Incidental Mutation 'R1942:Vmn2r27'
ID 216283
Institutional Source Beutler Lab
Gene Symbol Vmn2r27
Ensembl Gene ENSMUSG00000072778
Gene Name vomeronasal 2, receptor27
Synonyms EG232367
MMRRC Submission 039960-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # R1942 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 124168555-124208743 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 124200722 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 412 (A412T)
Ref Sequence ENSEMBL: ENSMUSP00000098528 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100968]
AlphaFold D3YUK6
Predicted Effect probably damaging
Transcript: ENSMUST00000100968
AA Change: A412T

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000098528
Gene: ENSMUSG00000072778
AA Change: A412T

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:ANF_receptor 81 475 1.1e-27 PFAM
Pfam:NCD3G 519 570 1.3e-18 PFAM
Pfam:7tm_3 603 838 2.6e-50 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 93.7%
Validation Efficiency 100% (75/75)
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930407I10Rik A T 15: 81,949,625 (GRCm39) Y1174F probably damaging Het
Ahnak A G 19: 8,992,447 (GRCm39) E4577G probably damaging Het
Anapc4 T C 5: 53,004,056 (GRCm39) V291A probably benign Het
Apba2 A G 7: 64,345,218 (GRCm39) E136G possibly damaging Het
Arhgap20 C A 9: 51,742,998 (GRCm39) Q279K probably benign Het
B3galnt1 A T 3: 69,483,258 (GRCm39) M1K probably null Het
C4bp C A 1: 130,583,804 (GRCm39) probably benign Het
Catsperg1 G A 7: 28,906,232 (GRCm39) T157I possibly damaging Het
Cfap90 A C 13: 68,761,090 (GRCm39) I171L probably benign Het
Chrm1 T A 19: 8,655,637 (GRCm39) M114K probably damaging Het
Clasp1 A G 1: 118,429,078 (GRCm39) E329G possibly damaging Het
Clrn2 A C 5: 45,611,337 (GRCm39) Y62S probably benign Het
Col12a1 T G 9: 79,542,748 (GRCm39) D2339A probably damaging Het
Copa T A 1: 171,939,455 (GRCm39) L564Q probably damaging Het
Cpeb2 C A 5: 43,392,596 (GRCm39) probably benign Het
Dhx57 A T 17: 80,572,573 (GRCm39) M647K probably damaging Het
Diaph3 C T 14: 87,378,556 (GRCm39) probably benign Het
Eomes A G 9: 118,313,716 (GRCm39) D587G probably benign Het
Gm5142 T A 14: 59,416,156 (GRCm39) M1L probably benign Het
Gnl2 A G 4: 124,923,957 (GRCm39) I12V probably benign Het
Gprin1 C T 13: 54,887,752 (GRCm39) C174Y probably benign Het
Grin2b A T 6: 135,709,730 (GRCm39) V1272E possibly damaging Het
Hdac9 A G 12: 34,479,544 (GRCm39) L227S probably damaging Het
Helz T A 11: 107,493,318 (GRCm39) L247Q probably benign Het
Hs6st1 T C 1: 36,107,803 (GRCm39) V22A probably benign Het
Hspg2 C A 4: 137,269,863 (GRCm39) A2304E possibly damaging Het
Htr3a T C 9: 48,819,911 (GRCm39) Y73C probably damaging Het
Il1rap A C 16: 26,541,205 (GRCm39) E482A probably damaging Het
Itsn2 T A 12: 4,689,670 (GRCm39) L581* probably null Het
Msmb A G 14: 31,870,034 (GRCm39) E2G probably benign Het
Muc19 T C 15: 91,776,666 (GRCm39) noncoding transcript Het
Muc4 A C 16: 32,569,460 (GRCm39) L173F probably damaging Het
Muc5b A T 7: 141,411,421 (GRCm39) S1456C unknown Het
Mylip A T 13: 45,560,172 (GRCm39) I203F probably damaging Het
Nckap5 A T 1: 125,952,039 (GRCm39) D1504E probably damaging Het
Neil1 C G 9: 57,053,891 (GRCm39) R143P probably benign Het
Nlrp2 T A 7: 5,325,447 (GRCm39) T742S probably damaging Het
Nme8 A G 13: 19,859,978 (GRCm39) V214A probably damaging Het
Nsun7 C T 5: 66,441,588 (GRCm39) T419I probably benign Het
Nup210l G A 3: 90,058,544 (GRCm39) E648K probably benign Het
Or10g6 T A 9: 39,934,031 (GRCm39) L114H probably damaging Het
Or10g6 T C 9: 39,934,048 (GRCm39) Y120H probably damaging Het
Or2y1c T C 11: 49,360,981 (GRCm39) M1T probably null Het
Or8s2 A G 15: 98,276,445 (GRCm39) L182P probably damaging Het
Parp11 A C 6: 127,447,663 (GRCm39) probably null Het
Pomgnt1 G T 4: 116,012,472 (GRCm39) probably null Het
Ppp1r14c T C 10: 3,413,417 (GRCm39) I150T probably damaging Het
Psd4 A G 2: 24,295,805 (GRCm39) E908G probably damaging Het
Psmd6 A T 14: 14,116,442 (GRCm38) V91E probably damaging Het
Ptk2b A T 14: 66,406,830 (GRCm39) V634D probably damaging Het
Rapgef6 A G 11: 54,548,089 (GRCm39) I753V possibly damaging Het
Rbm45 G A 2: 76,205,823 (GRCm39) probably null Het
Ric1 A G 19: 29,578,416 (GRCm39) probably benign Het
Sh3rf2 A G 18: 42,282,689 (GRCm39) K416E probably damaging Het
Six5 C T 7: 18,830,858 (GRCm39) A495V possibly damaging Het
Slc27a6 T A 18: 58,689,870 (GRCm39) M112K probably damaging Het
Slc5a4a T C 10: 75,983,422 (GRCm39) S20P unknown Het
Smg1 A G 7: 117,757,326 (GRCm39) probably benign Het
Sntb2 G A 8: 107,737,984 (GRCm39) A511T probably damaging Het
Stk31 A T 6: 49,416,061 (GRCm39) N622I probably damaging Het
Sulf1 T C 1: 12,918,397 (GRCm39) F38S probably damaging Het
Szt2 G T 4: 118,249,817 (GRCm39) T521K probably benign Het
Terf1 G T 1: 15,876,038 (GRCm39) R46I probably benign Het
Tmem245 A G 4: 56,923,511 (GRCm39) probably benign Het
Tmigd1 T C 11: 76,804,905 (GRCm39) probably null Het
Ugcg C T 4: 59,207,798 (GRCm39) P46S probably benign Het
Umod A G 7: 119,076,155 (GRCm39) Y204H probably damaging Het
Vcan T A 13: 89,851,543 (GRCm39) Q1139L probably benign Het
Vmn1r85 T A 7: 12,818,668 (GRCm39) T159S possibly damaging Het
Vmn2r103 T A 17: 20,032,562 (GRCm39) S779T probably benign Het
Zc3h12d A C 10: 7,729,077 (GRCm39) D147A probably damaging Het
Zfp800 A T 6: 28,243,272 (GRCm39) D564E probably benign Het
Zfp932 A G 5: 110,154,853 (GRCm39) E17G probably damaging Het
Other mutations in Vmn2r27
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01285:Vmn2r27 APN 6 124,169,370 (GRCm39) missense possibly damaging 0.86
IGL01388:Vmn2r27 APN 6 124,200,791 (GRCm39) missense possibly damaging 0.55
IGL01923:Vmn2r27 APN 6 124,177,484 (GRCm39) missense probably benign 0.20
IGL01954:Vmn2r27 APN 6 124,169,207 (GRCm39) missense probably damaging 1.00
IGL02105:Vmn2r27 APN 6 124,174,308 (GRCm39) splice site probably benign
IGL02586:Vmn2r27 APN 6 124,201,434 (GRCm39) nonsense probably null
IGL03130:Vmn2r27 APN 6 124,169,276 (GRCm39) missense possibly damaging 0.82
IGL03330:Vmn2r27 APN 6 124,207,139 (GRCm39) nonsense probably null
R0124:Vmn2r27 UTSW 6 124,208,578 (GRCm39) missense probably benign
R0234:Vmn2r27 UTSW 6 124,208,578 (GRCm39) missense probably benign
R0234:Vmn2r27 UTSW 6 124,208,578 (GRCm39) missense probably benign
R0384:Vmn2r27 UTSW 6 124,200,871 (GRCm39) missense probably benign 0.01
R0582:Vmn2r27 UTSW 6 124,201,249 (GRCm39) missense probably benign 0.02
R0733:Vmn2r27 UTSW 6 124,169,147 (GRCm39) missense probably benign 0.18
R0738:Vmn2r27 UTSW 6 124,200,661 (GRCm39) missense possibly damaging 0.48
R0835:Vmn2r27 UTSW 6 124,177,583 (GRCm39) missense probably damaging 0.99
R1183:Vmn2r27 UTSW 6 124,177,491 (GRCm39) missense probably benign
R1401:Vmn2r27 UTSW 6 124,168,591 (GRCm39) nonsense probably null
R1484:Vmn2r27 UTSW 6 124,177,474 (GRCm39) missense probably damaging 0.96
R1536:Vmn2r27 UTSW 6 124,177,649 (GRCm39) missense probably damaging 1.00
R1539:Vmn2r27 UTSW 6 124,168,730 (GRCm39) missense probably damaging 1.00
R1565:Vmn2r27 UTSW 6 124,208,593 (GRCm39) missense probably benign
R1595:Vmn2r27 UTSW 6 124,208,574 (GRCm39) missense probably benign 0.00
R1614:Vmn2r27 UTSW 6 124,200,893 (GRCm39) missense probably benign 0.01
R1742:Vmn2r27 UTSW 6 124,177,636 (GRCm39) missense possibly damaging 0.48
R1816:Vmn2r27 UTSW 6 124,207,330 (GRCm39) nonsense probably null
R1822:Vmn2r27 UTSW 6 124,208,593 (GRCm39) missense probably benign
R1824:Vmn2r27 UTSW 6 124,208,593 (GRCm39) missense probably benign
R1870:Vmn2r27 UTSW 6 124,201,170 (GRCm39) missense probably benign 0.11
R1962:Vmn2r27 UTSW 6 124,200,793 (GRCm39) missense possibly damaging 0.70
R2069:Vmn2r27 UTSW 6 124,201,442 (GRCm39) missense probably damaging 1.00
R2075:Vmn2r27 UTSW 6 124,177,510 (GRCm39) missense possibly damaging 0.85
R2379:Vmn2r27 UTSW 6 124,201,342 (GRCm39) missense possibly damaging 0.89
R3748:Vmn2r27 UTSW 6 124,207,351 (GRCm39) missense probably benign 0.35
R4384:Vmn2r27 UTSW 6 124,201,115 (GRCm39) missense probably benign 0.05
R4392:Vmn2r27 UTSW 6 124,207,135 (GRCm39) missense probably benign 0.01
R4758:Vmn2r27 UTSW 6 124,208,596 (GRCm39) missense possibly damaging 0.87
R5018:Vmn2r27 UTSW 6 124,201,141 (GRCm39) missense probably benign 0.02
R5235:Vmn2r27 UTSW 6 124,169,013 (GRCm39) missense probably damaging 0.99
R5718:Vmn2r27 UTSW 6 124,169,103 (GRCm39) missense possibly damaging 0.66
R5859:Vmn2r27 UTSW 6 124,177,647 (GRCm39) missense probably damaging 1.00
R5958:Vmn2r27 UTSW 6 124,208,686 (GRCm39) missense probably benign 0.00
R6044:Vmn2r27 UTSW 6 124,208,731 (GRCm39) missense probably benign
R6086:Vmn2r27 UTSW 6 124,168,958 (GRCm39) missense probably damaging 1.00
R6396:Vmn2r27 UTSW 6 124,201,125 (GRCm39) nonsense probably null
R6546:Vmn2r27 UTSW 6 124,169,369 (GRCm39) missense possibly damaging 0.49
R6746:Vmn2r27 UTSW 6 124,177,552 (GRCm39) missense possibly damaging 0.47
R6976:Vmn2r27 UTSW 6 124,201,312 (GRCm39) nonsense probably null
R7091:Vmn2r27 UTSW 6 124,200,904 (GRCm39) missense possibly damaging 0.85
R7145:Vmn2r27 UTSW 6 124,168,711 (GRCm39) missense probably benign
R7176:Vmn2r27 UTSW 6 124,168,995 (GRCm39) missense probably benign 0.01
R7382:Vmn2r27 UTSW 6 124,174,276 (GRCm39) missense probably damaging 1.00
R7482:Vmn2r27 UTSW 6 124,201,220 (GRCm39) missense probably damaging 1.00
R7853:Vmn2r27 UTSW 6 124,168,980 (GRCm39) missense probably damaging 1.00
R7859:Vmn2r27 UTSW 6 124,201,201 (GRCm39) missense probably benign 0.00
R7959:Vmn2r27 UTSW 6 124,169,040 (GRCm39) missense probably benign
R8266:Vmn2r27 UTSW 6 124,168,937 (GRCm39) missense probably benign 0.00
R8353:Vmn2r27 UTSW 6 124,169,404 (GRCm39) missense probably damaging 0.99
R8394:Vmn2r27 UTSW 6 124,168,776 (GRCm39) missense possibly damaging 0.71
R8463:Vmn2r27 UTSW 6 124,169,168 (GRCm39) missense probably damaging 1.00
R8477:Vmn2r27 UTSW 6 124,201,200 (GRCm39) missense probably benign 0.11
R8705:Vmn2r27 UTSW 6 124,207,188 (GRCm39) missense probably damaging 1.00
R8752:Vmn2r27 UTSW 6 124,201,018 (GRCm39) missense probably benign 0.00
R9109:Vmn2r27 UTSW 6 124,174,224 (GRCm39) missense possibly damaging 0.95
R9140:Vmn2r27 UTSW 6 124,169,207 (GRCm39) missense probably damaging 1.00
R9157:Vmn2r27 UTSW 6 124,201,244 (GRCm39) missense probably benign 0.09
R9431:Vmn2r27 UTSW 6 124,168,856 (GRCm39) missense probably damaging 1.00
R9477:Vmn2r27 UTSW 6 124,168,910 (GRCm39) missense probably damaging 0.99
R9758:Vmn2r27 UTSW 6 124,168,637 (GRCm39) missense possibly damaging 0.89
Z1177:Vmn2r27 UTSW 6 124,168,860 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CATAAGGAACTATGCTAGCATAAGG -3'
(R):5'- AGGAGTTTCTCAGAAATCTTCAACC -3'

Sequencing Primer
(F):5'- CAGCTAATGCTACCTTCC -3'
(R):5'- GCACAAAGTCAGGGAACT -3'
Posted On 2014-08-01