Mutagenetix > Incidental Mutation

Incidental Mutation 'R1962:Dchs1'

216983

Institutional Source

Beutler Lab

Gene Symbol

Dchs1

Ensembl Gene

ENSMUSG00000036862

Gene Name

dachsous cadherin related 1

Synonyms

3110041P15Rik, C130033F22Rik

MMRRC Submission

039976-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R1962 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

105752990-105787654 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 105764201 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Histidine at position 1136 (Y1136H)

Ref Sequence

ENSEMBL: ENSMUSP00000077574 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078482]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000078482
AA Change: Y1136H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000077574
Gene: ENSMUSG00000036862
AA Change: Y1136H

Domain	Start	End	E-Value	Type
signal peptide	1	36	N/A	INTRINSIC
CA	58	135	5.2e-11	SMART
CA	159	247	6.1e-17	SMART
CA	271	354	2.6e-30	SMART
CA	382	464	7.8e-26	SMART
CA	489	570	1.2e-34	SMART
CA	594	677	1.9e-27	SMART
CA	701	782	5.3e-11	SMART
CA	806	886	1e-12	SMART
CA	910	990	3.3e-14	SMART
CA	1016	1097	3.6e-18	SMART
CA	1121	1203	3.1e-34	SMART
CA	1233	1307	8.8e-16	SMART
low complexity region	1323	1335	N/A	INTRINSIC
CA	1344	1427	9.9e-9	SMART
CA	1451	1537	1.5e-23	SMART
CA	1560	1640	7.2e-32	SMART
CA	1664	1742	1.8e-31	SMART
CA	1765	1846	7.8e-30	SMART
CA	1870	1951	3.7e-26	SMART
low complexity region	1957	1965	N/A	INTRINSIC
CA	1979	2059	1.1e-6	SMART
CA	2083	2162	2.7e-18	SMART
CA	2186	2268	2.2e-26	SMART
CA	2291	2367	1e-18	SMART
CA	2391	2473	1.8e-23	SMART
CA	2497	2593	3.5e-21	SMART
CA	2617	2697	1.2e-25	SMART
CA	2721	2804	1.9e-18	SMART
CA	2828	2919	3e-3	SMART
transmembrane domain	2932	2954	N/A	INTRINSIC
low complexity region	3001	3017	N/A	INTRINSIC
low complexity region	3046	3055	N/A	INTRINSIC
low complexity region	3088	3097	N/A	INTRINSIC
low complexity region	3185	3196	N/A	INTRINSIC
low complexity region	3237	3259	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000131504

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000154659

Coding Region Coverage

1x: 99.1%
3x: 98.4%
10x: 96.6%
20x: 93.4%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the cadherin superfamily whose members encode calcium-dependent cell-cell adhesion molecules. The encoded protein has a signal peptide, 27 cadherin repeat domains and a unique cytoplasmic region. This particular cadherin family member is expressed in fibroblasts but not in melanocytes or keratinocytes. The cell-cell adhesion of fibroblasts is thought to be necessary for wound healing. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit postnatal lethality, growth retardation, small lungs, abnormal cochlea morphology, abnormal kidney morphology, cardiovascular abnormalities and skeletal abnormalities. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 108 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca15	A	G	7: 120,341,245 (GRCm38)	I354M	probably damaging	Het
Abca8a	T	C	11: 110,026,905 (GRCm38)		probably null	Het
Abca8b	T	C	11: 109,979,898 (GRCm38)	R143G	probably benign	Het
Actn4	T	C	7: 28,894,622 (GRCm38)	D840G	probably damaging	Het
Agpat5	T	C	8: 18,878,010 (GRCm38)	L197P	probably damaging	Het
Akr1d1	T	C	6: 37,536,048 (GRCm38)	V93A	probably benign	Het
Arap2	T	C	5: 62,676,664 (GRCm38)	K820R	possibly damaging	Het
Armc9	T	A	1: 86,207,974 (GRCm38)	C551S	probably damaging	Het
Atg7	T	C	6: 114,706,230 (GRCm38)	L418P	probably damaging	Het
Awat2	G	A	X: 100,404,559 (GRCm38)	P148S	probably damaging	Het
Brms1	C	T	19: 5,045,999 (GRCm38)	R34W	probably damaging	Het
Cbx2	A	G	11: 119,028,569 (GRCm38)	Q320R	possibly damaging	Het
Ccdc106	G	A	7: 5,059,540 (GRCm38)	D11N	possibly damaging	Het
Ccdc30	C	T	4: 119,339,791 (GRCm38)	R426Q	probably benign	Het
Cdc42bpg	T	A	19: 6,306,855 (GRCm38)	V47E	probably damaging	Het
Cep170b	C	T	12: 112,738,061 (GRCm38)	S751L	probably damaging	Het
Cfap46	A	T	7: 139,667,041 (GRCm38)	L328Q	probably damaging	Het
Crtc3	A	G	7: 80,589,931 (GRCm38)	F558L	probably damaging	Het
Cyp2d34	A	G	15: 82,618,608 (GRCm38)	V139A	probably benign	Het
Dhrs4	T	C	14: 55,487,603 (GRCm38)	V185A	probably damaging	Het
Dnah7b	A	G	1: 46,242,103 (GRCm38)	K2775E	possibly damaging	Het
Dst	C	A	1: 34,191,016 (GRCm38)	S2238R	possibly damaging	Het
Duox2	T	C	2: 122,297,372 (GRCm38)		probably null	Het
Dusp16	G	T	6: 134,718,136 (GRCm38)	Y577*	probably null	Het
Dync1h1	G	A	12: 110,636,509 (GRCm38)	E2195K	probably benign	Het
Eml5	A	G	12: 98,876,311 (GRCm38)	F176S	probably damaging	Het
Esco2	C	A	14: 65,831,533 (GRCm38)	R109S	probably damaging	Het
Galnt7	C	T	8: 57,532,714 (GRCm38)	E541K	probably benign	Het
Gbf1	C	T	19: 46,267,219 (GRCm38)	T707I	probably damaging	Het
Gdf5	A	G	2: 155,941,752 (GRCm38)	C427R	probably damaging	Het
Glyctk	T	C	9: 106,157,865 (GRCm38)	M1V	probably null	Het
Gm5478	T	C	15: 101,644,395 (GRCm38)	E367G	probably damaging	Het
Gm9268	T	C	7: 43,047,400 (GRCm38)	V620A	probably benign	Het
Golga7b	G	A	19: 42,263,329 (GRCm38)	V5I	probably benign	Het
Gpt2	T	C	8: 85,493,135 (GRCm38)	L70P	probably damaging	Het
Gsdmc3	C	A	15: 63,858,466 (GRCm38)	Q416H	probably damaging	Het
Hoxb5	A	G	11: 96,304,092 (GRCm38)	E160G	probably benign	Het
Ift81	A	T	5: 122,560,709 (GRCm38)	Y532N	probably benign	Het
Igf1	G	A	10: 87,864,864 (GRCm38)	C66Y	probably damaging	Het
Igf1r	T	C	7: 68,207,275 (GRCm38)	V995A	probably damaging	Het
Ip6k1	T	C	9: 108,041,088 (GRCm38)		probably null	Het
Jaml	T	C	9: 45,104,197 (GRCm38)	I333T	possibly damaging	Het
Kdm4c	T	C	4: 74,307,016 (GRCm38)		probably benign	Het
Kdm6b	T	C	11: 69,401,365 (GRCm38)		probably benign	Het
Krt6a	C	T	15: 101,691,465 (GRCm38)	R404H	probably damaging	Het
Larp4b	C	A	13: 9,136,842 (GRCm38)	H69N	probably benign	Het
Lcat	A	T	8: 105,941,723 (GRCm38)	W222R	probably damaging	Het
Lrrc40	T	A	3: 158,040,449 (GRCm38)	C54S	probably benign	Het
Mcpt9	T	A	14: 56,027,567 (GRCm38)	H159L	probably benign	Het
Megf8	T	C	7: 25,363,551 (GRCm38)	V2444A	probably damaging	Het
Memo1	T	C	17: 74,245,008 (GRCm38)	T98A	possibly damaging	Het
Micalcl	A	T	7: 112,412,844 (GRCm38)	I634L	probably benign	Het
Mov10	C	T	3: 104,796,977 (GRCm38)	R835Q	probably damaging	Het
Mybpc1	A	T	10: 88,548,826 (GRCm38)	L546Q	probably damaging	Het
Myo6	T	C	9: 80,260,835 (GRCm38)	V427A	probably damaging	Het
Myom2	T	A	8: 15,132,599 (GRCm38)		probably null	Het
Mzt2	G	A	16: 15,848,679 (GRCm38)	R125C	probably damaging	Het
Neb	T	A	2: 52,272,937 (GRCm38)	R2031*	probably null	Het
Nphp3	T	C	9: 104,021,338 (GRCm38)	S447P	probably benign	Het
Nrp2	T	A	1: 62,718,931 (GRCm38)	D25E	probably benign	Het
Nts	A	G	10: 102,485,057 (GRCm38)	L57S	probably damaging	Het
Nudt9	G	A	5: 104,065,105 (GRCm38)	R348H	probably benign	Het
Olfr1299	T	C	2: 111,664,889 (GRCm38)	I221T	probably damaging	Het
Olfr198	T	A	16: 59,201,908 (GRCm38)	I173F	possibly damaging	Het
Olfr211	C	T	6: 116,493,764 (GRCm38)	P52S	probably benign	Het
Olfr401	C	A	11: 74,121,824 (GRCm38)	D178E	probably benign	Het
Olfr976	T	C	9: 39,956,683 (GRCm38)	Y84C	probably benign	Het
Pafah1b1	T	C	11: 74,699,351 (GRCm38)		probably benign	Het
Piezo2	C	A	18: 63,078,840 (GRCm38)	M1291I	probably damaging	Het
Pik3ca	T	C	3: 32,443,867 (GRCm38)	F486S	probably benign	Het
Podnl1	C	T	8: 84,127,297 (GRCm38)	H99Y	probably benign	Het
Prdm6	A	T	18: 53,568,161 (GRCm38)	Y341F	probably damaging	Het
Prr5l	C	T	2: 101,758,509 (GRCm38)		probably null	Het
Psmd4	G	T	3: 95,036,701 (GRCm38)	T24N	possibly damaging	Het
Rbbp8nl	G	A	2: 180,280,874 (GRCm38)	T242M	probably benign	Het
Rsf1	GCG	GCGACG	7: 97,579,907 (GRCm38)		probably benign	Het
Rsf1	GGCGGCGGCGGCGGCGGCGGCGGCGGCGGC	GGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGC	7: 97,579,906 (GRCm38)		probably benign	Het
Scfd1	T	C	12: 51,422,986 (GRCm38)	V438A	probably benign	Het
Scn9a	A	G	2: 66,484,311 (GRCm38)	C1677R	probably damaging	Het
Sgsm2	T	A	11: 74,892,028 (GRCm38)	H34L	probably damaging	Het
Shank1	T	A	7: 44,344,323 (GRCm38)		probably null	Het
Smarca2	G	T	19: 26,672,724 (GRCm38)	E24*	probably null	Het
Sncaip	C	T	18: 52,871,362 (GRCm38)	H354Y	probably damaging	Het
St8sia2	T	A	7: 73,943,309 (GRCm38)	D333V	probably damaging	Het
Stxbp2	C	A	8: 3,642,672 (GRCm38)	R575S	probably benign	Het
Syt9	T	A	7: 107,425,107 (GRCm38)	V69D	probably damaging	Het
Tanc2	A	G	11: 105,798,732 (GRCm38)	N240S	probably benign	Het
Tcl1b1	T	C	12: 105,164,468 (GRCm38)	L70S	probably benign	Het
Tmem44	C	T	16: 30,543,401 (GRCm38)		probably null	Het
Tor1b	A	G	2: 30,956,919 (GRCm38)	R293G	probably benign	Het
Trim29	T	C	9: 43,311,318 (GRCm38)	V148A	probably benign	Het
Trmt10b	C	A	4: 45,314,378 (GRCm38)	Y271*	probably null	Het
Ubqln5	A	T	7: 104,128,888 (GRCm38)	V243E	possibly damaging	Het
Ubqln5	T	C	7: 104,128,927 (GRCm38)	D230G	probably damaging	Het
Ugt2b37	A	G	5: 87,254,334 (GRCm38)	F146S	probably damaging	Het
Vmn1r160	T	A	7: 22,871,402 (GRCm38)	V60E	probably damaging	Het
Vmn2r109	T	A	17: 20,553,923 (GRCm38)	D390V	probably damaging	Het
Vmn2r27	C	T	6: 124,223,834 (GRCm38)	R388Q	possibly damaging	Het
Vmn2r72	A	T	7: 85,749,161 (GRCm38)	V537D	probably benign	Het
Vmn2r84	A	G	10: 130,390,722 (GRCm38)	S416P	probably damaging	Het
Vmn2r98	C	A	17: 19,065,333 (GRCm38)	Y138*	probably null	Het
Xrra1	A	C	7: 99,911,020 (GRCm38)	E401A	probably damaging	Het
Zfp280d	T	A	9: 72,335,080 (GRCm38)	C688*	probably null	Het
Zfp3	T	A	11: 70,772,128 (GRCm38)	Y304*	probably null	Het
Zfp407	A	T	18: 84,559,336 (GRCm38)	D1217E	probably benign	Het
Zfp658	T	C	7: 43,573,821 (GRCm38)	Y507H	possibly damaging	Het
Zfyve16	T	C	13: 92,522,744 (GRCm38)	T220A	possibly damaging	Het
Zmym4	C	G	4: 126,902,670 (GRCm38)	K820N	possibly damaging	Het

Other mutations in Dchs1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00235:Dchs1	APN	7	105,758,743 (GRCm38)	missense	probably damaging	1.00
IGL00422:Dchs1	APN	7	105,758,029 (GRCm38)	missense	possibly damaging	0.88
IGL00427:Dchs1	APN	7	105,758,424 (GRCm38)	missense	probably damaging	0.98
IGL00469:Dchs1	APN	7	105,755,261 (GRCm38)	missense	probably damaging	1.00
IGL00470:Dchs1	APN	7	105,758,207 (GRCm38)	missense	probably damaging	1.00
IGL00534:Dchs1	APN	7	105,757,943 (GRCm38)	missense	probably benign
IGL01292:Dchs1	APN	7	105,760,891 (GRCm38)	missense	probably damaging	0.98
IGL01380:Dchs1	APN	7	105,762,211 (GRCm38)	missense	probably damaging	1.00
IGL01396:Dchs1	APN	7	105,772,283 (GRCm38)	missense	probably damaging	1.00
IGL01448:Dchs1	APN	7	105,771,927 (GRCm38)	missense	probably damaging	0.98
IGL01759:Dchs1	APN	7	105,755,302 (GRCm38)	missense	probably benign	0.00
IGL01829:Dchs1	APN	7	105,755,397 (GRCm38)	missense	probably damaging	0.99
IGL01946:Dchs1	APN	7	105,759,105 (GRCm38)	missense	probably damaging	1.00
IGL01955:Dchs1	APN	7	105,757,591 (GRCm38)	missense	probably benign	0.00
IGL02012:Dchs1	APN	7	105,764,297 (GRCm38)	missense	probably damaging	0.98
IGL02222:Dchs1	APN	7	105,764,887 (GRCm38)	missense	probably damaging	1.00
IGL02261:Dchs1	APN	7	105,772,569 (GRCm38)	missense	probably damaging	1.00
IGL02365:Dchs1	APN	7	105,755,188 (GRCm38)	missense	probably benign	0.22
IGL02430:Dchs1	APN	7	105,771,971 (GRCm38)	missense	probably benign	0.34
IGL02500:Dchs1	APN	7	105,755,806 (GRCm38)	missense	probably benign
IGL02741:Dchs1	APN	7	105,757,323 (GRCm38)	missense	probably damaging	1.00
IGL02890:Dchs1	APN	7	105,756,491 (GRCm38)	missense	probably damaging	1.00
IGL03213:Dchs1	APN	7	105,755,072 (GRCm38)	missense	probably damaging	1.00
G1patch:Dchs1	UTSW	7	105,758,793 (GRCm38)	missense	probably damaging	0.99
P0026:Dchs1	UTSW	7	105,758,405 (GRCm38)	missense	probably damaging	0.99
PIT4377001:Dchs1	UTSW	7	105,757,588 (GRCm38)	missense	probably damaging	1.00
PIT4791001:Dchs1	UTSW	7	105,758,971 (GRCm38)	missense	probably damaging	1.00
R0013:Dchs1	UTSW	7	105,755,836 (GRCm38)	missense	possibly damaging	0.90
R0090:Dchs1	UTSW	7	105,755,932 (GRCm38)	missense	probably benign	0.18
R0091:Dchs1	UTSW	7	105,766,094 (GRCm38)	splice site	probably benign
R0193:Dchs1	UTSW	7	105,764,983 (GRCm38)	missense	probably benign	0.40
R0395:Dchs1	UTSW	7	105,758,538 (GRCm38)	missense	probably damaging	1.00
R0448:Dchs1	UTSW	7	105,765,927 (GRCm38)	missense	probably benign	0.00
R0480:Dchs1	UTSW	7	105,771,489 (GRCm38)	missense	probably benign	0.14
R0485:Dchs1	UTSW	7	105,772,727 (GRCm38)	missense	probably benign	0.00
R0566:Dchs1	UTSW	7	105,759,195 (GRCm38)	missense	probably benign	0.00
R0571:Dchs1	UTSW	7	105,771,996 (GRCm38)	missense	probably damaging	1.00
R0573:Dchs1	UTSW	7	105,758,778 (GRCm38)	missense	probably damaging	0.98
R0577:Dchs1	UTSW	7	105,764,255 (GRCm38)	missense	possibly damaging	0.78
R0622:Dchs1	UTSW	7	105,763,449 (GRCm38)	missense	probably damaging	1.00
R0654:Dchs1	UTSW	7	105,772,349 (GRCm38)	missense	probably damaging	1.00
R0677:Dchs1	UTSW	7	105,764,984 (GRCm38)	missense	probably damaging	1.00
R1171:Dchs1	UTSW	7	105,757,714 (GRCm38)	missense	probably benign
R1241:Dchs1	UTSW	7	105,758,178 (GRCm38)	missense	probably damaging	1.00
R1389:Dchs1	UTSW	7	105,755,571 (GRCm38)	missense	probably benign	0.40
R1427:Dchs1	UTSW	7	105,766,191 (GRCm38)	missense	probably benign	0.06
R1458:Dchs1	UTSW	7	105,755,244 (GRCm38)	missense	probably damaging	1.00
R1513:Dchs1	UTSW	7	105,772,071 (GRCm38)	nonsense	probably null
R1524:Dchs1	UTSW	7	105,764,525 (GRCm38)	missense	probably damaging	1.00
R1525:Dchs1	UTSW	7	105,758,931 (GRCm38)	missense	probably damaging	1.00
R1534:Dchs1	UTSW	7	105,772,040 (GRCm38)	missense	probably damaging	0.98
R1567:Dchs1	UTSW	7	105,771,861 (GRCm38)	missense	probably benign	0.01
R1577:Dchs1	UTSW	7	105,765,955 (GRCm38)	missense	probably damaging	1.00
R1603:Dchs1	UTSW	7	105,762,770 (GRCm38)	missense	probably benign	0.24
R1676:Dchs1	UTSW	7	105,754,921 (GRCm38)	missense	probably benign	0.40
R1794:Dchs1	UTSW	7	105,771,720 (GRCm38)	missense	probably benign	0.02
R1826:Dchs1	UTSW	7	105,757,627 (GRCm38)	missense	probably damaging	1.00
R1892:Dchs1	UTSW	7	105,764,156 (GRCm38)	missense	probably benign	0.00
R1924:Dchs1	UTSW	7	105,772,280 (GRCm38)	missense	possibly damaging	0.81
R1932:Dchs1	UTSW	7	105,765,902 (GRCm38)	missense	probably damaging	1.00
R1985:Dchs1	UTSW	7	105,772,398 (GRCm38)	missense	possibly damaging	0.72
R1993:Dchs1	UTSW	7	105,762,548 (GRCm38)	missense	probably benign	0.00
R2007:Dchs1	UTSW	7	105,755,325 (GRCm38)	missense	probably damaging	1.00
R2316:Dchs1	UTSW	7	105,764,204 (GRCm38)	missense	possibly damaging	0.71
R2351:Dchs1	UTSW	7	105,754,094 (GRCm38)	missense	probably benign
R2474:Dchs1	UTSW	7	105,772,838 (GRCm38)	missense	probably damaging	1.00
R2474:Dchs1	UTSW	7	105,755,074 (GRCm38)	missense	probably benign	0.37
R3429:Dchs1	UTSW	7	105,756,504 (GRCm38)	missense	possibly damaging	0.85
R3430:Dchs1	UTSW	7	105,756,504 (GRCm38)	missense	possibly damaging	0.85
R3737:Dchs1	UTSW	7	105,762,316 (GRCm38)	missense	possibly damaging	0.88
R3767:Dchs1	UTSW	7	105,757,085 (GRCm38)	missense	possibly damaging	0.67
R3874:Dchs1	UTSW	7	105,761,635 (GRCm38)	missense	probably damaging	1.00
R3883:Dchs1	UTSW	7	105,762,563 (GRCm38)	missense	probably damaging	1.00
R4105:Dchs1	UTSW	7	105,765,140 (GRCm38)	missense	probably damaging	1.00
R4209:Dchs1	UTSW	7	105,766,190 (GRCm38)	missense	probably damaging	0.99
R4329:Dchs1	UTSW	7	105,753,759 (GRCm38)	missense	probably damaging	1.00
R4516:Dchs1	UTSW	7	105,754,852 (GRCm38)	missense	probably damaging	1.00
R4579:Dchs1	UTSW	7	105,758,973 (GRCm38)	missense	probably benign
R4579:Dchs1	UTSW	7	105,754,765 (GRCm38)	missense	probably damaging	1.00
R4588:Dchs1	UTSW	7	105,756,041 (GRCm38)	missense	probably benign
R4613:Dchs1	UTSW	7	105,772,724 (GRCm38)	missense	probably damaging	1.00
R4632:Dchs1	UTSW	7	105,754,355 (GRCm38)	missense	probably benign	0.02
R4696:Dchs1	UTSW	7	105,764,627 (GRCm38)	missense	probably damaging	1.00
R4725:Dchs1	UTSW	7	105,765,552 (GRCm38)	missense	probably damaging	1.00
R4725:Dchs1	UTSW	7	105,755,253 (GRCm38)	missense	probably damaging	0.98
R4738:Dchs1	UTSW	7	105,758,673 (GRCm38)	missense	probably damaging	0.96
R4768:Dchs1	UTSW	7	105,771,620 (GRCm38)	missense	possibly damaging	0.96
R4784:Dchs1	UTSW	7	105,765,926 (GRCm38)	missense	probably damaging	1.00
R4864:Dchs1	UTSW	7	105,755,253 (GRCm38)	missense	probably damaging	0.98
R4880:Dchs1	UTSW	7	105,755,730 (GRCm38)	missense	probably benign	0.00
R4909:Dchs1	UTSW	7	105,766,255 (GRCm38)	missense	probably damaging	1.00
R5102:Dchs1	UTSW	7	105,772,177 (GRCm38)	missense	probably benign	0.09
R5109:Dchs1	UTSW	7	105,765,014 (GRCm38)	missense	probably benign
R5126:Dchs1	UTSW	7	105,753,517 (GRCm38)	missense	probably damaging	1.00
R5149:Dchs1	UTSW	7	105,755,658 (GRCm38)	missense	probably damaging	0.98
R5330:Dchs1	UTSW	7	105,754,602 (GRCm38)	missense	probably damaging	1.00
R5384:Dchs1	UTSW	7	105,772,055 (GRCm38)	missense	probably damaging	1.00
R5384:Dchs1	UTSW	7	105,758,029 (GRCm38)	missense	probably damaging	1.00
R5386:Dchs1	UTSW	7	105,758,029 (GRCm38)	missense	probably damaging	1.00
R5622:Dchs1	UTSW	7	105,755,293 (GRCm38)	missense	probably benign	0.11
R5623:Dchs1	UTSW	7	105,772,769 (GRCm38)	missense	probably damaging	1.00
R5708:Dchs1	UTSW	7	105,772,809 (GRCm38)	missense	probably damaging	1.00
R5718:Dchs1	UTSW	7	105,755,748 (GRCm38)	missense	probably benign	0.01
R5743:Dchs1	UTSW	7	105,771,596 (GRCm38)	missense	probably benign
R5759:Dchs1	UTSW	7	105,764,176 (GRCm38)	missense	probably damaging	0.99
R5772:Dchs1	UTSW	7	105,773,040 (GRCm38)	missense	probably damaging	1.00
R5860:Dchs1	UTSW	7	105,772,035 (GRCm38)	missense	probably damaging	1.00
R5916:Dchs1	UTSW	7	105,759,166 (GRCm38)	missense	probably damaging	1.00
R5965:Dchs1	UTSW	7	105,755,925 (GRCm38)	missense	probably damaging	1.00
R5997:Dchs1	UTSW	7	105,754,095 (GRCm38)	missense	probably benign	0.08
R6065:Dchs1	UTSW	7	105,755,421 (GRCm38)	missense	probably damaging	1.00
R6136:Dchs1	UTSW	7	105,760,925 (GRCm38)	missense	probably benign
R6137:Dchs1	UTSW	7	105,765,106 (GRCm38)	missense	probably damaging	0.99
R6324:Dchs1	UTSW	7	105,764,938 (GRCm38)	missense	probably benign	0.05
R6363:Dchs1	UTSW	7	105,758,472 (GRCm38)	missense	probably benign	0.12
R6466:Dchs1	UTSW	7	105,764,541 (GRCm38)	missense	probably benign	0.09
R6544:Dchs1	UTSW	7	105,758,178 (GRCm38)	missense	probably damaging	1.00
R6572:Dchs1	UTSW	7	105,758,806 (GRCm38)	missense	possibly damaging	0.94
R6579:Dchs1	UTSW	7	105,762,913 (GRCm38)	missense	probably benign	0.17
R6632:Dchs1	UTSW	7	105,761,878 (GRCm38)	missense	probably damaging	1.00
R6725:Dchs1	UTSW	7	105,758,793 (GRCm38)	missense	probably damaging	0.99
R6789:Dchs1	UTSW	7	105,757,003 (GRCm38)	missense	possibly damaging	0.61
R6868:Dchs1	UTSW	7	105,763,503 (GRCm38)	missense	possibly damaging	0.91
R7058:Dchs1	UTSW	7	105,757,021 (GRCm38)	missense	probably benign
R7064:Dchs1	UTSW	7	105,763,185 (GRCm38)	missense	probably damaging	0.99
R7076:Dchs1	UTSW	7	105,761,871 (GRCm38)	missense	probably benign	0.04
R7191:Dchs1	UTSW	7	105,765,439 (GRCm38)	missense	possibly damaging	0.89
R7298:Dchs1	UTSW	7	105,755,131 (GRCm38)	nonsense	probably null
R7380:Dchs1	UTSW	7	105,758,628 (GRCm38)	missense	probably benign	0.35
R7438:Dchs1	UTSW	7	105,754,948 (GRCm38)	missense	probably benign	0.30
R7496:Dchs1	UTSW	7	105,761,859 (GRCm38)	missense	probably damaging	1.00
R7534:Dchs1	UTSW	7	105,772,373 (GRCm38)	missense	probably benign	0.00
R7604:Dchs1	UTSW	7	105,765,982 (GRCm38)	missense	probably damaging	1.00
R7631:Dchs1	UTSW	7	105,759,238 (GRCm38)	missense	probably benign
R7821:Dchs1	UTSW	7	105,765,145 (GRCm38)	missense	probably benign	0.00
R7834:Dchs1	UTSW	7	105,765,567 (GRCm38)	missense	probably benign	0.39
R7841:Dchs1	UTSW	7	105,762,973 (GRCm38)	missense	probably benign
R7913:Dchs1	UTSW	7	105,759,228 (GRCm38)	missense	possibly damaging	0.61
R8041:Dchs1	UTSW	7	105,755,188 (GRCm38)	missense	probably benign	0.45
R8076:Dchs1	UTSW	7	105,761,982 (GRCm38)	missense	probably damaging	1.00
R8076:Dchs1	UTSW	7	105,755,921 (GRCm38)	missense	possibly damaging	0.52
R8087:Dchs1	UTSW	7	105,753,499 (GRCm38)	missense	probably benign	0.41
R8125:Dchs1	UTSW	7	105,764,882 (GRCm38)	missense	possibly damaging	0.91
R8223:Dchs1	UTSW	7	105,762,617 (GRCm38)	missense	possibly damaging	0.81
R8239:Dchs1	UTSW	7	105,765,511 (GRCm38)	missense	probably benign	0.22
R8476:Dchs1	UTSW	7	105,758,808 (GRCm38)	missense	probably benign	0.05
R8497:Dchs1	UTSW	7	105,758,961 (GRCm38)	missense	probably damaging	1.00
R8770:Dchs1	UTSW	7	105,771,738 (GRCm38)	missense	probably damaging	1.00
R8856:Dchs1	UTSW	7	105,760,857 (GRCm38)	missense	probably damaging	1.00
R8866:Dchs1	UTSW	7	105,755,390 (GRCm38)	missense	probably benign	0.00
R8948:Dchs1	UTSW	7	105,759,005 (GRCm38)	missense	probably benign	0.30
R8950:Dchs1	UTSW	7	105,759,005 (GRCm38)	missense	probably benign	0.30
R9029:Dchs1	UTSW	7	105,753,712 (GRCm38)	missense	probably benign	0.13
R9039:Dchs1	UTSW	7	105,756,008 (GRCm38)	missense	probably benign	0.11
R9081:Dchs1	UTSW	7	105,754,429 (GRCm38)	missense	probably benign	0.00
R9134:Dchs1	UTSW	7	105,755,703 (GRCm38)	missense	probably damaging	0.96
R9159:Dchs1	UTSW	7	105,765,919 (GRCm38)	missense	probably benign
R9162:Dchs1	UTSW	7	105,765,525 (GRCm38)	missense	probably damaging	1.00
R9169:Dchs1	UTSW	7	105,772,907 (GRCm38)	missense	probably damaging	1.00
R9262:Dchs1	UTSW	7	105,755,626 (GRCm38)	missense	probably damaging	1.00
R9292:Dchs1	UTSW	7	105,753,913 (GRCm38)	missense	probably damaging	1.00
R9325:Dchs1	UTSW	7	105,766,195 (GRCm38)	missense	possibly damaging	0.51
R9376:Dchs1	UTSW	7	105,765,774 (GRCm38)	critical splice donor site	probably null
R9392:Dchs1	UTSW	7	105,772,662 (GRCm38)	missense	probably benign	0.09
R9619:Dchs1	UTSW	7	105,764,455 (GRCm38)	missense	probably benign	0.07
R9680:Dchs1	UTSW	7	105,762,418 (GRCm38)	missense	probably damaging	1.00
R9687:Dchs1	UTSW	7	105,757,984 (GRCm38)	missense	probably damaging	0.99
R9747:Dchs1	UTSW	7	105,763,475 (GRCm38)	missense	probably damaging	1.00
Z1177:Dchs1	UTSW	7	105,757,693 (GRCm38)	missense	probably damaging	1.00
Z1177:Dchs1	UTSW	7	105,758,551 (GRCm38)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- GTGTGACCAAGTACCAAGGC -3'
(R):5'- ATTGAAGGTGATGGCTGTATCC -3'

Sequencing Primer
(F):5'- GGCTAAACTCCAGGCTGAATC -3'
(R):5'- CCGGTTCCAAAGCTGAATTG -3'

Posted On

2014-08-01