Incidental Mutation 'R1956:Ralgapa2'
| ID |
217756 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ralgapa2
|
| Ensembl Gene |
ENSMUSG00000037110 |
| Gene Name |
Ral GTPase activating protein, alpha subunit 2 (catalytic) |
| Synonyms |
AS250, A230067G21Rik, RGC2 |
| MMRRC Submission |
039970-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.250)
|
| Stock # |
R1956 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
146081799-146354264 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 146302679 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Leucine
at position 95
(F95L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153734
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000109986]
[ENSMUST00000131824]
[ENSMUST00000228797]
|
| AlphaFold |
A3KGS3 |
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000109982
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109986
AA Change: F95L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000105613
Gene: ENSMUSG00000037110
AA Change: F95L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
469 |
480 |
N/A |
INTRINSIC |
|
low complexity region
|
1017 |
1028 |
N/A |
INTRINSIC |
|
low complexity region
|
1296 |
1301 |
N/A |
INTRINSIC |
|
Pfam:Rap_GAP
|
1701 |
1877 |
6.8e-48 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000131824
AA Change: F95L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000122039
Gene: ENSMUSG00000037110
AA Change: F95L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
469 |
480 |
N/A |
INTRINSIC |
|
low complexity region
|
979 |
990 |
N/A |
INTRINSIC |
|
low complexity region
|
1258 |
1263 |
N/A |
INTRINSIC |
|
Pfam:Rap_GAP
|
1663 |
1842 |
1.3e-66 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000135974
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228797
AA Change: F95L
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 94.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased incidence and severity of induced urothelial bladder tumors. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 102 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aard |
A |
T |
15: 51,908,316 (GRCm39) |
D157V |
probably damaging |
Het |
| Abcg5 |
A |
G |
17: 84,977,803 (GRCm39) |
V151A |
probably damaging |
Het |
| Acss3 |
A |
G |
10: 106,772,029 (GRCm39) |
V682A |
probably benign |
Het |
| Adamts9 |
A |
T |
6: 92,836,830 (GRCm39) |
C641S |
probably damaging |
Het |
| Adipor1 |
T |
C |
1: 134,350,771 (GRCm39) |
S7P |
probably benign |
Het |
| Ankrd27 |
T |
A |
7: 35,303,264 (GRCm39) |
Y215N |
probably damaging |
Het |
| Arhgef7 |
T |
A |
8: 11,855,266 (GRCm39) |
L182Q |
probably damaging |
Het |
| Arnt |
C |
T |
3: 95,355,704 (GRCm39) |
S16L |
possibly damaging |
Het |
| Arrdc4 |
T |
C |
7: 68,391,547 (GRCm39) |
K240R |
probably benign |
Het |
| Atg2b |
T |
C |
12: 105,635,677 (GRCm39) |
Y197C |
probably damaging |
Het |
| Atp13a2 |
A |
G |
4: 140,731,572 (GRCm39) |
K907R |
possibly damaging |
Het |
| Cadps2 |
A |
T |
6: 23,287,685 (GRCm39) |
M1160K |
probably damaging |
Het |
| Cdk12 |
A |
G |
11: 98,110,042 (GRCm39) |
T688A |
probably benign |
Het |
| Cfap43 |
T |
A |
19: 47,885,649 (GRCm39) |
Y322F |
probably benign |
Het |
| Crabp2 |
T |
C |
3: 87,856,193 (GRCm39) |
F16L |
probably damaging |
Het |
| Creb3 |
A |
G |
4: 43,563,279 (GRCm39) |
|
probably null |
Het |
| Crk |
T |
C |
11: 75,583,496 (GRCm39) |
Y239H |
possibly damaging |
Het |
| Cyp3a13 |
A |
G |
5: 137,908,204 (GRCm39) |
I215T |
probably benign |
Het |
| D130043K22Rik |
A |
G |
13: 25,069,578 (GRCm39) |
Y879C |
probably damaging |
Het |
| Depdc5 |
T |
C |
5: 33,061,175 (GRCm39) |
V334A |
probably damaging |
Het |
| Dgkh |
T |
C |
14: 78,855,981 (GRCm39) |
N231S |
probably damaging |
Het |
| Disp2 |
T |
A |
2: 118,622,704 (GRCm39) |
H1145Q |
probably benign |
Het |
| Epb41l4b |
T |
C |
4: 57,038,553 (GRCm39) |
T563A |
possibly damaging |
Het |
| Ephb3 |
G |
A |
16: 21,040,132 (GRCm39) |
R498H |
probably damaging |
Het |
| F10 |
T |
C |
8: 13,105,422 (GRCm39) |
I329T |
probably damaging |
Het |
| Fam13b |
G |
T |
18: 34,578,382 (GRCm39) |
Q760K |
possibly damaging |
Het |
| Fmo4 |
G |
A |
1: 162,631,259 (GRCm39) |
T236I |
probably benign |
Het |
| Foxp4 |
C |
T |
17: 48,186,796 (GRCm39) |
R378Q |
unknown |
Het |
| Fpr-rs4 |
A |
G |
17: 18,242,518 (GRCm39) |
Y175C |
probably damaging |
Het |
| Fzd8 |
T |
A |
18: 9,214,502 (GRCm39) |
M528K |
probably damaging |
Het |
| Gcc2 |
A |
G |
10: 58,121,965 (GRCm39) |
H1134R |
possibly damaging |
Het |
| Gdf10 |
G |
A |
14: 33,654,710 (GRCm39) |
A406T |
probably benign |
Het |
| Ggn |
T |
A |
7: 28,871,341 (GRCm39) |
S240R |
probably damaging |
Het |
| Git2 |
C |
T |
5: 114,887,398 (GRCm39) |
W299* |
probably null |
Het |
| Gm42669 |
A |
T |
5: 107,656,738 (GRCm39) |
E355D |
possibly damaging |
Het |
| Gm5134 |
T |
C |
10: 75,840,680 (GRCm39) |
F508S |
possibly damaging |
Het |
| Gm9923 |
G |
T |
10: 72,145,490 (GRCm39) |
V114L |
probably benign |
Het |
| Has3 |
A |
T |
8: 107,605,435 (GRCm39) |
Y547F |
probably benign |
Het |
| Heatr5a |
A |
G |
12: 51,992,202 (GRCm39) |
|
probably null |
Het |
| Hnrnpk |
A |
T |
13: 58,544,000 (GRCm39) |
|
probably null |
Het |
| Ifna4 |
A |
T |
4: 88,760,311 (GRCm39) |
I72F |
probably damaging |
Het |
| Ip6k3 |
A |
T |
17: 27,370,142 (GRCm39) |
L92Q |
probably benign |
Het |
| Itpripl1 |
T |
C |
2: 126,983,927 (GRCm39) |
E65G |
probably damaging |
Het |
| Kcnh5 |
G |
C |
12: 74,944,358 (GRCm39) |
Q964E |
probably benign |
Het |
| Kmt2d |
A |
G |
15: 98,757,471 (GRCm39) |
|
probably benign |
Het |
| Lrrc69 |
A |
G |
4: 14,665,986 (GRCm39) |
V324A |
possibly damaging |
Het |
| Mefv |
T |
C |
16: 3,535,691 (GRCm39) |
Q79R |
probably damaging |
Het |
| Mettl17 |
T |
C |
14: 52,126,254 (GRCm39) |
S168P |
probably damaging |
Het |
| Mpp4 |
A |
T |
1: 59,197,811 (GRCm39) |
S23T |
probably benign |
Het |
| Nabp1 |
A |
T |
1: 51,517,004 (GRCm39) |
V24D |
probably damaging |
Het |
| Nod2 |
T |
A |
8: 89,390,836 (GRCm39) |
F359Y |
probably damaging |
Het |
| Or10g1b |
C |
T |
14: 52,628,037 (GRCm39) |
M64I |
probably benign |
Het |
| Or1p1c |
A |
T |
11: 74,160,670 (GRCm39) |
T152S |
probably damaging |
Het |
| Or51b17 |
T |
G |
7: 103,542,925 (GRCm39) |
S6R |
probably benign |
Het |
| Or52d3 |
C |
A |
7: 104,229,116 (GRCm39) |
L88M |
probably damaging |
Het |
| Or5ak4 |
T |
C |
2: 85,161,444 (GRCm39) |
D266G |
probably benign |
Het |
| Or5b107 |
T |
C |
19: 13,142,560 (GRCm39) |
Y61H |
probably damaging |
Het |
| Or6a2 |
C |
T |
7: 106,600,342 (GRCm39) |
A242T |
probably damaging |
Het |
| Or7a39 |
A |
G |
10: 78,715,267 (GRCm39) |
Q87R |
probably benign |
Het |
| Pcdh18 |
T |
C |
3: 49,710,400 (GRCm39) |
H305R |
probably benign |
Het |
| Phf1 |
T |
A |
17: 27,154,719 (GRCm39) |
|
probably null |
Het |
| Pold3 |
T |
C |
7: 99,737,318 (GRCm39) |
K379R |
probably benign |
Het |
| Polr1f |
T |
A |
12: 33,487,817 (GRCm39) |
V244D |
probably benign |
Het |
| Pou2f3 |
T |
A |
9: 43,056,534 (GRCm39) |
T108S |
probably benign |
Het |
| Prdm5 |
C |
A |
6: 65,913,060 (GRCm39) |
T203K |
probably damaging |
Het |
| Psma5 |
A |
G |
3: 108,173,760 (GRCm39) |
S79G |
probably benign |
Het |
| Psme4 |
T |
A |
11: 30,782,424 (GRCm39) |
S889T |
probably damaging |
Het |
| Ptk2 |
A |
T |
15: 73,087,832 (GRCm39) |
V902D |
possibly damaging |
Het |
| Rad54l |
T |
A |
4: 115,967,554 (GRCm39) |
I243F |
probably damaging |
Het |
| Rassf6 |
G |
A |
5: 90,763,730 (GRCm39) |
Q71* |
probably null |
Het |
| Ryr2 |
A |
T |
13: 11,695,966 (GRCm39) |
L2967H |
probably damaging |
Het |
| Scn5a |
T |
C |
9: 119,346,479 (GRCm39) |
T1058A |
possibly damaging |
Het |
| Sdk1 |
T |
C |
5: 142,080,336 (GRCm39) |
L1276P |
probably damaging |
Het |
| Serpina12 |
T |
G |
12: 104,002,048 (GRCm39) |
T223P |
probably damaging |
Het |
| Sh3yl1 |
A |
G |
12: 30,992,787 (GRCm39) |
|
probably null |
Het |
| Spata31g1 |
A |
T |
4: 42,970,105 (GRCm39) |
|
probably null |
Het |
| St6galnac5 |
T |
A |
3: 152,552,120 (GRCm39) |
Q149L |
probably benign |
Het |
| Stam2 |
T |
C |
2: 52,598,239 (GRCm39) |
|
probably null |
Het |
| Tac2 |
A |
G |
10: 127,564,349 (GRCm39) |
|
probably null |
Het |
| Tbata |
G |
A |
10: 61,019,256 (GRCm39) |
D271N |
probably damaging |
Het |
| Tbx3 |
T |
C |
5: 119,819,018 (GRCm39) |
V531A |
probably benign |
Het |
| Tektl1 |
A |
G |
10: 78,586,373 (GRCm39) |
|
probably null |
Het |
| Thra |
T |
A |
11: 98,654,567 (GRCm39) |
D312E |
probably benign |
Het |
| Tlr1 |
T |
A |
5: 65,082,520 (GRCm39) |
I686F |
probably damaging |
Het |
| Tmem86b |
A |
T |
7: 4,631,706 (GRCm39) |
F115L |
probably benign |
Het |
| Tmem94 |
A |
G |
11: 115,679,500 (GRCm39) |
D259G |
possibly damaging |
Het |
| Trim69 |
G |
A |
2: 122,004,956 (GRCm39) |
|
probably null |
Het |
| Usp43 |
T |
A |
11: 67,795,159 (GRCm39) |
Q243L |
probably damaging |
Het |
| Vcam1 |
T |
C |
3: 115,919,606 (GRCm39) |
Y226C |
probably damaging |
Het |
| Vmn2r104 |
A |
T |
17: 20,262,313 (GRCm39) |
N272K |
probably damaging |
Het |
| Vmn2r26 |
G |
A |
6: 124,030,846 (GRCm39) |
C527Y |
probably damaging |
Het |
| Vmn2r84 |
G |
A |
10: 130,226,677 (GRCm39) |
A387V |
probably benign |
Het |
| Vps13b |
A |
T |
15: 35,869,553 (GRCm39) |
I2686F |
probably damaging |
Het |
| Vps8 |
C |
T |
16: 21,279,892 (GRCm39) |
T281M |
probably damaging |
Het |
| Wdfy3 |
A |
G |
5: 102,067,275 (GRCm39) |
V1219A |
probably benign |
Het |
| Wnt9b |
A |
G |
11: 103,621,638 (GRCm39) |
C340R |
probably damaging |
Het |
| Zfhx3 |
T |
C |
8: 109,520,774 (GRCm39) |
V632A |
probably benign |
Het |
| Zfp1006 |
A |
T |
8: 129,948,309 (GRCm39) |
D41E |
possibly damaging |
Het |
| Zfp341 |
A |
T |
2: 154,480,132 (GRCm39) |
T528S |
probably benign |
Het |
| Zfp990 |
G |
A |
4: 145,261,452 (GRCm39) |
A33T |
probably damaging |
Het |
| Zranb1 |
T |
G |
7: 132,584,458 (GRCm39) |
S601R |
probably damaging |
Het |
| Zyx |
A |
T |
6: 42,328,289 (GRCm39) |
K166I |
probably damaging |
Het |
|
| Other mutations in Ralgapa2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00666:Ralgapa2
|
APN |
2 |
146,327,056 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
IGL00915:Ralgapa2
|
APN |
2 |
146,184,442 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01012:Ralgapa2
|
APN |
2 |
146,263,659 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL01018:Ralgapa2
|
APN |
2 |
146,252,112 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01018:Ralgapa2
|
APN |
2 |
146,252,113 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01902:Ralgapa2
|
APN |
2 |
146,156,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02160:Ralgapa2
|
APN |
2 |
146,190,360 (GRCm39) |
splice site |
probably benign |
|
|
IGL02321:Ralgapa2
|
APN |
2 |
146,254,736 (GRCm39) |
nonsense |
probably null |
|
|
IGL02412:Ralgapa2
|
APN |
2 |
146,254,052 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL03026:Ralgapa2
|
APN |
2 |
146,302,695 (GRCm39) |
splice site |
probably benign |
|
|
IGL03115:Ralgapa2
|
APN |
2 |
146,266,734 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03256:Ralgapa2
|
APN |
2 |
146,302,632 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03379:Ralgapa2
|
APN |
2 |
146,199,907 (GRCm39) |
missense |
probably benign |
0.01 |
|
Chow
|
UTSW |
2 |
146,188,638 (GRCm39) |
nonsense |
probably null |
|
|
purina
|
UTSW |
2 |
146,175,406 (GRCm39) |
missense |
probably damaging |
1.00 |
|
P4748:Ralgapa2
|
UTSW |
2 |
146,188,731 (GRCm39) |
nonsense |
probably null |
|
|
R0012:Ralgapa2
|
UTSW |
2 |
146,254,672 (GRCm39) |
missense |
probably benign |
|
|
R0012:Ralgapa2
|
UTSW |
2 |
146,254,672 (GRCm39) |
missense |
probably benign |
|
|
R0165:Ralgapa2
|
UTSW |
2 |
146,230,407 (GRCm39) |
splice site |
probably benign |
|
|
R0344:Ralgapa2
|
UTSW |
2 |
146,188,714 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R0402:Ralgapa2
|
UTSW |
2 |
146,276,729 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0419:Ralgapa2
|
UTSW |
2 |
146,270,592 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R0638:Ralgapa2
|
UTSW |
2 |
146,184,112 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0704:Ralgapa2
|
UTSW |
2 |
146,293,704 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0722:Ralgapa2
|
UTSW |
2 |
146,230,451 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0866:Ralgapa2
|
UTSW |
2 |
146,277,923 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1065:Ralgapa2
|
UTSW |
2 |
146,292,478 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1212:Ralgapa2
|
UTSW |
2 |
146,199,902 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1395:Ralgapa2
|
UTSW |
2 |
146,230,420 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1614:Ralgapa2
|
UTSW |
2 |
146,230,532 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1686:Ralgapa2
|
UTSW |
2 |
146,199,920 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1799:Ralgapa2
|
UTSW |
2 |
146,184,648 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1905:Ralgapa2
|
UTSW |
2 |
146,229,621 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2144:Ralgapa2
|
UTSW |
2 |
146,230,524 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2148:Ralgapa2
|
UTSW |
2 |
146,273,807 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2219:Ralgapa2
|
UTSW |
2 |
146,263,599 (GRCm39) |
missense |
probably benign |
0.09 |
|
R2220:Ralgapa2
|
UTSW |
2 |
146,263,599 (GRCm39) |
missense |
probably benign |
0.09 |
|
R2261:Ralgapa2
|
UTSW |
2 |
146,184,603 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2402:Ralgapa2
|
UTSW |
2 |
146,195,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2495:Ralgapa2
|
UTSW |
2 |
146,203,320 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R3752:Ralgapa2
|
UTSW |
2 |
146,263,551 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3953:Ralgapa2
|
UTSW |
2 |
146,277,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3956:Ralgapa2
|
UTSW |
2 |
146,277,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4177:Ralgapa2
|
UTSW |
2 |
146,327,083 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4182:Ralgapa2
|
UTSW |
2 |
146,277,914 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4193:Ralgapa2
|
UTSW |
2 |
146,184,493 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4332:Ralgapa2
|
UTSW |
2 |
146,102,288 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4507:Ralgapa2
|
UTSW |
2 |
146,195,168 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4574:Ralgapa2
|
UTSW |
2 |
146,277,919 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4585:Ralgapa2
|
UTSW |
2 |
146,156,944 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4627:Ralgapa2
|
UTSW |
2 |
146,203,373 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4647:Ralgapa2
|
UTSW |
2 |
146,229,549 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R4677:Ralgapa2
|
UTSW |
2 |
146,187,387 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4724:Ralgapa2
|
UTSW |
2 |
146,187,453 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4760:Ralgapa2
|
UTSW |
2 |
146,188,669 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4831:Ralgapa2
|
UTSW |
2 |
146,246,987 (GRCm39) |
intron |
probably benign |
|
|
R4962:Ralgapa2
|
UTSW |
2 |
146,276,754 (GRCm39) |
nonsense |
probably null |
|
|
R4993:Ralgapa2
|
UTSW |
2 |
146,289,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5041:Ralgapa2
|
UTSW |
2 |
146,327,071 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5120:Ralgapa2
|
UTSW |
2 |
146,254,004 (GRCm39) |
missense |
probably benign |
0.26 |
|
R5185:Ralgapa2
|
UTSW |
2 |
146,230,406 (GRCm39) |
splice site |
probably null |
|
|
R5393:Ralgapa2
|
UTSW |
2 |
146,187,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5428:Ralgapa2
|
UTSW |
2 |
146,176,414 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5439:Ralgapa2
|
UTSW |
2 |
146,184,430 (GRCm39) |
missense |
probably benign |
0.08 |
|
R5476:Ralgapa2
|
UTSW |
2 |
146,289,356 (GRCm39) |
missense |
probably benign |
|
|
R5695:Ralgapa2
|
UTSW |
2 |
146,175,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5705:Ralgapa2
|
UTSW |
2 |
146,291,193 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5718:Ralgapa2
|
UTSW |
2 |
146,295,326 (GRCm39) |
splice site |
probably null |
|
|
R5817:Ralgapa2
|
UTSW |
2 |
146,175,406 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5877:Ralgapa2
|
UTSW |
2 |
146,230,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5994:Ralgapa2
|
UTSW |
2 |
146,203,373 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6048:Ralgapa2
|
UTSW |
2 |
146,276,765 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6158:Ralgapa2
|
UTSW |
2 |
146,266,596 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6169:Ralgapa2
|
UTSW |
2 |
146,292,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6280:Ralgapa2
|
UTSW |
2 |
146,184,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6301:Ralgapa2
|
UTSW |
2 |
146,169,331 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6650:Ralgapa2
|
UTSW |
2 |
146,230,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6959:Ralgapa2
|
UTSW |
2 |
146,184,621 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7020:Ralgapa2
|
UTSW |
2 |
146,188,638 (GRCm39) |
nonsense |
probably null |
|
|
R7035:Ralgapa2
|
UTSW |
2 |
146,353,777 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7167:Ralgapa2
|
UTSW |
2 |
146,190,374 (GRCm39) |
missense |
probably benign |
|
|
R7186:Ralgapa2
|
UTSW |
2 |
146,230,406 (GRCm39) |
splice site |
probably null |
|
|
R7252:Ralgapa2
|
UTSW |
2 |
146,184,671 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7266:Ralgapa2
|
UTSW |
2 |
146,176,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7371:Ralgapa2
|
UTSW |
2 |
146,189,046 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7432:Ralgapa2
|
UTSW |
2 |
146,276,776 (GRCm39) |
missense |
probably benign |
0.41 |
|
R7470:Ralgapa2
|
UTSW |
2 |
146,266,587 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7663:Ralgapa2
|
UTSW |
2 |
146,260,335 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7780:Ralgapa2
|
UTSW |
2 |
146,184,334 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7973:Ralgapa2
|
UTSW |
2 |
146,230,481 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8018:Ralgapa2
|
UTSW |
2 |
146,182,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8063:Ralgapa2
|
UTSW |
2 |
146,285,775 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8070:Ralgapa2
|
UTSW |
2 |
146,195,199 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8264:Ralgapa2
|
UTSW |
2 |
146,175,370 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8309:Ralgapa2
|
UTSW |
2 |
146,246,786 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8409:Ralgapa2
|
UTSW |
2 |
146,086,897 (GRCm39) |
missense |
|
|
|
R8474:Ralgapa2
|
UTSW |
2 |
146,266,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8487:Ralgapa2
|
UTSW |
2 |
146,230,463 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8492:Ralgapa2
|
UTSW |
2 |
146,184,524 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R8733:Ralgapa2
|
UTSW |
2 |
146,266,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8856:Ralgapa2
|
UTSW |
2 |
146,184,139 (GRCm39) |
missense |
probably benign |
0.30 |
|
R8858:Ralgapa2
|
UTSW |
2 |
146,102,285 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8862:Ralgapa2
|
UTSW |
2 |
146,266,731 (GRCm39) |
missense |
probably benign |
0.41 |
|
R9146:Ralgapa2
|
UTSW |
2 |
146,184,252 (GRCm39) |
missense |
probably benign |
|
|
R9324:Ralgapa2
|
UTSW |
2 |
146,302,645 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9439:Ralgapa2
|
UTSW |
2 |
146,254,058 (GRCm39) |
missense |
probably benign |
|
|
R9457:Ralgapa2
|
UTSW |
2 |
146,176,474 (GRCm39) |
missense |
probably damaging |
0.99 |
|
RF019:Ralgapa2
|
UTSW |
2 |
146,203,423 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
X0019:Ralgapa2
|
UTSW |
2 |
146,230,572 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
Z1088:Ralgapa2
|
UTSW |
2 |
146,276,825 (GRCm39) |
missense |
probably benign |
0.20 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTTTCCTACAAAGTTCAAGTTGGAC -3'
(R):5'- GCCCAGTATTCTTGAGTTTCAG -3'
Sequencing Primer
(F):5'- TTGGACTTGATTTAAATTACAAAGCC -3'
(R):5'- TGGGTGCTTTCCTAAGTACAAC -3'
|
| Posted On |
2014-08-01 |
Incidental Mutation