Incidental Mutation 'R1932:Heatr1'
| ID |
215497 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Heatr1
|
| Ensembl Gene |
ENSMUSG00000050244 |
| Gene Name |
HEAT repeat containing 1 |
| Synonyms |
B130016L12Rik |
| MMRRC Submission |
039950-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.971)
|
| Stock # |
R1932 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
13 |
| Chromosomal Location |
12395027-12440289 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 12435185 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Lysine
at position 620
(M620K)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000059270]
[ENSMUST00000099820]
[ENSMUST00000099821]
[ENSMUST00000124888]
[ENSMUST00000135166]
[ENSMUST00000143693]
|
| AlphaFold |
G3X9B1 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000059270
AA Change: M2020K
PolyPhen 2
Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000054084
Gene: ENSMUSG00000050244
AA Change: M2020K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
4 |
15 |
N/A |
INTRINSIC |
|
Pfam:U3snoRNP10
|
238 |
354 |
7e-30 |
PFAM |
|
SCOP:d1qbkb_
|
919 |
1795 |
3e-8 |
SMART |
|
low complexity region
|
1805 |
1814 |
N/A |
INTRINSIC |
|
BP28CT
|
1856 |
2009 |
2.25e-77 |
SMART |
|
Blast:BP28CT
|
2015 |
2061 |
2e-15 |
BLAST |
|
coiled coil region
|
2109 |
2137 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000099820
|
| SMART Domains |
Protein: ENSMUSP00000097408
Gene: ENSMUSG00000057554
| Domain | Start | End | E-Value | Type |
|---|
|
GLECT
|
16 |
151 |
3.05e-50 |
SMART |
|
Gal-bind_lectin
|
22 |
150 |
7.41e-55 |
SMART |
|
GLECT
|
184 |
316 |
1.38e-48 |
SMART |
|
Gal-bind_lectin
|
190 |
315 |
1.28e-49 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000099821
|
| SMART Domains |
Protein: ENSMUSP00000097409
Gene: ENSMUSG00000057554
| Domain | Start | End | E-Value | Type |
|---|
|
GLECT
|
16 |
151 |
3.05e-50 |
SMART |
|
Gal-bind_lectin
|
22 |
150 |
7.41e-55 |
SMART |
|
GLECT
|
184 |
316 |
1.38e-48 |
SMART |
|
Gal-bind_lectin
|
190 |
315 |
1.28e-49 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000124888
|
| SMART Domains |
Protein: ENSMUSP00000115094
Gene: ENSMUSG00000057554
| Domain | Start | End | E-Value | Type |
|---|
|
GLECT
|
16 |
151 |
3.05e-50 |
SMART |
|
Gal-bind_lectin
|
22 |
150 |
7.41e-55 |
SMART |
|
GLECT
|
184 |
316 |
1.38e-48 |
SMART |
|
Gal-bind_lectin
|
190 |
315 |
1.28e-49 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000133143
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000135166
|
| SMART Domains |
Protein: ENSMUSP00000120210
Gene: ENSMUSG00000057554
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Gal-bind_lectin
|
1 |
57 |
4e-16 |
PFAM |
|
GLECT
|
91 |
223 |
1.38e-48 |
SMART |
|
Gal-bind_lectin
|
97 |
222 |
1.28e-49 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000143693
|
| SMART Domains |
Protein: ENSMUSP00000118925
Gene: ENSMUSG00000057554
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Gal-bind_lectin
|
1 |
57 |
4e-16 |
PFAM |
|
GLECT
|
91 |
223 |
1.38e-48 |
SMART |
|
Gal-bind_lectin
|
97 |
222 |
1.28e-49 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000221051
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000221616
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000222091
AA Change: M620K
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 97.0%
- 10x: 95.6%
- 20x: 93.3%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 92 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcg4 |
T |
A |
9: 44,279,394 (GRCm38) |
Q278H |
probably benign |
Het |
| Ace3 |
T |
C |
11: 106,004,610 (GRCm38) |
|
probably null |
Het |
| Aco1 |
T |
C |
4: 40,176,499 (GRCm38) |
V221A |
probably damaging |
Het |
| Adamts20 |
T |
A |
15: 94,404,010 (GRCm38) |
H27L |
probably benign |
Het |
| Adamts8 |
A |
G |
9: 30,956,512 (GRCm38) |
D544G |
probably benign |
Het |
| Angptl4 |
C |
A |
17: 33,781,275 (GRCm38) |
E40* |
probably null |
Het |
| Arsi |
G |
A |
18: 60,916,651 (GRCm38) |
G202E |
probably benign |
Het |
| Atf7ip2 |
T |
A |
16: 10,241,703 (GRCm38) |
I369N |
possibly damaging |
Het |
| Atp6ap1l |
T |
A |
13: 90,883,687 (GRCm38) |
Y292F |
probably damaging |
Het |
| Atp6v1b2 |
A |
T |
8: 69,102,807 (GRCm38) |
K217* |
probably null |
Het |
| Bid |
C |
T |
6: 120,897,255 (GRCm38) |
A110T |
possibly damaging |
Het |
| Blvra |
T |
A |
2: 127,095,148 (GRCm38) |
W174R |
probably damaging |
Het |
| Catsperg1 |
C |
T |
7: 29,198,143 (GRCm38) |
G239R |
probably damaging |
Het |
| Ccdc157 |
G |
T |
11: 4,146,549 (GRCm38) |
A400D |
probably damaging |
Het |
| Chd2 |
G |
T |
7: 73,454,445 (GRCm38) |
P1298T |
probably damaging |
Het |
| CK137956 |
G |
A |
4: 127,946,858 (GRCm38) |
L352F |
possibly damaging |
Het |
| Col22a1 |
G |
A |
15: 71,870,140 (GRCm38) |
P503S |
unknown |
Het |
| Cox15 |
C |
T |
19: 43,746,785 (GRCm38) |
R181H |
probably benign |
Het |
| Crem |
C |
T |
18: 3,299,284 (GRCm38) |
G47R |
probably benign |
Het |
| Crygs |
T |
A |
16: 22,806,554 (GRCm38) |
T46S |
probably benign |
Het |
| Cts8 |
T |
A |
13: 61,253,615 (GRCm38) |
H62L |
probably damaging |
Het |
| Cyp4a32 |
T |
A |
4: 115,611,277 (GRCm38) |
F319I |
possibly damaging |
Het |
| Dchs1 |
T |
C |
7: 105,765,902 (GRCm38) |
S692G |
probably damaging |
Het |
| Ddx23 |
G |
A |
15: 98,650,718 (GRCm38) |
R370W |
possibly damaging |
Het |
| Defa29 |
A |
T |
8: 21,326,849 (GRCm38) |
S43T |
probably damaging |
Het |
| Dnajc14 |
A |
G |
10: 128,816,792 (GRCm38) |
D573G |
probably damaging |
Het |
| Drd5 |
A |
G |
5: 38,319,976 (GRCm38) |
Y104C |
probably benign |
Het |
| Efcab7 |
C |
T |
4: 99,911,018 (GRCm38) |
P102L |
probably damaging |
Het |
| Efhc1 |
A |
G |
1: 20,967,400 (GRCm38) |
Y267C |
probably damaging |
Het |
| Eif2ak4 |
T |
C |
2: 118,448,486 (GRCm38) |
Y243H |
probably damaging |
Het |
| Gfm2 |
T |
A |
13: 97,141,967 (GRCm38) |
I7N |
probably damaging |
Het |
| Gmds |
A |
G |
13: 32,127,997 (GRCm38) |
F150L |
possibly damaging |
Het |
| Gp2 |
T |
C |
7: 119,454,232 (GRCm38) |
T169A |
possibly damaging |
Het |
| Grb14 |
A |
G |
2: 64,912,802 (GRCm38) |
F508L |
probably damaging |
Het |
| Hdac5 |
T |
A |
11: 102,195,872 (GRCm38) |
|
probably benign |
Het |
| Herc3 |
A |
G |
6: 58,876,793 (GRCm38) |
E608G |
probably damaging |
Het |
| Hoxb4 |
T |
C |
11: 96,320,041 (GRCm38) |
Y156H |
probably damaging |
Het |
| Ifi205 |
T |
A |
1: 174,028,414 (GRCm38) |
I17F |
possibly damaging |
Het |
| Il2rb |
A |
T |
15: 78,491,777 (GRCm38) |
S25T |
possibly damaging |
Het |
| Kansl1 |
T |
C |
11: 104,335,097 (GRCm38) |
T998A |
probably damaging |
Het |
| Kcna6 |
G |
T |
6: 126,738,488 (GRCm38) |
H479Q |
probably benign |
Het |
| Kif2a |
T |
C |
13: 106,978,091 (GRCm38) |
K350R |
probably benign |
Het |
| Lct |
G |
T |
1: 128,294,161 (GRCm38) |
A1547E |
probably damaging |
Het |
| Lhx9 |
T |
A |
1: 138,842,009 (GRCm38) |
|
probably benign |
Het |
| Lingo1 |
T |
A |
9: 56,619,650 (GRCm38) |
I552F |
possibly damaging |
Het |
| Lrp4 |
G |
A |
2: 91,497,355 (GRCm38) |
W1516* |
probably null |
Het |
| Lrp5 |
C |
T |
19: 3,610,131 (GRCm38) |
V978I |
probably benign |
Het |
| Ltbp1 |
T |
A |
17: 75,313,034 (GRCm38) |
D719E |
probably benign |
Het |
| Ltbp4 |
A |
G |
7: 27,307,766 (GRCm38) |
|
probably null |
Het |
| Macf1 |
A |
G |
4: 123,452,037 (GRCm38) |
I1326T |
probably damaging |
Het |
| Manba |
T |
C |
3: 135,544,740 (GRCm38) |
F376S |
probably benign |
Het |
| Mink1 |
T |
C |
11: 70,608,428 (GRCm38) |
|
probably null |
Het |
| Nfatc2ip |
C |
T |
7: 126,384,992 (GRCm38) |
V410I |
probably damaging |
Het |
| Nlrp1b |
A |
T |
11: 71,182,138 (GRCm38) |
I293N |
probably damaging |
Het |
| Olfr432 |
T |
C |
1: 174,050,678 (GRCm38) |
Y102H |
probably damaging |
Het |
| Otol1 |
A |
C |
3: 70,028,104 (GRCm38) |
E476D |
probably benign |
Het |
| Pcdhb4 |
C |
T |
18: 37,309,541 (GRCm38) |
P635S |
probably benign |
Het |
| Pfkfb4 |
T |
A |
9: 108,999,169 (GRCm38) |
F91I |
probably damaging |
Het |
| Polq |
G |
A |
16: 37,062,304 (GRCm38) |
R1610Q |
possibly damaging |
Het |
| Polr3c |
A |
T |
3: 96,719,298 (GRCm38) |
L270H |
probably damaging |
Het |
| Ppp1r15b |
C |
T |
1: 133,131,625 (GRCm38) |
|
probably benign |
Het |
| Prkca |
T |
G |
11: 108,192,149 (GRCm38) |
D90A |
probably benign |
Het |
| Sall3 |
T |
C |
18: 80,969,753 (GRCm38) |
D1156G |
probably benign |
Het |
| Scn7a |
A |
T |
2: 66,676,102 (GRCm38) |
L1481H |
probably damaging |
Het |
| Selenon |
A |
T |
4: 134,544,618 (GRCm38) |
I292N |
probably damaging |
Het |
| Sema6d |
T |
A |
2: 124,659,886 (GRCm38) |
|
probably null |
Het |
| Sgpp1 |
G |
T |
12: 75,716,179 (GRCm38) |
Y409* |
probably null |
Het |
| Sh3pxd2a |
A |
G |
19: 47,267,508 (GRCm38) |
S924P |
probably benign |
Het |
| Slc25a13 |
A |
G |
6: 6,042,264 (GRCm38) |
V638A |
probably benign |
Het |
| Snhg11 |
T |
C |
2: 158,376,826 (GRCm38) |
|
probably benign |
Het |
| Sorbs2 |
A |
G |
8: 45,796,352 (GRCm38) |
Q800R |
probably benign |
Het |
| Srf |
C |
A |
17: 46,549,986 (GRCm38) |
G401C |
probably damaging |
Het |
| Stradb |
A |
C |
1: 58,991,105 (GRCm38) |
N173H |
probably benign |
Het |
| Swap70 |
C |
T |
7: 110,279,263 (GRCm38) |
A480V |
possibly damaging |
Het |
| Sycp2 |
A |
G |
2: 178,381,957 (GRCm38) |
V422A |
probably damaging |
Het |
| Taf4 |
G |
A |
2: 179,932,029 (GRCm38) |
T682M |
probably damaging |
Het |
| Tet3 |
T |
C |
6: 83,404,379 (GRCm38) |
N269S |
possibly damaging |
Het |
| Thap12 |
A |
T |
7: 98,716,838 (GRCm38) |
I738F |
possibly damaging |
Het |
| Tiam2 |
C |
T |
17: 3,514,725 (GRCm38) |
R1413C |
possibly damaging |
Het |
| Tmem229a |
A |
T |
6: 24,955,011 (GRCm38) |
F248Y |
probably damaging |
Het |
| Tmprss7 |
G |
A |
16: 45,684,593 (GRCm38) |
Q145* |
probably null |
Het |
| Tnc |
A |
T |
4: 63,993,025 (GRCm38) |
|
probably null |
Het |
| Tonsl |
A |
T |
15: 76,624,597 (GRCm38) |
Y21N |
probably damaging |
Het |
| Tpr |
A |
G |
1: 150,421,663 (GRCm38) |
D1009G |
probably benign |
Het |
| Trpm2 |
G |
A |
10: 77,941,158 (GRCm38) |
A435V |
probably damaging |
Het |
| Ubr3 |
T |
A |
2: 69,953,476 (GRCm38) |
|
probably null |
Het |
| Vcan |
T |
C |
13: 89,705,534 (GRCm38) |
N436D |
possibly damaging |
Het |
| Vmn2r104 |
T |
A |
17: 20,040,769 (GRCm38) |
Y464F |
probably damaging |
Het |
| Vmn2r44 |
T |
A |
7: 8,367,982 (GRCm38) |
R688S |
probably benign |
Het |
| Wdr74 |
G |
T |
19: 8,737,947 (GRCm38) |
V157L |
probably benign |
Het |
| Wnt7a |
T |
A |
6: 91,394,548 (GRCm38) |
D144V |
probably benign |
Het |
| Zfp106 |
C |
T |
2: 120,531,681 (GRCm38) |
A986T |
possibly damaging |
Het |
|
| Other mutations in Heatr1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00666:Heatr1
|
APN |
13 |
12,410,450 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL00863:Heatr1
|
APN |
13 |
12,435,128 (GRCm38) |
missense |
probably benign |
0.02 |
|
IGL00899:Heatr1
|
APN |
13 |
12,435,176 (GRCm38) |
missense |
probably benign |
0.31 |
|
IGL01147:Heatr1
|
APN |
13 |
12,437,912 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01317:Heatr1
|
APN |
13 |
12,399,027 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01323:Heatr1
|
APN |
13 |
12,398,938 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
IGL01625:Heatr1
|
APN |
13 |
12,413,528 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL01973:Heatr1
|
APN |
13 |
12,429,799 (GRCm38) |
missense |
probably benign |
|
|
IGL02803:Heatr1
|
APN |
13 |
12,433,986 (GRCm38) |
missense |
probably damaging |
0.96 |
|
IGL02830:Heatr1
|
APN |
13 |
12,426,212 (GRCm38) |
missense |
possibly damaging |
0.57 |
|
IGL02956:Heatr1
|
APN |
13 |
12,416,059 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
IGL03000:Heatr1
|
APN |
13 |
12,434,411 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL03024:Heatr1
|
APN |
13 |
12,407,509 (GRCm38) |
unclassified |
probably benign |
|
|
IGL03035:Heatr1
|
APN |
13 |
12,413,219 (GRCm38) |
splice site |
probably benign |
|
|
IGL03301:Heatr1
|
APN |
13 |
12,434,205 (GRCm38) |
missense |
probably damaging |
1.00 |
|
hasan
|
UTSW |
13 |
12,417,447 (GRCm38) |
splice site |
probably benign |
|
|
H8562:Heatr1
|
UTSW |
13 |
12,408,713 (GRCm38) |
missense |
probably benign |
0.13 |
|
R0226:Heatr1
|
UTSW |
13 |
12,410,562 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0571:Heatr1
|
UTSW |
13 |
12,430,240 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0722:Heatr1
|
UTSW |
13 |
12,406,037 (GRCm38) |
missense |
probably benign |
0.14 |
|
R1264:Heatr1
|
UTSW |
13 |
12,424,610 (GRCm38) |
unclassified |
probably benign |
|
|
R1371:Heatr1
|
UTSW |
13 |
12,417,632 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
R1388:Heatr1
|
UTSW |
13 |
12,417,447 (GRCm38) |
splice site |
probably benign |
|
|
R1396:Heatr1
|
UTSW |
13 |
12,406,046 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R1519:Heatr1
|
UTSW |
13 |
12,412,159 (GRCm38) |
missense |
probably benign |
|
|
R1689:Heatr1
|
UTSW |
13 |
12,424,625 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1696:Heatr1
|
UTSW |
13 |
12,423,721 (GRCm38) |
missense |
possibly damaging |
0.96 |
|
R1756:Heatr1
|
UTSW |
13 |
12,396,460 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1859:Heatr1
|
UTSW |
13 |
12,403,159 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1957:Heatr1
|
UTSW |
13 |
12,396,538 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2018:Heatr1
|
UTSW |
13 |
12,414,478 (GRCm38) |
missense |
possibly damaging |
0.68 |
|
R2106:Heatr1
|
UTSW |
13 |
12,412,058 (GRCm38) |
missense |
probably benign |
0.03 |
|
R2119:Heatr1
|
UTSW |
13 |
12,432,646 (GRCm38) |
missense |
probably null |
1.00 |
|
R2121:Heatr1
|
UTSW |
13 |
12,403,264 (GRCm38) |
missense |
probably benign |
0.10 |
|
R2122:Heatr1
|
UTSW |
13 |
12,403,264 (GRCm38) |
missense |
probably benign |
0.10 |
|
R2367:Heatr1
|
UTSW |
13 |
12,433,724 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3777:Heatr1
|
UTSW |
13 |
12,413,348 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R3783:Heatr1
|
UTSW |
13 |
12,434,460 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3784:Heatr1
|
UTSW |
13 |
12,434,460 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3786:Heatr1
|
UTSW |
13 |
12,434,460 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3787:Heatr1
|
UTSW |
13 |
12,434,460 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3843:Heatr1
|
UTSW |
13 |
12,435,121 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4533:Heatr1
|
UTSW |
13 |
12,434,511 (GRCm38) |
missense |
probably benign |
0.05 |
|
R4725:Heatr1
|
UTSW |
13 |
12,424,662 (GRCm38) |
nonsense |
probably null |
|
|
R4763:Heatr1
|
UTSW |
13 |
12,430,930 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R4793:Heatr1
|
UTSW |
13 |
12,431,837 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4797:Heatr1
|
UTSW |
13 |
12,412,048 (GRCm38) |
missense |
probably benign |
0.36 |
|
R4798:Heatr1
|
UTSW |
13 |
12,412,048 (GRCm38) |
missense |
probably benign |
0.36 |
|
R4942:Heatr1
|
UTSW |
13 |
12,413,510 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R4952:Heatr1
|
UTSW |
13 |
12,410,599 (GRCm38) |
missense |
probably benign |
0.38 |
|
R4954:Heatr1
|
UTSW |
13 |
12,407,516 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R5370:Heatr1
|
UTSW |
13 |
12,401,522 (GRCm38) |
missense |
probably benign |
0.02 |
|
R5464:Heatr1
|
UTSW |
13 |
12,433,643 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5483:Heatr1
|
UTSW |
13 |
12,398,914 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5497:Heatr1
|
UTSW |
13 |
12,421,064 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R5504:Heatr1
|
UTSW |
13 |
12,406,619 (GRCm38) |
missense |
possibly damaging |
0.64 |
|
R5527:Heatr1
|
UTSW |
13 |
12,404,948 (GRCm38) |
missense |
probably benign |
|
|
R5527:Heatr1
|
UTSW |
13 |
12,402,760 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5836:Heatr1
|
UTSW |
13 |
12,408,736 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5916:Heatr1
|
UTSW |
13 |
12,434,471 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6018:Heatr1
|
UTSW |
13 |
12,406,058 (GRCm38) |
missense |
probably benign |
0.26 |
|
R6018:Heatr1
|
UTSW |
13 |
12,404,947 (GRCm38) |
missense |
probably benign |
|
|
R6216:Heatr1
|
UTSW |
13 |
12,432,664 (GRCm38) |
missense |
probably benign |
0.16 |
|
R6396:Heatr1
|
UTSW |
13 |
12,406,097 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R6472:Heatr1
|
UTSW |
13 |
12,434,230 (GRCm38) |
missense |
probably benign |
0.29 |
|
R6922:Heatr1
|
UTSW |
13 |
12,435,075 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7077:Heatr1
|
UTSW |
13 |
12,418,164 (GRCm38) |
missense |
possibly damaging |
0.63 |
|
R7297:Heatr1
|
UTSW |
13 |
12,421,060 (GRCm38) |
nonsense |
probably null |
|
|
R7445:Heatr1
|
UTSW |
13 |
12,431,038 (GRCm38) |
missense |
possibly damaging |
0.70 |
|
R7669:Heatr1
|
UTSW |
13 |
12,411,262 (GRCm38) |
missense |
probably benign |
0.33 |
|
R7672:Heatr1
|
UTSW |
13 |
12,438,664 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R7772:Heatr1
|
UTSW |
13 |
12,417,641 (GRCm38) |
missense |
probably benign |
0.03 |
|
R8205:Heatr1
|
UTSW |
13 |
12,416,047 (GRCm38) |
missense |
probably benign |
|
|
R8518:Heatr1
|
UTSW |
13 |
12,410,534 (GRCm38) |
missense |
probably benign |
|
|
R8754:Heatr1
|
UTSW |
13 |
12,413,294 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8874:Heatr1
|
UTSW |
13 |
12,430,912 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8992:Heatr1
|
UTSW |
13 |
12,401,114 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R9045:Heatr1
|
UTSW |
13 |
12,413,352 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9077:Heatr1
|
UTSW |
13 |
12,413,366 (GRCm38) |
missense |
probably benign |
|
|
R9183:Heatr1
|
UTSW |
13 |
12,421,385 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9186:Heatr1
|
UTSW |
13 |
12,421,346 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9223:Heatr1
|
UTSW |
13 |
12,404,921 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9242:Heatr1
|
UTSW |
13 |
12,433,925 (GRCm38) |
missense |
probably benign |
|
|
R9267:Heatr1
|
UTSW |
13 |
12,406,608 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9289:Heatr1
|
UTSW |
13 |
12,432,727 (GRCm38) |
missense |
probably benign |
0.13 |
|
R9310:Heatr1
|
UTSW |
13 |
12,438,610 (GRCm38) |
missense |
probably benign |
|
|
R9312:Heatr1
|
UTSW |
13 |
12,431,684 (GRCm38) |
missense |
probably benign |
|
|
R9358:Heatr1
|
UTSW |
13 |
12,418,206 (GRCm38) |
missense |
probably benign |
0.09 |
|
R9385:Heatr1
|
UTSW |
13 |
12,406,542 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9530:Heatr1
|
UTSW |
13 |
12,424,726 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9532:Heatr1
|
UTSW |
13 |
12,414,425 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
R9647:Heatr1
|
UTSW |
13 |
12,426,798 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9683:Heatr1
|
UTSW |
13 |
12,434,259 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9695:Heatr1
|
UTSW |
13 |
12,423,743 (GRCm38) |
missense |
probably damaging |
1.00 |
|
RF011:Heatr1
|
UTSW |
13 |
12,407,544 (GRCm38) |
missense |
probably benign |
0.00 |
|
Z1176:Heatr1
|
UTSW |
13 |
12,399,008 (GRCm38) |
missense |
possibly damaging |
0.68 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACCAGGACTGAGTGTTTTGC -3'
(R):5'- AGCGAGGCTCCTTTAACAATAG -3'
Sequencing Primer
(F):5'- ACCAGGACTGAGTGTTTTGCATTTG -3'
(R):5'- GCGAGGCTCCTTTAACAATAGTTAAC -3'
|
| Posted On |
2014-07-14 |
Incidental Mutation