38)	missense	possibly damaging	0.77
IGL00916:Mycbp2	APN	14	103,291,283 (GRCm38)	splice site	probably benign
IGL00960:Mycbp2	APN	14	103,229,384 (GRCm38)	missense	possibly damaging	0.95
IGL00977:Mycbp2	APN	14	103,172,642 (GRCm38)	missense	probably damaging	0.98
IGL01349:Mycbp2	APN	14	103,122,547 (GRCm38)	missense	probably damaging	0.98
IGL01369:Mycbp2	APN	14	103,155,510 (GRCm38)	missense	possibly damaging	0.61
IGL01410:Mycbp2	APN	14	103,229,492 (GRCm38)	splice site	probably null
IGL01586:Mycbp2	APN	14	103,140,869 (GRCm38)	critical splice donor site	probably null
IGL01593:Mycbp2	APN	14	103,291,287 (GRCm38)	critical splice donor site	probably null
IGL01693:Mycbp2	APN	14	103,127,979 (GRCm38)	missense	probably damaging	0.99
IGL01730:Mycbp2	APN	14	103,135,204 (GRCm38)	nonsense	probably null
IGL01820:Mycbp2	APN	14	103,188,501 (GRCm38)	missense	probably damaging	1.00
IGL01974:Mycbp2	APN	14	103,143,211 (GRCm38)	missense	possibly damaging	0.88
IGL02071:Mycbp2	APN	14	103,154,907 (GRCm38)	nonsense	probably null
IGL02178:Mycbp2	APN	14	103,224,366 (GRCm38)	missense	probably benign	0.01
IGL02324:Mycbp2	APN	14	103,242,207 (GRCm38)	missense	probably damaging	1.00
IGL02442:Mycbp2	APN	14	103,314,375 (GRCm38)	missense	probably benign
IGL02607:Mycbp2	APN	14	103,285,273 (GRCm38)	missense	probably damaging	1.00
IGL02679:Mycbp2	APN	14	103,205,185 (GRCm38)	missense	probably benign
IGL02702:Mycbp2	APN	14	103,220,124 (GRCm38)	missense	probably benign	0.01
IGL02709:Mycbp2	APN	14	103,155,261 (GRCm38)	missense	probably damaging	0.97
IGL02736:Mycbp2	APN	14	103,114,242 (GRCm38)	splice site	probably benign
IGL02866:Mycbp2	APN	14	103,129,992 (GRCm38)	missense	probably damaging	0.98
IGL02939:Mycbp2	APN	14	103,177,279 (GRCm38)	missense	probably benign
IGL03082:Mycbp2	APN	14	103,204,369 (GRCm38)	missense	probably benign	0.23
IGL03142:Mycbp2	APN	14	103,298,776 (GRCm38)	missense	probably damaging	0.99
IGL03155:Mycbp2	APN	14	103,155,453 (GRCm38)	missense	probably benign	0.06
IGL03236:Mycbp2	APN	14	103,298,698 (GRCm38)	missense	probably damaging	0.99
IGL03256:Mycbp2	APN	14	103,188,589 (GRCm38)	missense	possibly damaging	0.92
IGL03303:Mycbp2	APN	14	103,247,758 (GRCm38)	missense	probably damaging	1.00
compost	UTSW	14	103,156,453 (GRCm38)	missense	probably damaging	1.00
decompose	UTSW	14	103,219,979 (GRCm38)	missense	probably benign	0.12
moulder	UTSW	14	103,188,592 (GRCm38)	missense	probably damaging	1.00
N/A - 293:Mycbp2	UTSW	14	103,224,462 (GRCm38)	splice site	probably benign
R0040:Mycbp2	UTSW	14	103,224,272 (GRCm38)	missense	probably benign	0.11
R0040:Mycbp2	UTSW	14	103,224,272 (GRCm38)	missense	probably benign	0.11
R0057:Mycbp2	UTSW	14	103,152,142 (GRCm38)	missense	probably damaging	0.97
R0063:Mycbp2	UTSW	14	103,156,634 (GRCm38)	unclassified	probably benign
R0097:Mycbp2	UTSW	14	103,155,762 (GRCm38)	missense	probably damaging	1.00
R0097:Mycbp2	UTSW	14	103,155,762 (GRCm38)	missense	probably damaging	1.00
R0268:Mycbp2	UTSW	14	103,314,325 (GRCm38)	nonsense	probably null
R0388:Mycbp2	UTSW	14	103,156,667 (GRCm38)	missense	probably benign	0.01
R0410:Mycbp2	UTSW	14	103,135,133 (GRCm38)	missense	probably damaging	1.00
R0530:Mycbp2	UTSW	14	103,182,459 (GRCm38)	missense	probably damaging	1.00
R0591:Mycbp2	UTSW	14	103,196,391 (GRCm38)	unclassified	probably benign
R0671:Mycbp2	UTSW	14	103,194,588 (GRCm38)	missense	possibly damaging	0.95
R0755:Mycbp2	UTSW	14	103,174,794 (GRCm38)	missense	probably damaging	1.00
R0817:Mycbp2	UTSW	14	103,229,418 (GRCm38)	missense	probably damaging	0.99
R0818:Mycbp2	UTSW	14	103,229,418 (GRCm38)	missense	probably damaging	0.99
R0819:Mycbp2	UTSW	14	103,229,418 (GRCm38)	missense	probably damaging	0.99
R0881:Mycbp2	UTSW	14	103,220,013 (GRCm38)	missense	probably benign
R0903:Mycbp2	UTSW	14	103,275,857 (GRCm38)	missense	probably damaging	0.99
R0940:Mycbp2	UTSW	14	103,262,693 (GRCm38)	unclassified	probably benign
R0961:Mycbp2	UTSW	14	103,184,835 (GRCm38)	missense	probably damaging	1.00
R1004:Mycbp2	UTSW	14	103,140,917 (GRCm38)	missense	probably benign	0.00
R1138:Mycbp2	UTSW	14	103,174,826 (GRCm38)	missense	possibly damaging	0.84
R1170:Mycbp2	UTSW	14	103,200,152 (GRCm38)	nonsense	probably null
R1211:Mycbp2	UTSW	14	103,120,563 (GRCm38)	missense	probably benign	0.31
R1268:Mycbp2	UTSW	14	103,208,782 (GRCm38)	missense	probably damaging	1.00
R1298:Mycbp2	UTSW	14	103,155,898 (GRCm38)	missense	probably damaging	1.00
R1341:Mycbp2	UTSW	14	103,298,867 (GRCm38)	splice site	probably benign
R1469:Mycbp2	UTSW	14	103,188,520 (GRCm38)	missense	probably damaging	0.99
R1469:Mycbp2	UTSW	14	103,188,520 (GRCm38)	missense	probably damaging	0.99
R1513:Mycbp2	UTSW	14	103,204,389 (GRCm38)	missense	probably damaging	1.00
R1528:Mycbp2	UTSW	14	103,232,597 (GRCm38)	missense	possibly damaging	0.91
R1564:Mycbp2	UTSW	14	103,169,851 (GRCm38)	splice site	probably null
R1565:Mycbp2	UTSW	14	103,252,509 (GRCm38)	missense	possibly damaging	0.82
R1656:Mycbp2	UTSW	14	103,247,758 (GRCm38)	missense	probably damaging	1.00
R1694:Mycbp2	UTSW	14	103,227,511 (GRCm38)	missense	probably damaging	1.00
R1709:Mycbp2	UTSW	14	103,224,416 (GRCm38)	missense	probably damaging	1.00
R1728:Mycbp2	UTSW	14	103,155,178 (GRCm38)	missense	probably damaging	0.98
R1751:Mycbp2	UTSW	14	103,248,405 (GRCm38)	missense	probably damaging	0.98
R1767:Mycbp2	UTSW	14	103,248,405 (GRCm38)	missense	probably damaging	0.98
R1772:Mycbp2	UTSW	14	103,182,419 (GRCm38)	missense	probably damaging	1.00
R1784:Mycbp2	UTSW	14	103,155,178 (GRCm38)	missense	probably damaging	0.98
R1823:Mycbp2	UTSW	14	103,252,509 (GRCm38)	missense	possibly damaging	0.82
R1824:Mycbp2	UTSW	14	103,252,509 (GRCm38)	missense	possibly damaging	0.82
R1844:Mycbp2	UTSW	14	103,155,714 (GRCm38)	missense	possibly damaging	0.94
R1944:Mycbp2	UTSW	14	103,229,404 (GRCm38)	missense	probably damaging	1.00
R1983:Mycbp2	UTSW	14	103,145,971 (GRCm38)	missense	probably damaging	0.97
R2002:Mycbp2	UTSW	14	103,248,403 (GRCm38)	missense	probably damaging	0.98
R2031:Mycbp2	UTSW	14	103,188,592 (GRCm38)	missense	probably damaging	1.00
R2035:Mycbp2	UTSW	14	103,260,239 (GRCm38)	missense	probably damaging	1.00
R2048:Mycbp2	UTSW	14	103,232,524 (GRCm38)	critical splice donor site	probably null
R2061:Mycbp2	UTSW	14	103,287,260 (GRCm38)	missense	probably damaging	0.99
R2113:Mycbp2	UTSW	14	103,220,076 (GRCm38)	missense	probably damaging	0.99
R2128:Mycbp2	UTSW	14	103,201,230 (GRCm38)	missense	probably benign	0.01
R2134:Mycbp2	UTSW	14	103,208,893 (GRCm38)	missense	probably damaging	1.00
R2135:Mycbp2	UTSW	14	103,208,893 (GRCm38)	missense	probably damaging	1.00
R2135:Mycbp2	UTSW	14	103,145,942 (GRCm38)	missense	probably benign
R2146:Mycbp2	UTSW	14	103,155,922 (GRCm38)	missense	probably damaging	0.97
R2147:Mycbp2	UTSW	14	103,155,922 (GRCm38)	missense	probably damaging	0.97
R2148:Mycbp2	UTSW	14	103,155,922 (GRCm38)	missense	probably damaging	0.97
R2150:Mycbp2	UTSW	14	103,155,922 (GRCm38)	missense	probably damaging	0.97
R2163:Mycbp2	UTSW	14	103,169,855 (GRCm38)	critical splice donor site	probably null
R2248:Mycbp2	UTSW	14	103,169,859 (GRCm38)	missense	possibly damaging	0.50
R2265:Mycbp2	UTSW	14	103,262,749 (GRCm38)	missense	probably benign	0.39
R2272:Mycbp2	UTSW	14	103,144,338 (GRCm38)	missense	probably null	0.66
R2379:Mycbp2	UTSW	14	103,174,950 (GRCm38)	missense	probably benign
R2495:Mycbp2	UTSW	14	103,200,118 (GRCm38)	missense	probably damaging	0.99
R2508:Mycbp2	UTSW	14	103,131,245 (GRCm38)	missense	probably damaging	0.99
R2510:Mycbp2	UTSW	14	103,155,255 (GRCm38)	missense	probably damaging	0.96
R2851:Mycbp2	UTSW	14	103,144,333 (GRCm38)	missense	probably damaging	0.99
R2852:Mycbp2	UTSW	14	103,144,333 (GRCm38)	missense	probably damaging	0.99
R2965:Mycbp2	UTSW	14	103,297,358 (GRCm38)	missense	probably benign	0.00
R3156:Mycbp2	UTSW	14	103,208,743 (GRCm38)	splice site	probably benign
R3404:Mycbp2	UTSW	14	103,200,114 (GRCm38)	missense	probably damaging	0.99
R3410:Mycbp2	UTSW	14	103,135,117 (GRCm38)	missense	probably damaging	1.00
R3429:Mycbp2	UTSW	14	103,229,430 (GRCm38)	missense	probably damaging	1.00
R3706:Mycbp2	UTSW	14	103,156,414 (GRCm38)	missense	probably benign	0.31
R3772:Mycbp2	UTSW	14	103,133,788 (GRCm38)	missense	possibly damaging	0.82
R3778:Mycbp2	UTSW	14	103,197,285 (GRCm38)	missense	probably damaging	0.99
R3883:Mycbp2	UTSW	14	103,295,250 (GRCm38)	missense	probably damaging	0.97
R3884:Mycbp2	UTSW	14	103,295,250 (GRCm38)	missense	probably damaging	0.97
R3887:Mycbp2	UTSW	14	103,174,797 (GRCm38)	missense	probably damaging	0.98
R3923:Mycbp2	UTSW	14	103,126,713 (GRCm38)	missense	probably damaging	1.00
R3926:Mycbp2	UTSW	14	103,204,500 (GRCm38)	missense	probably damaging	1.00
R3959:Mycbp2	UTSW	14	103,295,252 (GRCm38)	missense	probably benign	0.00
R3966:Mycbp2	UTSW	14	103,138,725 (GRCm38)	splice site	probably benign
R4021:Mycbp2	UTSW	14	103,152,157 (GRCm38)	missense	probably damaging	0.97
R4363:Mycbp2	UTSW	14	103,248,457 (GRCm38)	missense	probably damaging	1.00
R4405:Mycbp2	UTSW	14	103,123,445 (GRCm38)	missense	probably damaging	1.00
R4407:Mycbp2	UTSW	14	103,287,228 (GRCm38)	missense	probably damaging	1.00
R4410:Mycbp2	UTSW	14	103,135,266 (GRCm38)	missense	probably damaging	1.00
R4434:Mycbp2	UTSW	14	103,133,789 (GRCm38)	missense	probably damaging	0.99
R4448:Mycbp2	UTSW	14	103,188,502 (GRCm38)	missense	possibly damaging	0.89
R4452:Mycbp2	UTSW	14	103,155,658 (GRCm38)	missense	probably damaging	0.99
R4573:Mycbp2	UTSW	14	103,346,297 (GRCm38)	missense	probably benign	0.05
R4589:Mycbp2	UTSW	14	103,177,313 (GRCm38)	missense	probably benign	0.04
R4621:Mycbp2	UTSW	14	103,219,979 (GRCm38)	missense	probably benign	0.12
R4622:Mycbp2	UTSW	14	103,219,979 (GRCm38)	missense	probably benign	0.12
R4729:Mycbp2	UTSW	14	103,188,591 (GRCm38)	missense	probably damaging	1.00
R4770:Mycbp2	UTSW	14	103,219,944 (GRCm38)	missense	probably benign	0.41
R4790:Mycbp2	UTSW	14	103,229,437 (GRCm38)	missense	probably damaging	1.00
R4884:Mycbp2	UTSW	14	103,211,295 (GRCm38)	missense	probably damaging	1.00
R4885:Mycbp2	UTSW	14	103,145,946 (GRCm38)	missense	possibly damaging	0.86
R4956:Mycbp2	UTSW	14	103,287,239 (GRCm38)	missense	probably damaging	0.99
R4980:Mycbp2	UTSW	14	103,260,385 (GRCm38)	splice site	probably null
R4994:Mycbp2	UTSW	14	103,169,994 (GRCm38)	missense	probably benign
R5029:Mycbp2	UTSW	14	103,156,510 (GRCm38)	missense	probably benign	0.21
R5038:Mycbp2	UTSW	14	103,296,939 (GRCm38)	missense	probably damaging	1.00
R5044:Mycbp2	UTSW	14	103,139,235 (GRCm38)	critical splice donor site	probably null
R5231:Mycbp2	UTSW	14	103,346,214 (GRCm38)	critical splice donor site	probably null
R5305:Mycbp2	UTSW	14	103,346,321 (GRCm38)	missense	probably benign	0.00
R5322:Mycbp2	UTSW	14	103,185,683 (GRCm38)	critical splice acceptor site	probably null
R5376:Mycbp2	UTSW	14	103,242,432 (GRCm38)	nonsense	probably null
R5414:Mycbp2	UTSW	14	103,306,261 (GRCm38)	missense	probably damaging	1.00
R5453:Mycbp2	UTSW	14	103,201,401 (GRCm38)	missense	probably damaging	0.99
R5462:Mycbp2	UTSW	14	103,200,126 (GRCm38)	missense	probably damaging	1.00
R5499:Mycbp2	UTSW	14	103,242,179 (GRCm38)	missense	probably damaging	1.00
R5502:Mycbp2	UTSW	14	103,173,814 (GRCm38)	missense	probably damaging	1.00
R5524:Mycbp2	UTSW	14	103,295,237 (GRCm38)	missense	probably damaging	1.00
R5533:Mycbp2	UTSW	14	103,282,645 (GRCm38)	nonsense	probably null
R5569:Mycbp2	UTSW	14	103,135,243 (GRCm38)	missense	probably damaging	1.00
R5574:Mycbp2	UTSW	14	103,142,767 (GRCm38)	missense	possibly damaging	0.94
R5579:Mycbp2	UTSW	14	103,291,333 (GRCm38)	missense	probably damaging	0.98
R5590:Mycbp2	UTSW	14	103,123,355 (GRCm38)	missense	probably damaging	1.00
R5592:Mycbp2	UTSW	14	103,194,677 (GRCm38)	missense	probably benign	0.02
R5643:Mycbp2	UTSW	14	103,287,334 (GRCm38)	missense	probably damaging	1.00
R5644:Mycbp2	UTSW	14	103,287,334 (GRCm38)	missense	probably damaging	1.00
R5645:Mycbp2	UTSW	14	103,188,615 (GRCm38)	critical splice acceptor site	probably null
R5645:Mycbp2	UTSW	14	103,188,608 (GRCm38)	missense	probably damaging	1.00
R5646:Mycbp2	UTSW	14	103,169,910 (GRCm38)	missense	probably benign	0.09
R5648:Mycbp2	UTSW	14	103,291,342 (GRCm38)	missense	probably damaging	1.00
R5651:Mycbp2	UTSW	14	103,282,665 (GRCm38)	missense	probably null	0.99
R5668:Mycbp2	UTSW	14	103,120,519 (GRCm38)	missense	possibly damaging	0.62
R5745:Mycbp2	UTSW	14	103,156,453 (GRCm38)	missense	possibly damaging	0.94
R5751:Mycbp2	UTSW	14	103,148,550 (GRCm38)	missense	probably damaging	0.99
R5756:Mycbp2	UTSW	14	103,133,974 (GRCm38)	missense	probably damaging	0.99
R5837:Mycbp2	UTSW	14	103,124,403 (GRCm38)	missense	probably damaging	1.00
R5984:Mycbp2	UTSW	14	103,126,684 (GRCm38)	missense	probably damaging	0.98
R6005:Mycbp2	UTSW	14	103,156,723 (GRCm38)	missense	probably benign
R6063:Mycbp2	UTSW	14	103,135,146 (GRCm38)	missense	probably damaging	1.00
R6091:Mycbp2	UTSW	14	103,223,046 (GRCm38)	missense	probably damaging	1.00
R6120:Mycbp2	UTSW	14	103,275,887 (GRCm38)	missense	probably benign	0.01
R6129:Mycbp2	UTSW	14	103,285,400 (GRCm38)	missense	probably benign	0.21
R6147:Mycbp2	UTSW	14	103,155,509 (GRCm38)	nonsense	probably null
R6161:Mycbp2	UTSW	14	103,298,747 (GRCm38)	missense	probably damaging	1.00
R6187:Mycbp2	UTSW	14	103,147,017 (GRCm38)	missense	probably damaging	1.00
R6208:Mycbp2	UTSW	14	103,295,228 (GRCm38)	missense	probably benign	0.11
R6228:Mycbp2	UTSW	14	103,260,229 (GRCm38)	missense	probably benign	0.24
R6301:Mycbp2	UTSW	14	103,155,426 (GRCm38)	missense	probably damaging	1.00
R6311:Mycbp2	UTSW	14	103,262,740 (GRCm38)	missense	possibly damaging	0.93
R6329:Mycbp2	UTSW	14	103,155,852 (GRCm38)	missense	probably benign	0.00
R6439:Mycbp2	UTSW	14	103,155,475 (GRCm38)	missense	probably benign	0.00
R6462:Mycbp2	UTSW	14	103,136,557 (GRCm38)	critical splice donor site	probably null
R6528:Mycbp2	UTSW	14	103,142,881 (GRCm38)	missense	probably damaging	0.99
R6736:Mycbp2	UTSW	14	103,191,567 (GRCm38)	missense	probably null	1.00
R6821:Mycbp2	UTSW	14	103,139,409 (GRCm38)	missense	probably damaging	1.00
R6851:Mycbp2	UTSW	14	103,260,194 (GRCm38)	critical splice donor site	probably null
R6948:Mycbp2	UTSW	14	103,285,267 (GRCm38)	missense	possibly damaging	0.94
R6977:Mycbp2	UTSW	14	103,154,906 (GRCm38)	missense	probably damaging	0.99
R6985:Mycbp2	UTSW	14	103,206,681 (GRCm38)	missense	possibly damaging	0.79
R7035:Mycbp2	UTSW	14	103,174,981 (GRCm38)	missense	probably benign
R7054:Mycbp2	UTSW	14	103,156,098 (GRCm38)	missense	possibly damaging	0.90
R7108:Mycbp2	UTSW	14	103,122,603 (GRCm38)	missense	probably damaging	1.00
R7117:Mycbp2	UTSW	14	103,154,077 (GRCm38)	missense	probably benign	0.21
R7137:Mycbp2	UTSW	14	103,282,679 (GRCm38)	missense	possibly damaging	0.94
R7169:Mycbp2	UTSW	14	103,260,200 (GRCm38)	missense	possibly damaging	0.78
R7218:Mycbp2	UTSW	14	103,133,846 (GRCm38)	missense	probably benign
R7234:Mycbp2	UTSW	14	103,215,337 (GRCm38)	missense	probably damaging	0.98
R7238:Mycbp2	UTSW	14	103,156,297 (GRCm38)	missense	probably damaging	1.00
R7244:Mycbp2	UTSW	14	103,208,909 (GRCm38)	missense	probably damaging	0.98
R7265:Mycbp2	UTSW	14	103,197,243 (GRCm38)	critical splice donor site	probably null
R7286:Mycbp2	UTSW	14	103,120,591 (GRCm38)	missense	probably damaging	1.00
R7332:Mycbp2	UTSW	14	103,197,357 (GRCm38)	missense	probably damaging	0.97
R7332:Mycbp2	UTSW	14	103,156,453 (GRCm38)	missense	probably damaging	1.00
R7384:Mycbp2	UTSW	14	103,276,393 (GRCm38)	missense	probably damaging	0.99
R7392:Mycbp2	UTSW	14	103,243,128 (GRCm38)	missense	probably damaging	0.99
R7392:Mycbp2	UTSW	14	103,152,191 (GRCm38)	missense	probably damaging	1.00
R7409:Mycbp2	UTSW	14	103,288,744 (GRCm38)	missense	probably damaging	1.00
R7486:Mycbp2	UTSW	14	103,197,254 (GRCm38)	missense	probably damaging	0.97
R7643:Mycbp2	UTSW	14	103,346,265 (GRCm38)	missense	probably benign
R7661:Mycbp2	UTSW	14	103,212,623 (GRCm38)	missense	probably damaging	1.00
R7663:Mycbp2	UTSW	14	103,191,609 (GRCm38)	missense	probably damaging	0.99
R7730:Mycbp2	UTSW	14	103,123,355 (GRCm38)	missense	probably damaging	0.99
R7757:Mycbp2	UTSW	14	103,191,619 (GRCm38)	missense	probably damaging	1.00
R7773:Mycbp2	UTSW	14	103,248,404 (GRCm38)	missense	probably damaging	0.97
R7787:Mycbp2	UTSW	14	103,127,097 (GRCm38)	missense	probably damaging	1.00
R7822:Mycbp2	UTSW	14	103,139,415 (GRCm38)	missense	probably benign	0.00
R7838:Mycbp2	UTSW	14	103,177,293 (GRCm38)	missense	probably benign	0.10
R7841:Mycbp2	UTSW	14	103,146,831 (GRCm38)	critical splice donor site	probably null
R7858:Mycbp2	UTSW	14	103,156,305 (GRCm38)	missense	probably damaging	1.00
R7873:Mycbp2	UTSW	14	103,156,146 (GRCm38)	missense	probably damaging	1.00
R7911:Mycbp2	UTSW	14	103,200,185 (GRCm38)	missense	probably damaging	0.99
R7942:Mycbp2	UTSW	14	103,155,238 (GRCm38)	missense	probably damaging	0.99
R7951:Mycbp2	UTSW	14	103,215,462 (GRCm38)	missense	probably damaging	0.99
R7958:Mycbp2	UTSW	14	103,129,964 (GRCm38)	missense	probably benign	0.00
R8235:Mycbp2	UTSW	14	103,198,674 (GRCm38)	missense	probably damaging	0.99
R8246:Mycbp2	UTSW	14	103,155,204 (GRCm38)	missense	probably damaging	0.99
R8338:Mycbp2	UTSW	14	103,135,265 (GRCm38)	missense	probably damaging	1.00
R8343:Mycbp2	UTSW	14	103,160,675 (GRCm38)	splice site	probably null
R8361:Mycbp2	UTSW	14	103,138,814 (GRCm38)	missense	probably damaging	1.00
R8490:Mycbp2	UTSW	14	103,208,831 (GRCm38)	missense	probably benign	0.00
R8524:Mycbp2	UTSW	14	103,155,459 (GRCm38)	missense	probably benign	0.23
R8525:Mycbp2	UTSW	14	103,212,719 (GRCm38)	missense	probably damaging	1.00
R8711:Mycbp2	UTSW	14	103,169,994 (GRCm38)	missense	probably benign	0.08
R8735:Mycbp2	UTSW	14	103,223,150 (GRCm38)	missense	probably damaging	0.99
R8825:Mycbp2	UTSW	14	103,229,435 (GRCm38)	missense	probably damaging	1.00
R8928:Mycbp2	UTSW	14	103,156,345 (GRCm38)	missense	probably benign
R8974:Mycbp2	UTSW	14	103,124,421 (GRCm38)	missense	probably damaging	1.00
R8987:Mycbp2	UTSW	14	103,208,796 (GRCm38)	missense	probably damaging	1.00
R9021:Mycbp2	UTSW	14	103,314,316 (GRCm38)	missense	probably benign	0.08
R9062:Mycbp2	UTSW	14	103,242,360 (GRCm38)	missense	probably benign	0.00
R9077:Mycbp2	UTSW	14	103,232,538 (GRCm38)	missense	probably damaging	1.00
R9208:Mycbp2	UTSW	14	103,295,228 (GRCm38)	missense	probably benign	0.01
R9285:Mycbp2	UTSW	14	103,197,317 (GRCm38)	missense	probably damaging	0.97
R9290:Mycbp2	UTSW	14	103,188,524 (GRCm38)	missense	probably damaging	0.99
R9362:Mycbp2	UTSW	14	103,260,206 (GRCm38)	missense	probably damaging	0.97
R9520:Mycbp2	UTSW	14	103,260,269 (GRCm38)	missense	probably benign	0.02
R9557:Mycbp2	UTSW	14	103,135,261 (GRCm38)	missense	probably benign	0.03
R9639:Mycbp2	UTSW	14	103,196,381 (GRCm38)	missense	probably damaging	1.00
R9666:Mycbp2	UTSW	14	103,134,038 (GRCm38)	missense	probably damaging	0.98
R9732:Mycbp2	UTSW	14	103,211,313 (GRCm38)	missense	probably damaging	1.00
R9736:Mycbp2	UTSW	14	103,197,416 (GRCm38)	missense	probably damaging	0.96
R9739:Mycbp2	UTSW	14	103,282,793 (GRCm38)	missense	probably benign	0.11
R9755:Mycbp2	UTSW	14	103,314,370 (GRCm38)	missense	probably benign
X0024:Mycbp2	UTSW	14	103,146,942 (GRCm38)	missense	probably damaging	1.00
Z1176:Mycbp2	UTSW	14	103,346,249 (GRCm38)	missense	probably benign
Z1176:Mycbp2	UTSW	14	103,156,637 (GRCm38)	missense	probably benign	0.06
Z1177:Mycbp2	UTSW	14	103,169,873 (GRCm38)	missense	possibly damaging	0.83
Z1177:Mycbp2	UTSW	14	103,135,123 (GRCm38)	missense	probably damaging	1.00
Z1177:Mycbp2	UTSW	14	103,127,063 (GRCm38)	critical splice donor site	probably null

Predicted Primers

PCR Primer
(F):5'- CCAAAGGGACTGGTAATAAGTTAGA -3'
(R):5'- CAAATATTCTCACGTACTTAGAGGTC -3'

Sequencing Primer
(F):5'- TCCAAAACTGTTTAGAACCC -3'
(R):5'- CACTGCTGTTTTAAGGAAACCAGCTC -3'

Posted On

2014-07-14