Incidental Mutation 'R0021:Pou2f1'
| ID |
218427 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Pou2f1
|
| Ensembl Gene |
ENSMUSG00000026565 |
| Gene Name |
POU domain, class 2, transcription factor 1 |
| Synonyms |
Oct-1z, Oct-1A, Oct-1B, Oct-1C, oct-1, Oct1, 2810482H01Rik, Otf-1, Otf1 |
| MMRRC Submission |
038316-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0021 (G1)
|
| Quality Score |
64 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
165692723-165830247 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 165703587 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Methionine
at position 654
(T654M)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000138962
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000027850]
[ENSMUST00000069609]
[ENSMUST00000111426]
[ENSMUST00000111427]
[ENSMUST00000111429]
[ENSMUST00000159212]
[ENSMUST00000160260]
[ENSMUST00000160908]
[ENSMUST00000184643]
[ENSMUST00000178336]
[ENSMUST00000161971]
[ENSMUST00000187313]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000027850
AA Change: T614M
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000027850
Gene: ENSMUSG00000026565
AA Change: T614M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
22 |
N/A |
INTRINSIC |
|
low complexity region
|
94 |
123 |
N/A |
INTRINSIC |
|
low complexity region
|
137 |
152 |
N/A |
INTRINSIC |
|
low complexity region
|
171 |
192 |
N/A |
INTRINSIC |
|
low complexity region
|
199 |
217 |
N/A |
INTRINSIC |
|
POU
|
241 |
315 |
1.55e-52 |
SMART |
|
low complexity region
|
316 |
332 |
N/A |
INTRINSIC |
|
HOX
|
342 |
404 |
2.54e-19 |
SMART |
|
low complexity region
|
422 |
448 |
N/A |
INTRINSIC |
|
low complexity region
|
453 |
520 |
N/A |
INTRINSIC |
|
low complexity region
|
529 |
567 |
N/A |
INTRINSIC |
|
low complexity region
|
675 |
685 |
N/A |
INTRINSIC |
|
low complexity region
|
688 |
705 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000069609
AA Change: T666M
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000064000
Gene: ENSMUSG00000026565
AA Change: T666M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
83 |
112 |
N/A |
INTRINSIC |
|
low complexity region
|
130 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
189 |
204 |
N/A |
INTRINSIC |
|
low complexity region
|
223 |
244 |
N/A |
INTRINSIC |
|
low complexity region
|
251 |
269 |
N/A |
INTRINSIC |
|
POU
|
293 |
367 |
1.55e-52 |
SMART |
|
low complexity region
|
368 |
384 |
N/A |
INTRINSIC |
|
HOX
|
394 |
456 |
2.54e-19 |
SMART |
|
low complexity region
|
474 |
500 |
N/A |
INTRINSIC |
|
low complexity region
|
505 |
572 |
N/A |
INTRINSIC |
|
low complexity region
|
581 |
619 |
N/A |
INTRINSIC |
|
low complexity region
|
727 |
737 |
N/A |
INTRINSIC |
|
low complexity region
|
740 |
757 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000082225
|
| SMART Domains |
Protein: ENSMUSP00000080856
Gene: ENSMUSG00000026565
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
83 |
112 |
N/A |
INTRINSIC |
|
low complexity region
|
130 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
189 |
204 |
N/A |
INTRINSIC |
|
POU
|
233 |
309 |
4.88e-27 |
SMART |
|
low complexity region
|
310 |
326 |
N/A |
INTRINSIC |
|
HOX
|
336 |
398 |
2.54e-19 |
SMART |
|
low complexity region
|
416 |
442 |
N/A |
INTRINSIC |
|
low complexity region
|
447 |
514 |
N/A |
INTRINSIC |
|
low complexity region
|
523 |
561 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000111426
|
| SMART Domains |
Protein: ENSMUSP00000107055
Gene: ENSMUSG00000026565
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
83 |
112 |
N/A |
INTRINSIC |
|
low complexity region
|
130 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
189 |
204 |
N/A |
INTRINSIC |
|
low complexity region
|
223 |
244 |
N/A |
INTRINSIC |
|
low complexity region
|
251 |
269 |
N/A |
INTRINSIC |
|
POU
|
293 |
367 |
6.7e-55 |
SMART |
|
low complexity region
|
368 |
384 |
N/A |
INTRINSIC |
|
HOX
|
394 |
456 |
1.3e-21 |
SMART |
|
low complexity region
|
474 |
500 |
N/A |
INTRINSIC |
|
low complexity region
|
531 |
596 |
N/A |
INTRINSIC |
|
low complexity region
|
605 |
643 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000111427
AA Change: T690M
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000107056
Gene: ENSMUSG00000026565
AA Change: T690M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
83 |
112 |
N/A |
INTRINSIC |
|
low complexity region
|
130 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
189 |
204 |
N/A |
INTRINSIC |
|
low complexity region
|
223 |
244 |
N/A |
INTRINSIC |
|
low complexity region
|
251 |
269 |
N/A |
INTRINSIC |
|
POU
|
293 |
367 |
1.55e-52 |
SMART |
|
low complexity region
|
368 |
384 |
N/A |
INTRINSIC |
|
HOX
|
394 |
456 |
2.54e-19 |
SMART |
|
low complexity region
|
474 |
500 |
N/A |
INTRINSIC |
|
low complexity region
|
531 |
596 |
N/A |
INTRINSIC |
|
low complexity region
|
605 |
643 |
N/A |
INTRINSIC |
|
low complexity region
|
751 |
761 |
N/A |
INTRINSIC |
|
low complexity region
|
764 |
781 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000111429
AA Change: T654M
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000107057
Gene: ENSMUSG00000026565
AA Change: T654M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
71 |
100 |
N/A |
INTRINSIC |
|
low complexity region
|
118 |
160 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
192 |
N/A |
INTRINSIC |
|
low complexity region
|
211 |
232 |
N/A |
INTRINSIC |
|
low complexity region
|
239 |
257 |
N/A |
INTRINSIC |
|
POU
|
281 |
355 |
6.7e-55 |
SMART |
|
low complexity region
|
356 |
372 |
N/A |
INTRINSIC |
|
HOX
|
382 |
444 |
1.3e-21 |
SMART |
|
low complexity region
|
462 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
493 |
560 |
N/A |
INTRINSIC |
|
low complexity region
|
569 |
607 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159212
|
| SMART Domains |
Protein: ENSMUSP00000125371
Gene: ENSMUSG00000026565
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
71 |
100 |
N/A |
INTRINSIC |
|
low complexity region
|
118 |
160 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
192 |
N/A |
INTRINSIC |
|
low complexity region
|
211 |
232 |
N/A |
INTRINSIC |
|
low complexity region
|
239 |
257 |
N/A |
INTRINSIC |
|
POU
|
281 |
355 |
1.55e-52 |
SMART |
|
low complexity region
|
356 |
372 |
N/A |
INTRINSIC |
|
HOX
|
382 |
444 |
2.54e-19 |
SMART |
|
low complexity region
|
462 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
493 |
560 |
N/A |
INTRINSIC |
|
low complexity region
|
569 |
607 |
N/A |
INTRINSIC |
|
low complexity region
|
715 |
725 |
N/A |
INTRINSIC |
|
low complexity region
|
728 |
745 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000160260
AA Change: T701M
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000124738
Gene: ENSMUSG00000026565
AA Change: T701M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
22 |
N/A |
INTRINSIC |
|
low complexity region
|
94 |
123 |
N/A |
INTRINSIC |
|
low complexity region
|
141 |
183 |
N/A |
INTRINSIC |
|
low complexity region
|
200 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
234 |
255 |
N/A |
INTRINSIC |
|
low complexity region
|
262 |
280 |
N/A |
INTRINSIC |
|
POU
|
304 |
378 |
1.55e-52 |
SMART |
|
low complexity region
|
379 |
395 |
N/A |
INTRINSIC |
|
HOX
|
405 |
467 |
2.54e-19 |
SMART |
|
low complexity region
|
485 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
607 |
N/A |
INTRINSIC |
|
low complexity region
|
616 |
654 |
N/A |
INTRINSIC |
|
low complexity region
|
762 |
772 |
N/A |
INTRINSIC |
|
low complexity region
|
775 |
792 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000160908
AA Change: T677M
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000125444
Gene: ENSMUSG00000026565
AA Change: T677M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
22 |
N/A |
INTRINSIC |
|
low complexity region
|
94 |
123 |
N/A |
INTRINSIC |
|
low complexity region
|
141 |
183 |
N/A |
INTRINSIC |
|
low complexity region
|
200 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
234 |
255 |
N/A |
INTRINSIC |
|
low complexity region
|
262 |
280 |
N/A |
INTRINSIC |
|
POU
|
304 |
378 |
1.55e-52 |
SMART |
|
low complexity region
|
379 |
395 |
N/A |
INTRINSIC |
|
HOX
|
405 |
467 |
2.54e-19 |
SMART |
|
low complexity region
|
485 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
516 |
583 |
N/A |
INTRINSIC |
|
low complexity region
|
592 |
630 |
N/A |
INTRINSIC |
|
low complexity region
|
738 |
748 |
N/A |
INTRINSIC |
|
low complexity region
|
751 |
768 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000184643
AA Change: T654M
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000138962
Gene: ENSMUSG00000026565
AA Change: T654M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
71 |
100 |
N/A |
INTRINSIC |
|
low complexity region
|
118 |
160 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
192 |
N/A |
INTRINSIC |
|
low complexity region
|
211 |
232 |
N/A |
INTRINSIC |
|
low complexity region
|
239 |
257 |
N/A |
INTRINSIC |
|
POU
|
281 |
355 |
6.7e-55 |
SMART |
|
low complexity region
|
356 |
372 |
N/A |
INTRINSIC |
|
HOX
|
382 |
444 |
1.3e-21 |
SMART |
|
low complexity region
|
462 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
493 |
560 |
N/A |
INTRINSIC |
|
low complexity region
|
569 |
607 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000162411
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000176004
|
| SMART Domains |
Protein: ENSMUSP00000135153
Gene: ENSMUSG00000026565
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
41 |
N/A |
INTRINSIC |
|
low complexity region
|
149 |
159 |
N/A |
INTRINSIC |
|
low complexity region
|
162 |
179 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000176942
|
| SMART Domains |
Protein: ENSMUSP00000135052
Gene: ENSMUSG00000026565
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
65 |
94 |
N/A |
INTRINSIC |
|
low complexity region
|
112 |
154 |
N/A |
INTRINSIC |
|
low complexity region
|
171 |
186 |
N/A |
INTRINSIC |
|
low complexity region
|
205 |
226 |
N/A |
INTRINSIC |
|
low complexity region
|
233 |
251 |
N/A |
INTRINSIC |
|
POU
|
275 |
349 |
1.55e-52 |
SMART |
|
low complexity region
|
350 |
366 |
N/A |
INTRINSIC |
|
HOX
|
376 |
438 |
2.54e-19 |
SMART |
|
low complexity region
|
456 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
487 |
554 |
N/A |
INTRINSIC |
|
low complexity region
|
563 |
601 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000178336
|
| SMART Domains |
Protein: ENSMUSP00000136456
Gene: ENSMUSG00000005763
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:TCR_zetazeta
|
28 |
60 |
1.7e-23 |
PFAM |
|
ITAM
|
69 |
89 |
6.91e-5 |
SMART |
|
ITAM
|
108 |
129 |
1.27e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000161971
|
| SMART Domains |
Protein: ENSMUSP00000124297
Gene: ENSMUSG00000005763
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:TCR_zetazeta
|
28 |
60 |
1.5e-23 |
PFAM |
|
ITAM
|
69 |
89 |
6.91e-5 |
SMART |
|
ITAM
|
108 |
129 |
1.27e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000187313
|
| SMART Domains |
Protein: ENSMUSP00000140926
Gene: ENSMUSG00000005763
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:TCR_zetazeta
|
28 |
60 |
2.5e-23 |
PFAM |
|
ITAM
|
69 |
89 |
6.91e-5 |
SMART |
|
ITAM
|
108 |
129 |
1.27e-3 |
SMART |
|
low complexity region
|
195 |
204 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000184799
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000194366
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.8%
- 10x: 97.6%
- 20x: 95.8%
|
| Validation Efficiency |
97% (60/62) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.[supplied by OMIM, Jul 2010]
PHENOTYPE: Homozygous mutation of this gene results in prenatal lethality, with earlier lethality on either a 129/Sv or C57BL/6 background than a mixed 129/Sv and C57BL/6 background. Embryos show decreased erythropoiesis and partial penetrance of small lens size. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 36 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310016G11Rik |
A |
G |
7: 44,326,620 (GRCm39) |
|
noncoding transcript |
Het |
| Abcc5 |
T |
A |
16: 20,197,411 (GRCm39) |
K647* |
probably null |
Het |
| Aplp1 |
A |
G |
7: 30,135,241 (GRCm39) |
|
probably benign |
Het |
| Arhgef25 |
A |
G |
10: 127,025,423 (GRCm39) |
I43T |
probably benign |
Het |
| Brinp3 |
T |
G |
1: 146,777,189 (GRCm39) |
S545R |
probably benign |
Het |
| Btnl1 |
A |
G |
17: 34,598,468 (GRCm39) |
E28G |
probably benign |
Het |
| C5ar2 |
A |
G |
7: 15,971,601 (GRCm39) |
F109L |
probably benign |
Het |
| D630045J12Rik |
G |
A |
6: 38,160,902 (GRCm39) |
Q1081* |
probably null |
Het |
| Dhx36 |
T |
C |
3: 62,385,016 (GRCm39) |
I699V |
possibly damaging |
Het |
| Dnah9 |
A |
G |
11: 65,860,805 (GRCm39) |
I2855T |
probably benign |
Het |
| Dock8 |
T |
C |
19: 25,140,411 (GRCm39) |
I1317T |
probably benign |
Het |
| Galnt11 |
A |
T |
5: 25,453,855 (GRCm39) |
D27V |
probably damaging |
Het |
| Gm5134 |
T |
A |
10: 75,829,718 (GRCm39) |
C335S |
probably damaging |
Het |
| Hdhd2 |
A |
T |
18: 77,058,311 (GRCm39) |
K227N |
probably damaging |
Het |
| Impg1 |
A |
T |
9: 80,317,479 (GRCm39) |
L36Q |
probably damaging |
Het |
| Krtcap3 |
A |
G |
5: 31,410,303 (GRCm39) |
H227R |
probably benign |
Het |
| Lrrc7 |
A |
G |
3: 157,866,298 (GRCm39) |
Y1148H |
probably damaging |
Het |
| Map2k4 |
A |
G |
11: 65,603,110 (GRCm39) |
I174T |
probably damaging |
Het |
| Mef2c |
C |
A |
13: 83,804,359 (GRCm39) |
L282M |
probably damaging |
Het |
| Nkapd1 |
A |
C |
9: 50,521,725 (GRCm39) |
D65E |
probably damaging |
Het |
| Nqo2 |
T |
C |
13: 34,165,490 (GRCm39) |
I129T |
probably benign |
Het |
| Pdgfrb |
T |
A |
18: 61,197,998 (GRCm39) |
|
probably benign |
Het |
| Phf7 |
C |
T |
14: 30,960,443 (GRCm39) |
|
probably benign |
Het |
| Plac8 |
T |
A |
5: 100,704,434 (GRCm39) |
T88S |
probably benign |
Het |
| Ptprk |
T |
A |
10: 28,468,891 (GRCm39) |
V1425E |
probably damaging |
Het |
| Saal1 |
A |
T |
7: 46,342,316 (GRCm39) |
S376T |
probably damaging |
Het |
| Scart2 |
G |
A |
7: 139,876,310 (GRCm39) |
R594H |
probably benign |
Het |
| Serpini1 |
T |
C |
3: 75,526,620 (GRCm39) |
Y291H |
probably damaging |
Het |
| Siah2 |
T |
C |
3: 58,583,713 (GRCm39) |
H191R |
probably benign |
Het |
| Spaca6 |
T |
A |
17: 18,058,498 (GRCm39) |
Y39* |
probably null |
Het |
| Tbc1d10a |
T |
C |
11: 4,163,680 (GRCm39) |
C277R |
probably damaging |
Het |
| Trim45 |
A |
T |
3: 100,832,736 (GRCm39) |
D323V |
probably damaging |
Het |
| Trim55 |
A |
C |
3: 19,698,866 (GRCm39) |
M32L |
probably benign |
Het |
| Unc5b |
T |
C |
10: 60,614,698 (GRCm39) |
T200A |
probably benign |
Het |
| Uqcc4 |
A |
G |
17: 25,403,957 (GRCm39) |
E99G |
possibly damaging |
Het |
| V1rd19 |
A |
T |
7: 23,703,029 (GRCm39) |
D165V |
probably damaging |
Het |
|
| Other mutations in Pou2f1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00090:Pou2f1
|
APN |
1 |
165,729,867 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00392:Pou2f1
|
APN |
1 |
165,724,159 (GRCm39) |
splice site |
probably benign |
|
|
IGL01627:Pou2f1
|
APN |
1 |
165,708,002 (GRCm39) |
unclassified |
probably benign |
|
|
IGL01707:Pou2f1
|
APN |
1 |
165,742,685 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02735:Pou2f1
|
APN |
1 |
165,703,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02740:Pou2f1
|
APN |
1 |
165,710,685 (GRCm39) |
nonsense |
probably null |
|
|
IGL03117:Pou2f1
|
APN |
1 |
165,762,382 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03272:Pou2f1
|
APN |
1 |
165,724,049 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R1437:Pou2f1
|
UTSW |
1 |
165,719,399 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2171:Pou2f1
|
UTSW |
1 |
165,707,925 (GRCm39) |
unclassified |
probably benign |
|
|
R3722:Pou2f1
|
UTSW |
1 |
165,722,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3789:Pou2f1
|
UTSW |
1 |
165,722,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3790:Pou2f1
|
UTSW |
1 |
165,722,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3901:Pou2f1
|
UTSW |
1 |
165,722,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4225:Pou2f1
|
UTSW |
1 |
165,738,889 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4459:Pou2f1
|
UTSW |
1 |
165,722,575 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4460:Pou2f1
|
UTSW |
1 |
165,722,575 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4573:Pou2f1
|
UTSW |
1 |
165,740,830 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4820:Pou2f1
|
UTSW |
1 |
165,719,517 (GRCm39) |
intron |
probably benign |
|
|
R4838:Pou2f1
|
UTSW |
1 |
165,744,492 (GRCm39) |
missense |
probably null |
1.00 |
|
R5579:Pou2f1
|
UTSW |
1 |
165,742,731 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5856:Pou2f1
|
UTSW |
1 |
165,742,699 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5951:Pou2f1
|
UTSW |
1 |
165,710,625 (GRCm39) |
unclassified |
probably benign |
|
|
R6128:Pou2f1
|
UTSW |
1 |
165,703,056 (GRCm39) |
unclassified |
probably benign |
|
|
R6145:Pou2f1
|
UTSW |
1 |
165,703,002 (GRCm39) |
unclassified |
probably benign |
|
|
R6216:Pou2f1
|
UTSW |
1 |
165,707,889 (GRCm39) |
unclassified |
probably benign |
|
|
R6971:Pou2f1
|
UTSW |
1 |
165,759,258 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7052:Pou2f1
|
UTSW |
1 |
165,742,684 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R7403:Pou2f1
|
UTSW |
1 |
165,738,955 (GRCm39) |
missense |
unknown |
|
|
R7404:Pou2f1
|
UTSW |
1 |
165,738,955 (GRCm39) |
missense |
unknown |
|
|
R7741:Pou2f1
|
UTSW |
1 |
165,703,444 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8011:Pou2f1
|
UTSW |
1 |
165,722,472 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8478:Pou2f1
|
UTSW |
1 |
165,759,287 (GRCm39) |
start codon destroyed |
probably null |
|
|
R8804:Pou2f1
|
UTSW |
1 |
165,708,039 (GRCm39) |
missense |
unknown |
|
|
R8892:Pou2f1
|
UTSW |
1 |
165,708,027 (GRCm39) |
missense |
unknown |
|
|
R9126:Pou2f1
|
UTSW |
1 |
165,722,603 (GRCm39) |
missense |
unknown |
|
|
R9151:Pou2f1
|
UTSW |
1 |
165,703,640 (GRCm39) |
intron |
probably benign |
|
|
R9469:Pou2f1
|
UTSW |
1 |
165,740,830 (GRCm39) |
missense |
probably benign |
0.29 |
|
R9665:Pou2f1
|
UTSW |
1 |
165,703,600 (GRCm39) |
missense |
probably damaging |
0.99 |
|
RF012:Pou2f1
|
UTSW |
1 |
165,740,800 (GRCm39) |
missense |
unknown |
|
|
X0022:Pou2f1
|
UTSW |
1 |
165,724,025 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TAGTGAGGAAAGCCTGTGGCAACC -3'
(R):5'- TCAGTACAGCATCACAGTGGAGGG -3'
Sequencing Primer
(F):5'- AGCTCACTGTGCCTTGGAG -3'
(R):5'- TCACAGTGGAGGGGAGAGTC -3'
|
| Posted On |
2014-08-08 |
Incidental Mutation