Mutagenetix > Incidental Mutation

Incidental Mutation 'R1958:Gm11444'

218056

Institutional Source

Beutler Lab

Gene Symbol

Gm11444

Ensembl Gene

ENSMUSG00000069785

Gene Name

predicted gene 11444

Synonyms

MMRRC Submission

039972-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.080) question?

Stock #

R1958 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

85846790-85850333 bp(-) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

A to T at 85848173 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s):

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000146433

SMART Domains

Protein: ENSMUSP00000116236
Gene: ENSMUSG00000069785

Domain	Start	End	E-Value	Type
low complexity region	130	143	N/A	INTRINSIC

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.7%
20x: 94.0%

Validation Efficiency

97% (99/102)

Allele List at MGI

Other mutations in this stock

Total: 100 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933430I17Rik	A	T	4: 62,538,909	N155I	probably benign	Het
Abca14	A	G	7: 120,325,159	Y1678C	probably damaging	Het
Adamts19	A	T	18: 58,970,006	R706S	probably benign	Het
Adipor1	T	C	1: 134,423,033	S7P	probably benign	Het
Adss	A	G	1: 177,769,978	I372T	probably damaging	Het
Arhgap15	T	A	2: 44,243,124	D347E	possibly damaging	Het
Arnt	C	T	3: 95,448,393	S16L	possibly damaging	Het
Asb8	T	C	15: 98,136,216	T153A	possibly damaging	Het
Aspscr1	G	T	11: 120,689,208	G191V	probably null	Het
Atm	T	C	9: 53,471,418	H1957R	probably damaging	Het
Atp13a5	A	G	16: 29,314,601	Y411H	probably damaging	Het
Cadm1	T	G	9: 47,850,335	I411S	probably damaging	Het
Cdh23	T	A	10: 60,410,873	M927L	probably benign	Het
Cdk15	A	T	1: 59,344,316	R423W	probably damaging	Het
Cep250	T	A	2: 155,976,381		probably null	Het
Cfap43	T	A	19: 47,897,210	Y322F	probably benign	Het
Cfap54	T	C	10: 92,997,342	S1141G	probably benign	Het
Clnk	T	C	5: 38,706,626	Y428C	possibly damaging	Het
Cnksr1	A	G	4: 134,228,416	S668P	probably benign	Het
Cpxm2	A	T	7: 132,062,147	I349N	probably damaging	Het
Csmd3	A	G	15: 48,004,639		probably null	Het
Dnmt1	C	T	9: 20,927,146	R207H	probably benign	Het
Dph2	A	T	4: 117,891,844	F5I	probably damaging	Het
Dst	T	A	1: 34,163,721	F325L	probably damaging	Het
Edem3	T	C	1: 151,804,325	L474S	probably damaging	Het
Emilin1	T	A	5: 30,917,816	L467Q	probably benign	Het
Fam170a	G	A	18: 50,282,114	E276K	probably benign	Het
Farp1	A	T	14: 121,219,375		probably null	Het
Fbrs	A	T	7: 127,485,991	T584S	possibly damaging	Het
Fbxo22	T	A	9: 55,209,342		probably null	Het
Fhod3	T	G	18: 25,090,465	L956R	probably damaging	Het
Fmo4	G	A	1: 162,803,690	T236I	probably benign	Het
Foxp4	C	T	17: 47,875,871	R378Q	unknown	Het
Gdf10	G	A	14: 33,932,753	A406T	probably benign	Het
Gm14443	T	C	2: 175,169,704	I316M	probably benign	Het
Gm4758	T	C	16: 36,312,565	L68P	possibly damaging	Het
Has3	A	T	8: 106,878,803	Y547F	probably benign	Het
Hdhd2	A	G	18: 76,965,145	T164A	probably benign	Het
Hoxb9	T	A	11: 96,272,054	D171E	possibly damaging	Het
Hpx	A	G	7: 105,596,396	Y118H	probably damaging	Het
Iqsec1	T	C	6: 90,670,459	K858E	probably damaging	Het
Kifc1	G	A	17: 33,884,711	R195C	probably benign	Het
Lama2	C	A	10: 26,981,598	R3085L	probably damaging	Het
Lyst	C	A	13: 13,616,618	A22E	probably damaging	Het
Man2a1	T	C	17: 64,750,835	F1079L	probably benign	Het
Marco	C	T	1: 120,484,864	G303R	probably damaging	Het
Marveld2	A	C	13: 100,597,350	I536R	probably damaging	Het
Mcm5	A	G	8: 75,121,629	D502G	probably benign	Het
Mdga1	A	T	17: 29,840,888	L653Q	probably damaging	Het
Micalcl	A	G	7: 112,381,104	D161G	probably benign	Het
Mroh2a	C	T	1: 88,237,491	R445*	probably null	Het
Mrpl46	A	T	7: 78,781,398		probably null	Het
Nckipsd	C	A	9: 108,814,664		probably null	Het
Nek11	T	C	9: 105,293,717	D373G	probably benign	Het
Nle1	G	A	11: 82,904,242	S321F	probably benign	Het
Noxa1	A	G	2: 25,090,608	S130P	probably damaging	Het
Olfr1156	A	T	2: 87,949,465	L256H	probably damaging	Het
Olfr620	T	A	7: 103,611,411	*314L	probably null	Het
Olfr713	A	G	7: 107,036,271	T39A	possibly damaging	Het
Olfr887	T	A	9: 38,085,123	C96S	probably damaging	Het
Parp3	T	G	9: 106,474,822		probably null	Het
Pask	A	T	1: 93,321,458	I740N	probably benign	Het
Pelp1	A	G	11: 70,398,521	F221S	probably damaging	Het
Pkd1l1	T	G	11: 8,874,161	K1135Q	probably benign	Het
Plcl2	A	T	17: 50,608,081	Q706L	probably damaging	Het
Psg26	T	C	7: 18,478,339	T364A	probably benign	Het
Ptprb	C	T	10: 116,341,536	T1047M	probably benign	Het
Ptpro	T	A	6: 137,443,594	V1007D	probably damaging	Het
Rab37	C	T	11: 115,160,351	A155V	probably damaging	Het
Rbbp6	A	C	7: 123,001,945		probably benign	Het
Rbmxl2	A	G	7: 107,210,198	D230G	probably benign	Het
Rsf1	CGGCGGCGGCGGCGGCGGCGGCGGCGGC	CGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGC	7: 97,579,908		probably benign	Het
Sass6	G	T	3: 116,610,296	K194N	possibly damaging	Het
Sgpp1	T	G	12: 75,735,448	D39A	probably benign	Het
Shank3	T	C	15: 89,503,148	V198A	probably damaging	Het
Sin3a	T	A	9: 57,105,609	S591T	probably damaging	Het
Slc12a6	C	T	2: 112,355,158	T924I	possibly damaging	Het
Sln	T	A	9: 53,853,501	I10N	probably benign	Het
St3gal3	A	T	4: 117,940,071	M309K	probably damaging	Het
Syne2	T	A	12: 75,969,545	D3301E	probably benign	Het
Tgtp2	A	G	11: 49,059,092	S218P	probably damaging	Het
Tha1	C	T	11: 117,869,353		probably benign	Het
Tmem102	A	G	11: 69,804,399	V249A	probably benign	Het
Top3b	G	A	16: 16,884,302	E268K	possibly damaging	Het
Trip4	T	C	9: 65,839,025	S530G	possibly damaging	Het
Tut1	T	A	19: 8,959,313	V167E	probably damaging	Het
Ube2u	A	T	4: 100,481,636	M33L	probably benign	Het
Unc79	T	C	12: 102,991,362	I12T	probably damaging	Het
Unc79	A	T	12: 103,074,919	D737V	probably benign	Het
Vmn1r26	A	G	6: 58,008,301	V301A	probably benign	Het
Vmn1r86	A	G	7: 13,102,694	V35A	possibly damaging	Het
Vmn2r98	A	C	17: 19,066,418	N393H	possibly damaging	Het
Vps13b	T	G	15: 35,878,689	S2945A	probably damaging	Het
Whrn	C	T	4: 63,435,429	R367H	possibly damaging	Het
Zcchc11	A	T	4: 108,555,706	S1535C	probably damaging	Het
Zfp235	A	T	7: 24,140,346	L133F	probably damaging	Het
Zfp74	T	C	7: 29,935,711	T191A	probably benign	Het
Zfp943	A	T	17: 21,992,998	K355I	probably damaging	Het
Zranb1	T	G	7: 132,982,729	S601R	probably damaging	Het
Zscan29	A	T	2: 121,169,808		probably null	Het

Other mutations in Gm11444

Allele	Source	Chr	Coord	Type	Predicted Effect
IGL01298:Gm11444	APN	11	85848094	missense	unknown
R5199:Gm11444	UTSW	11	85848019	missense	unknown
R6283:Gm11444	UTSW	11	85846791	splice site	probably null
R7088:Gm11444	UTSW	11	85847036	missense
R7579:Gm11444	UTSW	11	85850243	missense	unknown
R8378:Gm11444	UTSW	11	85850249	missense
R8708:Gm11444	UTSW	11	85846897	missense
R9803:Gm11444	UTSW	11	85846873	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- TGACTTCCTTAAGGCATAGTTGG -3'
(R):5'- CTAGGACTGAAGCTGAAGGC -3'

Sequencing Primer
(F):5'- CACTCCAGGAGTCAGATTTGTTACG -3'
(R):5'- GCTGAAGGCCAACAGGAATTCTC -3'

Posted On

2014-08-01