|Institutional Source||Beutler Lab|
|Gene Name||protein phosphatase 2, regulatory subunit B', epsilon|
|Synonyms||B56beta, protein phosphatase 2A subunit beta, 4633401M22Rik|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R1933 (G1)|
|Chromosomal Location||75450881-75596245 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||C to G at 75469567 bp (GRCm38)|
|Amino Acid Change||Alanine to Proline at position 239 (A239P)|
|Ref Sequence||ENSEMBL: ENSMUSP00000021447 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000021447] [ENSMUST00000218012] [ENSMUST00000220035]|
AA Change: A239P
PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
AA Change: A239P
AA Change: A205P
PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
|Meta Mutation Damage Score||0.6233|
|Coding Region Coverage||
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an epsilon isoform of the regulatory subunit B56 subfamily. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Ppp2r5e||
(F):5'- TTGGGAAACAGGCTAAGCAC -3'
(R):5'- CAGGATTTATGGCAAGTTTCTCGG -3'
(F):5'- GCTAAGCACAAATAAGAGGCC -3'
(R):5'- CAAGTTTCTCGGGCTTAGAGC -3'