Incidental Mutation 'R1954:Parp14'
| ID |
217608 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Parp14
|
| Ensembl Gene |
ENSMUSG00000034422 |
| Gene Name |
poly (ADP-ribose) polymerase family, member 14 |
| Synonyms |
CoaSt6, collaborator of Stat6, 1600029O10Rik |
| MMRRC Submission |
039968-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.466)
|
| Stock # |
R1954 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
16 |
| Chromosomal Location |
35653244-35691914 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 35678671 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Lysine
at position 432
(N432K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000037657
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000042665]
|
| AlphaFold |
Q2EMV9 |
| PDB Structure |
Solution structure of WWE domain in Parp14 protein [SOLUTION NMR]
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000042665
AA Change: N432K
PolyPhen 2
Score 0.080 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000037657
Gene: ENSMUSG00000034422
AA Change: N432K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
38 |
49 |
N/A |
INTRINSIC |
|
low complexity region
|
93 |
115 |
N/A |
INTRINSIC |
|
RRM
|
228 |
297 |
4.71e-2 |
SMART |
|
coiled coil region
|
443 |
468 |
N/A |
INTRINSIC |
|
Blast:A1pp
|
693 |
746 |
6e-6 |
BLAST |
|
low complexity region
|
771 |
795 |
N/A |
INTRINSIC |
|
A1pp
|
814 |
948 |
7.62e-41 |
SMART |
|
A1pp
|
1026 |
1160 |
5.88e-24 |
SMART |
|
A1pp
|
1239 |
1358 |
6.82e-20 |
SMART |
|
PDB:1X4R|A
|
1532 |
1619 |
9e-53 |
PDB |
|
Pfam:PARP
|
1632 |
1817 |
2.5e-29 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000142946
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 94.0%
|
| Validation Efficiency |
97% (101/104) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the poly(ADP-ribose) polymerase (PARP) protein family. The encoded anti-apoptotic protein may regulate aerobic glycolysis and promote survival of cancer cells. Increased expression of this gene has been reported in a variety of tumor types. [provided by RefSeq, Jul 2016]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit altered B cell subsets and inability to respond to the apoptosis protective affects of IL4. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 100 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamts15 |
T |
A |
9: 30,822,004 (GRCm39) |
M478L |
probably benign |
Het |
| Akap8l |
T |
A |
17: 32,555,710 (GRCm39) |
Y123F |
possibly damaging |
Het |
| Anapc4 |
T |
G |
5: 53,003,967 (GRCm39) |
|
probably benign |
Het |
| Arap3 |
A |
G |
18: 38,115,055 (GRCm39) |
V987A |
probably damaging |
Het |
| Atp2b4 |
T |
A |
1: 133,667,730 (GRCm39) |
T105S |
probably damaging |
Het |
| Atp6v0d1 |
A |
G |
8: 106,292,525 (GRCm39) |
L7P |
probably damaging |
Het |
| Atp6v1b2 |
T |
C |
8: 69,558,555 (GRCm39) |
V341A |
possibly damaging |
Het |
| Baz2b |
C |
A |
2: 59,799,087 (GRCm39) |
A346S |
probably benign |
Het |
| Brpf3 |
G |
A |
17: 29,025,533 (GRCm39) |
S202N |
probably benign |
Het |
| Btnl4 |
T |
C |
17: 34,691,904 (GRCm39) |
K233E |
possibly damaging |
Het |
| Capn7 |
A |
G |
14: 31,082,107 (GRCm39) |
T438A |
probably damaging |
Het |
| Cars2 |
A |
T |
8: 11,600,286 (GRCm39) |
Y68N |
probably damaging |
Het |
| Cbx2 |
G |
T |
11: 118,919,166 (GRCm39) |
G244W |
probably damaging |
Het |
| Ccr4 |
A |
T |
9: 114,321,753 (GRCm39) |
V104D |
probably damaging |
Het |
| Cdc5l |
T |
C |
17: 45,737,442 (GRCm39) |
|
probably null |
Het |
| Cep170 |
A |
T |
1: 176,583,950 (GRCm39) |
C810S |
probably benign |
Het |
| Cfap299 |
A |
T |
5: 98,714,612 (GRCm39) |
|
probably benign |
Het |
| Clp1 |
T |
C |
2: 84,554,395 (GRCm39) |
D258G |
probably damaging |
Het |
| Clstn3 |
T |
C |
6: 124,436,257 (GRCm39) |
E164G |
possibly damaging |
Het |
| Col28a1 |
T |
C |
6: 7,998,516 (GRCm39) |
E1131G |
probably damaging |
Het |
| Cps1 |
A |
G |
1: 67,234,355 (GRCm39) |
D914G |
possibly damaging |
Het |
| Ctnnal1 |
C |
T |
4: 56,817,242 (GRCm39) |
|
probably benign |
Het |
| Cyp2c38 |
A |
G |
19: 39,393,131 (GRCm39) |
L312P |
probably damaging |
Het |
| Cytip |
T |
C |
2: 58,038,265 (GRCm39) |
N99D |
possibly damaging |
Het |
| Dennd4a |
A |
T |
9: 64,759,749 (GRCm39) |
T285S |
probably benign |
Het |
| Dhx8 |
A |
G |
11: 101,644,105 (GRCm39) |
S842G |
probably damaging |
Het |
| Disp1 |
A |
T |
1: 182,870,107 (GRCm39) |
M771K |
probably damaging |
Het |
| Dnah17 |
A |
G |
11: 117,915,557 (GRCm39) |
I4326T |
probably damaging |
Het |
| Efcab7 |
T |
C |
4: 99,757,887 (GRCm39) |
F345L |
probably damaging |
Het |
| Erc1 |
G |
T |
6: 119,774,266 (GRCm39) |
Q230K |
probably damaging |
Het |
| Ern1 |
A |
T |
11: 106,312,800 (GRCm39) |
|
probably benign |
Het |
| Espl1 |
T |
C |
15: 102,206,823 (GRCm39) |
Y96H |
probably damaging |
Het |
| Fam135a |
A |
T |
1: 24,068,683 (GRCm39) |
L533I |
probably damaging |
Het |
| Fat2 |
G |
A |
11: 55,201,910 (GRCm39) |
T388I |
probably benign |
Het |
| Galnt1 |
T |
G |
18: 24,404,831 (GRCm39) |
|
probably benign |
Het |
| Glmn |
A |
G |
5: 107,720,243 (GRCm39) |
F212S |
probably damaging |
Het |
| Gm3604 |
A |
T |
13: 62,517,025 (GRCm39) |
N444K |
probably damaging |
Het |
| Gvin-ps5 |
A |
C |
7: 105,928,888 (GRCm39) |
D336E |
probably damaging |
Het |
| H1f2 |
T |
C |
13: 23,923,385 (GRCm39) |
V185A |
unknown |
Het |
| H1f3 |
A |
G |
13: 23,739,690 (GRCm39) |
|
probably benign |
Het |
| H2-M10.3 |
T |
C |
17: 36,678,390 (GRCm39) |
D145G |
probably damaging |
Het |
| Hic2 |
T |
A |
16: 17,076,857 (GRCm39) |
L562Q |
probably damaging |
Het |
| Hip1r |
G |
T |
5: 124,139,907 (GRCm39) |
E1003D |
probably damaging |
Het |
| Hsfy2 |
C |
T |
1: 56,676,342 (GRCm39) |
C65Y |
probably benign |
Het |
| Inpp1 |
T |
C |
1: 52,833,788 (GRCm39) |
T103A |
probably damaging |
Het |
| Ints5 |
T |
C |
19: 8,872,260 (GRCm39) |
V73A |
probably damaging |
Het |
| Iqch |
A |
T |
9: 63,455,298 (GRCm39) |
D166E |
probably benign |
Het |
| Klhdc3 |
A |
T |
17: 46,988,901 (GRCm39) |
N96K |
probably damaging |
Het |
| Klk1b8 |
C |
T |
7: 43,603,272 (GRCm39) |
|
probably benign |
Het |
| Klrb1 |
T |
C |
6: 128,700,036 (GRCm39) |
|
probably null |
Het |
| Krt71 |
C |
A |
15: 101,643,901 (GRCm39) |
G446* |
probably null |
Het |
| Lars1 |
G |
A |
18: 42,343,115 (GRCm39) |
R1101C |
probably damaging |
Het |
| Lemd3 |
G |
T |
10: 120,814,845 (GRCm39) |
S129R |
probably damaging |
Het |
| Lrp1b |
A |
G |
2: 40,748,453 (GRCm39) |
L3015P |
probably damaging |
Het |
| Mdga2 |
T |
C |
12: 66,533,482 (GRCm39) |
|
probably benign |
Het |
| Mlst8 |
A |
T |
17: 24,696,195 (GRCm39) |
I178N |
probably damaging |
Het |
| Mon2 |
A |
T |
10: 122,874,388 (GRCm39) |
I320N |
probably damaging |
Het |
| Morc2b |
T |
C |
17: 33,356,464 (GRCm39) |
Y436C |
probably damaging |
Het |
| Moxd1 |
T |
A |
10: 24,155,781 (GRCm39) |
M295K |
probably benign |
Het |
| Mrps5 |
T |
A |
2: 127,438,817 (GRCm39) |
|
probably null |
Het |
| Mtor |
C |
A |
4: 148,552,730 (GRCm39) |
S744R |
probably damaging |
Het |
| Myo3a |
T |
A |
2: 22,246,037 (GRCm39) |
D61E |
probably damaging |
Het |
| Nars1 |
C |
T |
18: 64,633,635 (GRCm39) |
R545Q |
probably damaging |
Het |
| Ncoa6 |
A |
G |
2: 155,248,741 (GRCm39) |
V1521A |
possibly damaging |
Het |
| Ndor1 |
T |
C |
2: 25,145,305 (GRCm39) |
E20G |
possibly damaging |
Het |
| Nipsnap3b |
T |
C |
4: 53,017,213 (GRCm39) |
|
probably benign |
Het |
| Notch3 |
G |
T |
17: 32,385,652 (GRCm39) |
A39E |
probably benign |
Het |
| Or1j16 |
A |
G |
2: 36,530,227 (GRCm39) |
M59V |
possibly damaging |
Het |
| Or2a14 |
T |
C |
6: 43,130,911 (GRCm39) |
I224T |
possibly damaging |
Het |
| Or6z3 |
G |
T |
7: 6,464,144 (GRCm39) |
W212L |
probably benign |
Het |
| Otud3 |
T |
C |
4: 138,625,343 (GRCm39) |
K237R |
possibly damaging |
Het |
| Papola |
T |
A |
12: 105,794,532 (GRCm39) |
|
probably null |
Het |
| Parl |
T |
A |
16: 20,121,077 (GRCm39) |
M1L |
possibly damaging |
Het |
| Patz1 |
T |
G |
11: 3,241,088 (GRCm39) |
S159A |
probably damaging |
Het |
| Prpf6 |
T |
G |
2: 181,273,870 (GRCm39) |
M338R |
probably benign |
Het |
| Psd3 |
A |
G |
8: 68,149,727 (GRCm39) |
L343P |
probably damaging |
Het |
| Ptpn23 |
A |
T |
9: 110,215,393 (GRCm39) |
N1422K |
probably damaging |
Het |
| Rab19 |
A |
T |
6: 39,361,016 (GRCm39) |
T55S |
probably benign |
Het |
| Sh3yl1 |
A |
G |
12: 30,972,332 (GRCm39) |
K34E |
possibly damaging |
Het |
| Skint8 |
T |
A |
4: 111,807,278 (GRCm39) |
F321L |
possibly damaging |
Het |
| Slc25a46 |
A |
T |
18: 31,733,294 (GRCm39) |
|
probably null |
Het |
| Slc26a3 |
T |
C |
12: 31,500,815 (GRCm39) |
L184S |
probably damaging |
Het |
| Slc39a10 |
A |
T |
1: 46,874,334 (GRCm39) |
S323T |
possibly damaging |
Het |
| Sorbs2 |
G |
T |
8: 46,198,775 (GRCm39) |
R20L |
probably benign |
Het |
| Stk32a |
A |
T |
18: 43,345,090 (GRCm39) |
D13V |
probably benign |
Het |
| Tab2 |
T |
C |
10: 7,795,094 (GRCm39) |
T463A |
probably damaging |
Het |
| Tenm2 |
T |
A |
11: 35,938,374 (GRCm39) |
N1433I |
possibly damaging |
Het |
| Tmem200c |
A |
T |
17: 69,147,956 (GRCm39) |
I180F |
probably damaging |
Het |
| Tmem232 |
G |
T |
17: 65,791,482 (GRCm39) |
H129N |
probably benign |
Het |
| Tmem242 |
T |
C |
17: 5,489,854 (GRCm39) |
T47A |
possibly damaging |
Het |
| Ube2d1 |
A |
T |
10: 71,120,953 (GRCm39) |
M1K |
probably null |
Het |
| Ube2frt |
A |
G |
12: 36,140,595 (GRCm39) |
|
probably benign |
Het |
| Uckl1 |
T |
C |
2: 181,212,320 (GRCm39) |
Q332R |
probably benign |
Het |
| Unc5b |
T |
C |
10: 60,605,044 (GRCm39) |
|
probably benign |
Het |
| Vmn2r114 |
T |
C |
17: 23,530,086 (GRCm39) |
Y107C |
probably benign |
Het |
| Vmn2r82 |
A |
T |
10: 79,231,890 (GRCm39) |
S630C |
probably damaging |
Het |
| Wdr25 |
T |
A |
12: 108,864,467 (GRCm39) |
V204E |
probably damaging |
Het |
| Xab2 |
T |
A |
8: 3,666,094 (GRCm39) |
D227V |
probably damaging |
Het |
| Zfp286 |
A |
G |
11: 62,674,534 (GRCm39) |
S104P |
possibly damaging |
Het |
| Zfp345 |
T |
C |
2: 150,316,741 (GRCm39) |
D22G |
probably damaging |
Het |
|
| Other mutations in Parp14 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00337:Parp14
|
APN |
16 |
35,661,445 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00497:Parp14
|
APN |
16 |
35,655,206 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00754:Parp14
|
APN |
16 |
35,659,741 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL00960:Parp14
|
APN |
16 |
35,661,589 (GRCm39) |
missense |
probably benign |
0.20 |
|
IGL01321:Parp14
|
APN |
16 |
35,676,929 (GRCm39) |
missense |
probably benign |
|
|
IGL01397:Parp14
|
APN |
16 |
35,679,098 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL01591:Parp14
|
APN |
16 |
35,678,877 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL01728:Parp14
|
APN |
16 |
35,677,805 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01734:Parp14
|
APN |
16 |
35,678,970 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02156:Parp14
|
APN |
16 |
35,678,967 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL02951:Parp14
|
APN |
16 |
35,678,903 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL03067:Parp14
|
APN |
16 |
35,676,878 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL03135:Parp14
|
APN |
16 |
35,678,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03141:Parp14
|
APN |
16 |
35,659,663 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03146:Parp14
|
APN |
16 |
35,678,823 (GRCm39) |
nonsense |
probably null |
|
|
IGL03333:Parp14
|
APN |
16 |
35,661,800 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL03391:Parp14
|
APN |
16 |
35,678,640 (GRCm39) |
missense |
probably benign |
|
|
thurston
|
UTSW |
16 |
35,664,785 (GRCm39) |
splice site |
probably benign |
|
|
PIT4585001:Parp14
|
UTSW |
16 |
35,678,975 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0306:Parp14
|
UTSW |
16 |
35,676,944 (GRCm39) |
missense |
probably benign |
|
|
R0506:Parp14
|
UTSW |
16 |
35,661,779 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R0586:Parp14
|
UTSW |
16 |
35,661,382 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0606:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0612:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0699:Parp14
|
UTSW |
16 |
35,680,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0786:Parp14
|
UTSW |
16 |
35,661,172 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R0883:Parp14
|
UTSW |
16 |
35,678,888 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0900:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1087:Parp14
|
UTSW |
16 |
35,678,658 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1104:Parp14
|
UTSW |
16 |
35,664,785 (GRCm39) |
splice site |
probably benign |
|
|
R1120:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1134:Parp14
|
UTSW |
16 |
35,655,272 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1153:Parp14
|
UTSW |
16 |
35,678,041 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R1159:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1160:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1237:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1238:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1239:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1423:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1511:Parp14
|
UTSW |
16 |
35,677,594 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1518:Parp14
|
UTSW |
16 |
35,677,008 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R1619:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1707:Parp14
|
UTSW |
16 |
35,678,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1792:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1831:Parp14
|
UTSW |
16 |
35,678,958 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1840:Parp14
|
UTSW |
16 |
35,683,819 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1889:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1902:Parp14
|
UTSW |
16 |
35,673,888 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1943:Parp14
|
UTSW |
16 |
35,656,499 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2115:Parp14
|
UTSW |
16 |
35,678,904 (GRCm39) |
missense |
probably benign |
0.16 |
|
R2216:Parp14
|
UTSW |
16 |
35,677,575 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2519:Parp14
|
UTSW |
16 |
35,678,573 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R3851:Parp14
|
UTSW |
16 |
35,674,118 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4052:Parp14
|
UTSW |
16 |
35,678,771 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4671:Parp14
|
UTSW |
16 |
35,678,691 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4867:Parp14
|
UTSW |
16 |
35,677,697 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4941:Parp14
|
UTSW |
16 |
35,666,403 (GRCm39) |
missense |
probably benign |
|
|
R4992:Parp14
|
UTSW |
16 |
35,661,512 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5055:Parp14
|
UTSW |
16 |
35,664,733 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5073:Parp14
|
UTSW |
16 |
35,655,077 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5170:Parp14
|
UTSW |
16 |
35,677,649 (GRCm39) |
missense |
probably benign |
0.21 |
|
R5422:Parp14
|
UTSW |
16 |
35,686,545 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5543:Parp14
|
UTSW |
16 |
35,655,137 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5549:Parp14
|
UTSW |
16 |
35,661,505 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5553:Parp14
|
UTSW |
16 |
35,677,306 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5691:Parp14
|
UTSW |
16 |
35,683,909 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5774:Parp14
|
UTSW |
16 |
35,678,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5855:Parp14
|
UTSW |
16 |
35,661,297 (GRCm39) |
nonsense |
probably null |
|
|
R5942:Parp14
|
UTSW |
16 |
35,659,737 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5990:Parp14
|
UTSW |
16 |
35,661,827 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5991:Parp14
|
UTSW |
16 |
35,661,827 (GRCm39) |
missense |
probably benign |
0.14 |
|
R6018:Parp14
|
UTSW |
16 |
35,661,827 (GRCm39) |
missense |
probably benign |
0.14 |
|
R6022:Parp14
|
UTSW |
16 |
35,661,827 (GRCm39) |
missense |
probably benign |
0.14 |
|
R6075:Parp14
|
UTSW |
16 |
35,677,389 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6395:Parp14
|
UTSW |
16 |
35,676,918 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6525:Parp14
|
UTSW |
16 |
35,680,811 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6683:Parp14
|
UTSW |
16 |
35,655,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7525:Parp14
|
UTSW |
16 |
35,677,861 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8011:Parp14
|
UTSW |
16 |
35,677,004 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8192:Parp14
|
UTSW |
16 |
35,691,584 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8367:Parp14
|
UTSW |
16 |
35,678,124 (GRCm39) |
missense |
probably benign |
0.36 |
|
R8526:Parp14
|
UTSW |
16 |
35,661,307 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8751:Parp14
|
UTSW |
16 |
35,677,181 (GRCm39) |
missense |
probably benign |
0.32 |
|
R8962:Parp14
|
UTSW |
16 |
35,677,187 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9231:Parp14
|
UTSW |
16 |
35,661,583 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9363:Parp14
|
UTSW |
16 |
35,678,586 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9366:Parp14
|
UTSW |
16 |
35,659,630 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9379:Parp14
|
UTSW |
16 |
35,680,853 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9562:Parp14
|
UTSW |
16 |
35,677,775 (GRCm39) |
missense |
probably benign |
0.16 |
|
R9565:Parp14
|
UTSW |
16 |
35,677,775 (GRCm39) |
missense |
probably benign |
0.16 |
|
R9696:Parp14
|
UTSW |
16 |
35,661,252 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9696:Parp14
|
UTSW |
16 |
35,661,251 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
X0026:Parp14
|
UTSW |
16 |
35,677,527 (GRCm39) |
nonsense |
probably null |
|
|
X0060:Parp14
|
UTSW |
16 |
35,655,077 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1088:Parp14
|
UTSW |
16 |
35,661,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Parp14
|
UTSW |
16 |
35,665,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Parp14
|
UTSW |
16 |
35,691,573 (GRCm39) |
missense |
probably benign |
0.16 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAAGCCCTTCAAGTACAGGAAC -3'
(R):5'- AGCATTAAGACCTGGCAGAG -3'
Sequencing Primer
(F):5'- GAGATCTCCATCTCTGGGAACCC -3'
(R):5'- ACCTGGCAGAGAGACGCATC -3'
|
| Posted On |
2014-08-01 |
Incidental Mutation