Incidental Mutation 'R0015:Zgrf1'
ID 216014
Institutional Source Beutler Lab
Gene Symbol Zgrf1
Ensembl Gene ENSMUSG00000051278
Gene Name zinc finger, GRF-type containing 1
Synonyms 4930422G04Rik
MMRRC Submission 038310-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # R0015 (G1)
Quality Score 65
Status Validated
Chromosome 3
Chromosomal Location 127553489-127618023 bp(+) (GRCm38)
Type of Mutation splice site
DNA Base Change (assembly) T to C at 127555397 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000143585 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029588] [ENSMUST00000043108] [ENSMUST00000195955] [ENSMUST00000196141] [ENSMUST00000197668] [ENSMUST00000199888] [ENSMUST00000200490]
AlphaFold Q0VGT4
Predicted Effect probably benign
Transcript: ENSMUST00000029588
SMART Domains Protein: ENSMUSP00000029588
Gene: ENSMUSG00000027968

DomainStartEndE-ValueType
LA 26 106 1.29e-30 SMART
RRM 120 196 5.37e-15 SMART
low complexity region 210 226 N/A INTRINSIC
low complexity region 257 273 N/A INTRINSIC
low complexity region 302 311 N/A INTRINSIC
low complexity region 350 364 N/A INTRINSIC
Pfam:RRM_3 442 540 1.3e-31 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000043108
SMART Domains Protein: ENSMUSP00000044432
Gene: ENSMUSG00000051278

DomainStartEndE-ValueType
Pfam:DUF2439 3 81 3.7e-23 PFAM
low complexity region 92 105 N/A INTRINSIC
low complexity region 628 639 N/A INTRINSIC
low complexity region 896 906 N/A INTRINSIC
Pfam:zf-GRF 1109 1153 1.5e-17 PFAM
low complexity region 1316 1328 N/A INTRINSIC
Pfam:AAA_11 1501 1608 1.6e-21 PFAM
Pfam:AAA_12 1616 1802 1.3e-51 PFAM
coiled coil region 1833 1861 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000195955
SMART Domains Protein: ENSMUSP00000142886
Gene: ENSMUSG00000051278

DomainStartEndE-ValueType
Pfam:DUF2439 3 82 1.6e-25 PFAM
low complexity region 92 105 N/A INTRINSIC
low complexity region 628 639 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000196141
SMART Domains Protein: ENSMUSP00000143761
Gene: ENSMUSG00000051278

DomainStartEndE-ValueType
Pfam:DUF2439 3 81 3.7e-23 PFAM
low complexity region 92 105 N/A INTRINSIC
low complexity region 628 639 N/A INTRINSIC
low complexity region 896 906 N/A INTRINSIC
Pfam:zf-GRF 1109 1153 1.5e-17 PFAM
low complexity region 1316 1328 N/A INTRINSIC
Pfam:AAA_11 1501 1608 1.6e-21 PFAM
Pfam:AAA_12 1616 1802 1.3e-51 PFAM
coiled coil region 1833 1861 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196949
Predicted Effect probably benign
Transcript: ENSMUST00000197668
SMART Domains Protein: ENSMUSP00000143331
Gene: ENSMUSG00000027968

DomainStartEndE-ValueType
LA 26 80 9.2e-10 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197698
Predicted Effect probably benign
Transcript: ENSMUST00000199888
SMART Domains Protein: ENSMUSP00000142693
Gene: ENSMUSG00000051278

DomainStartEndE-ValueType
Pfam:DUF2439 3 82 3.5e-22 PFAM
low complexity region 92 105 N/A INTRINSIC
low complexity region 628 639 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000200490
SMART Domains Protein: ENSMUSP00000143585
Gene: ENSMUSG00000051278

DomainStartEndE-ValueType
Pfam:DUF2439 3 81 3.4e-20 PFAM
low complexity region 92 105 N/A INTRINSIC
low complexity region 628 639 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.2%
Validation Efficiency 97% (71/73)
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410089E03Rik G A 15: 8,186,184 (GRCm38) R408H probably damaging Het
A130050O07Rik A G 1: 137,928,656 (GRCm38) Y23C unknown Het
Adcy3 G A 12: 4,195,260 (GRCm38) probably null Het
Aldh6a1 G A 12: 84,441,780 (GRCm38) L86F probably damaging Het
Arl10 G T 13: 54,575,957 (GRCm38) probably benign Het
Armc3 A G 2: 19,296,321 (GRCm38) probably null Het
Astn2 T G 4: 66,266,382 (GRCm38) probably null Het
Cacna1d G A 14: 30,114,971 (GRCm38) T804I probably benign Het
Ccny A C 18: 9,316,682 (GRCm38) probably benign Het
Cdh5 C T 8: 104,140,927 (GRCm38) T612I probably benign Het
Cfap58 A G 19: 48,029,100 (GRCm38) M800V probably benign Het
Clrn1 A T 3: 58,846,427 (GRCm38) I171K probably damaging Het
Cnp T A 11: 100,578,908 (GRCm38) probably null Het
Col12a1 T C 9: 79,651,385 (GRCm38) T1933A probably damaging Het
Cwf19l2 A G 9: 3,454,666 (GRCm38) S660G probably benign Het
Dync1i2 C A 2: 71,214,484 (GRCm38) R13S probably damaging Het
Eps8l1 A T 7: 4,477,557 (GRCm38) probably benign Het
Espn T C 4: 152,139,152 (GRCm38) T188A possibly damaging Het
F2 T C 2: 91,630,607 (GRCm38) E260G probably benign Het
Fat4 T A 3: 38,982,503 (GRCm38) S3435T probably damaging Het
Fchsd1 A G 18: 37,962,959 (GRCm38) C533R probably benign Het
Fstl5 G A 3: 76,322,191 (GRCm38) V100M probably damaging Het
Gls2 T G 10: 128,209,350 (GRCm38) L572R probably damaging Het
Gm20939 A T 17: 94,876,768 (GRCm38) E281D probably benign Het
Gpr35 T G 1: 92,983,232 (GRCm38) L222W probably damaging Het
Hsf5 C A 11: 87,657,335 (GRCm38) H615N probably benign Het
Id2 C T 12: 25,095,803 (GRCm38) D70N probably damaging Het
Ints2 T C 11: 86,249,287 (GRCm38) T240A probably damaging Het
Kcnn3 A C 3: 89,662,773 (GRCm38) D631A probably damaging Het
Klhdc8a A G 1: 132,303,005 (GRCm38) T203A probably damaging Het
Lama4 C T 10: 39,075,436 (GRCm38) T1059M possibly damaging Het
Lgals8 A G 13: 12,447,298 (GRCm38) L226P probably damaging Het
Lifr T A 15: 7,188,186 (GRCm38) probably null Het
Lonp1 T A 17: 56,618,406 (GRCm38) Q462L probably benign Het
Lypd1 A G 1: 125,910,438 (GRCm38) V48A possibly damaging Het
Mapkapk2 A G 1: 131,097,326 (GRCm38) I67T possibly damaging Het
Mbd3l1 A T 9: 18,484,858 (GRCm38) D93V probably benign Het
Mdh1b T C 1: 63,721,800 (GRCm38) probably benign Het
Myh7b C T 2: 155,622,286 (GRCm38) P569L probably damaging Het
Ncapd3 C A 9: 27,051,809 (GRCm38) A470E probably damaging Het
Ndrg2 A G 14: 51,910,445 (GRCm38) probably benign Het
Nprl2 A T 9: 107,544,419 (GRCm38) I209F probably damaging Het
Ntrk1 A G 3: 87,791,750 (GRCm38) probably benign Het
Olfm2 T C 9: 20,668,741 (GRCm38) E268G probably damaging Het
Olfr884 T A 9: 38,047,667 (GRCm38) Y148* probably null Het
Pcf11 T A 7: 92,658,317 (GRCm38) H881L probably benign Het
Pde10a A G 17: 8,977,197 (GRCm38) D640G probably damaging Het
Pde9a G A 17: 31,386,356 (GRCm38) probably null Het
Pianp G T 6: 125,001,540 (GRCm38) G236V probably damaging Het
Polr2g A G 19: 8,793,652 (GRCm38) I160T probably damaging Het
Ppp1r3a A G 6: 14,717,661 (GRCm38) S1085P possibly damaging Het
Pter G A 2: 13,001,000 (GRCm38) G328D probably damaging Het
Rad51 T A 2: 119,116,327 (GRCm38) M5K probably benign Het
Rbm43 T A 2: 51,925,667 (GRCm38) I181F probably benign Het
Rgs12 T C 5: 35,022,776 (GRCm38) probably benign Het
Rnf213 A C 11: 119,441,606 (GRCm38) D2547A possibly damaging Het
Slc20a2 C A 8: 22,535,345 (GRCm38) A21E probably damaging Het
Stab2 A G 10: 86,843,617 (GRCm38) S2503P probably benign Het
Sv2b A T 7: 75,125,641 (GRCm38) F479L probably damaging Het
Sybu T C 15: 44,673,500 (GRCm38) R349G probably damaging Het
Tead3 T C 17: 28,341,351 (GRCm38) Y2C probably damaging Het
Tnrc6c T A 11: 117,721,458 (GRCm38) N307K probably damaging Het
Ubxn11 C G 4: 134,116,025 (GRCm38) probably null Het
Ust T C 10: 8,330,065 (GRCm38) probably benign Het
Vmn2r116 T A 17: 23,401,849 (GRCm38) N852K probably benign Het
Other mutations in Zgrf1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01088:Zgrf1 APN 3 127,588,141 (GRCm38) splice site probably benign
IGL01153:Zgrf1 APN 3 127,602,406 (GRCm38) missense probably damaging 1.00
IGL01330:Zgrf1 APN 3 127,584,007 (GRCm38) missense probably damaging 1.00
IGL01501:Zgrf1 APN 3 127,602,562 (GRCm38) splice site probably null
IGL01827:Zgrf1 APN 3 127,616,281 (GRCm38) missense probably benign 0.06
IGL02600:Zgrf1 APN 3 127,600,974 (GRCm38) splice site probably benign
IGL03122:Zgrf1 APN 3 127,588,133 (GRCm38) missense possibly damaging 0.91
IGL03365:Zgrf1 APN 3 127,598,774 (GRCm38) missense possibly damaging 0.48
R0015_Zgrf1_014 UTSW 3 127,555,397 (GRCm38) splice site probably benign
R1298_Zgrf1_204 UTSW 3 127,583,889 (GRCm38) missense possibly damaging 0.95
R7175_zgrf1_533 UTSW 3 127,563,590 (GRCm38) missense probably damaging 1.00
R0243:Zgrf1 UTSW 3 127,615,446 (GRCm38) missense probably damaging 0.99
R0468:Zgrf1 UTSW 3 127,562,041 (GRCm38) missense possibly damaging 0.72
R0497:Zgrf1 UTSW 3 127,584,650 (GRCm38) splice site probably benign
R0505:Zgrf1 UTSW 3 127,573,238 (GRCm38) missense probably benign 0.30
R0511:Zgrf1 UTSW 3 127,584,660 (GRCm38) missense possibly damaging 0.93
R0539:Zgrf1 UTSW 3 127,615,192 (GRCm38) missense probably damaging 1.00
R0617:Zgrf1 UTSW 3 127,588,038 (GRCm38) missense probably benign 0.39
R1298:Zgrf1 UTSW 3 127,583,889 (GRCm38) missense possibly damaging 0.95
R1353:Zgrf1 UTSW 3 127,611,803 (GRCm38) missense probably damaging 1.00
R1593:Zgrf1 UTSW 3 127,561,026 (GRCm38) missense possibly damaging 0.86
R1846:Zgrf1 UTSW 3 127,615,463 (GRCm38) missense probably damaging 1.00
R1912:Zgrf1 UTSW 3 127,563,137 (GRCm38) missense probably benign
R2062:Zgrf1 UTSW 3 127,613,350 (GRCm38) missense probably damaging 1.00
R2064:Zgrf1 UTSW 3 127,613,350 (GRCm38) missense probably damaging 1.00
R2065:Zgrf1 UTSW 3 127,613,350 (GRCm38) missense probably damaging 1.00
R2066:Zgrf1 UTSW 3 127,613,350 (GRCm38) missense probably damaging 1.00
R2067:Zgrf1 UTSW 3 127,613,350 (GRCm38) missense probably damaging 1.00
R2256:Zgrf1 UTSW 3 127,561,997 (GRCm38) missense probably benign 0.18
R2321:Zgrf1 UTSW 3 127,562,407 (GRCm38) nonsense probably null
R2381:Zgrf1 UTSW 3 127,556,214 (GRCm38) missense probably benign 0.02
R2913:Zgrf1 UTSW 3 127,598,707 (GRCm38) missense possibly damaging 0.65
R3147:Zgrf1 UTSW 3 127,584,148 (GRCm38) missense possibly damaging 0.84
R3236:Zgrf1 UTSW 3 127,613,375 (GRCm38) missense probably damaging 1.00
R3237:Zgrf1 UTSW 3 127,613,375 (GRCm38) missense probably damaging 1.00
R4433:Zgrf1 UTSW 3 127,562,078 (GRCm38) missense probably benign
R4441:Zgrf1 UTSW 3 127,586,137 (GRCm38) missense possibly damaging 0.45
R4457:Zgrf1 UTSW 3 127,595,929 (GRCm38) missense probably damaging 1.00
R4498:Zgrf1 UTSW 3 127,586,100 (GRCm38) nonsense probably null
R4598:Zgrf1 UTSW 3 127,601,030 (GRCm38) missense probably benign 0.14
R4701:Zgrf1 UTSW 3 127,598,704 (GRCm38) missense probably benign 0.03
R4898:Zgrf1 UTSW 3 127,602,436 (GRCm38) missense probably damaging 1.00
R4944:Zgrf1 UTSW 3 127,561,868 (GRCm38) nonsense probably null
R5256:Zgrf1 UTSW 3 127,602,445 (GRCm38) missense probably damaging 1.00
R5294:Zgrf1 UTSW 3 127,600,980 (GRCm38) missense probably benign 0.14
R5358:Zgrf1 UTSW 3 127,567,703 (GRCm38) critical splice donor site probably null
R5359:Zgrf1 UTSW 3 127,601,165 (GRCm38) missense possibly damaging 0.95
R5447:Zgrf1 UTSW 3 127,563,119 (GRCm38) missense possibly damaging 0.73
R5569:Zgrf1 UTSW 3 127,561,025 (GRCm38) missense probably benign 0.33
R5887:Zgrf1 UTSW 3 127,584,765 (GRCm38) missense probably damaging 1.00
R5914:Zgrf1 UTSW 3 127,561,023 (GRCm38) missense probably damaging 0.99
R5925:Zgrf1 UTSW 3 127,573,204 (GRCm38) missense possibly damaging 0.84
R5936:Zgrf1 UTSW 3 127,562,253 (GRCm38) missense possibly damaging 0.72
R6087:Zgrf1 UTSW 3 127,615,486 (GRCm38) missense probably damaging 1.00
R6089:Zgrf1 UTSW 3 127,595,993 (GRCm38) missense probably damaging 1.00
R6181:Zgrf1 UTSW 3 127,587,941 (GRCm38) missense probably damaging 1.00
R6277:Zgrf1 UTSW 3 127,598,812 (GRCm38) missense possibly damaging 0.81
R6441:Zgrf1 UTSW 3 127,588,034 (GRCm38) missense possibly damaging 0.93
R6659:Zgrf1 UTSW 3 127,616,506 (GRCm38) missense probably damaging 0.99
R6857:Zgrf1 UTSW 3 127,581,447 (GRCm38) missense probably damaging 0.99
R6932:Zgrf1 UTSW 3 127,559,632 (GRCm38) critical splice donor site probably null
R7008:Zgrf1 UTSW 3 127,561,772 (GRCm38) missense probably benign 0.18
R7175:Zgrf1 UTSW 3 127,563,590 (GRCm38) missense probably damaging 1.00
R7264:Zgrf1 UTSW 3 127,563,569 (GRCm38) missense probably benign 0.00
R7272:Zgrf1 UTSW 3 127,598,760 (GRCm38) missense probably damaging 0.99
R7298:Zgrf1 UTSW 3 127,583,650 (GRCm38) nonsense probably null
R7412:Zgrf1 UTSW 3 127,563,071 (GRCm38) missense probably benign 0.06
R7836:Zgrf1 UTSW 3 127,563,431 (GRCm38) missense probably damaging 0.96
R7945:Zgrf1 UTSW 3 127,562,760 (GRCm38) missense probably benign 0.37
R7996:Zgrf1 UTSW 3 127,595,924 (GRCm38) missense possibly damaging 0.94
R8165:Zgrf1 UTSW 3 127,563,383 (GRCm38) missense possibly damaging 0.76
R8198:Zgrf1 UTSW 3 127,596,024 (GRCm38) critical splice donor site probably null
R8296:Zgrf1 UTSW 3 127,583,995 (GRCm38) missense probably damaging 0.99
R8298:Zgrf1 UTSW 3 127,615,229 (GRCm38) missense probably damaging 1.00
R8341:Zgrf1 UTSW 3 127,560,915 (GRCm38) nonsense probably null
R8445:Zgrf1 UTSW 3 127,586,205 (GRCm38) critical splice donor site probably null
R9088:Zgrf1 UTSW 3 127,583,677 (GRCm38) missense probably benign 0.21
R9236:Zgrf1 UTSW 3 127,584,663 (GRCm38) missense probably benign 0.09
R9250:Zgrf1 UTSW 3 127,586,148 (GRCm38) missense probably damaging 1.00
R9253:Zgrf1 UTSW 3 127,598,779 (GRCm38) missense probably damaging 1.00
R9464:Zgrf1 UTSW 3 127,584,092 (GRCm38) missense probably benign 0.03
R9647:Zgrf1 UTSW 3 127,561,602 (GRCm38) missense probably benign 0.02
R9680:Zgrf1 UTSW 3 127,615,567 (GRCm38) missense probably benign 0.38
RF015:Zgrf1 UTSW 3 127,563,233 (GRCm38) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- AGCAAGCCACTGGAGAGATGTTTAC -3'
(R):5'- CGTCAGAGGAAGAATGCAGTTCCC -3'

Sequencing Primer
(F):5'- GTCCTCCATGACAGATACAGTTTTG -3'
(R):5'- GCTGCATGTTACTACCTCAAATG -3'
Posted On 2014-07-17