Incidental Mutation 'R0586:Brwd1'
ID |
216005 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Brwd1
|
Ensembl Gene |
ENSMUSG00000022914 |
Gene Name |
bromodomain and WD repeat domain containing 1 |
Synonyms |
5330419I02Rik, Wdr9, G1-403-16, D530019K20Rik, repro5 |
MMRRC Submission |
038776-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R0586 (G1)
|
Quality Score |
58 |
Status
|
Validated
|
Chromosome |
16 |
Chromosomal Location |
95793292-95883726 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 95844286 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Glutamic Acid to Glycine
at position 756
(E756G)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000117066
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000023631]
[ENSMUST00000099502]
[ENSMUST00000113829]
[ENSMUST00000124370]
[ENSMUST00000131322]
[ENSMUST00000153398]
|
AlphaFold |
Q921C3 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000023631
AA Change: E756G
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
SMART Domains |
Protein: ENSMUSP00000023631 Gene: ENSMUSG00000022914 AA Change: E756G
Domain | Start | End | E-Value | Type |
low complexity region
|
36 |
48 |
N/A |
INTRINSIC |
WD40
|
175 |
214 |
1.3e-7 |
SMART |
WD40
|
217 |
256 |
2.26e-7 |
SMART |
WD40
|
259 |
302 |
1.83e-7 |
SMART |
WD40
|
311 |
352 |
3.82e1 |
SMART |
WD40
|
357 |
396 |
4.27e-8 |
SMART |
WD40
|
417 |
454 |
8.59e-1 |
SMART |
WD40
|
457 |
497 |
1.47e-6 |
SMART |
WD40
|
504 |
544 |
9.21e0 |
SMART |
low complexity region
|
660 |
676 |
N/A |
INTRINSIC |
low complexity region
|
753 |
767 |
N/A |
INTRINSIC |
low complexity region
|
852 |
868 |
N/A |
INTRINSIC |
low complexity region
|
906 |
927 |
N/A |
INTRINSIC |
BROMO
|
1156 |
1267 |
1.72e-6 |
SMART |
low complexity region
|
1277 |
1292 |
N/A |
INTRINSIC |
BROMO
|
1317 |
1422 |
2.65e-30 |
SMART |
low complexity region
|
1497 |
1513 |
N/A |
INTRINSIC |
low complexity region
|
1543 |
1558 |
N/A |
INTRINSIC |
internal_repeat_1
|
1574 |
1762 |
1.42e-9 |
PROSPERO |
low complexity region
|
1764 |
1775 |
N/A |
INTRINSIC |
internal_repeat_1
|
1857 |
2050 |
1.42e-9 |
PROSPERO |
low complexity region
|
2165 |
2174 |
N/A |
INTRINSIC |
low complexity region
|
2260 |
2270 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000099502
AA Change: E756G
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
SMART Domains |
Protein: ENSMUSP00000097101 Gene: ENSMUSG00000022914 AA Change: E756G
Domain | Start | End | E-Value | Type |
low complexity region
|
36 |
48 |
N/A |
INTRINSIC |
WD40
|
175 |
214 |
1.3e-7 |
SMART |
WD40
|
217 |
256 |
2.26e-7 |
SMART |
WD40
|
259 |
302 |
1.83e-7 |
SMART |
WD40
|
311 |
352 |
3.82e1 |
SMART |
WD40
|
357 |
396 |
4.27e-8 |
SMART |
WD40
|
417 |
454 |
8.59e-1 |
SMART |
WD40
|
457 |
497 |
1.47e-6 |
SMART |
WD40
|
504 |
544 |
9.21e0 |
SMART |
low complexity region
|
660 |
676 |
N/A |
INTRINSIC |
low complexity region
|
753 |
767 |
N/A |
INTRINSIC |
low complexity region
|
852 |
868 |
N/A |
INTRINSIC |
low complexity region
|
906 |
927 |
N/A |
INTRINSIC |
BROMO
|
1156 |
1267 |
1.72e-6 |
SMART |
low complexity region
|
1277 |
1292 |
N/A |
INTRINSIC |
BROMO
|
1317 |
1422 |
2.65e-30 |
SMART |
low complexity region
|
1497 |
1513 |
N/A |
INTRINSIC |
low complexity region
|
1543 |
1558 |
N/A |
INTRINSIC |
internal_repeat_1
|
1574 |
1762 |
1.42e-9 |
PROSPERO |
low complexity region
|
1764 |
1775 |
N/A |
INTRINSIC |
internal_repeat_1
|
1857 |
2050 |
1.42e-9 |
PROSPERO |
low complexity region
|
2165 |
2174 |
N/A |
INTRINSIC |
low complexity region
|
2260 |
2270 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000113829
AA Change: E756G
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
SMART Domains |
Protein: ENSMUSP00000109460 Gene: ENSMUSG00000022914 AA Change: E756G
Domain | Start | End | E-Value | Type |
low complexity region
|
36 |
48 |
N/A |
INTRINSIC |
WD40
|
175 |
214 |
1.3e-7 |
SMART |
WD40
|
217 |
256 |
2.26e-7 |
SMART |
WD40
|
259 |
302 |
1.83e-7 |
SMART |
WD40
|
311 |
352 |
3.82e1 |
SMART |
WD40
|
357 |
396 |
4.27e-8 |
SMART |
WD40
|
417 |
454 |
8.59e-1 |
SMART |
WD40
|
457 |
497 |
1.47e-6 |
SMART |
WD40
|
504 |
544 |
9.21e0 |
SMART |
low complexity region
|
660 |
676 |
N/A |
INTRINSIC |
low complexity region
|
753 |
767 |
N/A |
INTRINSIC |
low complexity region
|
852 |
868 |
N/A |
INTRINSIC |
low complexity region
|
906 |
927 |
N/A |
INTRINSIC |
BROMO
|
1156 |
1267 |
1.72e-6 |
SMART |
low complexity region
|
1277 |
1292 |
N/A |
INTRINSIC |
BROMO
|
1317 |
1422 |
2.65e-30 |
SMART |
low complexity region
|
1497 |
1513 |
N/A |
INTRINSIC |
low complexity region
|
1543 |
1558 |
N/A |
INTRINSIC |
internal_repeat_1
|
1574 |
1762 |
1.13e-9 |
PROSPERO |
low complexity region
|
1764 |
1775 |
N/A |
INTRINSIC |
internal_repeat_1
|
1857 |
2050 |
1.13e-9 |
PROSPERO |
low complexity region
|
2165 |
2174 |
N/A |
INTRINSIC |
low complexity region
|
2177 |
2188 |
N/A |
INTRINSIC |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000124370
AA Change: E479G
PolyPhen 2
Score 0.693 (Sensitivity: 0.86; Specificity: 0.92)
|
SMART Domains |
Protein: ENSMUSP00000118423 Gene: ENSMUSG00000022914 AA Change: E479G
Domain | Start | End | E-Value | Type |
WD40
|
34 |
75 |
3.82e1 |
SMART |
WD40
|
80 |
119 |
4.27e-8 |
SMART |
WD40
|
140 |
177 |
8.59e-1 |
SMART |
WD40
|
180 |
220 |
1.47e-6 |
SMART |
WD40
|
227 |
267 |
9.21e0 |
SMART |
low complexity region
|
383 |
399 |
N/A |
INTRINSIC |
low complexity region
|
476 |
490 |
N/A |
INTRINSIC |
low complexity region
|
531 |
547 |
N/A |
INTRINSIC |
low complexity region
|
585 |
602 |
N/A |
INTRINSIC |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000126629
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000131322
AA Change: E203G
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
SMART Domains |
Protein: ENSMUSP00000118327 Gene: ENSMUSG00000022914 AA Change: E203G
Domain | Start | End | E-Value | Type |
low complexity region
|
107 |
123 |
N/A |
INTRINSIC |
low complexity region
|
200 |
214 |
N/A |
INTRINSIC |
low complexity region
|
299 |
315 |
N/A |
INTRINSIC |
low complexity region
|
353 |
374 |
N/A |
INTRINSIC |
Blast:BROMO
|
496 |
582 |
4e-37 |
BLAST |
Blast:BROMO
|
603 |
627 |
5e-8 |
BLAST |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000153398
AA Change: E756G
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000117066 Gene: ENSMUSG00000022914 AA Change: E756G
Domain | Start | End | E-Value | Type |
low complexity region
|
36 |
48 |
N/A |
INTRINSIC |
WD40
|
175 |
214 |
1.3e-7 |
SMART |
WD40
|
217 |
256 |
2.26e-7 |
SMART |
WD40
|
259 |
302 |
1.83e-7 |
SMART |
WD40
|
311 |
352 |
3.82e1 |
SMART |
WD40
|
357 |
396 |
4.27e-8 |
SMART |
WD40
|
417 |
454 |
8.59e-1 |
SMART |
WD40
|
457 |
497 |
1.47e-6 |
SMART |
WD40
|
504 |
544 |
9.21e0 |
SMART |
low complexity region
|
660 |
676 |
N/A |
INTRINSIC |
low complexity region
|
753 |
767 |
N/A |
INTRINSIC |
low complexity region
|
852 |
868 |
N/A |
INTRINSIC |
low complexity region
|
906 |
927 |
N/A |
INTRINSIC |
BROMO
|
1156 |
1267 |
1.72e-6 |
SMART |
low complexity region
|
1277 |
1292 |
N/A |
INTRINSIC |
BROMO
|
1317 |
1422 |
2.65e-30 |
SMART |
internal_repeat_1
|
1491 |
1957 |
1.45e-251 |
PROSPERO |
internal_repeat_1
|
1956 |
2422 |
1.45e-251 |
PROSPERO |
low complexity region
|
2630 |
2639 |
N/A |
INTRINSIC |
|
Predicted Effect |
|
SMART Domains |
Protein: ENSMUSP00000121141 Gene: ENSMUSG00000022914 AA Change: K406E
Domain | Start | End | E-Value | Type |
WD40
|
23 |
64 |
3.82e1 |
SMART |
WD40
|
69 |
108 |
4.27e-8 |
SMART |
WD40
|
129 |
166 |
8.59e-1 |
SMART |
WD40
|
169 |
209 |
1.47e-6 |
SMART |
WD40
|
216 |
256 |
9.21e0 |
SMART |
low complexity region
|
372 |
388 |
N/A |
INTRINSIC |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000184285
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000146222
|
Meta Mutation Damage Score |
0.2020 |
Coding Region Coverage |
- 1x: 99.7%
- 3x: 99.1%
- 10x: 97.5%
- 20x: 94.4%
|
Validation Efficiency |
100% (74/74) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.[provided by RefSeq, Jun 2011] PHENOTYPE: Homozygous males and females are infertile. Spermiogenesis is impaired; males have low epididymal sperm concentration with low motility and abnormal sperm head morphology. Female oocytes commonly contain vacuoles and have low developmental competence to 2-cell and blastocyst stages. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 69 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abca1 |
A |
T |
4: 53,092,860 (GRCm39) |
V308E |
probably benign |
Het |
Amy1 |
A |
G |
3: 113,356,418 (GRCm39) |
|
probably benign |
Het |
Astn2 |
C |
T |
4: 66,103,379 (GRCm39) |
V345M |
unknown |
Het |
Ccpg1 |
C |
T |
9: 72,909,103 (GRCm39) |
L135F |
probably benign |
Het |
Cecr2 |
C |
T |
6: 120,734,845 (GRCm39) |
H694Y |
probably damaging |
Het |
Cfh |
G |
A |
1: 140,110,920 (GRCm39) |
T14I |
probably damaging |
Het |
Cfhr2 |
G |
A |
1: 139,741,172 (GRCm39) |
R268* |
probably null |
Het |
Clca3a1 |
T |
A |
3: 144,738,350 (GRCm39) |
I53L |
probably benign |
Het |
Clcn6 |
A |
G |
4: 148,123,206 (GRCm39) |
|
probably benign |
Het |
Cnfn |
C |
T |
7: 25,067,256 (GRCm39) |
V98I |
probably benign |
Het |
Cntnap1 |
C |
T |
11: 101,077,840 (GRCm39) |
R1122W |
probably damaging |
Het |
Cpne9 |
A |
T |
6: 113,272,024 (GRCm39) |
E384V |
probably damaging |
Het |
Ctr9 |
T |
C |
7: 110,648,705 (GRCm39) |
|
probably benign |
Het |
Ctsj |
T |
A |
13: 61,151,515 (GRCm39) |
|
probably benign |
Het |
Cyp2c39 |
A |
C |
19: 39,501,934 (GRCm39) |
|
probably benign |
Het |
Dock5 |
A |
C |
14: 68,046,481 (GRCm39) |
I767S |
probably damaging |
Het |
Eftud2 |
T |
C |
11: 102,737,446 (GRCm39) |
T552A |
probably damaging |
Het |
Epdr1 |
A |
G |
13: 19,778,715 (GRCm39) |
I25T |
probably damaging |
Het |
Fcgbp |
A |
T |
7: 27,789,138 (GRCm39) |
D568V |
probably damaging |
Het |
Fcgbpl1 |
T |
A |
7: 27,836,516 (GRCm39) |
V145D |
probably damaging |
Het |
Fhip1b |
T |
C |
7: 105,038,654 (GRCm39) |
E195G |
probably damaging |
Het |
Frem2 |
T |
A |
3: 53,555,342 (GRCm39) |
T1732S |
probably damaging |
Het |
Fuz |
T |
C |
7: 44,547,982 (GRCm39) |
V183A |
possibly damaging |
Het |
Grb7 |
T |
C |
11: 98,344,046 (GRCm39) |
S284P |
probably damaging |
Het |
Hoxb4 |
G |
T |
11: 96,209,713 (GRCm39) |
G40C |
probably damaging |
Het |
Kcnn1 |
T |
C |
8: 71,316,513 (GRCm39) |
|
probably benign |
Het |
Kmt2d |
C |
A |
15: 98,733,088 (GRCm39) |
|
probably benign |
Het |
L3mbtl3 |
A |
G |
10: 26,203,732 (GRCm39) |
V366A |
unknown |
Het |
Ldlr |
G |
A |
9: 21,651,040 (GRCm39) |
R486H |
probably benign |
Het |
Lnpep |
A |
T |
17: 17,795,658 (GRCm39) |
|
probably benign |
Het |
Mical3 |
A |
T |
6: 121,006,602 (GRCm39) |
|
probably benign |
Het |
Myh15 |
T |
C |
16: 48,992,250 (GRCm39) |
|
probably benign |
Het |
Nup155 |
T |
A |
15: 8,159,716 (GRCm39) |
H542Q |
probably benign |
Het |
Opn4 |
A |
G |
14: 34,320,930 (GRCm39) |
|
probably benign |
Het |
Or13a20 |
T |
C |
7: 140,231,976 (GRCm39) |
F28S |
probably benign |
Het |
Or4a68 |
T |
A |
2: 89,269,698 (GRCm39) |
R308S |
possibly damaging |
Het |
Or6c68 |
A |
G |
10: 129,157,916 (GRCm39) |
I141M |
probably benign |
Het |
Or8g4 |
A |
T |
9: 39,662,414 (GRCm39) |
H244L |
probably damaging |
Het |
Or8h10 |
T |
C |
2: 86,809,126 (GRCm39) |
N5D |
probably damaging |
Het |
Pak3 |
TTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC |
TTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC |
X: 142,526,889 (GRCm39) |
|
probably benign |
Het |
Parp14 |
T |
C |
16: 35,661,382 (GRCm39) |
K1522R |
probably benign |
Het |
Pkhd1 |
A |
T |
1: 20,594,335 (GRCm39) |
D1259E |
probably benign |
Het |
Pogz |
C |
T |
3: 94,786,664 (GRCm39) |
A1084V |
probably damaging |
Het |
Popdc3 |
G |
A |
10: 45,191,359 (GRCm39) |
V157M |
probably benign |
Het |
Prrt4 |
T |
C |
6: 29,171,183 (GRCm39) |
Y423C |
probably damaging |
Het |
Qrich1 |
C |
T |
9: 108,411,719 (GRCm39) |
H415Y |
probably damaging |
Het |
Rabgap1 |
A |
G |
2: 37,433,235 (GRCm39) |
N801D |
probably benign |
Het |
Rb1 |
A |
G |
14: 73,525,124 (GRCm39) |
|
probably benign |
Het |
Rp1 |
A |
T |
1: 4,418,060 (GRCm39) |
N1017K |
possibly damaging |
Het |
Ryr2 |
T |
C |
13: 11,650,445 (GRCm39) |
D356G |
probably null |
Het |
Skint8 |
C |
G |
4: 111,794,126 (GRCm39) |
P172R |
probably damaging |
Het |
Slc12a8 |
T |
G |
16: 33,478,600 (GRCm39) |
M643R |
possibly damaging |
Het |
Sult1c2 |
A |
T |
17: 54,271,113 (GRCm39) |
|
probably benign |
Het |
Tasor2 |
A |
G |
13: 3,640,321 (GRCm39) |
L272P |
probably damaging |
Het |
Tcaf1 |
T |
A |
6: 42,650,473 (GRCm39) |
M869L |
probably damaging |
Het |
Tecpr1 |
T |
C |
5: 144,154,219 (GRCm39) |
N78S |
probably damaging |
Het |
Tectb |
A |
T |
19: 55,170,356 (GRCm39) |
Y69F |
probably damaging |
Het |
Them4 |
A |
T |
3: 94,237,101 (GRCm39) |
N187I |
possibly damaging |
Het |
Tm9sf3 |
A |
G |
19: 41,244,582 (GRCm39) |
|
probably null |
Het |
Tnik |
G |
T |
3: 28,631,510 (GRCm39) |
|
probably benign |
Het |
Tns2 |
G |
T |
15: 102,018,020 (GRCm39) |
|
probably benign |
Het |
Tnxb |
A |
G |
17: 34,891,118 (GRCm39) |
D487G |
probably damaging |
Het |
Trim33 |
T |
A |
3: 103,217,660 (GRCm39) |
C202S |
probably damaging |
Het |
Trpm2 |
T |
A |
10: 77,759,350 (GRCm39) |
I1145F |
probably damaging |
Het |
Trpv2 |
A |
G |
11: 62,483,596 (GRCm39) |
T478A |
probably benign |
Het |
Ube2e3 |
T |
C |
2: 78,750,334 (GRCm39) |
Y187H |
probably benign |
Het |
Ubxn11 |
A |
G |
4: 133,836,963 (GRCm39) |
R64G |
possibly damaging |
Het |
Wwtr1 |
T |
C |
3: 57,366,487 (GRCm39) |
T407A |
probably damaging |
Het |
Zfyve26 |
A |
T |
12: 79,315,502 (GRCm39) |
S1325T |
possibly damaging |
Het |
|
Other mutations in Brwd1 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00690:Brwd1
|
APN |
16 |
95,818,786 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL00974:Brwd1
|
APN |
16 |
95,844,226 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01014:Brwd1
|
APN |
16 |
95,817,373 (GRCm39) |
missense |
probably benign |
0.04 |
IGL01447:Brwd1
|
APN |
16 |
95,848,579 (GRCm39) |
nonsense |
probably null |
|
IGL01459:Brwd1
|
APN |
16 |
95,848,620 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01631:Brwd1
|
APN |
16 |
95,847,666 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02184:Brwd1
|
APN |
16 |
95,815,029 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02264:Brwd1
|
APN |
16 |
95,820,656 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL02679:Brwd1
|
APN |
16 |
95,804,023 (GRCm39) |
missense |
probably benign |
|
IGL02833:Brwd1
|
APN |
16 |
95,853,771 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02960:Brwd1
|
APN |
16 |
95,858,666 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03053:Brwd1
|
APN |
16 |
95,818,877 (GRCm39) |
missense |
possibly damaging |
0.75 |
IGL03074:Brwd1
|
APN |
16 |
95,813,050 (GRCm39) |
missense |
probably benign |
0.00 |
IGL03135:Brwd1
|
APN |
16 |
95,822,458 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL03168:Brwd1
|
APN |
16 |
95,818,877 (GRCm39) |
missense |
possibly damaging |
0.75 |
IGL03214:Brwd1
|
APN |
16 |
95,839,100 (GRCm39) |
missense |
probably benign |
0.26 |
IGL03328:Brwd1
|
APN |
16 |
95,803,925 (GRCm39) |
missense |
probably damaging |
0.99 |
bromide
|
UTSW |
16 |
95,866,087 (GRCm39) |
missense |
probably damaging |
1.00 |
Embers
|
UTSW |
16 |
95,818,804 (GRCm39) |
missense |
probably damaging |
1.00 |
Glowing
|
UTSW |
16 |
95,837,159 (GRCm39) |
missense |
probably damaging |
1.00 |
Soporific
|
UTSW |
16 |
95,835,043 (GRCm39) |
nonsense |
probably null |
|
G1citation:Brwd1
|
UTSW |
16 |
95,842,474 (GRCm39) |
missense |
probably benign |
0.42 |
PIT4243001:Brwd1
|
UTSW |
16 |
95,803,871 (GRCm39) |
nonsense |
probably null |
|
R0012:Brwd1
|
UTSW |
16 |
95,860,852 (GRCm39) |
missense |
probably damaging |
0.98 |
R0012:Brwd1
|
UTSW |
16 |
95,860,852 (GRCm39) |
missense |
probably damaging |
0.98 |
R0030:Brwd1
|
UTSW |
16 |
95,822,456 (GRCm39) |
missense |
probably damaging |
1.00 |
R0135:Brwd1
|
UTSW |
16 |
95,848,304 (GRCm39) |
missense |
probably damaging |
1.00 |
R0366:Brwd1
|
UTSW |
16 |
95,839,164 (GRCm39) |
nonsense |
probably null |
|
R0551:Brwd1
|
UTSW |
16 |
95,837,174 (GRCm39) |
missense |
probably damaging |
1.00 |
R0865:Brwd1
|
UTSW |
16 |
95,869,784 (GRCm39) |
missense |
probably damaging |
1.00 |
R1226:Brwd1
|
UTSW |
16 |
95,832,748 (GRCm39) |
missense |
probably benign |
0.35 |
R1329:Brwd1
|
UTSW |
16 |
95,804,434 (GRCm39) |
missense |
probably benign |
0.07 |
R1378:Brwd1
|
UTSW |
16 |
95,842,570 (GRCm39) |
missense |
probably benign |
0.06 |
R1420:Brwd1
|
UTSW |
16 |
95,837,234 (GRCm39) |
missense |
probably damaging |
1.00 |
R1441:Brwd1
|
UTSW |
16 |
95,867,351 (GRCm39) |
missense |
probably damaging |
0.99 |
R1484:Brwd1
|
UTSW |
16 |
95,829,491 (GRCm39) |
splice site |
probably null |
|
R1624:Brwd1
|
UTSW |
16 |
95,809,344 (GRCm39) |
missense |
possibly damaging |
0.67 |
R1636:Brwd1
|
UTSW |
16 |
95,860,841 (GRCm39) |
missense |
probably damaging |
1.00 |
R1988:Brwd1
|
UTSW |
16 |
95,822,437 (GRCm39) |
missense |
probably damaging |
0.96 |
R1998:Brwd1
|
UTSW |
16 |
95,822,488 (GRCm39) |
missense |
probably damaging |
1.00 |
R2066:Brwd1
|
UTSW |
16 |
95,847,665 (GRCm39) |
missense |
probably benign |
0.01 |
R2898:Brwd1
|
UTSW |
16 |
95,867,300 (GRCm39) |
missense |
probably damaging |
0.99 |
R2983:Brwd1
|
UTSW |
16 |
95,867,774 (GRCm39) |
missense |
probably damaging |
0.98 |
R3966:Brwd1
|
UTSW |
16 |
95,845,730 (GRCm39) |
missense |
probably damaging |
1.00 |
R4086:Brwd1
|
UTSW |
16 |
95,847,572 (GRCm39) |
missense |
probably benign |
0.03 |
R4257:Brwd1
|
UTSW |
16 |
95,824,696 (GRCm39) |
missense |
probably damaging |
1.00 |
R4290:Brwd1
|
UTSW |
16 |
95,818,804 (GRCm39) |
missense |
probably damaging |
1.00 |
R4292:Brwd1
|
UTSW |
16 |
95,818,804 (GRCm39) |
missense |
probably damaging |
1.00 |
R4293:Brwd1
|
UTSW |
16 |
95,818,804 (GRCm39) |
missense |
probably damaging |
1.00 |
R4614:Brwd1
|
UTSW |
16 |
95,848,559 (GRCm39) |
missense |
probably damaging |
1.00 |
R4771:Brwd1
|
UTSW |
16 |
95,804,518 (GRCm39) |
missense |
probably benign |
0.00 |
R5025:Brwd1
|
UTSW |
16 |
95,855,172 (GRCm39) |
missense |
probably damaging |
0.97 |
R5155:Brwd1
|
UTSW |
16 |
95,803,993 (GRCm39) |
nonsense |
probably null |
|
R5229:Brwd1
|
UTSW |
16 |
95,803,409 (GRCm39) |
missense |
possibly damaging |
0.87 |
R5246:Brwd1
|
UTSW |
16 |
95,803,757 (GRCm39) |
missense |
probably damaging |
1.00 |
R5668:Brwd1
|
UTSW |
16 |
95,817,350 (GRCm39) |
missense |
probably damaging |
1.00 |
R5763:Brwd1
|
UTSW |
16 |
95,835,043 (GRCm39) |
nonsense |
probably null |
|
R5782:Brwd1
|
UTSW |
16 |
95,844,243 (GRCm39) |
nonsense |
probably null |
|
R5831:Brwd1
|
UTSW |
16 |
95,820,636 (GRCm39) |
missense |
probably damaging |
1.00 |
R5836:Brwd1
|
UTSW |
16 |
95,865,958 (GRCm39) |
missense |
probably damaging |
1.00 |
R5906:Brwd1
|
UTSW |
16 |
95,859,938 (GRCm39) |
missense |
probably damaging |
1.00 |
R5995:Brwd1
|
UTSW |
16 |
95,865,987 (GRCm39) |
missense |
probably damaging |
1.00 |
R6143:Brwd1
|
UTSW |
16 |
95,804,156 (GRCm39) |
missense |
probably benign |
0.00 |
R6241:Brwd1
|
UTSW |
16 |
95,815,074 (GRCm39) |
missense |
probably damaging |
1.00 |
R6313:Brwd1
|
UTSW |
16 |
95,809,141 (GRCm39) |
missense |
probably benign |
0.01 |
R6362:Brwd1
|
UTSW |
16 |
95,803,507 (GRCm39) |
missense |
probably damaging |
1.00 |
R6551:Brwd1
|
UTSW |
16 |
95,795,162 (GRCm39) |
missense |
possibly damaging |
0.55 |
R6736:Brwd1
|
UTSW |
16 |
95,869,772 (GRCm39) |
missense |
probably damaging |
1.00 |
R6822:Brwd1
|
UTSW |
16 |
95,842,474 (GRCm39) |
missense |
probably benign |
0.42 |
R7080:Brwd1
|
UTSW |
16 |
95,810,730 (GRCm39) |
missense |
probably benign |
0.01 |
R7131:Brwd1
|
UTSW |
16 |
95,867,698 (GRCm39) |
missense |
probably damaging |
1.00 |
R7208:Brwd1
|
UTSW |
16 |
95,837,159 (GRCm39) |
missense |
probably damaging |
1.00 |
R7322:Brwd1
|
UTSW |
16 |
95,867,319 (GRCm39) |
missense |
probably damaging |
1.00 |
R7483:Brwd1
|
UTSW |
16 |
95,857,373 (GRCm39) |
missense |
probably damaging |
0.99 |
R7615:Brwd1
|
UTSW |
16 |
95,835,039 (GRCm39) |
missense |
probably damaging |
0.96 |
R7621:Brwd1
|
UTSW |
16 |
95,866,087 (GRCm39) |
missense |
probably damaging |
1.00 |
R7665:Brwd1
|
UTSW |
16 |
95,842,543 (GRCm39) |
missense |
probably benign |
0.09 |
R7697:Brwd1
|
UTSW |
16 |
95,847,601 (GRCm39) |
missense |
probably benign |
0.10 |
R7740:Brwd1
|
UTSW |
16 |
95,828,568 (GRCm39) |
missense |
probably damaging |
1.00 |
R8120:Brwd1
|
UTSW |
16 |
95,820,649 (GRCm39) |
missense |
probably benign |
0.23 |
R8187:Brwd1
|
UTSW |
16 |
95,803,934 (GRCm39) |
missense |
probably damaging |
0.98 |
R8359:Brwd1
|
UTSW |
16 |
95,817,409 (GRCm39) |
missense |
probably damaging |
1.00 |
R8480:Brwd1
|
UTSW |
16 |
95,848,630 (GRCm39) |
missense |
probably damaging |
0.98 |
R8511:Brwd1
|
UTSW |
16 |
95,859,938 (GRCm39) |
missense |
probably damaging |
1.00 |
R9046:Brwd1
|
UTSW |
16 |
95,829,402 (GRCm39) |
missense |
probably damaging |
1.00 |
R9074:Brwd1
|
UTSW |
16 |
95,824,610 (GRCm39) |
missense |
|
|
R9102:Brwd1
|
UTSW |
16 |
95,869,725 (GRCm39) |
missense |
probably benign |
0.43 |
R9115:Brwd1
|
UTSW |
16 |
95,848,314 (GRCm39) |
missense |
probably damaging |
1.00 |
R9130:Brwd1
|
UTSW |
16 |
95,866,130 (GRCm39) |
missense |
probably damaging |
1.00 |
R9200:Brwd1
|
UTSW |
16 |
95,839,154 (GRCm39) |
missense |
probably benign |
0.00 |
R9246:Brwd1
|
UTSW |
16 |
95,804,016 (GRCm39) |
missense |
probably benign |
0.00 |
R9407:Brwd1
|
UTSW |
16 |
95,803,693 (GRCm39) |
missense |
possibly damaging |
0.74 |
R9444:Brwd1
|
UTSW |
16 |
95,855,180 (GRCm39) |
missense |
possibly damaging |
0.89 |
R9451:Brwd1
|
UTSW |
16 |
95,845,703 (GRCm39) |
missense |
probably damaging |
1.00 |
R9673:Brwd1
|
UTSW |
16 |
95,813,096 (GRCm39) |
missense |
probably benign |
0.00 |
R9751:Brwd1
|
UTSW |
16 |
95,795,015 (GRCm39) |
missense |
possibly damaging |
0.83 |
R9753:Brwd1
|
UTSW |
16 |
95,825,028 (GRCm39) |
missense |
probably damaging |
1.00 |
X0017:Brwd1
|
UTSW |
16 |
95,845,691 (GRCm39) |
missense |
probably damaging |
1.00 |
X0028:Brwd1
|
UTSW |
16 |
95,813,123 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
Predicted Primers |
PCR Primer
(F):5'- CAGAGGTGAGTGCCTTTAATCCCAG -3'
(R):5'- CAGGTGAGTCTTGACCGTGATGAG -3'
Sequencing Primer
(F):5'- AGTTCTATGTTGGCTTTAAATGCCC -3'
(R):5'- ACCGTGATGAGGCGCTG -3'
|
Posted On |
2014-07-16 |