Incidental Mutation 'R1931:Tiam2'
| ID |
215405 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tiam2
|
| Ensembl Gene |
ENSMUSG00000023800 |
| Gene Name |
T cell lymphoma invasion and metastasis 2 |
| Synonyms |
STEF, 3000002F19Rik |
| MMRRC Submission |
039949-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1931 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
3376675-3569672 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 3565000 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Cysteine
at position 1413
(R1413C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000125842
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000041003]
[ENSMUST00000072156]
[ENSMUST00000169838]
[ENSMUST00000227405]
|
| AlphaFold |
Q6ZPF3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000041003
|
| SMART Domains |
Protein: ENSMUSP00000035291
Gene: ENSMUSG00000036983
| Domain | Start | End | E-Value | Type |
|---|
|
rADc
|
43 |
234 |
5.56e-69 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000072156
AA Change: R1413C
PolyPhen 2
Score 0.681 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000072020
Gene: ENSMUSG00000023800
AA Change: R1413C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
230 |
245 |
N/A |
INTRINSIC |
|
low complexity region
|
267 |
281 |
N/A |
INTRINSIC |
|
low complexity region
|
471 |
492 |
N/A |
INTRINSIC |
|
PH
|
505 |
620 |
7.82e-16 |
SMART |
|
RBD
|
831 |
902 |
1.32e-26 |
SMART |
|
PDZ
|
921 |
995 |
2.38e-7 |
SMART |
|
RhoGEF
|
1124 |
1313 |
2.23e-61 |
SMART |
|
PH
|
1347 |
1478 |
2.86e0 |
SMART |
|
low complexity region
|
1522 |
1532 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000169838
AA Change: R1413C
PolyPhen 2
Score 0.681 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000125842
Gene: ENSMUSG00000023800
AA Change: R1413C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
230 |
245 |
N/A |
INTRINSIC |
|
low complexity region
|
267 |
281 |
N/A |
INTRINSIC |
|
low complexity region
|
471 |
492 |
N/A |
INTRINSIC |
|
PH
|
505 |
620 |
7.82e-16 |
SMART |
|
RBD
|
831 |
902 |
1.32e-26 |
SMART |
|
PDZ
|
921 |
995 |
2.38e-7 |
SMART |
|
RhoGEF
|
1124 |
1313 |
2.23e-61 |
SMART |
|
PH
|
1347 |
1478 |
2.86e0 |
SMART |
|
low complexity region
|
1522 |
1532 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000226434
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000226913
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000226997
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227405
|
| Coding Region Coverage |
- 1x: 97.3%
- 3x: 96.8%
- 10x: 95.3%
- 20x: 92.8%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 85 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aak1 |
T |
G |
6: 86,933,318 (GRCm39) |
S430A |
unknown |
Het |
| Abhd16a |
T |
A |
17: 35,319,991 (GRCm39) |
F337L |
probably benign |
Het |
| Acsl1 |
C |
A |
8: 46,984,023 (GRCm39) |
A514E |
probably benign |
Het |
| Adam29 |
T |
C |
8: 56,326,124 (GRCm39) |
Y110C |
probably damaging |
Het |
| Adamts12 |
C |
A |
15: 11,270,685 (GRCm39) |
Q647K |
probably benign |
Het |
| Adamts20 |
T |
A |
15: 94,301,891 (GRCm39) |
H27L |
probably benign |
Het |
| Adamtsl1 |
A |
G |
4: 86,260,648 (GRCm39) |
E961G |
possibly damaging |
Het |
| AW011738 |
T |
C |
4: 156,287,997 (GRCm39) |
|
probably benign |
Het |
| Bcl9 |
T |
C |
3: 97,112,460 (GRCm39) |
M1332V |
probably damaging |
Het |
| Birc6 |
T |
C |
17: 74,872,977 (GRCm39) |
I412T |
probably damaging |
Het |
| Cav1 |
A |
T |
6: 17,339,331 (GRCm39) |
I139F |
probably damaging |
Het |
| Col4a4 |
A |
C |
1: 82,444,321 (GRCm39) |
|
probably null |
Het |
| Coro2a |
A |
T |
4: 46,539,138 (GRCm39) |
*544R |
probably null |
Het |
| Cox15 |
C |
T |
19: 43,735,224 (GRCm39) |
R181H |
probably benign |
Het |
| Ddx23 |
G |
A |
15: 98,548,599 (GRCm39) |
R370W |
possibly damaging |
Het |
| Dennd2c |
A |
G |
3: 103,040,568 (GRCm39) |
N278D |
probably benign |
Het |
| Dgkh |
T |
C |
14: 78,853,945 (GRCm39) |
I265V |
probably damaging |
Het |
| Dpp3 |
A |
T |
19: 4,967,888 (GRCm39) |
|
probably benign |
Het |
| Drc7 |
G |
A |
8: 95,797,881 (GRCm39) |
R433H |
possibly damaging |
Het |
| Ece1 |
A |
G |
4: 137,666,074 (GRCm39) |
K306R |
probably benign |
Het |
| Eif4b |
T |
C |
15: 101,997,411 (GRCm39) |
S309P |
unknown |
Het |
| Eml3 |
G |
A |
19: 8,914,507 (GRCm39) |
V507M |
probably benign |
Het |
| Ezhip |
T |
C |
X: 5,994,817 (GRCm39) |
E66G |
probably benign |
Het |
| Fat1 |
C |
T |
8: 45,497,265 (GRCm39) |
T4250M |
possibly damaging |
Het |
| Fezf1 |
T |
G |
6: 23,246,906 (GRCm39) |
I309L |
probably damaging |
Het |
| Fsip2 |
T |
A |
2: 82,817,077 (GRCm39) |
L4270H |
probably damaging |
Het |
| Gabra4 |
T |
C |
5: 71,795,580 (GRCm39) |
K206E |
probably damaging |
Het |
| Gfm1 |
A |
G |
3: 67,363,918 (GRCm39) |
K465E |
probably benign |
Het |
| Gpld1 |
A |
T |
13: 25,127,693 (GRCm39) |
I32L |
possibly damaging |
Het |
| H4c12 |
A |
T |
13: 21,934,682 (GRCm39) |
|
probably null |
Het |
| Hoxd12 |
A |
G |
2: 74,505,857 (GRCm39) |
T143A |
probably benign |
Het |
| Hoxd12 |
A |
G |
2: 74,505,875 (GRCm39) |
T149A |
probably benign |
Het |
| Hspg2 |
T |
A |
4: 137,267,541 (GRCm39) |
S2050T |
probably damaging |
Het |
| Il31ra |
T |
A |
13: 112,677,756 (GRCm39) |
N287I |
probably damaging |
Het |
| Itga4 |
G |
A |
2: 79,144,188 (GRCm39) |
|
probably null |
Het |
| Itpr2 |
A |
G |
6: 146,141,852 (GRCm39) |
V1730A |
probably benign |
Het |
| Klkb1 |
T |
A |
8: 45,728,514 (GRCm39) |
Q415L |
probably benign |
Het |
| Lcn10 |
A |
G |
2: 25,574,347 (GRCm39) |
Y118C |
probably damaging |
Het |
| Lgi3 |
T |
C |
14: 70,773,708 (GRCm39) |
V294A |
probably damaging |
Het |
| Lrp5 |
C |
T |
19: 3,660,131 (GRCm39) |
V978I |
probably benign |
Het |
| Naaa |
A |
G |
5: 92,425,894 (GRCm39) |
V33A |
probably benign |
Het |
| Nckap5l |
A |
G |
15: 99,325,142 (GRCm39) |
F454L |
probably damaging |
Het |
| Nol10 |
A |
G |
12: 17,398,555 (GRCm39) |
M1V |
probably null |
Het |
| Olfm1 |
G |
A |
2: 28,112,674 (GRCm39) |
|
probably null |
Het |
| Or2at4 |
G |
T |
7: 99,385,067 (GRCm39) |
R239L |
possibly damaging |
Het |
| Or6c208 |
T |
A |
10: 129,223,745 (GRCm39) |
M81K |
probably benign |
Het |
| Or7g30 |
T |
C |
9: 19,352,647 (GRCm39) |
L146P |
possibly damaging |
Het |
| Osbp2 |
T |
C |
11: 3,676,333 (GRCm39) |
|
probably null |
Het |
| Osbpl1a |
T |
A |
18: 13,038,251 (GRCm39) |
Q269L |
probably benign |
Het |
| Papss2 |
T |
A |
19: 32,616,368 (GRCm39) |
C191* |
probably null |
Het |
| Pbxip1 |
A |
T |
3: 89,354,984 (GRCm39) |
|
probably null |
Het |
| Pdp1 |
A |
G |
4: 11,962,074 (GRCm39) |
I79T |
probably benign |
Het |
| Peg10 |
A |
G |
6: 4,755,778 (GRCm39) |
Y118C |
probably damaging |
Het |
| Pnisr |
A |
G |
4: 21,873,612 (GRCm39) |
T452A |
probably benign |
Het |
| Polr2a |
A |
T |
11: 69,626,201 (GRCm39) |
Y1612N |
unknown |
Het |
| Polr3c |
A |
T |
3: 96,626,614 (GRCm39) |
L270H |
probably damaging |
Het |
| Prr11 |
A |
T |
11: 86,996,868 (GRCm39) |
L32* |
probably null |
Het |
| Ptgfr |
T |
A |
3: 151,540,831 (GRCm39) |
T226S |
probably benign |
Het |
| Ptprz1 |
T |
A |
6: 23,007,354 (GRCm39) |
V1639E |
probably damaging |
Het |
| Pttg1ip2 |
C |
A |
5: 5,502,019 (GRCm39) |
W144C |
probably benign |
Het |
| Rps6kb1 |
A |
G |
11: 86,423,647 (GRCm39) |
V111A |
possibly damaging |
Het |
| Sfxn1 |
A |
T |
13: 54,247,952 (GRCm39) |
I226F |
probably damaging |
Het |
| Sh3pxd2a |
A |
G |
19: 47,255,947 (GRCm39) |
S924P |
probably benign |
Het |
| Slc16a5 |
A |
T |
11: 115,360,194 (GRCm39) |
I126F |
probably damaging |
Het |
| Slc8a3 |
G |
T |
12: 81,361,220 (GRCm39) |
T533N |
probably damaging |
Het |
| Snrnp40 |
C |
G |
4: 130,271,836 (GRCm39) |
|
probably null |
Het |
| Spata3 |
A |
C |
1: 85,949,783 (GRCm39) |
|
probably benign |
Het |
| St8sia6 |
A |
G |
2: 13,797,623 (GRCm39) |
S48P |
probably benign |
Het |
| Stra6l |
A |
T |
4: 45,882,698 (GRCm39) |
R470* |
probably null |
Het |
| Stradb |
A |
C |
1: 59,030,264 (GRCm39) |
N173H |
probably benign |
Het |
| Sugp1 |
T |
A |
8: 70,524,190 (GRCm39) |
D598E |
probably benign |
Het |
| Tekt2 |
T |
C |
4: 126,216,610 (GRCm39) |
|
probably null |
Het |
| Tmprss2 |
T |
C |
16: 97,370,262 (GRCm39) |
S301G |
probably benign |
Het |
| Tnrc18 |
A |
T |
5: 142,762,079 (GRCm39) |
N515K |
unknown |
Het |
| Togaram1 |
A |
G |
12: 65,013,709 (GRCm39) |
Y320C |
probably damaging |
Het |
| Trim41 |
A |
G |
11: 48,698,319 (GRCm39) |
V549A |
probably damaging |
Het |
| Ugt2b1 |
T |
A |
5: 87,065,700 (GRCm39) |
L446F |
probably damaging |
Het |
| Unc5b |
T |
C |
10: 60,608,348 (GRCm39) |
T621A |
probably benign |
Het |
| Utp25 |
T |
A |
1: 192,800,617 (GRCm39) |
K401I |
probably damaging |
Het |
| Vmn1r214 |
C |
A |
13: 23,219,494 (GRCm39) |
H329Q |
possibly damaging |
Het |
| Vmn2r109 |
T |
A |
17: 20,774,072 (GRCm39) |
K428* |
probably null |
Het |
| Vmn2r81 |
A |
C |
10: 79,129,328 (GRCm39) |
I740L |
probably damaging |
Het |
| Wdfy3 |
A |
G |
5: 102,089,358 (GRCm39) |
L612P |
probably damaging |
Het |
| Zfp109 |
G |
A |
7: 23,928,161 (GRCm39) |
T424M |
probably damaging |
Het |
| Zfp735 |
A |
T |
11: 73,602,677 (GRCm39) |
K540N |
possibly damaging |
Het |
|
| Other mutations in Tiam2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01011:Tiam2
|
APN |
17 |
3,465,303 (GRCm39) |
missense |
probably benign |
0.21 |
|
IGL01320:Tiam2
|
APN |
17 |
3,556,020 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01384:Tiam2
|
APN |
17 |
3,477,477 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01575:Tiam2
|
APN |
17 |
3,504,591 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01769:Tiam2
|
APN |
17 |
3,477,565 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02395:Tiam2
|
APN |
17 |
3,471,756 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL02652:Tiam2
|
APN |
17 |
3,489,971 (GRCm39) |
splice site |
probably benign |
|
|
IGL03102:Tiam2
|
APN |
17 |
3,559,823 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03222:Tiam2
|
APN |
17 |
3,488,983 (GRCm39) |
missense |
probably damaging |
0.97 |
|
Feste_burg
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R0257:Tiam2
|
UTSW |
17 |
3,501,088 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R0420:Tiam2
|
UTSW |
17 |
3,553,193 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0528:Tiam2
|
UTSW |
17 |
3,561,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0532:Tiam2
|
UTSW |
17 |
3,471,921 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0551:Tiam2
|
UTSW |
17 |
3,479,229 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0554:Tiam2
|
UTSW |
17 |
3,488,956 (GRCm39) |
nonsense |
probably null |
|
|
R0645:Tiam2
|
UTSW |
17 |
3,564,973 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0726:Tiam2
|
UTSW |
17 |
3,563,108 (GRCm39) |
unclassified |
probably benign |
|
|
R1139:Tiam2
|
UTSW |
17 |
3,527,542 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R1392:Tiam2
|
UTSW |
17 |
3,464,472 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1392:Tiam2
|
UTSW |
17 |
3,464,472 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1529:Tiam2
|
UTSW |
17 |
3,566,978 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1671:Tiam2
|
UTSW |
17 |
3,557,109 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1731:Tiam2
|
UTSW |
17 |
3,568,698 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1759:Tiam2
|
UTSW |
17 |
3,566,278 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1850:Tiam2
|
UTSW |
17 |
3,487,510 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1853:Tiam2
|
UTSW |
17 |
3,465,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1855:Tiam2
|
UTSW |
17 |
3,465,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1932:Tiam2
|
UTSW |
17 |
3,565,000 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1993:Tiam2
|
UTSW |
17 |
3,465,401 (GRCm39) |
nonsense |
probably null |
|
|
R2211:Tiam2
|
UTSW |
17 |
3,465,193 (GRCm39) |
nonsense |
probably null |
|
|
R2217:Tiam2
|
UTSW |
17 |
3,465,389 (GRCm39) |
missense |
probably benign |
0.34 |
|
R2278:Tiam2
|
UTSW |
17 |
3,477,495 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2407:Tiam2
|
UTSW |
17 |
3,527,536 (GRCm39) |
missense |
probably benign |
0.14 |
|
R2516:Tiam2
|
UTSW |
17 |
3,503,657 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2991:Tiam2
|
UTSW |
17 |
3,568,525 (GRCm39) |
missense |
probably benign |
|
|
R3086:Tiam2
|
UTSW |
17 |
3,471,857 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3121:Tiam2
|
UTSW |
17 |
3,489,977 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3686:Tiam2
|
UTSW |
17 |
3,471,959 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R3740:Tiam2
|
UTSW |
17 |
3,464,388 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R3742:Tiam2
|
UTSW |
17 |
3,464,388 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R3826:Tiam2
|
UTSW |
17 |
3,557,976 (GRCm39) |
splice site |
probably benign |
|
|
R3829:Tiam2
|
UTSW |
17 |
3,557,976 (GRCm39) |
splice site |
probably benign |
|
|
R3844:Tiam2
|
UTSW |
17 |
3,471,926 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3970:Tiam2
|
UTSW |
17 |
3,479,106 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4060:Tiam2
|
UTSW |
17 |
3,479,255 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4296:Tiam2
|
UTSW |
17 |
3,501,120 (GRCm39) |
missense |
probably benign |
|
|
R4357:Tiam2
|
UTSW |
17 |
3,501,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4368:Tiam2
|
UTSW |
17 |
3,464,958 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4369:Tiam2
|
UTSW |
17 |
3,464,242 (GRCm39) |
start gained |
probably benign |
|
|
R4524:Tiam2
|
UTSW |
17 |
3,564,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4619:Tiam2
|
UTSW |
17 |
3,568,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4715:Tiam2
|
UTSW |
17 |
3,504,443 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4723:Tiam2
|
UTSW |
17 |
3,500,592 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4979:Tiam2
|
UTSW |
17 |
3,555,985 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5182:Tiam2
|
UTSW |
17 |
3,488,996 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5451:Tiam2
|
UTSW |
17 |
3,479,271 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5728:Tiam2
|
UTSW |
17 |
3,465,231 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5827:Tiam2
|
UTSW |
17 |
3,498,764 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5879:Tiam2
|
UTSW |
17 |
3,487,540 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5960:Tiam2
|
UTSW |
17 |
3,488,915 (GRCm39) |
missense |
probably benign |
0.24 |
|
R5974:Tiam2
|
UTSW |
17 |
3,465,084 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R6198:Tiam2
|
UTSW |
17 |
3,464,396 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6222:Tiam2
|
UTSW |
17 |
3,503,613 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6295:Tiam2
|
UTSW |
17 |
3,559,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6355:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6356:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6454:Tiam2
|
UTSW |
17 |
3,488,938 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6497:Tiam2
|
UTSW |
17 |
3,557,102 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6579:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6580:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6581:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6582:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6648:Tiam2
|
UTSW |
17 |
3,557,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6705:Tiam2
|
UTSW |
17 |
3,568,518 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6758:Tiam2
|
UTSW |
17 |
3,568,678 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6836:Tiam2
|
UTSW |
17 |
3,464,655 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6924:Tiam2
|
UTSW |
17 |
3,558,070 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6977:Tiam2
|
UTSW |
17 |
3,568,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7051:Tiam2
|
UTSW |
17 |
3,498,758 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7151:Tiam2
|
UTSW |
17 |
3,498,660 (GRCm39) |
missense |
probably benign |
0.36 |
|
R7214:Tiam2
|
UTSW |
17 |
3,568,687 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7332:Tiam2
|
UTSW |
17 |
3,503,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7334:Tiam2
|
UTSW |
17 |
3,553,283 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7414:Tiam2
|
UTSW |
17 |
3,464,388 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R7660:Tiam2
|
UTSW |
17 |
3,532,880 (GRCm39) |
start codon destroyed |
probably null |
0.66 |
|
R7743:Tiam2
|
UTSW |
17 |
3,568,431 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7755:Tiam2
|
UTSW |
17 |
3,471,591 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7805:Tiam2
|
UTSW |
17 |
3,559,685 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7813:Tiam2
|
UTSW |
17 |
3,487,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7842:Tiam2
|
UTSW |
17 |
3,568,399 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7989:Tiam2
|
UTSW |
17 |
3,568,524 (GRCm39) |
nonsense |
probably null |
|
|
R8011:Tiam2
|
UTSW |
17 |
3,498,671 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8221:Tiam2
|
UTSW |
17 |
3,568,860 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8260:Tiam2
|
UTSW |
17 |
3,568,594 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8292:Tiam2
|
UTSW |
17 |
3,557,142 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8406:Tiam2
|
UTSW |
17 |
3,558,065 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8424:Tiam2
|
UTSW |
17 |
3,566,317 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8424:Tiam2
|
UTSW |
17 |
3,566,316 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8430:Tiam2
|
UTSW |
17 |
3,568,537 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8530:Tiam2
|
UTSW |
17 |
3,501,087 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8692:Tiam2
|
UTSW |
17 |
3,479,082 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8902:Tiam2
|
UTSW |
17 |
3,527,471 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9067:Tiam2
|
UTSW |
17 |
3,561,407 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9080:Tiam2
|
UTSW |
17 |
3,464,519 (GRCm39) |
missense |
probably benign |
|
|
R9090:Tiam2
|
UTSW |
17 |
3,465,011 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9211:Tiam2
|
UTSW |
17 |
3,498,729 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9271:Tiam2
|
UTSW |
17 |
3,465,011 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9347:Tiam2
|
UTSW |
17 |
3,471,923 (GRCm39) |
missense |
probably benign |
0.37 |
|
R9353:Tiam2
|
UTSW |
17 |
3,558,074 (GRCm39) |
nonsense |
probably null |
|
|
R9407:Tiam2
|
UTSW |
17 |
3,553,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9460:Tiam2
|
UTSW |
17 |
3,487,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9550:Tiam2
|
UTSW |
17 |
3,559,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9748:Tiam2
|
UTSW |
17 |
3,561,440 (GRCm39) |
missense |
probably benign |
0.20 |
|
X0027:Tiam2
|
UTSW |
17 |
3,464,275 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
X0060:Tiam2
|
UTSW |
17 |
3,500,629 (GRCm39) |
splice site |
probably null |
|
|
X0065:Tiam2
|
UTSW |
17 |
3,555,983 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Tiam2
|
UTSW |
17 |
3,465,294 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1176:Tiam2
|
UTSW |
17 |
3,556,051 (GRCm39) |
missense |
probably null |
1.00 |
|
Z1177:Tiam2
|
UTSW |
17 |
3,477,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCTGGGAGGTCTTTGAGAAC -3'
(R):5'- ATGCACATCAAGCCTGGAG -3'
Sequencing Primer
(F):5'- CTTTGAGAACTGGGTGTGTACC -3'
(R):5'- CAGAGGTGTGCTCTCAGTCACTAAG -3'
|
| Posted On |
2014-07-14 |
Incidental Mutation