Incidental Mutation 'R1956:Vps8'
| ID |
217848 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vps8
|
| Ensembl Gene |
ENSMUSG00000033653 |
| Gene Name |
VPS8 CORVET complex subunit |
| Synonyms |
|
| MMRRC Submission |
039970-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1956 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
16 |
| Chromosomal Location |
21241868-21463430 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 21279892 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Methionine
at position 281
(T281M)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000112636
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000096191]
[ENSMUST00000096192]
[ENSMUST00000115397]
[ENSMUST00000117598]
[ENSMUST00000118923]
|
| AlphaFold |
Q0P5W1 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000096191
AA Change: T279M
PolyPhen 2
Score 0.938 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000093905
Gene: ENSMUSG00000033653
AA Change: T279M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
296 |
1e-8 |
SMART |
|
Blast:WD40
|
184 |
225 |
7e-22 |
BLAST |
|
Blast:WD40
|
228 |
268 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
610 |
794 |
1.7e-61 |
PFAM |
|
low complexity region
|
992 |
1007 |
N/A |
INTRINSIC |
|
low complexity region
|
1085 |
1097 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1137 |
N/A |
INTRINSIC |
|
Blast:RING
|
1257 |
1277 |
1e-5 |
BLAST |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000096192
AA Change: T281M
PolyPhen 2
Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000093906
Gene: ENSMUSG00000033653
AA Change: T281M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
298 |
1e-8 |
SMART |
|
Blast:WD40
|
186 |
227 |
8e-22 |
BLAST |
|
Blast:WD40
|
230 |
270 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
612 |
796 |
1.4e-61 |
PFAM |
|
low complexity region
|
969 |
979 |
N/A |
INTRINSIC |
|
low complexity region
|
1057 |
1069 |
N/A |
INTRINSIC |
|
low complexity region
|
1098 |
1109 |
N/A |
INTRINSIC |
|
RING
|
1229 |
1280 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000115397
AA Change: T281M
PolyPhen 2
Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000111055
Gene: ENSMUSG00000033653
AA Change: T281M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
298 |
8e-9 |
SMART |
|
Blast:WD40
|
186 |
227 |
8e-22 |
BLAST |
|
Blast:WD40
|
230 |
270 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
613 |
796 |
1.3e-61 |
PFAM |
|
low complexity region
|
994 |
1009 |
N/A |
INTRINSIC |
|
low complexity region
|
1087 |
1099 |
N/A |
INTRINSIC |
|
low complexity region
|
1128 |
1139 |
N/A |
INTRINSIC |
|
RING
|
1259 |
1310 |
1.23e-4 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000117598
AA Change: T279M
PolyPhen 2
Score 0.938 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000112937
Gene: ENSMUSG00000033653
AA Change: T279M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
296 |
1e-8 |
SMART |
|
Blast:WD40
|
184 |
225 |
8e-22 |
BLAST |
|
Blast:WD40
|
228 |
268 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
610 |
794 |
1.9e-61 |
PFAM |
|
low complexity region
|
992 |
1007 |
N/A |
INTRINSIC |
|
low complexity region
|
1085 |
1097 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1137 |
N/A |
INTRINSIC |
|
RING
|
1257 |
1308 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000118923
AA Change: T281M
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000112636
Gene: ENSMUSG00000033653
AA Change: T281M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
298 |
9e-9 |
SMART |
|
Blast:WD40
|
186 |
227 |
8e-22 |
BLAST |
|
Blast:WD40
|
230 |
270 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
612 |
796 |
1.9e-61 |
PFAM |
|
low complexity region
|
969 |
979 |
N/A |
INTRINSIC |
|
low complexity region
|
1057 |
1069 |
N/A |
INTRINSIC |
|
low complexity region
|
1098 |
1109 |
N/A |
INTRINSIC |
|
RING
|
1229 |
1280 |
1.23e-4 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 94.2%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 102 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aard |
A |
T |
15: 51,908,316 (GRCm39) |
D157V |
probably damaging |
Het |
| Abcg5 |
A |
G |
17: 84,977,803 (GRCm39) |
V151A |
probably damaging |
Het |
| Acss3 |
A |
G |
10: 106,772,029 (GRCm39) |
V682A |
probably benign |
Het |
| Adamts9 |
A |
T |
6: 92,836,830 (GRCm39) |
C641S |
probably damaging |
Het |
| Adipor1 |
T |
C |
1: 134,350,771 (GRCm39) |
S7P |
probably benign |
Het |
| Ankrd27 |
T |
A |
7: 35,303,264 (GRCm39) |
Y215N |
probably damaging |
Het |
| Arhgef7 |
T |
A |
8: 11,855,266 (GRCm39) |
L182Q |
probably damaging |
Het |
| Arnt |
C |
T |
3: 95,355,704 (GRCm39) |
S16L |
possibly damaging |
Het |
| Arrdc4 |
T |
C |
7: 68,391,547 (GRCm39) |
K240R |
probably benign |
Het |
| Atg2b |
T |
C |
12: 105,635,677 (GRCm39) |
Y197C |
probably damaging |
Het |
| Atp13a2 |
A |
G |
4: 140,731,572 (GRCm39) |
K907R |
possibly damaging |
Het |
| Cadps2 |
A |
T |
6: 23,287,685 (GRCm39) |
M1160K |
probably damaging |
Het |
| Cdk12 |
A |
G |
11: 98,110,042 (GRCm39) |
T688A |
probably benign |
Het |
| Cfap43 |
T |
A |
19: 47,885,649 (GRCm39) |
Y322F |
probably benign |
Het |
| Crabp2 |
T |
C |
3: 87,856,193 (GRCm39) |
F16L |
probably damaging |
Het |
| Creb3 |
A |
G |
4: 43,563,279 (GRCm39) |
|
probably null |
Het |
| Crk |
T |
C |
11: 75,583,496 (GRCm39) |
Y239H |
possibly damaging |
Het |
| Cyp3a13 |
A |
G |
5: 137,908,204 (GRCm39) |
I215T |
probably benign |
Het |
| D130043K22Rik |
A |
G |
13: 25,069,578 (GRCm39) |
Y879C |
probably damaging |
Het |
| Depdc5 |
T |
C |
5: 33,061,175 (GRCm39) |
V334A |
probably damaging |
Het |
| Dgkh |
T |
C |
14: 78,855,981 (GRCm39) |
N231S |
probably damaging |
Het |
| Disp2 |
T |
A |
2: 118,622,704 (GRCm39) |
H1145Q |
probably benign |
Het |
| Epb41l4b |
T |
C |
4: 57,038,553 (GRCm39) |
T563A |
possibly damaging |
Het |
| Ephb3 |
G |
A |
16: 21,040,132 (GRCm39) |
R498H |
probably damaging |
Het |
| F10 |
T |
C |
8: 13,105,422 (GRCm39) |
I329T |
probably damaging |
Het |
| Fam13b |
G |
T |
18: 34,578,382 (GRCm39) |
Q760K |
possibly damaging |
Het |
| Fmo4 |
G |
A |
1: 162,631,259 (GRCm39) |
T236I |
probably benign |
Het |
| Foxp4 |
C |
T |
17: 48,186,796 (GRCm39) |
R378Q |
unknown |
Het |
| Fpr-rs4 |
A |
G |
17: 18,242,518 (GRCm39) |
Y175C |
probably damaging |
Het |
| Fzd8 |
T |
A |
18: 9,214,502 (GRCm39) |
M528K |
probably damaging |
Het |
| Gcc2 |
A |
G |
10: 58,121,965 (GRCm39) |
H1134R |
possibly damaging |
Het |
| Gdf10 |
G |
A |
14: 33,654,710 (GRCm39) |
A406T |
probably benign |
Het |
| Ggn |
T |
A |
7: 28,871,341 (GRCm39) |
S240R |
probably damaging |
Het |
| Git2 |
C |
T |
5: 114,887,398 (GRCm39) |
W299* |
probably null |
Het |
| Gm42669 |
A |
T |
5: 107,656,738 (GRCm39) |
E355D |
possibly damaging |
Het |
| Gm5134 |
T |
C |
10: 75,840,680 (GRCm39) |
F508S |
possibly damaging |
Het |
| Gm9923 |
G |
T |
10: 72,145,490 (GRCm39) |
V114L |
probably benign |
Het |
| Has3 |
A |
T |
8: 107,605,435 (GRCm39) |
Y547F |
probably benign |
Het |
| Heatr5a |
A |
G |
12: 51,992,202 (GRCm39) |
|
probably null |
Het |
| Hnrnpk |
A |
T |
13: 58,544,000 (GRCm39) |
|
probably null |
Het |
| Ifna4 |
A |
T |
4: 88,760,311 (GRCm39) |
I72F |
probably damaging |
Het |
| Ip6k3 |
A |
T |
17: 27,370,142 (GRCm39) |
L92Q |
probably benign |
Het |
| Itpripl1 |
T |
C |
2: 126,983,927 (GRCm39) |
E65G |
probably damaging |
Het |
| Kcnh5 |
G |
C |
12: 74,944,358 (GRCm39) |
Q964E |
probably benign |
Het |
| Kmt2d |
A |
G |
15: 98,757,471 (GRCm39) |
|
probably benign |
Het |
| Lrrc69 |
A |
G |
4: 14,665,986 (GRCm39) |
V324A |
possibly damaging |
Het |
| Mefv |
T |
C |
16: 3,535,691 (GRCm39) |
Q79R |
probably damaging |
Het |
| Mettl17 |
T |
C |
14: 52,126,254 (GRCm39) |
S168P |
probably damaging |
Het |
| Mpp4 |
A |
T |
1: 59,197,811 (GRCm39) |
S23T |
probably benign |
Het |
| Nabp1 |
A |
T |
1: 51,517,004 (GRCm39) |
V24D |
probably damaging |
Het |
| Nod2 |
T |
A |
8: 89,390,836 (GRCm39) |
F359Y |
probably damaging |
Het |
| Or10g1b |
C |
T |
14: 52,628,037 (GRCm39) |
M64I |
probably benign |
Het |
| Or1p1c |
A |
T |
11: 74,160,670 (GRCm39) |
T152S |
probably damaging |
Het |
| Or51b17 |
T |
G |
7: 103,542,925 (GRCm39) |
S6R |
probably benign |
Het |
| Or52d3 |
C |
A |
7: 104,229,116 (GRCm39) |
L88M |
probably damaging |
Het |
| Or5ak4 |
T |
C |
2: 85,161,444 (GRCm39) |
D266G |
probably benign |
Het |
| Or5b107 |
T |
C |
19: 13,142,560 (GRCm39) |
Y61H |
probably damaging |
Het |
| Or6a2 |
C |
T |
7: 106,600,342 (GRCm39) |
A242T |
probably damaging |
Het |
| Or7a39 |
A |
G |
10: 78,715,267 (GRCm39) |
Q87R |
probably benign |
Het |
| Pcdh18 |
T |
C |
3: 49,710,400 (GRCm39) |
H305R |
probably benign |
Het |
| Phf1 |
T |
A |
17: 27,154,719 (GRCm39) |
|
probably null |
Het |
| Pold3 |
T |
C |
7: 99,737,318 (GRCm39) |
K379R |
probably benign |
Het |
| Polr1f |
T |
A |
12: 33,487,817 (GRCm39) |
V244D |
probably benign |
Het |
| Pou2f3 |
T |
A |
9: 43,056,534 (GRCm39) |
T108S |
probably benign |
Het |
| Prdm5 |
C |
A |
6: 65,913,060 (GRCm39) |
T203K |
probably damaging |
Het |
| Psma5 |
A |
G |
3: 108,173,760 (GRCm39) |
S79G |
probably benign |
Het |
| Psme4 |
T |
A |
11: 30,782,424 (GRCm39) |
S889T |
probably damaging |
Het |
| Ptk2 |
A |
T |
15: 73,087,832 (GRCm39) |
V902D |
possibly damaging |
Het |
| Rad54l |
T |
A |
4: 115,967,554 (GRCm39) |
I243F |
probably damaging |
Het |
| Ralgapa2 |
A |
G |
2: 146,302,679 (GRCm39) |
F95L |
probably benign |
Het |
| Rassf6 |
G |
A |
5: 90,763,730 (GRCm39) |
Q71* |
probably null |
Het |
| Ryr2 |
A |
T |
13: 11,695,966 (GRCm39) |
L2967H |
probably damaging |
Het |
| Scn5a |
T |
C |
9: 119,346,479 (GRCm39) |
T1058A |
possibly damaging |
Het |
| Sdk1 |
T |
C |
5: 142,080,336 (GRCm39) |
L1276P |
probably damaging |
Het |
| Serpina12 |
T |
G |
12: 104,002,048 (GRCm39) |
T223P |
probably damaging |
Het |
| Sh3yl1 |
A |
G |
12: 30,992,787 (GRCm39) |
|
probably null |
Het |
| Spata31g1 |
A |
T |
4: 42,970,105 (GRCm39) |
|
probably null |
Het |
| St6galnac5 |
T |
A |
3: 152,552,120 (GRCm39) |
Q149L |
probably benign |
Het |
| Stam2 |
T |
C |
2: 52,598,239 (GRCm39) |
|
probably null |
Het |
| Tac2 |
A |
G |
10: 127,564,349 (GRCm39) |
|
probably null |
Het |
| Tbata |
G |
A |
10: 61,019,256 (GRCm39) |
D271N |
probably damaging |
Het |
| Tbx3 |
T |
C |
5: 119,819,018 (GRCm39) |
V531A |
probably benign |
Het |
| Tektl1 |
A |
G |
10: 78,586,373 (GRCm39) |
|
probably null |
Het |
| Thra |
T |
A |
11: 98,654,567 (GRCm39) |
D312E |
probably benign |
Het |
| Tlr1 |
T |
A |
5: 65,082,520 (GRCm39) |
I686F |
probably damaging |
Het |
| Tmem86b |
A |
T |
7: 4,631,706 (GRCm39) |
F115L |
probably benign |
Het |
| Tmem94 |
A |
G |
11: 115,679,500 (GRCm39) |
D259G |
possibly damaging |
Het |
| Trim69 |
G |
A |
2: 122,004,956 (GRCm39) |
|
probably null |
Het |
| Usp43 |
T |
A |
11: 67,795,159 (GRCm39) |
Q243L |
probably damaging |
Het |
| Vcam1 |
T |
C |
3: 115,919,606 (GRCm39) |
Y226C |
probably damaging |
Het |
| Vmn2r104 |
A |
T |
17: 20,262,313 (GRCm39) |
N272K |
probably damaging |
Het |
| Vmn2r26 |
G |
A |
6: 124,030,846 (GRCm39) |
C527Y |
probably damaging |
Het |
| Vmn2r84 |
G |
A |
10: 130,226,677 (GRCm39) |
A387V |
probably benign |
Het |
| Vps13b |
A |
T |
15: 35,869,553 (GRCm39) |
I2686F |
probably damaging |
Het |
| Wdfy3 |
A |
G |
5: 102,067,275 (GRCm39) |
V1219A |
probably benign |
Het |
| Wnt9b |
A |
G |
11: 103,621,638 (GRCm39) |
C340R |
probably damaging |
Het |
| Zfhx3 |
T |
C |
8: 109,520,774 (GRCm39) |
V632A |
probably benign |
Het |
| Zfp1006 |
A |
T |
8: 129,948,309 (GRCm39) |
D41E |
possibly damaging |
Het |
| Zfp341 |
A |
T |
2: 154,480,132 (GRCm39) |
T528S |
probably benign |
Het |
| Zfp990 |
G |
A |
4: 145,261,452 (GRCm39) |
A33T |
probably damaging |
Het |
| Zranb1 |
T |
G |
7: 132,584,458 (GRCm39) |
S601R |
probably damaging |
Het |
| Zyx |
A |
T |
6: 42,328,289 (GRCm39) |
K166I |
probably damaging |
Het |
|
| Other mutations in Vps8 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00500:Vps8
|
APN |
16 |
21,261,084 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
IGL00596:Vps8
|
APN |
16 |
21,267,162 (GRCm39) |
splice site |
probably benign |
|
|
IGL00985:Vps8
|
APN |
16 |
21,296,334 (GRCm39) |
splice site |
probably benign |
|
|
IGL01356:Vps8
|
APN |
16 |
21,336,107 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01375:Vps8
|
APN |
16 |
21,378,122 (GRCm39) |
nonsense |
probably null |
|
|
IGL01643:Vps8
|
APN |
16 |
21,336,972 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02159:Vps8
|
APN |
16 |
21,285,234 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL02214:Vps8
|
APN |
16 |
21,336,035 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02465:Vps8
|
APN |
16 |
21,340,653 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02651:Vps8
|
APN |
16 |
21,336,086 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03174:Vps8
|
APN |
16 |
21,285,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03337:Vps8
|
APN |
16 |
21,381,918 (GRCm39) |
missense |
probably benign |
|
|
IGL03383:Vps8
|
APN |
16 |
21,254,573 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03402:Vps8
|
APN |
16 |
21,267,148 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
empires
|
UTSW |
16 |
21,400,298 (GRCm39) |
nonsense |
probably null |
|
|
porky
|
UTSW |
16 |
21,279,988 (GRCm39) |
missense |
probably benign |
0.32 |
|
realm
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
realms
|
UTSW |
16 |
21,262,938 (GRCm39) |
splice site |
probably null |
|
|
Reich
|
UTSW |
16 |
21,297,189 (GRCm39) |
missense |
probably benign |
0.29 |
|
reichen
|
UTSW |
16 |
21,325,575 (GRCm39) |
splice site |
probably benign |
|
|
IGL03052:Vps8
|
UTSW |
16 |
21,267,115 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4677001:Vps8
|
UTSW |
16 |
21,319,084 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0066:Vps8
|
UTSW |
16 |
21,296,273 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0066:Vps8
|
UTSW |
16 |
21,296,273 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0125:Vps8
|
UTSW |
16 |
21,288,904 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0137:Vps8
|
UTSW |
16 |
21,323,136 (GRCm39) |
splice site |
probably benign |
|
|
R0362:Vps8
|
UTSW |
16 |
21,426,977 (GRCm39) |
intron |
probably benign |
|
|
R0384:Vps8
|
UTSW |
16 |
21,325,575 (GRCm39) |
splice site |
probably benign |
|
|
R0492:Vps8
|
UTSW |
16 |
21,261,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0525:Vps8
|
UTSW |
16 |
21,358,859 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0531:Vps8
|
UTSW |
16 |
21,278,561 (GRCm39) |
intron |
probably benign |
|
|
R0605:Vps8
|
UTSW |
16 |
21,378,087 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0636:Vps8
|
UTSW |
16 |
21,253,683 (GRCm39) |
missense |
probably benign |
0.32 |
|
R0707:Vps8
|
UTSW |
16 |
21,261,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0840:Vps8
|
UTSW |
16 |
21,275,071 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1170:Vps8
|
UTSW |
16 |
21,278,570 (GRCm39) |
intron |
probably benign |
|
|
R1203:Vps8
|
UTSW |
16 |
21,330,307 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1482:Vps8
|
UTSW |
16 |
21,400,348 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1531:Vps8
|
UTSW |
16 |
21,285,226 (GRCm39) |
nonsense |
probably null |
|
|
R1642:Vps8
|
UTSW |
16 |
21,400,329 (GRCm39) |
missense |
probably benign |
|
|
R2201:Vps8
|
UTSW |
16 |
21,395,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2287:Vps8
|
UTSW |
16 |
21,387,163 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2423:Vps8
|
UTSW |
16 |
21,378,087 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3151:Vps8
|
UTSW |
16 |
21,261,123 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3943:Vps8
|
UTSW |
16 |
21,288,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3944:Vps8
|
UTSW |
16 |
21,288,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4043:Vps8
|
UTSW |
16 |
21,345,146 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4302:Vps8
|
UTSW |
16 |
21,314,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4398:Vps8
|
UTSW |
16 |
21,323,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4477:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4478:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4479:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4480:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4571:Vps8
|
UTSW |
16 |
21,254,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4653:Vps8
|
UTSW |
16 |
21,318,960 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4664:Vps8
|
UTSW |
16 |
21,262,938 (GRCm39) |
splice site |
probably null |
|
|
R4713:Vps8
|
UTSW |
16 |
21,261,189 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4726:Vps8
|
UTSW |
16 |
21,267,154 (GRCm39) |
splice site |
probably null |
|
|
R4959:Vps8
|
UTSW |
16 |
21,278,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4973:Vps8
|
UTSW |
16 |
21,278,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4975:Vps8
|
UTSW |
16 |
21,285,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4992:Vps8
|
UTSW |
16 |
21,280,158 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R5144:Vps8
|
UTSW |
16 |
21,378,103 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5168:Vps8
|
UTSW |
16 |
21,351,849 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5168:Vps8
|
UTSW |
16 |
21,276,195 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5222:Vps8
|
UTSW |
16 |
21,400,298 (GRCm39) |
nonsense |
probably null |
|
|
R5231:Vps8
|
UTSW |
16 |
21,395,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5876:Vps8
|
UTSW |
16 |
21,280,189 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5963:Vps8
|
UTSW |
16 |
21,288,871 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R6010:Vps8
|
UTSW |
16 |
21,363,955 (GRCm39) |
intron |
probably benign |
|
|
R6023:Vps8
|
UTSW |
16 |
21,279,988 (GRCm39) |
missense |
probably benign |
0.32 |
|
R6173:Vps8
|
UTSW |
16 |
21,314,682 (GRCm39) |
splice site |
probably null |
|
|
R6185:Vps8
|
UTSW |
16 |
21,288,891 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6264:Vps8
|
UTSW |
16 |
21,378,099 (GRCm39) |
nonsense |
probably null |
|
|
R6409:Vps8
|
UTSW |
16 |
21,297,189 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6522:Vps8
|
UTSW |
16 |
21,261,129 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6528:Vps8
|
UTSW |
16 |
21,372,875 (GRCm39) |
nonsense |
probably null |
|
|
R6784:Vps8
|
UTSW |
16 |
21,381,957 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7040:Vps8
|
UTSW |
16 |
21,393,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7072:Vps8
|
UTSW |
16 |
21,400,329 (GRCm39) |
missense |
probably benign |
|
|
R7103:Vps8
|
UTSW |
16 |
21,345,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7149:Vps8
|
UTSW |
16 |
21,278,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7195:Vps8
|
UTSW |
16 |
21,275,032 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7206:Vps8
|
UTSW |
16 |
21,276,171 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7403:Vps8
|
UTSW |
16 |
21,253,722 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R7782:Vps8
|
UTSW |
16 |
21,330,308 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7806:Vps8
|
UTSW |
16 |
21,278,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7846:Vps8
|
UTSW |
16 |
21,351,070 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7943:Vps8
|
UTSW |
16 |
21,296,622 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8075:Vps8
|
UTSW |
16 |
21,340,644 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8190:Vps8
|
UTSW |
16 |
21,393,780 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8307:Vps8
|
UTSW |
16 |
21,314,652 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8483:Vps8
|
UTSW |
16 |
21,393,763 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8814:Vps8
|
UTSW |
16 |
21,395,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9064:Vps8
|
UTSW |
16 |
21,288,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9367:Vps8
|
UTSW |
16 |
21,340,668 (GRCm39) |
missense |
possibly damaging |
0.45 |
|
R9404:Vps8
|
UTSW |
16 |
21,426,927 (GRCm39) |
missense |
probably benign |
0.12 |
|
R9544:Vps8
|
UTSW |
16 |
21,336,893 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9570:Vps8
|
UTSW |
16 |
21,462,953 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9634:Vps8
|
UTSW |
16 |
21,372,893 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9702:Vps8
|
UTSW |
16 |
21,462,883 (GRCm39) |
missense |
probably benign |
0.17 |
|
| Predicted Primers |
PCR Primer
(F):5'- TACTTTCATACAGAGGCAGGTC -3'
(R):5'- TTGCAACTCTCACACGGTG -3'
Sequencing Primer
(F):5'- AGGCAGGTCTGTAGAATGTCCTTAC -3'
(R):5'- CACGGTGTTCAAAGTCTCTAGAGC -3'
|
| Posted On |
2014-08-01 |
Incidental Mutation