Incidental Mutation 'R1959:Shc2'
ID 218180
Institutional Source Beutler Lab
Gene Symbol Shc2
Ensembl Gene ENSMUSG00000020312
Gene Name SHC (Src homology 2 domain containing) transforming protein 2
Synonyms ShcB, Sli
MMRRC Submission 039973-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1959 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 79618051-79637918 bp(-) (GRCm38)
Type of Mutation splice site (9 bp from exon)
DNA Base Change (assembly) T to C at 79626791 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000020564] [ENSMUST00000020564]
AlphaFold Q8BMC3
Predicted Effect probably benign
Transcript: ENSMUST00000020564
SMART Domains Protein: ENSMUSP00000020564
Gene: ENSMUSG00000020312

DomainStartEndE-ValueType
PTB 1 154 4.43e-24 SMART
low complexity region 172 178 N/A INTRINSIC
SH2 341 420 5.81e-29 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000020564
SMART Domains Protein: ENSMUSP00000020564
Gene: ENSMUSG00000020312

DomainStartEndE-ValueType
PTB 1 154 4.43e-24 SMART
low complexity region 172 178 N/A INTRINSIC
SH2 341 420 5.81e-29 SMART
Predicted Effect probably null
Transcript: ENSMUST00000163867
SMART Domains Protein: ENSMUSP00000129491
Gene: ENSMUSG00000020312

DomainStartEndE-ValueType
low complexity region 4 16 N/A INTRINSIC
low complexity region 67 85 N/A INTRINSIC
PTB 126 289 7.41e-35 SMART
low complexity region 307 313 N/A INTRINSIC
SH2 476 555 5.81e-29 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000166450
Predicted Effect noncoding transcript
Transcript: ENSMUST00000168116
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 93.2%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for disruptions in this gene display sensory nerve defects related to nociception. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 130 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700123L14Rik A G 6: 96,165,269 (GRCm38) S265P possibly damaging Het
Abcc1 T C 16: 14,396,393 (GRCm38) Y191H probably damaging Het
Aco1 T C 4: 40,167,193 (GRCm38) probably null Het
Adap1 A G 5: 139,273,341 (GRCm38) Y364H probably benign Het
Add2 T C 6: 86,096,756 (GRCm38) F209S probably damaging Het
Adgb A T 10: 10,395,249 (GRCm38) D883E probably benign Het
Als2cr12 A T 1: 58,659,278 (GRCm38) V327D possibly damaging Het
Anapc1 C A 2: 128,633,415 (GRCm38) R1381S probably benign Het
Aoah A G 13: 20,794,394 (GRCm38) M1V probably null Het
Arap1 C A 7: 101,373,015 (GRCm38) A8E probably damaging Het
Arhgap10 A G 8: 77,409,626 (GRCm38) F319S possibly damaging Het
Btrc T G 19: 45,527,343 (GRCm38) I480S probably damaging Het
Cabin1 A T 10: 75,735,090 (GRCm38) V784E possibly damaging Het
Card9 T A 2: 26,354,873 (GRCm38) probably null Het
Cdk18 A G 1: 132,117,821 (GRCm38) I238T possibly damaging Het
Clec12a A C 6: 129,350,481 (GRCm38) T21P possibly damaging Het
Commd3 A T 2: 18,673,963 (GRCm38) I70F probably benign Het
Cspg5 G A 9: 110,251,026 (GRCm38) V340M probably damaging Het
Cyb5r4 G A 9: 87,055,849 (GRCm38) S307N possibly damaging Het
Cyp26c1 T A 19: 37,687,377 (GRCm38) F230I probably damaging Het
Ddx11 A G 17: 66,130,728 (GRCm38) M150V probably benign Het
Dennd4b A G 3: 90,268,773 (GRCm38) Y190C probably damaging Het
Det1 A G 7: 78,843,443 (GRCm38) V271A probably benign Het
Dgkd C A 1: 87,929,827 (GRCm38) P754T possibly damaging Het
Dhx36 T C 3: 62,479,385 (GRCm38) S649G probably benign Het
Dlgap5 A G 14: 47,416,386 (GRCm38) I62T possibly damaging Het
Dmgdh A G 13: 93,720,559 (GRCm38) M724V probably benign Het
Dnah7a A G 1: 53,684,983 (GRCm38) S108P probably benign Het
Dock4 A T 12: 40,710,798 (GRCm38) K495M probably damaging Het
Dse A G 10: 34,160,206 (GRCm38) Y225H probably damaging Het
Emx1 G A 6: 85,203,934 (GRCm38) R211K probably damaging Het
Ergic2 A G 6: 148,199,354 (GRCm38) probably null Het
Fbxo27 G A 7: 28,698,372 (GRCm38) C277Y possibly damaging Het
Fcrl1 T C 3: 87,376,520 (GRCm38) I9T possibly damaging Het
Fjx1 T C 2: 102,450,807 (GRCm38) E261G probably benign Het
Flnb C T 14: 7,884,735 (GRCm38) Q445* probably null Het
Flrt2 G A 12: 95,780,300 (GRCm38) V471I probably benign Het
Frmd4a G A 2: 4,535,186 (GRCm38) V210M probably damaging Het
Fsip2 A G 2: 82,991,550 (GRCm38) K5876E probably benign Het
Galnt10 T C 11: 57,765,617 (GRCm38) L209P probably damaging Het
Gata5 A T 2: 180,326,936 (GRCm38) S382T possibly damaging Het
Glt6d1 C A 2: 25,794,413 (GRCm38) V194L probably damaging Het
Gm10803 T G 2: 93,563,943 (GRCm38) V20G unknown Het
Gm44511 T G 6: 128,820,271 (GRCm38) T52P probably damaging Het
Gpat4 A T 8: 23,182,936 (GRCm38) L88Q possibly damaging Het
Gpr15 T A 16: 58,718,007 (GRCm38) I240L probably benign Het
Hivep2 A T 10: 14,132,709 (GRCm38) I1684F probably benign Het
Hmcn1 T C 1: 150,649,676 (GRCm38) T3366A probably benign Het
Hnmt A G 2: 24,003,882 (GRCm38) V200A possibly damaging Het
Hps6 A T 19: 46,004,335 (GRCm38) H237L probably benign Het
Hspg2 C T 4: 137,564,895 (GRCm38) P4033S probably damaging Het
Irf9 T A 14: 55,607,717 (GRCm38) S297T possibly damaging Het
Kdm3b T C 18: 34,812,395 (GRCm38) V753A possibly damaging Het
Kif21a G A 15: 90,970,848 (GRCm38) A703V probably damaging Het
Kif27 T G 13: 58,293,123 (GRCm38) R1159S probably benign Het
Krtap4-16 A G 11: 99,851,547 (GRCm38) V9A unknown Het
Lama2 G T 10: 27,422,618 (GRCm38) P161T probably damaging Het
Ltbp4 G A 7: 27,329,018 (GRCm38) P273L unknown Het
Lvrn T A 18: 46,894,717 (GRCm38) S866R probably damaging Het
Med13 A G 11: 86,298,979 (GRCm38) Y1035H probably damaging Het
Mertk T A 2: 128,759,090 (GRCm38) N331K probably damaging Het
Mios T A 6: 8,215,437 (GRCm38) F211Y probably benign Het
Mpeg1 G A 19: 12,462,911 (GRCm38) V578M probably damaging Het
Mphosph9 A T 5: 124,315,701 (GRCm38) S183T possibly damaging Het
Mrto4 A T 4: 139,349,638 (GRCm38) I56N probably damaging Het
Muc5b T C 7: 141,862,637 (GRCm38) C3107R possibly damaging Het
Ncoa2 A G 1: 13,160,252 (GRCm38) Y1023H probably damaging Het
Nlrp2 T C 7: 5,327,738 (GRCm38) E553G probably damaging Het
Nlrp6 GAGAAGAAGAAGAAGAAGAAGA GAGAAGAAGAAGAAGAAGA 7: 140,924,113 (GRCm38) probably benign Het
Nr2f1 T C 13: 78,189,816 (GRCm38) T237A probably damaging Het
Nup205 C A 6: 35,233,366 (GRCm38) Q1621K probably benign Het
Nxpe2 T A 9: 48,319,726 (GRCm38) S448C probably benign Het
Ogdh T A 11: 6,346,638 (GRCm38) C498S possibly damaging Het
Olfr1176 T C 2: 88,340,201 (GRCm38) L212P probably damaging Het
Olfr281 T C 15: 98,456,753 (GRCm38) S148P probably damaging Het
Olfr294 A T 7: 86,616,431 (GRCm38) F71L probably benign Het
Olfr414 A T 1: 174,430,905 (GRCm38) K159M probably damaging Het
Olfr697 T C 7: 106,741,394 (GRCm38) E180G probably damaging Het
Olfr715 A T 7: 107,128,510 (GRCm38) D294E possibly damaging Het
Olfr994 T C 2: 85,430,619 (GRCm38) D70G probably damaging Het
Oplah G A 15: 76,297,464 (GRCm38) T1119I probably damaging Het
Pcdhb9 T A 18: 37,403,316 (GRCm38) Y788N probably damaging Het
Pcsk5 T C 19: 17,433,418 (GRCm38) D1870G unknown Het
Pde6g A G 11: 120,448,136 (GRCm38) L76P probably damaging Het
Peak1 A T 9: 56,206,789 (GRCm38) Y593N probably damaging Het
Pfas C T 11: 68,994,284 (GRCm38) G16R probably damaging Het
Pkd1l2 A T 8: 117,043,231 (GRCm38) probably null Het
Pla2g3 C T 11: 3,490,983 (GRCm38) T316I probably benign Het
Ptpru T A 4: 131,803,477 (GRCm38) I489F probably damaging Het
Rere T G 4: 150,468,790 (GRCm38) H146Q probably benign Het
Rundc1 A T 11: 101,431,496 (GRCm38) Q272L probably damaging Het
Scml4 T C 10: 42,956,021 (GRCm38) L305P probably damaging Het
Sec16a A T 2: 26,430,132 (GRCm38) H1431Q probably benign Het
Serpina1a G A 12: 103,853,800 (GRCm38) Q373* probably null Het
Shank1 A T 7: 44,325,377 (GRCm38) N377I unknown Het
Slc22a29 C A 19: 8,169,193 (GRCm38) R415M probably benign Het
Slc7a2 A T 8: 40,914,965 (GRCm38) I589F probably damaging Het
Smim8 C T 4: 34,771,316 (GRCm38) R26Q probably damaging Het
Smox C A 2: 131,520,464 (GRCm38) A221D probably damaging Het
Sox5 A G 6: 143,874,105 (GRCm38) S62P possibly damaging Het
Spg21 A C 9: 65,484,492 (GRCm38) K240N probably damaging Het
Sv2c C T 13: 95,976,645 (GRCm38) V599M probably damaging Het
Tanc2 T A 11: 105,910,295 (GRCm38) H1112Q probably damaging Het
Tbata T C 10: 61,175,844 (GRCm38) I58T possibly damaging Het
Tbc1d2 T G 4: 46,606,419 (GRCm38) Y842S probably benign Het
Tctn1 A T 5: 122,241,840 (GRCm38) probably null Het
Tenm1 T C X: 42,827,201 (GRCm38) D402G probably benign Het
Tfcp2l1 T C 1: 118,669,389 (GRCm38) V400A probably benign Het
Tm9sf2 T A 14: 122,126,164 (GRCm38) L99I probably benign Het
Top2a T C 11: 98,995,977 (GRCm38) probably null Het
Traf7 C A 17: 24,513,281 (GRCm38) G191C probably damaging Het
Trpm1 T A 7: 64,230,230 (GRCm38) L661Q probably damaging Het
Ttc30b C T 2: 75,937,099 (GRCm38) E437K probably benign Het
Ttn T C 2: 76,750,623 (GRCm38) I23309V probably benign Het
Usp50 T C 2: 126,777,961 (GRCm38) K199E possibly damaging Het
Vmn1r218 T C 13: 23,136,513 (GRCm38) F10S probably damaging Het
Vmn2r89 C A 14: 51,457,440 (GRCm38) T459K probably benign Het
Vps13a T G 19: 16,677,938 (GRCm38) S1909R possibly damaging Het
Vwa5b2 T C 16: 20,602,191 (GRCm38) probably null Het
Vwa8 A G 14: 78,982,360 (GRCm38) H516R possibly damaging Het
Wnk1 T C 6: 119,969,247 (GRCm38) I648M probably damaging Het
Zfat G C 15: 68,146,543 (GRCm38) P974R probably benign Het
Zfc3h1 T A 10: 115,423,253 (GRCm38) I1601K probably benign Het
Zfp239 A G 6: 117,871,817 (GRCm38) K172R probably benign Het
Zfp335 C T 2: 164,894,802 (GRCm38) G971D probably damaging Het
Zfp532 A T 18: 65,624,492 (GRCm38) I499F probably damaging Het
Zfp647 T C 15: 76,911,114 (GRCm38) T449A possibly damaging Het
Zfp938 C T 10: 82,225,631 (GRCm38) G385D probably damaging Het
Zfp959 T G 17: 55,897,404 (GRCm38) V147G probably damaging Het
Znfx1 A T 2: 167,050,350 (GRCm38) C649S probably damaging Het
Other mutations in Shc2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00341:Shc2 APN 10 79,621,069 (GRCm38) missense probably damaging 1.00
IGL01586:Shc2 APN 10 79,622,304 (GRCm38) missense probably damaging 0.99
IGL01965:Shc2 APN 10 79,627,189 (GRCm38) splice site probably benign
IGL02149:Shc2 APN 10 79,622,268 (GRCm38) missense probably damaging 1.00
IGL02252:Shc2 APN 10 79,626,370 (GRCm38) missense probably benign 0.00
shrine UTSW 10 79,629,917 (GRCm38) missense probably damaging 0.99
R0538:Shc2 UTSW 10 79,630,140 (GRCm38) splice site probably benign
R0630:Shc2 UTSW 10 79,626,141 (GRCm38) splice site probably null
R0894:Shc2 UTSW 10 79,629,917 (GRCm38) missense probably damaging 0.99
R1166:Shc2 UTSW 10 79,621,112 (GRCm38) missense probably damaging 1.00
R1339:Shc2 UTSW 10 79,626,416 (GRCm38) missense probably benign 0.00
R1465:Shc2 UTSW 10 79,631,302 (GRCm38) missense probably damaging 1.00
R1465:Shc2 UTSW 10 79,631,302 (GRCm38) missense probably damaging 1.00
R1647:Shc2 UTSW 10 79,626,111 (GRCm38) missense probably benign
R1648:Shc2 UTSW 10 79,626,111 (GRCm38) missense probably benign
R3800:Shc2 UTSW 10 79,626,873 (GRCm38) missense probably benign 0.40
R4603:Shc2 UTSW 10 79,623,856 (GRCm38) missense probably benign 0.03
R4635:Shc2 UTSW 10 79,626,286 (GRCm38) missense probably benign 0.35
R4656:Shc2 UTSW 10 79,621,169 (GRCm38) missense probably damaging 1.00
R4715:Shc2 UTSW 10 79,622,379 (GRCm38) missense probably benign 0.01
R4841:Shc2 UTSW 10 79,622,461 (GRCm38) missense probably damaging 0.98
R4842:Shc2 UTSW 10 79,622,461 (GRCm38) missense probably damaging 0.98
R5057:Shc2 UTSW 10 79,623,872 (GRCm38) missense probably benign 0.01
R5394:Shc2 UTSW 10 79,630,099 (GRCm38) missense probably damaging 1.00
R6153:Shc2 UTSW 10 79,629,918 (GRCm38) missense possibly damaging 0.90
R6160:Shc2 UTSW 10 79,627,019 (GRCm38) critical splice donor site probably null
R6178:Shc2 UTSW 10 79,630,120 (GRCm38) missense probably damaging 1.00
R8773:Shc2 UTSW 10 79,621,090 (GRCm38) missense probably damaging 1.00
R8824:Shc2 UTSW 10 79,637,702 (GRCm38) missense probably benign
R8841:Shc2 UTSW 10 79,622,316 (GRCm38) missense probably damaging 1.00
R9081:Shc2 UTSW 10 79,626,928 (GRCm38) critical splice acceptor site probably null
Predicted Primers
Posted On 2014-08-01