Incidental Mutation 'R0133:Jmjd1c'
| ID |
21764 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Jmjd1c
|
| Ensembl Gene |
ENSMUSG00000037876 |
| Gene Name |
jumonji domain containing 1C |
| Synonyms |
D630035I23Rik, TRIP8, 5430433L24Rik |
| MMRRC Submission |
038418-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.655)
|
| Stock # |
R0133 (G1)
|
| Quality Score |
216 |
|
Status
|
Validated
(trace)
|
| Chromosome |
10 |
| Chromosomal Location |
66932189-67092105 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 67076587 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Alanine to Aspartic acid
at position 2137
(A2137D)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000134551
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000051446]
[ENSMUST00000173689]
[ENSMUST00000174408]
|
| AlphaFold |
Q69ZK6 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000051446
AA Change: A2136D
PolyPhen 2
Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
|
| SMART Domains |
Protein: ENSMUSP00000056227
Gene: ENSMUSG00000037876
AA Change: A2136D
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:JmjC
|
143 |
2236 |
N/A |
BLAST |
|
JmjC
|
2264 |
2488 |
3.29e-53 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000158873
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000173236
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000173689
AA Change: A1956D
PolyPhen 2
Score 0.221 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000133700
Gene: ENSMUSG00000037876
AA Change: A1956D
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:JmjC
|
1 |
2056 |
N/A |
BLAST |
|
JmjC
|
2084 |
2308 |
3.29e-53 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000173762
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000174408
AA Change: A2137D
PolyPhen 2
Score 0.221 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000134551
Gene: ENSMUSG00000037876
AA Change: A2137D
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:JmjC
|
143 |
2237 |
N/A |
BLAST |
|
JmjC
|
2265 |
2489 |
3.29e-53 |
SMART |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 98.8%
- 3x: 97.9%
- 10x: 95.2%
- 20x: 89.4%
|
| Validation Efficiency |
99% (83/84) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the DNA-damage response pathway by demethylating the mediator of DNA damage checkpoint 1 (MDC1) protein, and is required for the survival of acute myeloid leukemia. Mutations in this gene are associated with Rett syndrome and intellectual disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
PHENOTYPE: Mice homozygous for a null allele exhibit an age-dependent male infertility phenotype, characterized by early loss of undifferentiated spermatogonia, and a progressive reduction in testis size/weight and male germ cells, partly due to increased male germ cell apoptosis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 76 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acbd4 |
T |
C |
11: 102,996,214 (GRCm39) |
S172P |
probably damaging |
Het |
| Akap6 |
A |
T |
12: 53,186,254 (GRCm39) |
K1223* |
probably null |
Het |
| Akna |
G |
A |
4: 63,297,598 (GRCm39) |
Q819* |
probably null |
Het |
| Ankrd2 |
T |
C |
19: 42,032,510 (GRCm39) |
V257A |
probably benign |
Het |
| Arap1 |
T |
A |
7: 101,035,436 (GRCm39) |
D30E |
probably damaging |
Het |
| Atp6v0d2 |
T |
C |
4: 19,910,578 (GRCm39) |
|
probably benign |
Het |
| Blm |
T |
A |
7: 80,152,115 (GRCm39) |
I611F |
possibly damaging |
Het |
| Ccng2 |
A |
G |
5: 93,421,240 (GRCm39) |
K250R |
probably benign |
Het |
| Cdhr3 |
A |
G |
12: 33,142,751 (GRCm39) |
L8P |
possibly damaging |
Het |
| Csf2rb |
T |
G |
15: 78,223,204 (GRCm39) |
|
probably benign |
Het |
| Ctbs |
A |
G |
3: 146,163,223 (GRCm39) |
I204V |
probably benign |
Het |
| Cxcl16 |
T |
A |
11: 70,349,596 (GRCm39) |
E76D |
possibly damaging |
Het |
| Dhx15 |
T |
C |
5: 52,311,414 (GRCm39) |
I689V |
possibly damaging |
Het |
| Dlk2 |
T |
C |
17: 46,609,868 (GRCm39) |
|
probably benign |
Het |
| Dnah2 |
A |
T |
11: 69,311,835 (GRCm39) |
M4452K |
probably damaging |
Het |
| Dok4 |
T |
A |
8: 95,591,991 (GRCm39) |
I280F |
probably benign |
Het |
| Dsc3 |
T |
C |
18: 20,104,639 (GRCm39) |
T563A |
probably damaging |
Het |
| Dsg1b |
C |
T |
18: 20,537,935 (GRCm39) |
A617V |
probably damaging |
Het |
| Eps8l2 |
C |
T |
7: 140,942,120 (GRCm39) |
P721S |
unknown |
Het |
| Evx2 |
T |
C |
2: 74,489,426 (GRCm39) |
D112G |
possibly damaging |
Het |
| Fam124a |
C |
A |
14: 62,843,782 (GRCm39) |
T430K |
possibly damaging |
Het |
| Fbrs |
C |
T |
7: 127,088,782 (GRCm39) |
|
probably benign |
Het |
| Fbxw14 |
T |
C |
9: 109,103,647 (GRCm39) |
T22A |
probably benign |
Het |
| Fmo5 |
T |
G |
3: 97,552,952 (GRCm39) |
V300G |
probably damaging |
Het |
| Gadl1 |
T |
C |
9: 115,770,411 (GRCm39) |
S75P |
probably benign |
Het |
| Galnt2 |
T |
G |
8: 125,065,277 (GRCm39) |
I469S |
probably benign |
Het |
| Gga3 |
T |
A |
11: 115,479,805 (GRCm39) |
|
probably benign |
Het |
| Gm10647 |
T |
C |
9: 66,705,771 (GRCm39) |
|
probably benign |
Het |
| Gm14180 |
C |
A |
11: 99,625,043 (GRCm39) |
C25F |
unknown |
Het |
| Grid2 |
A |
T |
6: 64,297,116 (GRCm39) |
D493V |
probably damaging |
Het |
| Gzmc |
T |
A |
14: 56,469,754 (GRCm39) |
Y182F |
possibly damaging |
Het |
| Hecw2 |
A |
C |
1: 53,869,899 (GRCm39) |
L1443R |
probably damaging |
Het |
| Igkv4-62 |
A |
G |
6: 69,377,053 (GRCm39) |
I32T |
probably benign |
Het |
| Ikzf1 |
T |
A |
11: 11,691,015 (GRCm39) |
|
probably null |
Het |
| Il27ra |
G |
A |
8: 84,760,571 (GRCm39) |
|
probably benign |
Het |
| Kcnc2 |
T |
C |
10: 112,294,502 (GRCm39) |
C579R |
probably damaging |
Het |
| Kdr |
T |
C |
5: 76,112,498 (GRCm39) |
T862A |
probably damaging |
Het |
| Kif17 |
T |
C |
4: 138,005,556 (GRCm39) |
S182P |
possibly damaging |
Het |
| Klf5 |
A |
T |
14: 99,539,318 (GRCm39) |
T164S |
probably benign |
Het |
| Ksr2 |
T |
G |
5: 117,693,359 (GRCm39) |
V269G |
possibly damaging |
Het |
| Mcm5 |
T |
A |
8: 75,847,539 (GRCm39) |
D445E |
probably damaging |
Het |
| Mlkl |
T |
C |
8: 112,054,580 (GRCm39) |
I186V |
probably damaging |
Het |
| Muc4 |
A |
T |
16: 32,591,978 (GRCm39) |
S3017C |
possibly damaging |
Het |
| Myo15a |
T |
C |
11: 60,368,676 (GRCm39) |
F479L |
possibly damaging |
Het |
| Myo6 |
A |
G |
9: 80,181,257 (GRCm39) |
|
probably benign |
Het |
| Myom1 |
T |
A |
17: 71,354,782 (GRCm39) |
V393E |
probably damaging |
Het |
| Nup98 |
T |
A |
7: 101,788,859 (GRCm39) |
|
probably null |
Het |
| Odf2l |
A |
G |
3: 144,854,302 (GRCm39) |
N383S |
probably damaging |
Het |
| Olfml3 |
A |
C |
3: 103,644,342 (GRCm39) |
|
probably null |
Het |
| Or10q1 |
T |
A |
19: 13,727,352 (GRCm39) |
I294N |
probably damaging |
Het |
| Or7g17 |
G |
A |
9: 18,767,925 (GRCm39) |
M1I |
probably null |
Het |
| Or8g18 |
A |
G |
9: 39,149,307 (GRCm39) |
Y141H |
probably benign |
Het |
| Or8j3b |
A |
T |
2: 86,205,159 (GRCm39) |
V199E |
possibly damaging |
Het |
| Plxna4 |
A |
T |
6: 32,174,009 (GRCm39) |
D1195E |
probably benign |
Het |
| Ppp1r1a |
T |
A |
15: 103,446,247 (GRCm39) |
H20L |
probably damaging |
Het |
| Prdm4 |
A |
G |
10: 85,746,085 (GRCm39) |
|
probably null |
Het |
| Prom2 |
A |
G |
2: 127,380,258 (GRCm39) |
|
probably benign |
Het |
| Rasal3 |
T |
C |
17: 32,622,357 (GRCm39) |
M1V |
probably null |
Het |
| Rhoj |
A |
G |
12: 75,441,194 (GRCm39) |
|
probably null |
Het |
| Rnf40 |
C |
T |
7: 127,196,032 (GRCm39) |
|
probably null |
Het |
| Slc15a3 |
T |
C |
19: 10,820,614 (GRCm39) |
L77P |
probably damaging |
Het |
| Slc26a6 |
T |
C |
9: 108,738,522 (GRCm39) |
V586A |
possibly damaging |
Het |
| Slc30a10 |
T |
A |
1: 185,187,370 (GRCm39) |
L37Q |
probably damaging |
Het |
| Slc43a2 |
T |
A |
11: 75,454,403 (GRCm39) |
M316K |
probably benign |
Het |
| Smarcal1 |
T |
C |
1: 72,672,010 (GRCm39) |
F844L |
probably benign |
Het |
| Snx19 |
A |
G |
9: 30,339,912 (GRCm39) |
E350G |
possibly damaging |
Het |
| Tecta |
T |
A |
9: 42,278,524 (GRCm39) |
T995S |
probably benign |
Het |
| Tmc3 |
T |
G |
7: 83,261,681 (GRCm39) |
N586K |
probably damaging |
Het |
| Tmem107 |
T |
A |
11: 68,963,239 (GRCm39) |
|
probably benign |
Het |
| Tmem247 |
A |
G |
17: 87,225,989 (GRCm39) |
Q51R |
probably benign |
Het |
| Tmpo |
G |
T |
10: 90,999,900 (GRCm39) |
|
probably benign |
Het |
| Ubr5 |
T |
A |
15: 37,996,815 (GRCm39) |
T1894S |
probably damaging |
Het |
| Vmn2r92 |
C |
T |
17: 18,388,219 (GRCm39) |
A408V |
probably damaging |
Het |
| Xirp2 |
T |
A |
2: 67,347,468 (GRCm39) |
H3236Q |
probably benign |
Het |
| Zfand4 |
G |
A |
6: 116,291,700 (GRCm39) |
D545N |
probably benign |
Het |
| Zkscan3 |
G |
T |
13: 21,578,944 (GRCm39) |
P155T |
possibly damaging |
Het |
|
| Other mutations in Jmjd1c |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01062:Jmjd1c
|
APN |
10 |
67,062,494 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01604:Jmjd1c
|
APN |
10 |
67,085,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01753:Jmjd1c
|
APN |
10 |
67,067,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02081:Jmjd1c
|
APN |
10 |
67,055,305 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02128:Jmjd1c
|
APN |
10 |
67,079,648 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02134:Jmjd1c
|
APN |
10 |
67,056,171 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL02215:Jmjd1c
|
APN |
10 |
67,056,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02408:Jmjd1c
|
APN |
10 |
67,062,161 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02502:Jmjd1c
|
APN |
10 |
67,061,640 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL02546:Jmjd1c
|
APN |
10 |
67,061,115 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02943:Jmjd1c
|
APN |
10 |
67,055,433 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03171:Jmjd1c
|
APN |
10 |
67,061,277 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL03261:Jmjd1c
|
APN |
10 |
67,067,849 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Accordion
|
UTSW |
10 |
67,069,193 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4378001:Jmjd1c
|
UTSW |
10 |
67,065,692 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0126:Jmjd1c
|
UTSW |
10 |
67,055,105 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0201:Jmjd1c
|
UTSW |
10 |
67,054,888 (GRCm39) |
missense |
unknown |
|
|
R0396:Jmjd1c
|
UTSW |
10 |
67,055,302 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R0401:Jmjd1c
|
UTSW |
10 |
67,056,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0452:Jmjd1c
|
UTSW |
10 |
67,091,261 (GRCm39) |
missense |
probably benign |
0.28 |
|
R0488:Jmjd1c
|
UTSW |
10 |
67,076,506 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0504:Jmjd1c
|
UTSW |
10 |
67,061,534 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0555:Jmjd1c
|
UTSW |
10 |
67,061,568 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0673:Jmjd1c
|
UTSW |
10 |
67,062,588 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0718:Jmjd1c
|
UTSW |
10 |
67,054,725 (GRCm39) |
splice site |
probably null |
|
|
R0755:Jmjd1c
|
UTSW |
10 |
66,932,378 (GRCm39) |
intron |
probably benign |
|
|
R1142:Jmjd1c
|
UTSW |
10 |
67,061,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1196:Jmjd1c
|
UTSW |
10 |
67,075,015 (GRCm39) |
splice site |
probably benign |
|
|
R1413:Jmjd1c
|
UTSW |
10 |
67,085,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1619:Jmjd1c
|
UTSW |
10 |
67,055,654 (GRCm39) |
missense |
probably benign |
0.25 |
|
R1676:Jmjd1c
|
UTSW |
10 |
67,060,588 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1751:Jmjd1c
|
UTSW |
10 |
67,061,469 (GRCm39) |
missense |
probably benign |
|
|
R1950:Jmjd1c
|
UTSW |
10 |
67,075,701 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1968:Jmjd1c
|
UTSW |
10 |
67,061,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2049:Jmjd1c
|
UTSW |
10 |
66,993,777 (GRCm39) |
nonsense |
probably null |
|
|
R2061:Jmjd1c
|
UTSW |
10 |
67,054,205 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2202:Jmjd1c
|
UTSW |
10 |
67,075,242 (GRCm39) |
splice site |
probably null |
|
|
R2203:Jmjd1c
|
UTSW |
10 |
67,075,242 (GRCm39) |
splice site |
probably null |
|
|
R2256:Jmjd1c
|
UTSW |
10 |
67,061,073 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2312:Jmjd1c
|
UTSW |
10 |
67,074,629 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2349:Jmjd1c
|
UTSW |
10 |
67,091,279 (GRCm39) |
missense |
probably benign |
|
|
R2392:Jmjd1c
|
UTSW |
10 |
67,065,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3015:Jmjd1c
|
UTSW |
10 |
66,993,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3110:Jmjd1c
|
UTSW |
10 |
67,075,863 (GRCm39) |
splice site |
probably benign |
|
|
R4043:Jmjd1c
|
UTSW |
10 |
67,055,245 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R4097:Jmjd1c
|
UTSW |
10 |
67,054,787 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4118:Jmjd1c
|
UTSW |
10 |
67,055,532 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4193:Jmjd1c
|
UTSW |
10 |
66,932,460 (GRCm39) |
intron |
probably benign |
|
|
R4352:Jmjd1c
|
UTSW |
10 |
67,080,588 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4577:Jmjd1c
|
UTSW |
10 |
67,085,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4630:Jmjd1c
|
UTSW |
10 |
66,993,753 (GRCm39) |
nonsense |
probably null |
|
|
R4717:Jmjd1c
|
UTSW |
10 |
66,993,830 (GRCm39) |
nonsense |
probably null |
|
|
R4741:Jmjd1c
|
UTSW |
10 |
67,060,718 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R4774:Jmjd1c
|
UTSW |
10 |
67,060,571 (GRCm39) |
missense |
possibly damaging |
0.45 |
|
R4836:Jmjd1c
|
UTSW |
10 |
67,069,225 (GRCm39) |
missense |
probably benign |
0.21 |
|
R4914:Jmjd1c
|
UTSW |
10 |
67,054,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4939:Jmjd1c
|
UTSW |
10 |
67,081,916 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5211:Jmjd1c
|
UTSW |
10 |
67,067,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5215:Jmjd1c
|
UTSW |
10 |
67,076,480 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5514:Jmjd1c
|
UTSW |
10 |
67,053,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5530:Jmjd1c
|
UTSW |
10 |
67,085,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5624:Jmjd1c
|
UTSW |
10 |
67,069,193 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5640:Jmjd1c
|
UTSW |
10 |
67,061,857 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5654:Jmjd1c
|
UTSW |
10 |
67,065,785 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5742:Jmjd1c
|
UTSW |
10 |
67,056,112 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5764:Jmjd1c
|
UTSW |
10 |
67,062,291 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6118:Jmjd1c
|
UTSW |
10 |
67,075,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6163:Jmjd1c
|
UTSW |
10 |
67,083,827 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6256:Jmjd1c
|
UTSW |
10 |
67,056,187 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6266:Jmjd1c
|
UTSW |
10 |
67,085,439 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6358:Jmjd1c
|
UTSW |
10 |
67,061,718 (GRCm39) |
missense |
probably benign |
|
|
R6430:Jmjd1c
|
UTSW |
10 |
67,059,939 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R6455:Jmjd1c
|
UTSW |
10 |
67,061,795 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6887:Jmjd1c
|
UTSW |
10 |
67,025,599 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R6895:Jmjd1c
|
UTSW |
10 |
67,052,869 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7041:Jmjd1c
|
UTSW |
10 |
67,056,388 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7095:Jmjd1c
|
UTSW |
10 |
67,055,411 (GRCm39) |
missense |
probably benign |
0.39 |
|
R7113:Jmjd1c
|
UTSW |
10 |
66,993,780 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7225:Jmjd1c
|
UTSW |
10 |
67,061,844 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7249:Jmjd1c
|
UTSW |
10 |
67,025,596 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7361:Jmjd1c
|
UTSW |
10 |
67,054,143 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7383:Jmjd1c
|
UTSW |
10 |
67,025,537 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7460:Jmjd1c
|
UTSW |
10 |
67,052,815 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7475:Jmjd1c
|
UTSW |
10 |
67,061,092 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7502:Jmjd1c
|
UTSW |
10 |
67,067,794 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7699:Jmjd1c
|
UTSW |
10 |
67,054,195 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7745:Jmjd1c
|
UTSW |
10 |
67,052,824 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7897:Jmjd1c
|
UTSW |
10 |
67,075,644 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7908:Jmjd1c
|
UTSW |
10 |
67,061,621 (GRCm39) |
missense |
probably benign |
|
|
R7911:Jmjd1c
|
UTSW |
10 |
67,067,774 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7967:Jmjd1c
|
UTSW |
10 |
67,085,461 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8058:Jmjd1c
|
UTSW |
10 |
67,090,274 (GRCm39) |
missense |
not run |
|
|
R8224:Jmjd1c
|
UTSW |
10 |
67,080,628 (GRCm39) |
missense |
noncoding transcript |
|
|
R8251:Jmjd1c
|
UTSW |
10 |
67,075,068 (GRCm39) |
missense |
noncoding transcript |
|
|
R8797:Jmjd1c
|
UTSW |
10 |
67,060,616 (GRCm39) |
missense |
probably benign |
|
|
R8833:Jmjd1c
|
UTSW |
10 |
67,054,162 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9262:Jmjd1c
|
UTSW |
10 |
67,083,793 (GRCm39) |
missense |
probably benign |
0.39 |
|
R9354:Jmjd1c
|
UTSW |
10 |
67,059,875 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9373:Jmjd1c
|
UTSW |
10 |
66,932,495 (GRCm39) |
intron |
probably benign |
|
|
R9477:Jmjd1c
|
UTSW |
10 |
66,993,734 (GRCm39) |
nonsense |
probably null |
|
|
R9519:Jmjd1c
|
UTSW |
10 |
66,993,798 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R9701:Jmjd1c
|
UTSW |
10 |
67,060,745 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9802:Jmjd1c
|
UTSW |
10 |
67,060,745 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
RF011:Jmjd1c
|
UTSW |
10 |
67,055,978 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
Z1088:Jmjd1c
|
UTSW |
10 |
67,073,953 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Jmjd1c
|
UTSW |
10 |
67,073,953 (GRCm39) |
missense |
probably benign |
|
|
Z1177:Jmjd1c
|
UTSW |
10 |
67,081,904 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1177:Jmjd1c
|
UTSW |
10 |
67,073,953 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGGTCCACACCCGTGTGAAAAC -3'
(R):5'- TCTCCTCAGACCATGCAGTGTACC -3'
Sequencing Primer
(F):5'- GTTGCATTACCAAACTTAGGGTC -3'
(R):5'- TGCAGTGTACCATACATACCTG -3'
|
| Posted On |
2013-04-12 |
Incidental Mutation