Incidental Mutation 'R1966:Ubr2'
| ID |
219005 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ubr2
|
| Ensembl Gene |
ENSMUSG00000023977 |
| Gene Name |
ubiquitin protein ligase E3 component n-recognin 2 |
| Synonyms |
ENSMUSG00000043296, E130209G04Rik, 9930021A08Rik |
| MMRRC Submission |
039979-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.891)
|
| Stock # |
R1966 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
47239221-47321482 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 47265845 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 1163
(T1163A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000108963
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000113335]
[ENSMUST00000113337]
[ENSMUST00000225599]
|
| AlphaFold |
Q6WKZ8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113335
AA Change: T1163A
PolyPhen 2
Score 0.049 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000108961
Gene: ENSMUSG00000023977
AA Change: T1163A
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_UBR1
|
97 |
167 |
3.14e-32 |
SMART |
|
Pfam:ClpS
|
221 |
302 |
2.4e-23 |
PFAM |
|
low complexity region
|
635 |
646 |
N/A |
INTRINSIC |
|
low complexity region
|
749 |
760 |
N/A |
INTRINSIC |
|
low complexity region
|
872 |
886 |
N/A |
INTRINSIC |
|
coiled coil region
|
1019 |
1046 |
N/A |
INTRINSIC |
|
RING
|
1108 |
1213 |
7.66e-1 |
SMART |
|
low complexity region
|
1221 |
1235 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113337
AA Change: T1163A
PolyPhen 2
Score 0.049 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000108963
Gene: ENSMUSG00000023977
AA Change: T1163A
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_UBR1
|
97 |
167 |
3.14e-32 |
SMART |
|
Pfam:ClpS
|
222 |
301 |
6.2e-26 |
PFAM |
|
low complexity region
|
635 |
646 |
N/A |
INTRINSIC |
|
low complexity region
|
749 |
760 |
N/A |
INTRINSIC |
|
low complexity region
|
872 |
886 |
N/A |
INTRINSIC |
|
coiled coil region
|
1019 |
1046 |
N/A |
INTRINSIC |
|
RING
|
1108 |
1213 |
7.66e-1 |
SMART |
|
low complexity region
|
1221 |
1235 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000224759
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000225599
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000225751
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an E3 ubiquitin ligase of the N-end rule proteolytic pathway that targets proteins with destabilizing N-terminal residues for polyubiquitylation and proteasome-mediated degradation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
PHENOTYPE: On a mixed genetic background, female homozygotes for a targeted null mutation exhibit embryonic lethality, while males are viable, but sterile due to postnatal testicular degeneration. On an inbred background, both genders die in utero. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 100 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2410002F23Rik |
T |
A |
7: 43,900,650 (GRCm39) |
V185E |
probably benign |
Het |
| Abca1 |
A |
C |
4: 53,050,409 (GRCm39) |
V1608G |
probably damaging |
Het |
| Ap2b1 |
T |
C |
11: 83,237,721 (GRCm39) |
I557T |
probably benign |
Het |
| Arhgef15 |
G |
T |
11: 68,845,501 (GRCm39) |
P117Q |
probably damaging |
Het |
| Arhgef39 |
T |
C |
4: 43,496,710 (GRCm39) |
S335G |
probably benign |
Het |
| Blm |
A |
T |
7: 80,162,934 (GRCm39) |
F139Y |
possibly damaging |
Het |
| Cacna2d1 |
C |
T |
5: 16,538,783 (GRCm39) |
R581* |
probably null |
Het |
| Cadps |
C |
A |
14: 12,822,450 (GRCm38) |
E97* |
probably null |
Het |
| Cavin2 |
T |
A |
1: 51,328,801 (GRCm39) |
L86Q |
probably damaging |
Het |
| Ccdc136 |
A |
G |
6: 29,418,091 (GRCm39) |
E787G |
probably damaging |
Het |
| Ccdc39 |
T |
C |
3: 33,880,629 (GRCm39) |
K446R |
probably damaging |
Het |
| Cdh23 |
T |
C |
10: 60,159,361 (GRCm39) |
Y2138C |
probably damaging |
Het |
| Cdk12 |
T |
A |
11: 98,094,916 (GRCm39) |
Y241* |
probably null |
Het |
| Clcn4 |
T |
A |
7: 7,287,184 (GRCm39) |
*688L |
probably null |
Het |
| Cntnap1 |
T |
C |
11: 101,071,212 (GRCm39) |
V375A |
possibly damaging |
Het |
| Coq5 |
T |
A |
5: 115,432,890 (GRCm39) |
|
probably null |
Het |
| Cyp4b1 |
A |
G |
4: 115,483,076 (GRCm39) |
I405T |
probably benign |
Het |
| Det1 |
T |
C |
7: 78,492,966 (GRCm39) |
Y346C |
probably damaging |
Het |
| Enpp3 |
A |
T |
10: 24,683,389 (GRCm39) |
V276E |
probably damaging |
Het |
| Epb41l2 |
G |
A |
10: 25,317,666 (GRCm39) |
R61Q |
probably benign |
Het |
| Fam76b |
G |
A |
9: 13,739,362 (GRCm39) |
|
probably null |
Het |
| Fbxo45 |
A |
T |
16: 32,052,048 (GRCm39) |
D238E |
probably benign |
Het |
| Fnip2 |
G |
A |
3: 79,400,779 (GRCm39) |
T314I |
probably benign |
Het |
| Fsip2 |
T |
C |
2: 82,823,124 (GRCm39) |
S6286P |
possibly damaging |
Het |
| Gbf1 |
T |
C |
19: 46,260,003 (GRCm39) |
F999L |
probably damaging |
Het |
| Gnao1 |
C |
A |
8: 94,670,827 (GRCm39) |
T102K |
probably benign |
Het |
| Gpatch2 |
T |
A |
1: 187,054,498 (GRCm39) |
D76E |
probably damaging |
Het |
| Gpd1l |
A |
G |
9: 114,743,462 (GRCm39) |
I146T |
probably benign |
Het |
| Grik2 |
A |
T |
10: 49,232,005 (GRCm39) |
H508Q |
probably damaging |
Het |
| Hapstr1 |
A |
G |
16: 8,648,445 (GRCm39) |
E41G |
possibly damaging |
Het |
| Hk3 |
A |
T |
13: 55,162,268 (GRCm39) |
F112Y |
probably damaging |
Het |
| Hmcn2 |
T |
G |
2: 31,279,341 (GRCm39) |
I1781S |
probably damaging |
Het |
| Inhba |
A |
T |
13: 16,201,221 (GRCm39) |
K261M |
probably damaging |
Het |
| Jarid2 |
T |
A |
13: 45,059,752 (GRCm39) |
N661K |
probably damaging |
Het |
| Kcna2 |
T |
C |
3: 107,011,946 (GRCm39) |
S176P |
probably damaging |
Het |
| Kcnj3 |
A |
T |
2: 55,327,343 (GRCm39) |
Q44L |
probably damaging |
Het |
| Kcns1 |
G |
T |
2: 164,010,455 (GRCm39) |
F101L |
probably damaging |
Het |
| Kdm5b |
T |
A |
1: 134,541,611 (GRCm39) |
|
probably null |
Het |
| Klhl14 |
C |
T |
18: 21,687,730 (GRCm39) |
G564D |
probably damaging |
Het |
| Klhl18 |
A |
T |
9: 110,305,658 (GRCm39) |
V2E |
probably benign |
Het |
| Klhl6 |
T |
C |
16: 19,801,572 (GRCm39) |
E61G |
probably damaging |
Het |
| Krt1 |
T |
C |
15: 101,757,427 (GRCm39) |
D261G |
probably benign |
Het |
| Lama5 |
C |
A |
2: 179,830,145 (GRCm39) |
C1896F |
probably damaging |
Het |
| Lrba |
A |
G |
3: 86,513,175 (GRCm39) |
|
probably null |
Het |
| Lrch3 |
A |
G |
16: 32,734,755 (GRCm39) |
T82A |
possibly damaging |
Het |
| Maml3 |
C |
G |
3: 52,011,560 (GRCm39) |
G2A |
unknown |
Het |
| Mapkap1 |
T |
A |
2: 34,408,691 (GRCm39) |
N34K |
probably damaging |
Het |
| Muc13 |
A |
T |
16: 33,634,909 (GRCm39) |
I488F |
probably damaging |
Het |
| Muc5ac |
A |
G |
7: 141,357,113 (GRCm39) |
D1129G |
possibly damaging |
Het |
| Nacc1 |
A |
T |
8: 85,403,010 (GRCm39) |
N288K |
probably damaging |
Het |
| Nek1 |
T |
G |
8: 61,469,330 (GRCm39) |
I129R |
probably damaging |
Het |
| Nf1 |
T |
A |
11: 79,302,390 (GRCm39) |
S319R |
possibly damaging |
Het |
| Nle1 |
C |
T |
11: 82,792,614 (GRCm39) |
G432D |
probably damaging |
Het |
| Nol4l |
A |
G |
2: 153,371,375 (GRCm39) |
V103A |
probably benign |
Het |
| Oca2 |
A |
G |
7: 56,064,215 (GRCm39) |
I737V |
probably damaging |
Het |
| Or12k5 |
A |
T |
2: 36,894,960 (GRCm39) |
F222Y |
possibly damaging |
Het |
| Or1j17 |
G |
A |
2: 36,578,796 (GRCm39) |
V261I |
probably benign |
Het |
| Or4b1 |
T |
C |
2: 89,979,748 (GRCm39) |
S201G |
probably damaging |
Het |
| Or51l4 |
G |
T |
7: 103,404,375 (GRCm39) |
T139K |
probably damaging |
Het |
| Or52ac1 |
A |
G |
7: 104,246,008 (GRCm39) |
C127R |
probably damaging |
Het |
| Or6k6 |
G |
T |
1: 173,944,817 (GRCm39) |
S255* |
probably null |
Het |
| Or6s1 |
T |
A |
14: 51,308,614 (GRCm39) |
I79F |
probably damaging |
Het |
| Orc1 |
T |
A |
4: 108,469,414 (GRCm39) |
I746N |
probably damaging |
Het |
| Pbxip1 |
A |
G |
3: 89,352,795 (GRCm39) |
D147G |
probably damaging |
Het |
| Pirb |
A |
T |
7: 3,720,637 (GRCm39) |
L287Q |
probably benign |
Het |
| Plin5 |
T |
A |
17: 56,419,186 (GRCm39) |
D412V |
probably damaging |
Het |
| Plxna2 |
A |
T |
1: 194,327,008 (GRCm39) |
Y314F |
possibly damaging |
Het |
| Ppid |
A |
T |
3: 79,509,606 (GRCm39) |
K308* |
probably null |
Het |
| Prss38 |
T |
C |
11: 59,264,310 (GRCm39) |
Y219C |
probably damaging |
Het |
| Ptx3 |
C |
T |
3: 66,132,042 (GRCm39) |
R188C |
probably damaging |
Het |
| Ralgds |
T |
A |
2: 28,435,887 (GRCm39) |
V504E |
probably damaging |
Het |
| Rere |
T |
C |
4: 150,701,330 (GRCm39) |
Y1237H |
probably damaging |
Het |
| Rpp30 |
C |
T |
19: 36,066,549 (GRCm39) |
S94L |
probably damaging |
Het |
| Rrp15 |
C |
T |
1: 186,468,402 (GRCm39) |
V205I |
possibly damaging |
Het |
| Scpep1 |
A |
G |
11: 88,843,240 (GRCm39) |
W73R |
probably damaging |
Het |
| Sec23ip |
A |
G |
7: 128,357,077 (GRCm39) |
H376R |
probably damaging |
Het |
| Serping1 |
G |
T |
2: 84,596,072 (GRCm39) |
T454K |
probably damaging |
Het |
| Shtn1 |
T |
G |
19: 58,963,470 (GRCm39) |
Y615S |
probably benign |
Het |
| Slc20a2 |
C |
A |
8: 23,035,553 (GRCm39) |
P184T |
probably damaging |
Het |
| Slc22a29 |
C |
A |
19: 8,195,772 (GRCm39) |
R89L |
probably damaging |
Het |
| Slc2a2 |
A |
G |
3: 28,773,634 (GRCm39) |
Q313R |
probably damaging |
Het |
| Tas2r122 |
A |
T |
6: 132,688,157 (GRCm39) |
Y245* |
probably null |
Het |
| Ticrr |
C |
A |
7: 79,344,483 (GRCm39) |
C1449* |
probably null |
Het |
| Tmem181a |
T |
C |
17: 6,353,501 (GRCm39) |
V412A |
probably benign |
Het |
| Tmtc4 |
T |
A |
14: 123,165,011 (GRCm39) |
E616V |
probably benign |
Het |
| Tnrc6b |
A |
G |
15: 80,764,640 (GRCm39) |
K714R |
probably damaging |
Het |
| Trpm8 |
T |
A |
1: 88,260,470 (GRCm39) |
|
probably null |
Het |
| Ubr4 |
A |
G |
4: 139,178,555 (GRCm39) |
|
probably null |
Het |
| Ulk2 |
A |
T |
11: 61,710,297 (GRCm39) |
|
probably null |
Het |
| Ulk4 |
T |
A |
9: 121,086,182 (GRCm39) |
M350L |
probably benign |
Het |
| Vmn1r185 |
T |
C |
7: 26,310,956 (GRCm39) |
E183G |
probably benign |
Het |
| Vmn1r76 |
T |
A |
7: 11,664,441 (GRCm39) |
I223F |
probably damaging |
Het |
| Wdr27 |
T |
C |
17: 15,154,861 (GRCm39) |
T19A |
possibly damaging |
Het |
| Wdr59 |
T |
G |
8: 112,177,535 (GRCm39) |
T973P |
possibly damaging |
Het |
| Wnk2 |
A |
G |
13: 49,192,487 (GRCm39) |
S664P |
probably damaging |
Het |
| Zfp1004 |
T |
A |
2: 150,033,827 (GRCm39) |
D49E |
probably benign |
Het |
| Zfp120 |
A |
T |
2: 149,959,318 (GRCm39) |
C335S |
probably damaging |
Het |
| Zfp30 |
C |
A |
7: 29,491,877 (GRCm39) |
Q44K |
probably benign |
Het |
| Zfp541 |
T |
C |
7: 15,812,996 (GRCm39) |
S550P |
probably benign |
Het |
| Zw10 |
C |
A |
9: 48,980,133 (GRCm39) |
N421K |
probably damaging |
Het |
|
| Other mutations in Ubr2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00324:Ubr2
|
APN |
17 |
47,296,986 (GRCm39) |
splice site |
probably benign |
|
|
IGL00332:Ubr2
|
APN |
17 |
47,301,916 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL00518:Ubr2
|
APN |
17 |
47,303,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00693:Ubr2
|
APN |
17 |
47,283,907 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL00785:Ubr2
|
APN |
17 |
47,255,791 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL01144:Ubr2
|
APN |
17 |
47,268,247 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01459:Ubr2
|
APN |
17 |
47,241,435 (GRCm39) |
splice site |
probably benign |
|
|
IGL01637:Ubr2
|
APN |
17 |
47,267,580 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01710:Ubr2
|
APN |
17 |
47,254,335 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01726:Ubr2
|
APN |
17 |
47,303,907 (GRCm39) |
splice site |
probably benign |
|
|
IGL01925:Ubr2
|
APN |
17 |
47,265,875 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL01960:Ubr2
|
APN |
17 |
47,284,893 (GRCm39) |
missense |
probably benign |
0.45 |
|
IGL02170:Ubr2
|
APN |
17 |
47,278,123 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02308:Ubr2
|
APN |
17 |
47,245,119 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02387:Ubr2
|
APN |
17 |
47,274,076 (GRCm39) |
missense |
probably benign |
|
|
IGL02696:Ubr2
|
APN |
17 |
47,274,691 (GRCm39) |
missense |
probably benign |
|
|
IGL02726:Ubr2
|
APN |
17 |
47,283,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02750:Ubr2
|
APN |
17 |
47,280,208 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02934:Ubr2
|
APN |
17 |
47,268,266 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL02959:Ubr2
|
APN |
17 |
47,286,877 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL03018:Ubr2
|
APN |
17 |
47,264,972 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
IGL03343:Ubr2
|
APN |
17 |
47,262,844 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4280001:Ubr2
|
UTSW |
17 |
47,255,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0044:Ubr2
|
UTSW |
17 |
47,303,911 (GRCm39) |
splice site |
probably benign |
|
|
R0044:Ubr2
|
UTSW |
17 |
47,303,911 (GRCm39) |
splice site |
probably benign |
|
|
R0446:Ubr2
|
UTSW |
17 |
47,294,224 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0513:Ubr2
|
UTSW |
17 |
47,297,705 (GRCm39) |
nonsense |
probably null |
|
|
R0565:Ubr2
|
UTSW |
17 |
47,266,812 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0600:Ubr2
|
UTSW |
17 |
47,278,174 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0690:Ubr2
|
UTSW |
17 |
47,249,579 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0710:Ubr2
|
UTSW |
17 |
47,249,607 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0761:Ubr2
|
UTSW |
17 |
47,294,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0798:Ubr2
|
UTSW |
17 |
47,280,102 (GRCm39) |
splice site |
probably benign |
|
|
R0862:Ubr2
|
UTSW |
17 |
47,278,009 (GRCm39) |
nonsense |
probably null |
|
|
R0947:Ubr2
|
UTSW |
17 |
47,252,038 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0972:Ubr2
|
UTSW |
17 |
47,245,187 (GRCm39) |
splice site |
probably null |
|
|
R1500:Ubr2
|
UTSW |
17 |
47,297,615 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R1514:Ubr2
|
UTSW |
17 |
47,311,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1533:Ubr2
|
UTSW |
17 |
47,278,173 (GRCm39) |
nonsense |
probably null |
|
|
R1554:Ubr2
|
UTSW |
17 |
47,283,877 (GRCm39) |
missense |
probably benign |
|
|
R1575:Ubr2
|
UTSW |
17 |
47,243,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1602:Ubr2
|
UTSW |
17 |
47,251,987 (GRCm39) |
missense |
probably benign |
0.30 |
|
R1941:Ubr2
|
UTSW |
17 |
47,284,952 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2041:Ubr2
|
UTSW |
17 |
47,296,973 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2067:Ubr2
|
UTSW |
17 |
47,274,071 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2111:Ubr2
|
UTSW |
17 |
47,274,071 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2189:Ubr2
|
UTSW |
17 |
47,254,290 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2219:Ubr2
|
UTSW |
17 |
47,296,968 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2307:Ubr2
|
UTSW |
17 |
47,277,141 (GRCm39) |
nonsense |
probably null |
|
|
R3426:Ubr2
|
UTSW |
17 |
47,279,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3428:Ubr2
|
UTSW |
17 |
47,279,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3608:Ubr2
|
UTSW |
17 |
47,255,449 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4080:Ubr2
|
UTSW |
17 |
47,299,648 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4330:Ubr2
|
UTSW |
17 |
47,278,204 (GRCm39) |
missense |
probably null |
1.00 |
|
R4383:Ubr2
|
UTSW |
17 |
47,250,313 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4460:Ubr2
|
UTSW |
17 |
47,255,971 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4794:Ubr2
|
UTSW |
17 |
47,241,371 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4902:Ubr2
|
UTSW |
17 |
47,296,922 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4913:Ubr2
|
UTSW |
17 |
47,270,385 (GRCm39) |
splice site |
probably null |
|
|
R5092:Ubr2
|
UTSW |
17 |
47,280,173 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5209:Ubr2
|
UTSW |
17 |
47,279,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5226:Ubr2
|
UTSW |
17 |
47,294,196 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5250:Ubr2
|
UTSW |
17 |
47,241,368 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5437:Ubr2
|
UTSW |
17 |
47,274,623 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5607:Ubr2
|
UTSW |
17 |
47,245,126 (GRCm39) |
nonsense |
probably null |
|
|
R5848:Ubr2
|
UTSW |
17 |
47,267,581 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6089:Ubr2
|
UTSW |
17 |
47,293,218 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6382:Ubr2
|
UTSW |
17 |
47,268,241 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R6552:Ubr2
|
UTSW |
17 |
47,277,194 (GRCm39) |
splice site |
probably null |
|
|
R6630:Ubr2
|
UTSW |
17 |
47,262,910 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R6892:Ubr2
|
UTSW |
17 |
47,245,034 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6936:Ubr2
|
UTSW |
17 |
47,283,957 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7039:Ubr2
|
UTSW |
17 |
47,321,139 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7050:Ubr2
|
UTSW |
17 |
47,272,528 (GRCm39) |
missense |
probably benign |
0.30 |
|
R7078:Ubr2
|
UTSW |
17 |
47,266,779 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R7126:Ubr2
|
UTSW |
17 |
47,284,982 (GRCm39) |
splice site |
probably null |
|
|
R7219:Ubr2
|
UTSW |
17 |
47,246,360 (GRCm39) |
nonsense |
probably null |
|
|
R7262:Ubr2
|
UTSW |
17 |
47,311,665 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7352:Ubr2
|
UTSW |
17 |
47,241,352 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7366:Ubr2
|
UTSW |
17 |
47,266,771 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7449:Ubr2
|
UTSW |
17 |
47,275,714 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7496:Ubr2
|
UTSW |
17 |
47,301,917 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7759:Ubr2
|
UTSW |
17 |
47,296,974 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7869:Ubr2
|
UTSW |
17 |
47,301,934 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7916:Ubr2
|
UTSW |
17 |
47,279,308 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8236:Ubr2
|
UTSW |
17 |
47,262,835 (GRCm39) |
missense |
probably benign |
|
|
R8376:Ubr2
|
UTSW |
17 |
47,253,721 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9026:Ubr2
|
UTSW |
17 |
47,245,041 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9216:Ubr2
|
UTSW |
17 |
47,292,285 (GRCm39) |
missense |
probably benign |
0.36 |
|
R9339:Ubr2
|
UTSW |
17 |
47,284,865 (GRCm39) |
missense |
probably benign |
0.30 |
|
R9558:Ubr2
|
UTSW |
17 |
47,262,843 (GRCm39) |
missense |
probably benign |
|
|
R9606:Ubr2
|
UTSW |
17 |
47,245,020 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9644:Ubr2
|
UTSW |
17 |
47,266,706 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9731:Ubr2
|
UTSW |
17 |
47,274,071 (GRCm39) |
critical splice donor site |
probably null |
|
|
X0027:Ubr2
|
UTSW |
17 |
47,311,555 (GRCm39) |
missense |
probably damaging |
0.99 |
|
X0061:Ubr2
|
UTSW |
17 |
47,281,037 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
Z1177:Ubr2
|
UTSW |
17 |
47,311,692 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
Z1177:Ubr2
|
UTSW |
17 |
47,270,435 (GRCm39) |
missense |
probably benign |
|
|
Z1177:Ubr2
|
UTSW |
17 |
47,321,069 (GRCm39) |
missense |
probably benign |
0.33 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATCTCTGGAAAGATGGAGATTCTG -3'
(R):5'- TGCAGTTCAGGGCTACTTGAG -3'
Sequencing Primer
(F):5'- GATGGAGATTCTGATACAAAGCTATG -3'
(R):5'- CAGTTCAGGGCTACTTGAGTTTCAC -3'
|
| Posted On |
2014-08-25 |
Incidental Mutation