Incidental Mutation 'R1942:Vmn2r103'
| ID |
216330 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r103
|
| Ensembl Gene |
ENSMUSG00000091771 |
| Gene Name |
vomeronasal 2, receptor 103 |
| Synonyms |
EG627636 |
| MMRRC Submission |
039960-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.059)
|
| Stock # |
R1942 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
19773363-19812536 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 19812300 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Threonine
at position 779
(S779T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126756
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000172203]
|
| AlphaFold |
E9PWW0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000172203
AA Change: S779T
PolyPhen 2
Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000126756
Gene: ENSMUSG00000091771
AA Change: S779T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
449 |
1.3e-37 |
PFAM |
|
Pfam:NCD3G
|
509 |
562 |
3.5e-22 |
PFAM |
|
Pfam:7tm_3
|
595 |
830 |
1.1e-51 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.6%
- 20x: 93.7%
|
| Validation Efficiency |
100% (75/75) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 73 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700001L19Rik |
A |
C |
13: 68,612,971 (GRCm38) |
I171L |
probably benign |
Het |
| 4930407I10Rik |
A |
T |
15: 82,065,424 (GRCm38) |
Y1174F |
probably damaging |
Het |
| Ahnak |
A |
G |
19: 9,015,083 (GRCm38) |
E4577G |
probably damaging |
Het |
| Anapc4 |
T |
C |
5: 52,846,714 (GRCm38) |
V291A |
probably benign |
Het |
| Apba2 |
A |
G |
7: 64,695,470 (GRCm38) |
E136G |
possibly damaging |
Het |
| Arhgap20 |
C |
A |
9: 51,831,698 (GRCm38) |
Q279K |
probably benign |
Het |
| B3galnt1 |
A |
T |
3: 69,575,925 (GRCm38) |
M1K |
probably null |
Het |
| C4bp |
C |
A |
1: 130,656,067 (GRCm38) |
|
probably benign |
Het |
| Catsperg1 |
G |
A |
7: 29,206,807 (GRCm38) |
T157I |
possibly damaging |
Het |
| Chrm1 |
T |
A |
19: 8,678,273 (GRCm38) |
M114K |
probably damaging |
Het |
| Clasp1 |
A |
G |
1: 118,501,348 (GRCm38) |
E329G |
possibly damaging |
Het |
| Clrn2 |
A |
C |
5: 45,453,995 (GRCm38) |
Y62S |
probably benign |
Het |
| Col12a1 |
T |
G |
9: 79,635,466 (GRCm38) |
D2339A |
probably damaging |
Het |
| Copa |
T |
A |
1: 172,111,888 (GRCm38) |
L564Q |
probably damaging |
Het |
| Cpeb2 |
C |
A |
5: 43,235,253 (GRCm38) |
|
probably benign |
Het |
| Dhx57 |
A |
T |
17: 80,265,144 (GRCm38) |
M647K |
probably damaging |
Het |
| Diaph3 |
C |
T |
14: 87,141,120 (GRCm38) |
|
probably benign |
Het |
| Eomes |
A |
G |
9: 118,484,648 (GRCm38) |
D587G |
probably benign |
Het |
| Gm5142 |
T |
A |
14: 59,178,707 (GRCm38) |
M1L |
probably benign |
Het |
| Gnl2 |
A |
G |
4: 125,030,164 (GRCm38) |
I12V |
probably benign |
Het |
| Gprin1 |
C |
T |
13: 54,739,939 (GRCm38) |
C174Y |
probably benign |
Het |
| Grin2b |
A |
T |
6: 135,732,732 (GRCm38) |
V1272E |
possibly damaging |
Het |
| Hdac9 |
A |
G |
12: 34,429,545 (GRCm38) |
L227S |
probably damaging |
Het |
| Helz |
T |
A |
11: 107,602,492 (GRCm38) |
L247Q |
probably benign |
Het |
| Hs6st1 |
T |
C |
1: 36,068,722 (GRCm38) |
V22A |
probably benign |
Het |
| Hspg2 |
C |
A |
4: 137,542,552 (GRCm38) |
A2304E |
possibly damaging |
Het |
| Htr3a |
T |
C |
9: 48,908,611 (GRCm38) |
Y73C |
probably damaging |
Het |
| Il1rap |
A |
C |
16: 26,722,455 (GRCm38) |
E482A |
probably damaging |
Het |
| Itsn2 |
T |
A |
12: 4,639,670 (GRCm38) |
L581* |
probably null |
Het |
| Msmb |
A |
G |
14: 32,148,077 (GRCm38) |
E2G |
probably benign |
Het |
| Muc19 |
T |
C |
15: 91,892,472 (GRCm38) |
|
noncoding transcript |
Het |
| Muc4 |
A |
C |
16: 32,750,642 (GRCm38) |
L173F |
probably damaging |
Het |
| Muc5b |
A |
T |
7: 141,857,684 (GRCm38) |
S1456C |
unknown |
Het |
| Mylip |
A |
T |
13: 45,406,696 (GRCm38) |
I203F |
probably damaging |
Het |
| Nckap5 |
A |
T |
1: 126,024,302 (GRCm38) |
D1504E |
probably damaging |
Het |
| Neil1 |
C |
G |
9: 57,146,607 (GRCm38) |
R143P |
probably benign |
Het |
| Nlrp2 |
T |
A |
7: 5,322,448 (GRCm38) |
T742S |
probably damaging |
Het |
| Nme8 |
A |
G |
13: 19,675,808 (GRCm38) |
V214A |
probably damaging |
Het |
| Nsun7 |
C |
T |
5: 66,284,245 (GRCm38) |
T419I |
probably benign |
Het |
| Nup210l |
G |
A |
3: 90,151,237 (GRCm38) |
E648K |
probably benign |
Het |
| Olfr1386 |
T |
C |
11: 49,470,154 (GRCm38) |
M1T |
probably null |
Het |
| Olfr283 |
A |
G |
15: 98,378,564 (GRCm38) |
L182P |
probably damaging |
Het |
| Olfr981 |
T |
C |
9: 40,022,752 (GRCm38) |
Y120H |
probably damaging |
Het |
| Olfr981 |
T |
A |
9: 40,022,735 (GRCm38) |
L114H |
probably damaging |
Het |
| Parp11 |
A |
C |
6: 127,470,700 (GRCm38) |
|
probably null |
Het |
| Pomgnt1 |
G |
T |
4: 116,155,275 (GRCm38) |
|
probably null |
Het |
| Ppp1r14c |
T |
C |
10: 3,463,417 (GRCm38) |
I150T |
probably damaging |
Het |
| Psd4 |
A |
G |
2: 24,405,793 (GRCm38) |
E908G |
probably damaging |
Het |
| Psmd6 |
A |
T |
14: 14,116,442 (GRCm38) |
V91E |
probably damaging |
Het |
| Ptk2b |
A |
T |
14: 66,169,381 (GRCm38) |
V634D |
probably damaging |
Het |
| Rapgef6 |
A |
G |
11: 54,657,263 (GRCm38) |
I753V |
possibly damaging |
Het |
| Rbm45 |
G |
A |
2: 76,375,479 (GRCm38) |
|
probably null |
Het |
| Ric1 |
A |
G |
19: 29,601,016 (GRCm38) |
|
probably benign |
Het |
| Sh3rf2 |
A |
G |
18: 42,149,624 (GRCm38) |
K416E |
probably damaging |
Het |
| Six5 |
C |
T |
7: 19,096,933 (GRCm38) |
A495V |
possibly damaging |
Het |
| Slc27a6 |
T |
A |
18: 58,556,798 (GRCm38) |
M112K |
probably damaging |
Het |
| Slc5a4a |
T |
C |
10: 76,147,588 (GRCm38) |
S20P |
unknown |
Het |
| Smg1 |
A |
G |
7: 118,158,103 (GRCm38) |
|
probably benign |
Het |
| Sntb2 |
G |
A |
8: 107,011,352 (GRCm38) |
A511T |
probably damaging |
Het |
| Stk31 |
A |
T |
6: 49,439,127 (GRCm38) |
N622I |
probably damaging |
Het |
| Sulf1 |
T |
C |
1: 12,848,173 (GRCm38) |
F38S |
probably damaging |
Het |
| Szt2 |
G |
T |
4: 118,392,620 (GRCm38) |
T521K |
probably benign |
Het |
| Terf1 |
G |
T |
1: 15,805,814 (GRCm38) |
R46I |
probably benign |
Het |
| Tmem245 |
A |
G |
4: 56,923,511 (GRCm38) |
|
probably benign |
Het |
| Tmigd1 |
T |
C |
11: 76,914,079 (GRCm38) |
|
probably null |
Het |
| Ugcg |
C |
T |
4: 59,207,798 (GRCm38) |
P46S |
probably benign |
Het |
| Umod |
A |
G |
7: 119,476,932 (GRCm38) |
Y204H |
probably damaging |
Het |
| Vcan |
T |
A |
13: 89,703,424 (GRCm38) |
Q1139L |
probably benign |
Het |
| Vmn1r85 |
T |
A |
7: 13,084,741 (GRCm38) |
T159S |
possibly damaging |
Het |
| Vmn2r27 |
C |
T |
6: 124,223,763 (GRCm38) |
A412T |
probably damaging |
Het |
| Zc3h12d |
A |
C |
10: 7,853,313 (GRCm38) |
D147A |
probably damaging |
Het |
| Zfp800 |
A |
T |
6: 28,243,273 (GRCm38) |
D564E |
probably benign |
Het |
| Zfp932 |
A |
G |
5: 110,006,987 (GRCm38) |
E17G |
probably damaging |
Het |
|
| Other mutations in Vmn2r103 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00333:Vmn2r103
|
APN |
17 |
19,793,102 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL00939:Vmn2r103
|
APN |
17 |
19,794,965 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01120:Vmn2r103
|
APN |
17 |
19,792,997 (GRCm38) |
missense |
probably benign |
0.06 |
|
IGL01403:Vmn2r103
|
APN |
17 |
19,792,967 (GRCm38) |
missense |
probably benign |
|
|
IGL01404:Vmn2r103
|
APN |
17 |
19,812,434 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01713:Vmn2r103
|
APN |
17 |
19,794,068 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01802:Vmn2r103
|
APN |
17 |
19,799,208 (GRCm38) |
missense |
probably benign |
|
|
IGL02251:Vmn2r103
|
APN |
17 |
19,793,969 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
IGL02466:Vmn2r103
|
APN |
17 |
19,773,369 (GRCm38) |
missense |
probably benign |
|
|
IGL02555:Vmn2r103
|
APN |
17 |
19,811,611 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02668:Vmn2r103
|
APN |
17 |
19,794,127 (GRCm38) |
missense |
probably benign |
0.03 |
|
IGL02715:Vmn2r103
|
APN |
17 |
19,793,956 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL02735:Vmn2r103
|
APN |
17 |
19,812,248 (GRCm38) |
missense |
probably benign |
0.27 |
|
IGL03101:Vmn2r103
|
APN |
17 |
19,773,520 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0003:Vmn2r103
|
UTSW |
17 |
19,811,979 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0052:Vmn2r103
|
UTSW |
17 |
19,811,641 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0375:Vmn2r103
|
UTSW |
17 |
19,793,464 (GRCm38) |
missense |
probably benign |
0.12 |
|
R0375:Vmn2r103
|
UTSW |
17 |
19,792,859 (GRCm38) |
missense |
probably benign |
0.06 |
|
R0755:Vmn2r103
|
UTSW |
17 |
19,773,568 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0837:Vmn2r103
|
UTSW |
17 |
19,793,927 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1345:Vmn2r103
|
UTSW |
17 |
19,794,247 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1396:Vmn2r103
|
UTSW |
17 |
19,792,968 (GRCm38) |
missense |
probably benign |
|
|
R1488:Vmn2r103
|
UTSW |
17 |
19,793,660 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1533:Vmn2r103
|
UTSW |
17 |
19,773,400 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1590:Vmn2r103
|
UTSW |
17 |
19,794,234 (GRCm38) |
missense |
probably benign |
|
|
R1928:Vmn2r103
|
UTSW |
17 |
19,811,767 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R2071:Vmn2r103
|
UTSW |
17 |
19,793,794 (GRCm38) |
missense |
probably benign |
|
|
R2219:Vmn2r103
|
UTSW |
17 |
19,793,647 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2442:Vmn2r103
|
UTSW |
17 |
19,773,531 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2889:Vmn2r103
|
UTSW |
17 |
19,793,600 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3762:Vmn2r103
|
UTSW |
17 |
19,812,149 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R4014:Vmn2r103
|
UTSW |
17 |
19,793,604 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R4331:Vmn2r103
|
UTSW |
17 |
19,794,233 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4630:Vmn2r103
|
UTSW |
17 |
19,793,696 (GRCm38) |
missense |
probably benign |
0.04 |
|
R4631:Vmn2r103
|
UTSW |
17 |
19,793,696 (GRCm38) |
missense |
probably benign |
0.04 |
|
R4632:Vmn2r103
|
UTSW |
17 |
19,793,696 (GRCm38) |
missense |
probably benign |
0.04 |
|
R4660:Vmn2r103
|
UTSW |
17 |
19,811,815 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4801:Vmn2r103
|
UTSW |
17 |
19,795,076 (GRCm38) |
missense |
probably benign |
0.06 |
|
R4802:Vmn2r103
|
UTSW |
17 |
19,795,076 (GRCm38) |
missense |
probably benign |
0.06 |
|
R4931:Vmn2r103
|
UTSW |
17 |
19,811,769 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4995:Vmn2r103
|
UTSW |
17 |
19,773,511 (GRCm38) |
missense |
probably benign |
0.14 |
|
R5309:Vmn2r103
|
UTSW |
17 |
19,793,034 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5312:Vmn2r103
|
UTSW |
17 |
19,793,034 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5329:Vmn2r103
|
UTSW |
17 |
19,812,171 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5611:Vmn2r103
|
UTSW |
17 |
19,793,642 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5684:Vmn2r103
|
UTSW |
17 |
19,792,989 (GRCm38) |
missense |
probably benign |
0.02 |
|
R5715:Vmn2r103
|
UTSW |
17 |
19,794,939 (GRCm38) |
missense |
probably benign |
0.17 |
|
R5907:Vmn2r103
|
UTSW |
17 |
19,812,453 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R6029:Vmn2r103
|
UTSW |
17 |
19,794,216 (GRCm38) |
nonsense |
probably null |
|
|
R6114:Vmn2r103
|
UTSW |
17 |
19,812,325 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6285:Vmn2r103
|
UTSW |
17 |
19,812,144 (GRCm38) |
missense |
probably benign |
|
|
R6292:Vmn2r103
|
UTSW |
17 |
19,793,604 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R6334:Vmn2r103
|
UTSW |
17 |
19,794,082 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R6501:Vmn2r103
|
UTSW |
17 |
19,811,904 (GRCm38) |
missense |
probably benign |
0.29 |
|
R6710:Vmn2r103
|
UTSW |
17 |
19,811,977 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6774:Vmn2r103
|
UTSW |
17 |
19,773,511 (GRCm38) |
missense |
probably benign |
0.14 |
|
R6981:Vmn2r103
|
UTSW |
17 |
19,793,477 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7768:Vmn2r103
|
UTSW |
17 |
19,812,052 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7816:Vmn2r103
|
UTSW |
17 |
19,794,214 (GRCm38) |
missense |
probably benign |
0.06 |
|
R7885:Vmn2r103
|
UTSW |
17 |
19,793,123 (GRCm38) |
missense |
probably benign |
0.25 |
|
R8002:Vmn2r103
|
UTSW |
17 |
19,799,249 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8031:Vmn2r103
|
UTSW |
17 |
19,793,497 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8140:Vmn2r103
|
UTSW |
17 |
19,811,796 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8186:Vmn2r103
|
UTSW |
17 |
19,811,943 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8559:Vmn2r103
|
UTSW |
17 |
19,812,384 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9413:Vmn2r103
|
UTSW |
17 |
19,811,896 (GRCm38) |
missense |
possibly damaging |
0.54 |
|
R9591:Vmn2r103
|
UTSW |
17 |
19,811,659 (GRCm38) |
missense |
possibly damaging |
0.70 |
|
R9652:Vmn2r103
|
UTSW |
17 |
19,793,765 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9680:Vmn2r103
|
UTSW |
17 |
19,799,263 (GRCm38) |
nonsense |
probably null |
|
|
R9743:Vmn2r103
|
UTSW |
17 |
19,812,213 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r103
|
UTSW |
17 |
19,795,047 (GRCm38) |
missense |
probably benign |
0.08 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACTTCTCCACCATTCATTGATCAAG -3'
(R):5'- AGTATGTTTTCTTCCGCACATGAG -3'
Sequencing Primer
(F):5'- AGATGCTCATACTGAACATGGAC -3'
(R):5'- TTCTTCCGCACATGAGTAAATG -3'
|
| Posted On |
2014-08-01 |
Incidental Mutation