Incidental Mutation 'R0658:Zfp820'
ID218813
Institutional Source Beutler Lab
Gene Symbol Zfp820
Ensembl Gene ENSMUSG00000069743
Gene Namezinc finger protein 820
Synonyms2610036F08Rik
MMRRC Submission 038843-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.128) question?
Stock #R0658 (G1)
Quality Score68
Status Validated
Chromosome17
Chromosomal Location21816876-21845759 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 21818920 bp
ZygosityHeterozygous
Amino Acid Change Serine to Glycine at position 476 (S476G)
Ref Sequence ENSEMBL: ENSMUSP00000081158 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084141]
Predicted Effect probably benign
Transcript: ENSMUST00000084141
AA Change: S476G

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000081158
Gene: ENSMUSG00000069743
AA Change: S476G

DomainStartEndE-ValueType
KRAB 13 73 8.77e-20 SMART
ZnF_C2H2 183 205 6.32e-3 SMART
ZnF_C2H2 211 233 2.79e-4 SMART
ZnF_C2H2 239 261 4.3e-5 SMART
ZnF_C2H2 267 289 4.61e-5 SMART
ZnF_C2H2 295 317 1.2e-3 SMART
ZnF_C2H2 323 345 1.22e-4 SMART
ZnF_C2H2 351 373 2.75e-3 SMART
ZnF_C2H2 379 401 2.95e-3 SMART
ZnF_C2H2 407 429 5.29e-5 SMART
ZnF_C2H2 435 457 1.42e-5 SMART
ZnF_C2H2 463 485 1.2e-3 SMART
ZnF_C2H2 491 513 1.13e-4 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.6%
  • 20x: 95.6%
Validation Efficiency 99% (78/79)
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abraxas1 C T 5: 100,817,961 probably null Het
Acsl3 A G 1: 78,701,287 D520G probably damaging Het
Adgrl3 T C 5: 81,648,713 V623A probably benign Het
Ak9 G T 10: 41,347,222 V454L probably damaging Het
Alpk2 C A 18: 65,349,487 K483N probably damaging Het
Arhgef12 T C 9: 42,981,985 Y974C probably damaging Het
Armc8 C T 9: 99,536,158 probably benign Het
Atp2a2 C T 5: 122,457,633 probably benign Het
Atrn T C 2: 130,970,227 probably null Het
Caps2 T A 10: 112,204,038 probably benign Het
Cep76 A G 18: 67,623,304 S486P probably damaging Het
Cep97 C T 16: 55,914,902 R583H probably benign Het
Cog7 A G 7: 121,956,140 probably benign Het
Commd5 T A 15: 76,900,568 V55E probably damaging Het
Csmd3 A T 15: 48,011,147 D684E possibly damaging Het
Ctxn2 T C 2: 125,147,456 M1T probably null Het
Exph5 A G 9: 53,377,475 D1952G unknown Het
Fmo2 A T 1: 162,876,774 L521Q possibly damaging Het
Fryl T A 5: 73,065,359 T1960S probably damaging Het
G6pd2 T C 5: 61,809,674 L264P probably damaging Het
Gm1966 C A 7: 106,602,886 V384L possibly damaging Het
Gne A T 4: 44,039,033 V647E possibly damaging Het
Grb14 G A 2: 64,914,727 Q96* probably null Het
Gtf3c1 A G 7: 125,698,962 F146L probably damaging Het
Irak2 A G 6: 113,638,564 Y6C probably damaging Het
Kel T A 6: 41,703,031 N75I probably damaging Het
Lgr4 T A 2: 110,011,787 F706I possibly damaging Het
Lox A T 18: 52,528,883 S149R probably benign Het
Lrrc66 T G 5: 73,610,944 D218A probably benign Het
Luc7l C T 17: 26,266,322 R99W probably damaging Het
Megf10 T C 18: 57,252,896 V327A probably benign Het
Mthfd1l G T 10: 4,047,976 probably null Het
Myh11 C A 16: 14,224,019 Q720H probably damaging Het
Myh8 G T 11: 67,284,532 probably null Het
Olfr1463 A T 19: 13,235,060 D270V possibly damaging Het
Pdia3 G A 2: 121,432,377 G275S probably damaging Het
Pgf C T 12: 85,169,385 R153K probably benign Het
Pramef8 A T 4: 143,417,600 Q172L probably damaging Het
Prdm2 A G 4: 143,135,265 V485A probably damaging Het
Rag1 T C 2: 101,642,683 T705A probably damaging Het
Rflna A C 5: 125,003,710 D48A possibly damaging Het
Rnf148 A T 6: 23,654,457 I180N probably damaging Het
Rtn4 T A 11: 29,706,475 S94T probably damaging Het
Scn11a G A 9: 119,811,160 T223I probably benign Het
Scube2 T A 7: 109,837,120 probably benign Het
Sept14 T C 5: 129,697,908 I68V probably benign Het
Sil1 A T 18: 35,266,857 L365Q possibly damaging Het
Sirt1 A G 10: 63,321,736 probably benign Het
Slc9a1 T C 4: 133,420,499 probably benign Het
Smpdl3a A G 10: 57,811,240 T355A probably damaging Het
Syne2 T C 12: 76,094,336 I6074T probably damaging Het
Thbs2 T A 17: 14,680,325 H540L probably benign Het
Tsc22d4 T C 5: 137,768,021 S450P probably benign Het
Tshr C A 12: 91,538,226 S54* probably null Het
Ubxn4 G A 1: 128,262,904 E256K probably benign Het
Uncx G T 5: 139,544,187 C65F probably damaging Het
Vmn1r87 A T 7: 13,131,829 M177K probably damaging Het
Vmn2r56 A T 7: 12,710,308 C466S probably benign Het
Wnk1 G A 6: 119,948,505 P1831S probably damaging Het
Other mutations in Zfp820
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00424:Zfp820 APN 17 21819311 missense probably damaging 1.00
IGL00954:Zfp820 APN 17 21819879 missense probably damaging 1.00
IGL01088:Zfp820 APN 17 21821181 nonsense probably null
IGL03067:Zfp820 APN 17 21819820 missense possibly damaging 0.68
R0158:Zfp820 UTSW 17 21819819 missense probably benign 0.06
R0617:Zfp820 UTSW 17 21819704 missense probably damaging 0.99
R0696:Zfp820 UTSW 17 21820060 missense possibly damaging 0.94
R0791:Zfp820 UTSW 17 21819528 missense probably benign 0.05
R0792:Zfp820 UTSW 17 21819528 missense probably benign 0.05
R0882:Zfp820 UTSW 17 21823836 splice site probably benign
R1421:Zfp820 UTSW 17 21819880 missense possibly damaging 0.85
R1573:Zfp820 UTSW 17 21818756 missense probably benign 0.00
R1928:Zfp820 UTSW 17 21819335 missense probably benign 0.00
R3889:Zfp820 UTSW 17 21818896 missense probably benign 0.25
R4782:Zfp820 UTSW 17 21818985 missense probably benign 0.00
R4799:Zfp820 UTSW 17 21818985 missense probably benign 0.00
R4807:Zfp820 UTSW 17 21823872 start codon destroyed probably null 1.00
R4913:Zfp820 UTSW 17 21819219 missense probably benign 0.42
R5100:Zfp820 UTSW 17 21821073 missense possibly damaging 0.64
R5766:Zfp820 UTSW 17 21820002 missense probably damaging 0.96
R5772:Zfp820 UTSW 17 21818721 missense probably damaging 1.00
R6516:Zfp820 UTSW 17 21819373 missense probably damaging 1.00
R6577:Zfp820 UTSW 17 21819403 missense probably benign 0.00
R7094:Zfp820 UTSW 17 21819265 missense probably benign 0.41
R7570:Zfp820 UTSW 17 21819013 missense probably benign 0.14
R7794:Zfp820 UTSW 17 21820128 missense probably damaging 0.98
Predicted Primers
Posted On2014-08-21