Mutagenetix > Incidental Mutations

Incidental Mutation 'R0132:Vmn2r90'

21719

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r90

Ensembl Gene

ENSMUSG00000092120

Gene Name

vomeronasal 2, receptor 90

Synonyms

EG626942

MMRRC Submission

038417-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.105) question?

Stock #

R0132 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

17703747-17735156 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 17712249 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Arginine at position 139 (S139R)

Ref Sequence

ENSEMBL: ENSMUSP00000126650 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000169805] [ENSMUST00000231659] [ENSMUST00000232078] [ENSMUST00000232113]

AlphaFold

E9PXJ8

Predicted Effect

probably benign
Transcript: ENSMUST00000169805
AA Change: S139R

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000126650
Gene: ENSMUSG00000092120
AA Change: S139R

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	77	471	1.8e-43	PFAM
Pfam:NCD3G	514	567	3e-22	PFAM
Pfam:7tm_3	600	835	9.8e-54	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000231659

Predicted Effect

probably benign
Transcript: ENSMUST00000232078

Predicted Effect

probably benign
Transcript: ENSMUST00000232113

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.1%
3x: 97.9%
10x: 94.2%
20x: 84.8%

Validation Efficiency

90% (52/58)

Allele List at MGI

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9530053A07Rik	A	G	7: 28,137,615	R320G	probably damaging	Het
Abcc12	A	G	8: 86,531,568	I773T	probably benign	Het
Adamtsl1	T	A	4: 86,342,723	I1057N	possibly damaging	Het
Anxa5	G	A	3: 36,450,672	A247V	probably damaging	Het
Ascc3	T	G	10: 50,735,329	W1589G	probably damaging	Het
Atp2b2	G	A	6: 113,793,782	P389S	probably damaging	Het
Bpifa6	T	A	2: 153,982,931	S9T	probably benign	Het
Chd8	A	G	14: 52,205,326	V589A	probably benign	Het
Chrnb2	T	C	3: 89,764,406	M1V	probably null	Het
Col16a1	T	A	4: 130,067,096	V449E	unknown	Het
Cttnbp2nl	T	G	3: 105,005,857	K237T	probably damaging	Het
Dazap1	T	G	10: 80,278,226		probably null	Het
Fam187b	T	A	7: 30,989,120	V22E	probably damaging	Het
Gm4788	T	A	1: 139,754,271	T196S	probably damaging	Het
H2-T24	T	A	17: 36,014,986	I238F	probably damaging	Het
Hectd4	A	G	5: 121,333,024	E2658G	probably benign	Het
Herc1	A	C	9: 66,480,910	I3826L	probably benign	Het
Hinfp	A	G	9: 44,299,763	C67R	probably damaging	Het
Hp1bp3	C	T	4: 138,237,209	S348F	probably damaging	Het
Hspg2	T	C	4: 137,551,887	Y3094H	probably damaging	Het
Htr1f	A	G	16: 64,926,728	V67A	probably damaging	Het
Iqcc	T	G	4: 129,616,599	E374D	probably damaging	Het
Kcnj9	T	C	1: 172,326,198	T120A	probably damaging	Het
Kitl	C	T	10: 100,087,364	P208S	probably benign	Het
Lpcat4	A	G	2: 112,246,748	Y479C	probably damaging	Het
Lrrc74b	T	C	16: 17,553,152	N227S	probably damaging	Het
Mdc1	T	A	17: 35,852,581	V1007D	probably damaging	Het
Mocos	T	G	18: 24,679,762	I571S	probably benign	Het
Myh8	A	G	11: 67,292,188	N659D	probably damaging	Het
Naip2	A	G	13: 100,183,788	V240A	probably benign	Het
Nap1l1	T	C	10: 111,485,509	S37P	probably benign	Het
Nin	T	G	12: 70,051,141	K515T	probably damaging	Het
Npl	T	A	1: 153,509,118	K258*	probably null	Het
Ntn4	T	A	10: 93,644,707	S98T	possibly damaging	Het
Olfr177	C	A	16: 58,872,906	M81I	probably benign	Het
Olfr372	C	T	8: 72,058,400	T240M	probably damaging	Het
Olfr417	T	C	1: 174,369,586	V223A	probably damaging	Het
Ppox	C	A	1: 171,279,275	A192S	possibly damaging	Het
Prkdc	T	C	16: 15,713,653	L1380S	probably benign	Het
Psd4	C	A	2: 24,405,351	A839E	probably damaging	Het
Ptprn2	T	G	12: 116,722,091	F57V	probably damaging	Het
Ptprt	C	T	2: 162,278,110	V146I	probably benign	Het
R3hdm2	T	A	10: 127,498,453	M915K	probably damaging	Het
Rab26	C	T	17: 24,530,785		probably null	Het
Rnf213	A	G	11: 119,430,361	E1215G	probably benign	Het
Rprd2	T	C	3: 95,774,361	K407E	probably damaging	Het
Siah3	G	A	14: 75,456,134	V27I	possibly damaging	Het
Slc14a2	T	A	18: 78,192,123	N280Y	probably damaging	Het
Slc25a35	A	G	11: 68,971,960	Y247C	probably damaging	Het
Slc29a4	A	G	5: 142,705,530	D55G	probably benign	Het
Slc35d1	C	T	4: 103,208,181	V189I	probably benign	Het
Srrm1	G	A	4: 135,340,573	R322*	probably null	Het
Stac3	A	T	10: 127,503,650	R138S	probably damaging	Het
Tmem260	T	A	14: 48,483,322	C306*	probably null	Het
Tspyl1	A	G	10: 34,283,089	N270S	probably damaging	Het
Ugt2a2	T	A	5: 87,474,861	K293*	probably null	Het
Vmn2r102	A	C	17: 19,678,763	T456P	probably benign	Het
Zmym2	A	G	14: 56,943,258	N876D	probably benign	Het

Other mutations in Vmn2r90

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00092:Vmn2r90	APN	17	17733496	missense	probably benign	0.00
IGL01330:Vmn2r90	APN	17	17733280	missense	probably benign	0.00
IGL01989:Vmn2r90	APN	17	17713232	nonsense	probably null
IGL02080:Vmn2r90	APN	17	17712858	missense	probably damaging	1.00
IGL02112:Vmn2r90	APN	17	17712203	missense	probably damaging	0.98
IGL02123:Vmn2r90	APN	17	17733482	missense	probably benign	0.01
IGL02749:Vmn2r90	APN	17	17726860	makesense	probably null
IGL03114:Vmn2r90	APN	17	17733509	missense	probably damaging	1.00
R0131:Vmn2r90	UTSW	17	17712249	missense	probably benign	0.00
R0131:Vmn2r90	UTSW	17	17712249	missense	probably benign	0.00
R0184:Vmn2r90	UTSW	17	17726877	nonsense	probably null
R0379:Vmn2r90	UTSW	17	17728139	missense	probably damaging	1.00
R1022:Vmn2r90	UTSW	17	17728138	missense	probably damaging	1.00
R1024:Vmn2r90	UTSW	17	17728138	missense	probably damaging	1.00
R1897:Vmn2r90	UTSW	17	17733304	missense	probably damaging	1.00
R1993:Vmn2r90	UTSW	17	17713263	missense	probably damaging	1.00
R2472:Vmn2r90	UTSW	17	17728146	missense	probably damaging	1.00
R2508:Vmn2r90	UTSW	17	17733967	missense	probably damaging	1.00
R2679:Vmn2r90	UTSW	17	17712869	missense	possibly damaging	0.46
R3409:Vmn2r90	UTSW	17	17733376	missense	probably benign	0.00
R4693:Vmn2r90	UTSW	17	17733694	missense	possibly damaging	0.91
R4797:Vmn2r90	UTSW	17	17712305	missense	probably damaging	1.00
R5258:Vmn2r90	UTSW	17	17712852	missense	probably benign	0.12
R5358:Vmn2r90	UTSW	17	17704150	critical splice donor site	probably null
R5445:Vmn2r90	UTSW	17	17734124	missense	probably benign	0.04
R5446:Vmn2r90	UTSW	17	17712202	missense	probably damaging	0.99
R5567:Vmn2r90	UTSW	17	17712074	missense	probably damaging	1.00
R5680:Vmn2r90	UTSW	17	17726772	missense	possibly damaging	0.93
R5686:Vmn2r90	UTSW	17	17713450	missense	probably benign	0.02
R5751:Vmn2r90	UTSW	17	17733866	missense	probably damaging	0.96
R6156:Vmn2r90	UTSW	17	17733344	missense	probably benign	0.01
R6185:Vmn2r90	UTSW	17	17733382	missense	probably damaging	1.00
R6450:Vmn2r90	UTSW	17	17733236	missense	possibly damaging	0.47
R6707:Vmn2r90	UTSW	17	17728102	missense	probably damaging	1.00
R6802:Vmn2r90	UTSW	17	17712089	missense	probably damaging	1.00
R6913:Vmn2r90	UTSW	17	17704061	missense	probably damaging	1.00
R7070:Vmn2r90	UTSW	17	17704051	missense	probably damaging	0.98
R7237:Vmn2r90	UTSW	17	17703987	missense	possibly damaging	0.92
R7503:Vmn2r90	UTSW	17	17713248	missense	not run
R7698:Vmn2r90	UTSW	17	17733334	missense	probably benign
R7943:Vmn2r90	UTSW	17	17712304	missense	probably damaging	1.00
R8072:Vmn2r90	UTSW	17	17726880	missense	probably damaging	1.00
R8128:Vmn2r90	UTSW	17	17733893	missense	probably damaging	1.00
R8295:Vmn2r90	UTSW	17	17728096	missense	probably benign	0.03
R8345:Vmn2r90	UTSW	17	17712865	nonsense	probably null
R8682:Vmn2r90	UTSW	17	17712082	missense	possibly damaging	0.95
R8716:Vmn2r90	UTSW	17	17704081	missense	probably damaging	0.98
R9041:Vmn2r90	UTSW	17	17734024	missense	probably benign	0.00
R9412:Vmn2r90	UTSW	17	17733951	missense	probably damaging	1.00
Z1088:Vmn2r90	UTSW	17	17733617	missense	probably damaging	1.00
Z1176:Vmn2r90	UTSW	17	17712817	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GGCCCTGTTATTTGCCATTGAGGAG -3'
(R):5'- TGGGATAATCAGACCAACCCAGGAC -3'

Sequencing Primer
(F):5'- ATTTGCCATTGAGGAGATCAAC -3'
(R):5'- TCCCAAATTATGGACAGGTCTC -3'

Posted On

2013-04-11