Mutagenetix > Incidental Mutation

Incidental Mutation 'R0243:Kmt2d'

215993

Institutional Source

Beutler Lab

Gene Symbol

Kmt2d

Ensembl Gene

ENSMUSG00000048154

Gene Name

lysine (K)-specific methyltransferase 2D

Synonyms

Mll2, C430014K11Rik, Mll4

MMRRC Submission

038481-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R0243 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

98831669-98871204 bp(-) (GRCm38)

Type of Mutation

unclassified

DNA Base Change (assembly)

C to T at 98850137 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s): [ENSMUST00000023741] [ENSMUST00000178486] [ENSMUST00000184363]

AlphaFold

no structure available at present

Predicted Effect

unknown
Transcript: ENSMUST00000023741
AA Change: R3102H

SMART Domains

Protein: ENSMUSP00000023741
Gene: ENSMUSG00000048154
AA Change: R3102H

Domain	Start	End	E-Value	Type
low complexity region	135	145	N/A	INTRINSIC
PHD	171	218	1.65e-5	SMART
RING	172	217	2.01e0	SMART
PHD	228	274	2.13e-8	SMART
RING	229	273	2.11e-3	SMART
PHD	275	321	1.57e-11	SMART
RING	276	320	2.36e0	SMART
low complexity region	430	489	N/A	INTRINSIC
low complexity region	500	562	N/A	INTRINSIC
low complexity region	564	613	N/A	INTRINSIC
low complexity region	619	717	N/A	INTRINSIC
internal_repeat_3	719	768	2.82e-8	PROSPERO
internal_repeat_3	773	822	2.82e-8	PROSPERO
low complexity region	826	842	N/A	INTRINSIC
low complexity region	844	919	N/A	INTRINSIC
low complexity region	958	981	N/A	INTRINSIC
low complexity region	985	1023	N/A	INTRINSIC
low complexity region	1069	1076	N/A	INTRINSIC
low complexity region	1139	1153	N/A	INTRINSIC
low complexity region	1259	1285	N/A	INTRINSIC
low complexity region	1307	1314	N/A	INTRINSIC
PHD	1335	1384	7.01e-9	SMART
RING	1336	1383	1.46e1	SMART
PHD	1385	1431	8.56e-13	SMART
PHD	1462	1513	1.11e-6	SMART
RING	1463	1512	1.46e1	SMART
low complexity region	1514	1538	N/A	INTRINSIC
low complexity region	1567	1576	N/A	INTRINSIC
low complexity region	1589	1612	N/A	INTRINSIC
low complexity region	1634	1646	N/A	INTRINSIC
low complexity region	1707	1719	N/A	INTRINSIC
low complexity region	1883	1896	N/A	INTRINSIC
low complexity region	1931	1950	N/A	INTRINSIC
HMG	1969	2037	6.35e-6	SMART
low complexity region	2064	2079	N/A	INTRINSIC
low complexity region	2147	2167	N/A	INTRINSIC
low complexity region	2170	2181	N/A	INTRINSIC
low complexity region	2306	2323	N/A	INTRINSIC
low complexity region	2334	2359	N/A	INTRINSIC
low complexity region	2366	2388	N/A	INTRINSIC
low complexity region	2402	2419	N/A	INTRINSIC
low complexity region	2546	2559	N/A	INTRINSIC
low complexity region	2610	2622	N/A	INTRINSIC
coiled coil region	2632	2665	N/A	INTRINSIC
coiled coil region	2768	2813	N/A	INTRINSIC
low complexity region	2855	2868	N/A	INTRINSIC
low complexity region	2887	2899	N/A	INTRINSIC
low complexity region	3151	3165	N/A	INTRINSIC
low complexity region	3189	3204	N/A	INTRINSIC
low complexity region	3241	3263	N/A	INTRINSIC
low complexity region	3390	3400	N/A	INTRINSIC
low complexity region	3629	3659	N/A	INTRINSIC
coiled coil region	3712	3749	N/A	INTRINSIC
low complexity region	3781	3801	N/A	INTRINSIC
coiled coil region	3910	4003	N/A	INTRINSIC
low complexity region	4128	4159	N/A	INTRINSIC
low complexity region	4167	4183	N/A	INTRINSIC
low complexity region	4226	4246	N/A	INTRINSIC
low complexity region	4266	4293	N/A	INTRINSIC
low complexity region	4306	4322	N/A	INTRINSIC
low complexity region	4361	4378	N/A	INTRINSIC
coiled coil region	4591	4613	N/A	INTRINSIC
low complexity region	4661	4684	N/A	INTRINSIC
low complexity region	4745	4755	N/A	INTRINSIC
low complexity region	4877	4896	N/A	INTRINSIC
low complexity region	4957	4983	N/A	INTRINSIC
low complexity region	4989	5029	N/A	INTRINSIC
low complexity region	5100	5107	N/A	INTRINSIC
PHD	5142	5188	4.67e-5	SMART
RING	5143	5187	4.87e0	SMART
FYRN	5242	5285	5.07e-21	SMART
FYRC	5291	5378	2.51e-43	SMART
SET	5448	5570	5.69e-36	SMART
PostSET	5572	5588	3.58e-5	SMART

Predicted Effect

unknown
Transcript: ENSMUST00000178486
AA Change: R3102H

SMART Domains

Protein: ENSMUSP00000135941
Gene: ENSMUSG00000048154
AA Change: R3102H

Domain	Start	End	E-Value	Type
low complexity region	135	145	N/A	INTRINSIC
PHD	171	218	1.65e-5	SMART
RING	172	217	2.01e0	SMART
PHD	228	274	2.13e-8	SMART
RING	229	273	2.11e-3	SMART
PHD	275	321	1.57e-11	SMART
RING	276	320	2.36e0	SMART
low complexity region	430	489	N/A	INTRINSIC
low complexity region	500	562	N/A	INTRINSIC
low complexity region	564	613	N/A	INTRINSIC
low complexity region	619	717	N/A	INTRINSIC
internal_repeat_3	719	768	2.82e-8	PROSPERO
internal_repeat_3	773	822	2.82e-8	PROSPERO
low complexity region	826	842	N/A	INTRINSIC
low complexity region	844	919	N/A	INTRINSIC
low complexity region	958	981	N/A	INTRINSIC
low complexity region	985	1023	N/A	INTRINSIC
low complexity region	1069	1076	N/A	INTRINSIC
low complexity region	1139	1153	N/A	INTRINSIC
low complexity region	1259	1285	N/A	INTRINSIC
low complexity region	1307	1314	N/A	INTRINSIC
PHD	1335	1384	7.01e-9	SMART
RING	1336	1383	1.46e1	SMART
PHD	1385	1431	8.56e-13	SMART
PHD	1462	1513	1.11e-6	SMART
RING	1463	1512	1.46e1	SMART
low complexity region	1514	1538	N/A	INTRINSIC
low complexity region	1567	1576	N/A	INTRINSIC
low complexity region	1589	1612	N/A	INTRINSIC
low complexity region	1634	1646	N/A	INTRINSIC
low complexity region	1707	1719	N/A	INTRINSIC
low complexity region	1883	1896	N/A	INTRINSIC
low complexity region	1931	1950	N/A	INTRINSIC
HMG	1969	2037	6.35e-6	SMART
low complexity region	2064	2079	N/A	INTRINSIC
low complexity region	2147	2167	N/A	INTRINSIC
low complexity region	2170	2181	N/A	INTRINSIC
low complexity region	2306	2323	N/A	INTRINSIC
low complexity region	2334	2359	N/A	INTRINSIC
low complexity region	2366	2388	N/A	INTRINSIC
low complexity region	2402	2419	N/A	INTRINSIC
low complexity region	2546	2559	N/A	INTRINSIC
low complexity region	2610	2622	N/A	INTRINSIC
coiled coil region	2632	2665	N/A	INTRINSIC
coiled coil region	2768	2813	N/A	INTRINSIC
low complexity region	2855	2868	N/A	INTRINSIC
low complexity region	2887	2899	N/A	INTRINSIC
low complexity region	3151	3165	N/A	INTRINSIC
low complexity region	3189	3204	N/A	INTRINSIC
low complexity region	3241	3263	N/A	INTRINSIC
low complexity region	3390	3400	N/A	INTRINSIC
low complexity region	3629	3659	N/A	INTRINSIC
coiled coil region	3712	3749	N/A	INTRINSIC
low complexity region	3781	3801	N/A	INTRINSIC
coiled coil region	3910	4003	N/A	INTRINSIC
low complexity region	4128	4159	N/A	INTRINSIC
low complexity region	4167	4183	N/A	INTRINSIC
low complexity region	4226	4246	N/A	INTRINSIC
low complexity region	4266	4293	N/A	INTRINSIC
low complexity region	4306	4322	N/A	INTRINSIC
low complexity region	4361	4378	N/A	INTRINSIC
coiled coil region	4591	4613	N/A	INTRINSIC
low complexity region	4661	4684	N/A	INTRINSIC
low complexity region	4745	4755	N/A	INTRINSIC
low complexity region	4877	4896	N/A	INTRINSIC
low complexity region	4957	4983	N/A	INTRINSIC
low complexity region	4989	5029	N/A	INTRINSIC
low complexity region	5100	5107	N/A	INTRINSIC
PHD	5142	5188	4.67e-5	SMART
RING	5143	5187	4.87e0	SMART
FYRN	5242	5285	5.07e-21	SMART
FYRC	5291	5378	2.51e-43	SMART
SET	5448	5570	5.69e-36	SMART
PostSET	5572	5588	3.58e-5	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000184363

SMART Domains

Protein: ENSMUSP00000139020
Gene: ENSMUSG00000048154

Domain	Start	End	E-Value	Type
low complexity region	73	85	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000229651

Meta Mutation Damage Score

0.0621

Coding Region Coverage

1x: 99.1%
3x: 98.3%
10x: 96.2%
20x: 92.0%

Validation Efficiency

98% (148/151)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a histone methyltransferase that methylates the Lys-4 position of histone H3. The encoded protein is part of a large protein complex called ASCOM, which has been shown to be a transcriptional regulator of the beta-globin and estrogen receptor genes. Mutations in this gene have been shown to be a cause of Kabuki syndrome. [provided by RefSeq, Oct 2010]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit embryonic lethality around E9.5. Mice homozygous for a conditional allele activated in different cell-types exhibit impaired adipogenesis, impaired myogenesis, perturbed germinal B cell development and promoteion of lymphomagenesis. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 139 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
0610040J01Rik	T	G	5: 63,898,463 (GRCm38)	Y181D	probably benign	Het
1700029H14Rik	A	G	8: 13,554,715 (GRCm38)	V196A	possibly damaging	Het
2410004B18Rik	A	G	3: 145,938,078 (GRCm38)	D7G	probably damaging	Het
Acap1	A	G	11: 69,885,426 (GRCm38)	V249A	probably damaging	Het
Acat2	A	T	17: 12,944,021 (GRCm38)	D313E	probably benign	Het
Actn4	T	C	7: 28,905,398 (GRCm38)	T325A	probably benign	Het
Adamdec1	C	T	14: 68,581,958 (GRCm38)		probably null	Het
Adat2	A	G	10: 13,553,293 (GRCm38)	T10A	probably benign	Het
Aff4	T	A	11: 53,397,858 (GRCm38)	S400R	possibly damaging	Het
Agbl2	C	T	2: 90,791,481 (GRCm38)	P104L	possibly damaging	Het
Alox12	G	T	11: 70,242,716 (GRCm38)	T594K	possibly damaging	Het
Als2	C	A	1: 59,215,387 (GRCm38)	K270N	probably benign	Het
Ankhd1	T	A	18: 36,634,734 (GRCm38)	C1235S	probably damaging	Het
Ankrd24	T	A	10: 81,634,944 (GRCm38)	I69N	probably damaging	Het
Aox4	G	A	1: 58,213,076 (GRCm38)	V37I	probably benign	Het
Arfgap3	A	G	15: 83,330,513 (GRCm38)		probably benign	Het
Arhgef4	T	A	1: 34,806,999 (GRCm38)		probably null	Het
Asic1	C	T	15: 99,698,617 (GRCm38)		probably benign	Het
Atp8b5	A	G	4: 43,366,057 (GRCm38)	N776S	probably benign	Het
Bbs7	A	G	3: 36,605,734 (GRCm38)	I184T	probably benign	Het
Bbs9	A	T	9: 22,514,001 (GRCm38)	H117L	probably damaging	Het
Bnip2	T	C	9: 69,995,505 (GRCm38)	W10R	probably damaging	Het
Brd4	G	T	17: 32,224,123 (GRCm38)	Q175K	probably benign	Het
Bysl	A	T	17: 47,606,896 (GRCm38)	V124E	possibly damaging	Het
Cadm3	A	G	1: 173,346,573 (GRCm38)		probably benign	Het
Cc2d2a	T	C	5: 43,696,638 (GRCm38)		probably benign	Het
Ccdc134	G	T	15: 82,140,946 (GRCm38)	E215D	probably damaging	Het
Celsr3	G	T	9: 108,843,724 (GRCm38)		probably benign	Het
Cntn5	T	A	9: 9,781,775 (GRCm38)	D428V	probably damaging	Het
Cog1	A	G	11: 113,656,995 (GRCm38)		probably benign	Het
Col11a2	G	T	17: 34,062,546 (GRCm38)		probably benign	Het
Cyp4f13	G	A	17: 32,924,969 (GRCm38)		probably benign	Het
Dffb	T	A	4: 153,965,378 (GRCm38)	K343*	probably null	Het
Dnah9	T	A	11: 65,911,852 (GRCm38)	I224F	possibly damaging	Het
Dolk	A	T	2: 30,286,019 (GRCm38)	C5S	probably benign	Het
Dynlt2b	A	G	16: 32,426,887 (GRCm38)	D118G	probably damaging	Het
Ebf1	A	T	11: 44,869,088 (GRCm38)		probably benign	Het
Elac1	A	G	18: 73,742,363 (GRCm38)	L199P	probably damaging	Het
Elmod1	A	C	9: 53,935,547 (GRCm38)		probably benign	Het
Ep400	A	C	5: 110,724,407 (GRCm38)		probably benign	Het
F10	A	T	8: 13,048,196 (GRCm38)	N133I	probably damaging	Het
Fasn	A	G	11: 120,815,315 (GRCm38)	Y1068H	probably benign	Het
Fbxo24	T	C	5: 137,624,557 (GRCm38)	E12G	probably damaging	Het
Fer	G	T	17: 64,078,946 (GRCm38)	L304F	probably benign	Het
Filip1	A	C	9: 79,819,003 (GRCm38)	L778R	probably damaging	Het
Fli1	A	T	9: 32,423,981 (GRCm38)	I385N	probably benign	Het
Fpgs	A	T	2: 32,692,494 (GRCm38)	L89*	probably null	Het
Gab2	T	G	7: 97,299,241 (GRCm38)	I346R	probably damaging	Het
Gm10764	G	A	10: 87,290,979 (GRCm38)	G83R	unknown	Het
Gpr83	G	T	9: 14,864,842 (GRCm38)	C153F	possibly damaging	Het
Gtf3c3	A	G	1: 54,403,536 (GRCm38)	L783P	possibly damaging	Het
Gys2	A	G	6: 142,472,668 (GRCm38)		probably benign	Het
Heatr9	C	T	11: 83,513,338 (GRCm38)	V378I	possibly damaging	Het
Helz	A	T	11: 107,637,914 (GRCm38)	Y920F	possibly damaging	Het
Inpp5f	A	T	7: 128,695,183 (GRCm38)	Q459L	probably damaging	Het
Ints12	T	C	3: 133,109,045 (GRCm38)	S338P	probably benign	Het
Kif13a	T	C	13: 46,791,351 (GRCm38)	T925A	probably benign	Het
Kif1a	C	T	1: 93,042,093 (GRCm38)	V1051I	probably damaging	Het
Kif7	T	A	7: 79,699,560 (GRCm38)	H1119L	possibly damaging	Het
Krt90	C	T	15: 101,562,675 (GRCm38)	G51S	possibly damaging	Het
Krtap31-2	A	T	11: 99,936,746 (GRCm38)	I135F	possibly damaging	Het
Lrp2	T	C	2: 69,428,630 (GRCm38)	E4572G	probably benign	Het
Mapk8ip1	T	C	2: 92,385,944 (GRCm38)	E493G	probably damaging	Het
Matk	T	G	10: 81,258,492 (GRCm38)	L28V	probably benign	Het
Mcc	T	A	18: 44,759,299 (GRCm38)	T83S	probably benign	Het
Mtch1	A	T	17: 29,340,106 (GRCm38)	M204K	possibly damaging	Het
Muc4	T	G	16: 32,765,746 (GRCm38)	C2622G	possibly damaging	Het
Myo5a	G	A	9: 75,186,123 (GRCm38)		probably null	Het
Myoz3	T	C	18: 60,578,951 (GRCm38)	Y185C	probably damaging	Het
Nnmt	A	G	9: 48,592,138 (GRCm38)	V196A	probably benign	Het
Nr2f2	G	C	7: 70,360,175 (GRCm38)	P52R	probably damaging	Het
Nup214	T	A	2: 31,998,057 (GRCm38)		probably benign	Het
Or2aj4	T	G	16: 19,566,294 (GRCm38)	E196D	probably damaging	Het
Or2y13	T	C	11: 49,523,912 (GRCm38)	L63P	probably damaging	Het
Or4c126	T	A	2: 89,993,806 (GRCm38)	F138I	probably benign	Het
Pank3	T	C	11: 35,781,716 (GRCm38)		probably benign	Het
Parm1	A	T	5: 91,594,294 (GRCm38)	N174Y	possibly damaging	Het
Pcgf2	A	T	11: 97,692,418 (GRCm38)		probably null	Het
Pclo	A	T	5: 14,775,420 (GRCm38)	K4661M	unknown	Het
Pcsk7	A	C	9: 45,916,059 (GRCm38)	S375R	probably damaging	Het
Pdzrn4	G	T	15: 92,770,319 (GRCm38)	S784I	possibly damaging	Het
Pex6	T	A	17: 46,723,737 (GRCm38)		probably null	Het
Pi4ka	C	T	16: 17,297,635 (GRCm38)	V1384M	probably benign	Het
Polr3f	T	A	2: 144,536,275 (GRCm38)		probably benign	Het
Ppp2r3a	A	T	9: 101,212,284 (GRCm38)	V280E	probably damaging	Het
Prdm14	C	T	1: 13,122,448 (GRCm38)	G356R	probably damaging	Het
Prepl	A	G	17: 85,065,038 (GRCm38)		probably null	Het
Primpol	T	C	8: 46,599,814 (GRCm38)	D154G	probably damaging	Het
Ptchd4	A	C	17: 42,503,416 (GRCm38)	H736P	probably damaging	Het
Rab11fip1	A	G	8: 27,152,225 (GRCm38)	S849P	probably damaging	Het
Rap1gap	T	A	4: 137,719,351 (GRCm38)	D405E	probably damaging	Het
Rbm26	T	C	14: 105,131,938 (GRCm38)	T686A	probably benign	Het
Resf1	T	C	6: 149,326,241 (GRCm38)	Y262H	probably damaging	Het
Rint1	A	G	5: 23,816,932 (GRCm38)		probably benign	Het
Rnasek	G	T	11: 70,238,440 (GRCm38)	Y62*	probably null	Het
Rnf17	T	G	14: 56,482,084 (GRCm38)	N930K	possibly damaging	Het
Sap130	A	G	18: 31,680,681 (GRCm38)		probably benign	Het
Sectm1b	T	A	11: 121,055,785 (GRCm38)	I95F	probably damaging	Het
Sema4f	A	T	6: 82,939,466 (GRCm38)	I53N	possibly damaging	Het
Shld1	T	C	2: 132,750,639 (GRCm38)	V202A	probably benign	Het
Siglec1	T	C	2: 131,085,476 (GRCm38)	T137A	probably damaging	Het
Six5	A	C	7: 19,097,022 (GRCm38)		probably null	Het
Slc22a30	A	T	19: 8,345,357 (GRCm38)	I345N	probably benign	Het
Slc25a27	A	T	17: 43,643,627 (GRCm38)	M316K	probably benign	Het
Slc2a8	A	T	2: 32,980,104 (GRCm38)		probably benign	Het
Snx1	G	A	9: 66,101,326 (GRCm38)		probably benign	Het
Spag17	A	G	3: 100,085,368 (GRCm38)	T1727A	probably benign	Het
Spata20	T	C	11: 94,481,646 (GRCm38)	D633G	probably benign	Het
Spock1	C	T	13: 57,436,109 (GRCm38)		probably null	Het
Sra1	A	T	18: 36,675,706 (GRCm38)	Y291*	probably null	Het
Sspo	C	A	6: 48,493,186 (GRCm38)	P4520T	probably damaging	Het
Stat4	A	G	1: 52,011,857 (GRCm38)	N25S	probably benign	Het
Tbx18	A	T	9: 87,715,516 (GRCm38)		probably benign	Het
Tep1	T	A	14: 50,846,987 (GRCm38)	I187F	probably damaging	Het
Tfap2b	A	T	1: 19,234,123 (GRCm38)	I368F	probably damaging	Het
Tmtc1	A	T	6: 148,246,837 (GRCm38)	L711Q	probably damaging	Het
Tmx3	T	A	18: 90,538,489 (GRCm38)		probably benign	Het
Tnc	G	T	4: 63,970,420 (GRCm38)	T1803K	probably damaging	Het
Tnfrsf21	C	T	17: 43,038,213 (GRCm38)	H239Y	probably benign	Het
Tpgs1	C	T	10: 79,675,866 (GRCm38)	P281S	probably benign	Het
Trim45	A	G	3: 100,929,844 (GRCm38)	R499G	probably benign	Het
Tulp3	A	T	6: 128,325,958 (GRCm38)	Y299*	probably null	Het
Ube4a	A	T	9: 44,946,178 (GRCm38)		probably benign	Het
Ubr3	T	G	2: 69,951,405 (GRCm38)	S642R	probably damaging	Het
Vcpip1	A	T	1: 9,747,206 (GRCm38)	Y317*	probably null	Het
Vmn1r115	G	A	7: 20,844,402 (GRCm38)	T195I	probably benign	Het
Vmn1r226	G	A	17: 20,687,577 (GRCm38)	V24I	probably benign	Het
Wdr41	C	T	13: 95,017,406 (GRCm38)	A321V	probably damaging	Het
Wfdc5	T	C	2: 164,178,835 (GRCm38)	N44D	probably benign	Het
Wnt7b	C	A	15: 85,558,902 (GRCm38)		probably null	Het
Zfp108	T	C	7: 24,261,783 (GRCm38)	S600P	possibly damaging	Het
Zfp267	A	G	3: 36,165,154 (GRCm38)	H442R	possibly damaging	Het
Zfp385b	A	G	2: 77,415,728 (GRCm38)		probably null	Het
Zfp395	T	C	14: 65,386,480 (GRCm38)	S133P	probably benign	Het
Zfp407	T	A	18: 84,558,711 (GRCm38)	M1426L	probably damaging	Het
Zfp641	T	G	15: 98,289,127 (GRCm38)	N191T	possibly damaging	Het
Zfp687	T	C	3: 95,011,553 (GRCm38)	S303G	probably damaging	Het
Zfp759	T	A	13: 67,138,813 (GRCm38)	F143I	possibly damaging	Het
Zgrf1	G	C	3: 127,615,446 (GRCm38)	E1690Q	probably damaging	Het

Other mutations in Kmt2d

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00229:Kmt2d	APN	15	98,862,333 (GRCm38)	missense	unknown
IGL00927:Kmt2d	APN	15	98,845,009 (GRCm38)	unclassified	probably benign
IGL01123:Kmt2d	APN	15	98,837,148 (GRCm38)	missense	unknown
IGL01288:Kmt2d	APN	15	98,865,044 (GRCm38)	missense	probably damaging	1.00
IGL01538:Kmt2d	APN	15	98,860,657 (GRCm38)	unclassified	probably benign
IGL01575:Kmt2d	APN	15	98,846,855 (GRCm38)	utr 3 prime	probably benign
IGL01584:Kmt2d	APN	15	98,856,369 (GRCm38)	unclassified	probably benign
IGL01750:Kmt2d	APN	15	98,853,168 (GRCm38)	unclassified	probably benign
IGL02163:Kmt2d	APN	15	98,835,228 (GRCm38)	unclassified	probably benign
IGL02209:Kmt2d	APN	15	98,854,567 (GRCm38)	unclassified	probably benign
IGL02253:Kmt2d	APN	15	98,858,175 (GRCm38)	unclassified	probably benign
IGL02271:Kmt2d	APN	15	98,866,428 (GRCm38)	missense	possibly damaging	0.89
IGL02291:Kmt2d	APN	15	98,865,492 (GRCm38)	splice site	probably benign
IGL02448:Kmt2d	APN	15	98,844,110 (GRCm38)	unclassified	probably benign
IGL02472:Kmt2d	APN	15	98,850,077 (GRCm38)	missense	probably benign	0.23
IGL02496:Kmt2d	APN	15	98,857,558 (GRCm38)	unclassified	probably benign
IGL02527:Kmt2d	APN	15	98,841,747 (GRCm38)	unclassified	probably benign
IGL02576:Kmt2d	APN	15	98,864,120 (GRCm38)	missense	unknown
IGL02597:Kmt2d	APN	15	98,863,831 (GRCm38)	missense	unknown
IGL02609:Kmt2d	APN	15	98,851,793 (GRCm38)	unclassified	probably benign
IGL03085:Kmt2d	APN	15	98,839,940 (GRCm38)	unclassified	probably benign
IGL03102:Kmt2d	APN	15	98,855,543 (GRCm38)	missense	probably benign
IGL03123:Kmt2d	APN	15	98,861,771 (GRCm38)	missense	unknown
G1citation:Kmt2d	UTSW	15	98,849,459 (GRCm38)	unclassified	probably benign
R0091:Kmt2d	UTSW	15	98,844,479 (GRCm38)	unclassified	probably benign
R0136:Kmt2d	UTSW	15	98,854,278 (GRCm38)	unclassified	probably benign
R0276:Kmt2d	UTSW	15	98,850,311 (GRCm38)	unclassified	probably benign
R0477:Kmt2d	UTSW	15	98,853,581 (GRCm38)	unclassified	probably benign
R0478:Kmt2d	UTSW	15	98,853,581 (GRCm38)	unclassified	probably benign
R0586:Kmt2d	UTSW	15	98,835,207 (GRCm38)	unclassified	probably benign
R0632:Kmt2d	UTSW	15	98,853,581 (GRCm38)	unclassified	probably benign
R0678:Kmt2d	UTSW	15	98,850,413 (GRCm38)	unclassified	probably benign
R0780:Kmt2d	UTSW	15	98,862,857 (GRCm38)	missense	unknown
R0891:Kmt2d	UTSW	15	98,852,691 (GRCm38)	unclassified	probably benign
R1136:Kmt2d	UTSW	15	98,857,765 (GRCm38)	unclassified	probably benign
R1417:Kmt2d	UTSW	15	98,866,430 (GRCm38)	missense	probably damaging	0.99
R1499:Kmt2d	UTSW	15	98,844,938 (GRCm38)	unclassified	probably benign
R1510:Kmt2d	UTSW	15	98,856,377 (GRCm38)	unclassified	probably benign
R1586:Kmt2d	UTSW	15	98,865,053 (GRCm38)	splice site	probably benign
R1640:Kmt2d	UTSW	15	98,845,057 (GRCm38)	unclassified	probably benign
R1714:Kmt2d	UTSW	15	98,862,950 (GRCm38)	missense	unknown
R1725:Kmt2d	UTSW	15	98,845,234 (GRCm38)	unclassified	probably benign
R1728:Kmt2d	UTSW	15	98,865,132 (GRCm38)	missense	probably damaging	1.00
R1729:Kmt2d	UTSW	15	98,865,132 (GRCm38)	missense	probably damaging	1.00
R1741:Kmt2d	UTSW	15	98,845,234 (GRCm38)	unclassified	probably benign
R1744:Kmt2d	UTSW	15	98,865,047 (GRCm38)	missense	probably damaging	0.99
R1746:Kmt2d	UTSW	15	98,864,378 (GRCm38)	missense	probably damaging	0.97
R1753:Kmt2d	UTSW	15	98,843,482 (GRCm38)	unclassified	probably benign
R1782:Kmt2d	UTSW	15	98,857,548 (GRCm38)	unclassified	probably benign
R1789:Kmt2d	UTSW	15	98,852,074 (GRCm38)	unclassified	probably benign
R1802:Kmt2d	UTSW	15	98,862,985 (GRCm38)	missense	unknown
R1808:Kmt2d	UTSW	15	98,866,686 (GRCm38)	missense	probably damaging	1.00
R1822:Kmt2d	UTSW	15	98,861,780 (GRCm38)	missense	unknown
R1831:Kmt2d	UTSW	15	98,855,343 (GRCm38)	missense	probably damaging	0.97
R1920:Kmt2d	UTSW	15	98,855,591 (GRCm38)	missense	probably damaging	1.00
R1920:Kmt2d	UTSW	15	98,855,590 (GRCm38)	missense	probably damaging	0.96
R1956:Kmt2d	UTSW	15	98,859,590 (GRCm38)	unclassified	probably benign
R2100:Kmt2d	UTSW	15	98,846,480 (GRCm38)	unclassified	probably benign
R2120:Kmt2d	UTSW	15	98,839,529 (GRCm38)	unclassified	probably benign
R2188:Kmt2d	UTSW	15	98,839,300 (GRCm38)	unclassified	probably benign
R2191:Kmt2d	UTSW	15	98,861,049 (GRCm38)	critical splice donor site	probably null
R2234:Kmt2d	UTSW	15	98,865,248 (GRCm38)	missense	probably damaging	0.98
R2422:Kmt2d	UTSW	15	98,862,266 (GRCm38)	missense	unknown
R2762:Kmt2d	UTSW	15	98,852,055 (GRCm38)	unclassified	probably benign
R2895:Kmt2d	UTSW	15	98,843,939 (GRCm38)	unclassified	probably benign
R3624:Kmt2d	UTSW	15	98,842,902 (GRCm38)	unclassified	probably benign
R3791:Kmt2d	UTSW	15	98,844,149 (GRCm38)	unclassified	probably benign
R3794:Kmt2d	UTSW	15	98,837,359 (GRCm38)	unclassified	probably benign
R3871:Kmt2d	UTSW	15	98,851,021 (GRCm38)	unclassified	probably benign
R3958:Kmt2d	UTSW	15	98,855,549 (GRCm38)	missense	possibly damaging	0.69
R3983:Kmt2d	UTSW	15	98,846,046 (GRCm38)	unclassified	probably benign
R4211:Kmt2d	UTSW	15	98,840,189 (GRCm38)	unclassified	probably benign
R4212:Kmt2d	UTSW	15	98,845,003 (GRCm38)	unclassified	probably benign
R4240:Kmt2d	UTSW	15	98,844,571 (GRCm38)	unclassified	probably benign
R4246:Kmt2d	UTSW	15	98,840,089 (GRCm38)	unclassified	probably benign
R4361:Kmt2d	UTSW	15	98,863,670 (GRCm38)	missense	unknown
R4388:Kmt2d	UTSW	15	98,853,626 (GRCm38)	unclassified	probably benign
R4602:Kmt2d	UTSW	15	98,850,259 (GRCm38)	unclassified	probably benign
R4606:Kmt2d	UTSW	15	98,839,716 (GRCm38)	unclassified	probably benign
R4658:Kmt2d	UTSW	15	98,852,529 (GRCm38)	unclassified	probably benign
R4840:Kmt2d	UTSW	15	98,861,894 (GRCm38)	missense	unknown
R4895:Kmt2d	UTSW	15	98,844,487 (GRCm38)	unclassified	probably benign
R4906:Kmt2d	UTSW	15	98,849,539 (GRCm38)	unclassified	probably benign
R4976:Kmt2d	UTSW	15	98,847,194 (GRCm38)	utr 3 prime	probably benign
R5093:Kmt2d	UTSW	15	98,856,162 (GRCm38)	missense	probably damaging	1.00
R5119:Kmt2d	UTSW	15	98,847,194 (GRCm38)	utr 3 prime	probably benign
R5160:Kmt2d	UTSW	15	98,840,224 (GRCm38)	unclassified	probably benign
R5260:Kmt2d	UTSW	15	98,842,860 (GRCm38)	unclassified	probably benign
R5274:Kmt2d	UTSW	15	98,854,230 (GRCm38)	unclassified	probably benign
R5450:Kmt2d	UTSW	15	98,855,086 (GRCm38)	missense	probably damaging	1.00
R5461:Kmt2d	UTSW	15	98,852,109 (GRCm38)	unclassified	probably benign
R5462:Kmt2d	UTSW	15	98,852,109 (GRCm38)	unclassified	probably benign
R5463:Kmt2d	UTSW	15	98,852,109 (GRCm38)	unclassified	probably benign
R5465:Kmt2d	UTSW	15	98,852,109 (GRCm38)	unclassified	probably benign
R5467:Kmt2d	UTSW	15	98,852,109 (GRCm38)	unclassified	probably benign
R5481:Kmt2d	UTSW	15	98,862,005 (GRCm38)	missense	unknown
R5509:Kmt2d	UTSW	15	98,839,676 (GRCm38)	unclassified	probably benign
R5534:Kmt2d	UTSW	15	98,837,357 (GRCm38)	unclassified	probably benign
R5536:Kmt2d	UTSW	15	98,852,109 (GRCm38)	unclassified	probably benign
R5537:Kmt2d	UTSW	15	98,852,109 (GRCm38)	unclassified	probably benign
R5538:Kmt2d	UTSW	15	98,852,109 (GRCm38)	unclassified	probably benign
R5546:Kmt2d	UTSW	15	98,853,068 (GRCm38)	unclassified	probably benign
R5595:Kmt2d	UTSW	15	98,850,024 (GRCm38)	unclassified	probably benign
R5645:Kmt2d	UTSW	15	98,844,397 (GRCm38)	unclassified	probably benign
R5679:Kmt2d	UTSW	15	98,854,272 (GRCm38)	unclassified	probably benign
R5710:Kmt2d	UTSW	15	98,854,106 (GRCm38)	unclassified	probably benign
R5755:Kmt2d	UTSW	15	98,863,646 (GRCm38)	missense	unknown
R5817:Kmt2d	UTSW	15	98,862,363 (GRCm38)	missense	unknown
R5841:Kmt2d	UTSW	15	98,852,109 (GRCm38)	unclassified	probably benign
R5842:Kmt2d	UTSW	15	98,852,109 (GRCm38)	unclassified	probably benign
R5843:Kmt2d	UTSW	15	98,852,109 (GRCm38)	unclassified	probably benign
R5844:Kmt2d	UTSW	15	98,852,109 (GRCm38)	unclassified	probably benign
R5845:Kmt2d	UTSW	15	98,852,109 (GRCm38)	unclassified	probably benign
R6122:Kmt2d	UTSW	15	98,860,692 (GRCm38)	unclassified	probably benign
R6612:Kmt2d	UTSW	15	98,845,858 (GRCm38)	unclassified	probably benign
R6718:Kmt2d	UTSW	15	98,849,586 (GRCm38)	unclassified	probably benign
R6718:Kmt2d	UTSW	15	98,850,539 (GRCm38)	unclassified	probably benign
R6822:Kmt2d	UTSW	15	98,849,459 (GRCm38)	unclassified	probably benign
R6866:Kmt2d	UTSW	15	98,857,393 (GRCm38)	unclassified	probably benign
R6950:Kmt2d	UTSW	15	98,840,020 (GRCm38)	unclassified	probably benign
R7089:Kmt2d	UTSW	15	98,850,272 (GRCm38)	missense	unknown
R7120:Kmt2d	UTSW	15	98,861,065 (GRCm38)	missense	unknown
R7131:Kmt2d	UTSW	15	98,849,616 (GRCm38)	unclassified	probably benign
R7177:Kmt2d	UTSW	15	98,850,386 (GRCm38)	missense	unknown
R7194:Kmt2d	UTSW	15	98,843,833 (GRCm38)	missense	unknown
R7252:Kmt2d	UTSW	15	98,844,266 (GRCm38)	missense	unknown
R7282:Kmt2d	UTSW	15	98,854,104 (GRCm38)	missense	unknown
R7307:Kmt2d	UTSW	15	98,849,418 (GRCm38)	missense	unknown
R7313:Kmt2d	UTSW	15	98,856,623 (GRCm38)	missense	unknown
R7394:Kmt2d	UTSW	15	98,856,384 (GRCm38)	missense	unknown
R7404:Kmt2d	UTSW	15	98,845,495 (GRCm38)	missense	unknown
R7409:Kmt2d	UTSW	15	98,855,354 (GRCm38)	missense	probably damaging	1.00
R7414:Kmt2d	UTSW	15	98,839,856 (GRCm38)	missense	unknown
R7534:Kmt2d	UTSW	15	98,852,018 (GRCm38)	missense	unknown
R7575:Kmt2d	UTSW	15	98,849,611 (GRCm38)	unclassified	probably benign
R7650:Kmt2d	UTSW	15	98,850,870 (GRCm38)	missense	unknown
R7687:Kmt2d	UTSW	15	98,862,120 (GRCm38)	missense	unknown
R7699:Kmt2d	UTSW	15	98,843,719 (GRCm38)	missense	unknown
R7700:Kmt2d	UTSW	15	98,843,719 (GRCm38)	missense	unknown
R7765:Kmt2d	UTSW	15	98,852,334 (GRCm38)	missense	unknown
R7797:Kmt2d	UTSW	15	98,864,406 (GRCm38)	missense	probably benign	0.24
R7803:Kmt2d	UTSW	15	98,862,923 (GRCm38)	missense	unknown
R7952:Kmt2d	UTSW	15	98,850,768 (GRCm38)	missense	unknown
R8054:Kmt2d	UTSW	15	98,843,925 (GRCm38)	missense	unknown
R8084:Kmt2d	UTSW	15	98,842,064 (GRCm38)	missense	unknown
R8089:Kmt2d	UTSW	15	98,842,869 (GRCm38)	missense	unknown
R8133:Kmt2d	UTSW	15	98,864,942 (GRCm38)	missense	probably damaging	1.00
R8138:Kmt2d	UTSW	15	98,843,653 (GRCm38)	missense	unknown
R8343:Kmt2d	UTSW	15	98,852,597 (GRCm38)	missense	unknown
R8681:Kmt2d	UTSW	15	98,846,067 (GRCm38)	missense	unknown
R8694:Kmt2d	UTSW	15	98,844,734 (GRCm38)	missense	unknown
R8837:Kmt2d	UTSW	15	98,864,167 (GRCm38)	missense	unknown
R8855:Kmt2d	UTSW	15	98,856,356 (GRCm38)	missense	unknown
R8934:Kmt2d	UTSW	15	98,861,886 (GRCm38)	missense	unknown
R9100:Kmt2d	UTSW	15	98,849,951 (GRCm38)	missense	unknown
R9158:Kmt2d	UTSW	15	98,843,139 (GRCm38)	missense	unknown
R9190:Kmt2d	UTSW	15	98,852,015 (GRCm38)	missense	unknown
R9222:Kmt2d	UTSW	15	98,849,443 (GRCm38)	missense	unknown
R9263:Kmt2d	UTSW	15	98,849,618 (GRCm38)	frame shift	probably null
R9336:Kmt2d	UTSW	15	98,845,816 (GRCm38)	missense	unknown
R9397:Kmt2d	UTSW	15	98,850,113 (GRCm38)	missense	unknown
R9415:Kmt2d	UTSW	15	98,839,705 (GRCm38)	missense	unknown
R9482:Kmt2d	UTSW	15	98,865,165 (GRCm38)	missense	probably damaging	1.00
R9529:Kmt2d	UTSW	15	98,839,768 (GRCm38)	missense	unknown
R9610:Kmt2d	UTSW	15	98,845,176 (GRCm38)	unclassified	probably benign
R9611:Kmt2d	UTSW	15	98,845,176 (GRCm38)	unclassified	probably benign
R9611:Kmt2d	UTSW	15	98,845,173 (GRCm38)	unclassified	probably benign
R9612:Kmt2d	UTSW	15	98,845,176 (GRCm38)	unclassified	probably benign
R9613:Kmt2d	UTSW	15	98,845,176 (GRCm38)	unclassified	probably benign
R9644:Kmt2d	UTSW	15	98,845,504 (GRCm38)	missense	unknown
R9716:Kmt2d	UTSW	15	98,843,402 (GRCm38)	missense	unknown
R9763:Kmt2d	UTSW	15	98,845,176 (GRCm38)	unclassified	probably benign
R9782:Kmt2d	UTSW	15	98,866,716 (GRCm38)	missense	probably damaging	1.00
X0018:Kmt2d	UTSW	15	98,852,922 (GRCm38)	unclassified	probably benign
X0024:Kmt2d	UTSW	15	98,853,053 (GRCm38)	unclassified	probably benign
X0062:Kmt2d	UTSW	15	98,849,819 (GRCm38)	unclassified	probably benign
Z1187:Kmt2d	UTSW	15	98,851,744 (GRCm38)	missense	unknown
Z1188:Kmt2d	UTSW	15	98,851,744 (GRCm38)	missense	unknown
Z1189:Kmt2d	UTSW	15	98,851,744 (GRCm38)	missense	unknown
Z1190:Kmt2d	UTSW	15	98,851,744 (GRCm38)	missense	unknown
Z1192:Kmt2d	UTSW	15	98,851,744 (GRCm38)	missense	unknown

Predicted Primers

PCR Primer
(F):5'- TCAGCAAGTGAGCTGGTGTTCCTC -3'
(R):5'- CCTGGAAAACCTGGAGACGAATGAC -3'

Sequencing Primer
(F):5'- TGGGGAACGATCCTGTACC -3'
(R):5'- GATGACCTCCTCAATGGAGATG -3'

Posted On

2014-07-16