Incidental Mutation 'R1967:Lmo7'
| ID |
219101 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lmo7
|
| Ensembl Gene |
ENSMUSG00000033060 |
| Gene Name |
LIM domain only 7 |
| Synonyms |
FBXO20, LOC380928 |
| MMRRC Submission |
039980-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.141)
|
| Stock # |
R1967 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
14 |
| Chromosomal Location |
101967393-102172146 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 102137651 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Glutamine
at position 551
(H551Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124349
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000100337]
[ENSMUST00000159026]
[ENSMUST00000159258]
[ENSMUST00000159314]
[ENSMUST00000159597]
|
| AlphaFold |
E9PYF4 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000100337
AA Change: H784Q
PolyPhen 2
Score 0.166 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000097910
Gene: ENSMUSG00000033060
AA Change: H784Q
| Domain | Start | End | E-Value | Type |
|---|
|
CH
|
14 |
124 |
2.57e-13 |
SMART |
|
low complexity region
|
200 |
211 |
N/A |
INTRINSIC |
|
Pfam:DUF4757
|
242 |
348 |
2.2e-14 |
PFAM |
|
low complexity region
|
448 |
462 |
N/A |
INTRINSIC |
|
Pfam:DUF4757
|
568 |
735 |
1.8e-46 |
PFAM |
|
low complexity region
|
861 |
879 |
N/A |
INTRINSIC |
|
low complexity region
|
979 |
991 |
N/A |
INTRINSIC |
|
low complexity region
|
1003 |
1015 |
N/A |
INTRINSIC |
|
PDZ
|
1047 |
1119 |
1.05e-8 |
SMART |
|
coiled coil region
|
1222 |
1275 |
N/A |
INTRINSIC |
|
coiled coil region
|
1319 |
1411 |
N/A |
INTRINSIC |
|
low complexity region
|
1585 |
1596 |
N/A |
INTRINSIC |
|
low complexity region
|
1599 |
1617 |
N/A |
INTRINSIC |
|
LIM
|
1629 |
1687 |
6.54e-10 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159026
|
| SMART Domains |
Protein: ENSMUSP00000124605
Gene: ENSMUSG00000033060
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
215 |
229 |
N/A |
INTRINSIC |
|
coiled coil region
|
435 |
471 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159258
|
| SMART Domains |
Protein: ENSMUSP00000125465
Gene: ENSMUSG00000033060
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
215 |
229 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159314
AA Change: H551Q
PolyPhen 2
Score 0.362 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000124349
Gene: ENSMUSG00000033060
AA Change: H551Q
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
215 |
229 |
N/A |
INTRINSIC |
|
coiled coil region
|
435 |
492 |
N/A |
INTRINSIC |
|
low complexity region
|
628 |
646 |
N/A |
INTRINSIC |
|
low complexity region
|
746 |
758 |
N/A |
INTRINSIC |
|
low complexity region
|
770 |
782 |
N/A |
INTRINSIC |
|
PDZ
|
814 |
886 |
1.05e-8 |
SMART |
|
coiled coil region
|
989 |
1042 |
N/A |
INTRINSIC |
|
coiled coil region
|
1086 |
1178 |
N/A |
INTRINSIC |
|
low complexity region
|
1352 |
1363 |
N/A |
INTRINSIC |
|
low complexity region
|
1366 |
1384 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159597
AA Change: H662Q
PolyPhen 2
Score 0.233 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000123706
Gene: ENSMUSG00000033060
AA Change: H662Q
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
78 |
89 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
111 |
141 |
6.96e-5 |
PROSPERO |
|
internal_repeat_1
|
218 |
248 |
6.96e-5 |
PROSPERO |
|
low complexity region
|
326 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
546 |
603 |
N/A |
INTRINSIC |
|
low complexity region
|
739 |
757 |
N/A |
INTRINSIC |
|
low complexity region
|
857 |
869 |
N/A |
INTRINSIC |
|
low complexity region
|
881 |
893 |
N/A |
INTRINSIC |
|
PDZ
|
925 |
997 |
1.05e-8 |
SMART |
|
coiled coil region
|
1127 |
1180 |
N/A |
INTRINSIC |
|
coiled coil region
|
1224 |
1316 |
N/A |
INTRINSIC |
|
low complexity region
|
1490 |
1501 |
N/A |
INTRINSIC |
|
low complexity region
|
1504 |
1522 |
N/A |
INTRINSIC |
|
LIM
|
1534 |
1592 |
6.54e-10 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000159806
AA Change: H273Q
|
| SMART Domains |
Protein: ENSMUSP00000124300
Gene: ENSMUSG00000033060
AA Change: H273Q
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
45 |
N/A |
INTRINSIC |
|
Pfam:DUF4757
|
76 |
225 |
4.5e-53 |
PFAM |
|
low complexity region
|
351 |
369 |
N/A |
INTRINSIC |
|
low complexity region
|
469 |
481 |
N/A |
INTRINSIC |
|
low complexity region
|
493 |
505 |
N/A |
INTRINSIC |
|
PDZ
|
537 |
609 |
1.05e-8 |
SMART |
|
internal_repeat_1
|
620 |
691 |
9.31e-5 |
PROSPERO |
|
coiled coil region
|
711 |
764 |
N/A |
INTRINSIC |
|
coiled coil region
|
808 |
900 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
921 |
976 |
9.31e-5 |
PROSPERO |
|
low complexity region
|
1075 |
1086 |
N/A |
INTRINSIC |
|
low complexity region
|
1089 |
1107 |
N/A |
INTRINSIC |
|
LIM
|
1119 |
1177 |
6.54e-10 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159948
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000160876
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein containing a calponin homology (CH) domain, a PDZ domain, and a LIM domain, and may be involved in protein-protein interactions. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, however, the full-length nature of some variants is not known. [provided by RefSeq, Jan 2009]
PHENOTYPE: Targeted mutations in this gene result in postnatal lethality, growth defects, skeletal muscle abnormalities and retinal defects reflective of retinal degeneration. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 103 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930447A16Rik |
A |
C |
15: 37,439,842 (GRCm39) |
|
probably benign |
Het |
| Abca6 |
T |
C |
11: 110,077,974 (GRCm39) |
I1278V |
probably benign |
Het |
| Adamts15 |
C |
T |
9: 30,832,605 (GRCm39) |
W310* |
probably null |
Het |
| Adamts6 |
T |
A |
13: 104,563,459 (GRCm39) |
C650* |
probably null |
Het |
| Akap3 |
G |
T |
6: 126,842,061 (GRCm39) |
G227C |
probably benign |
Het |
| Alox12e |
A |
T |
11: 70,208,682 (GRCm39) |
S457T |
probably benign |
Het |
| Angpt1 |
C |
A |
15: 42,301,703 (GRCm39) |
C435F |
probably damaging |
Het |
| Anxa9 |
T |
C |
3: 95,207,919 (GRCm39) |
Q207R |
probably benign |
Het |
| Aplnr |
A |
T |
2: 84,967,950 (GRCm39) |
D325V |
probably benign |
Het |
| Art2b |
A |
C |
7: 101,229,414 (GRCm39) |
F162V |
probably damaging |
Het |
| Atp13a4 |
A |
G |
16: 29,298,672 (GRCm39) |
S96P |
probably damaging |
Het |
| Bnc1 |
A |
T |
7: 81,623,384 (GRCm39) |
H614Q |
probably benign |
Het |
| C6 |
A |
G |
15: 4,789,302 (GRCm39) |
D249G |
probably damaging |
Het |
| Camta1 |
A |
T |
4: 151,173,430 (GRCm39) |
F977I |
probably damaging |
Het |
| Chil6 |
T |
C |
3: 106,298,470 (GRCm39) |
S188G |
possibly damaging |
Het |
| Cntrob |
A |
T |
11: 69,211,789 (GRCm39) |
L145Q |
probably damaging |
Het |
| Coro7 |
T |
C |
16: 4,452,753 (GRCm39) |
E306G |
probably damaging |
Het |
| Cplane1 |
T |
G |
15: 8,232,904 (GRCm39) |
V1141G |
probably benign |
Het |
| Cpq |
T |
C |
15: 33,497,348 (GRCm39) |
S363P |
possibly damaging |
Het |
| Ctc1 |
A |
G |
11: 68,918,688 (GRCm39) |
|
probably null |
Het |
| Defb43 |
T |
A |
14: 63,255,246 (GRCm39) |
N26K |
probably benign |
Het |
| Dennd1a |
T |
C |
2: 37,734,845 (GRCm39) |
T41A |
probably benign |
Het |
| Dnah11 |
A |
C |
12: 117,880,523 (GRCm39) |
Y3866D |
probably damaging |
Het |
| Eml6 |
A |
G |
11: 29,974,545 (GRCm39) |
L11P |
probably damaging |
Het |
| Epha5 |
A |
G |
5: 84,564,288 (GRCm39) |
V26A |
probably benign |
Het |
| Fam13c |
A |
G |
10: 70,387,565 (GRCm39) |
D443G |
probably damaging |
Het |
| Fam227a |
G |
A |
15: 79,521,335 (GRCm39) |
L243F |
possibly damaging |
Het |
| Fat3 |
T |
G |
9: 15,879,591 (GRCm39) |
R3301S |
probably benign |
Het |
| Fbxw20 |
T |
C |
9: 109,046,578 (GRCm39) |
T461A |
probably benign |
Het |
| Fgf8 |
T |
A |
19: 45,730,007 (GRCm39) |
S61C |
probably damaging |
Het |
| Fgfrl1 |
A |
G |
5: 108,852,871 (GRCm39) |
E100G |
probably damaging |
Het |
| Gabra4 |
G |
A |
5: 71,729,412 (GRCm39) |
S456F |
possibly damaging |
Het |
| Gas6 |
T |
C |
8: 13,520,317 (GRCm39) |
E457G |
probably damaging |
Het |
| Gpr33 |
G |
A |
12: 52,070,991 (GRCm39) |
S16L |
probably benign |
Het |
| Greb1l |
A |
C |
18: 10,501,049 (GRCm39) |
N393T |
possibly damaging |
Het |
| Gtpbp4 |
T |
C |
13: 9,027,340 (GRCm39) |
K492E |
probably benign |
Het |
| Hsf2bp |
A |
T |
17: 32,206,378 (GRCm39) |
L251* |
probably null |
Het |
| Hyal5 |
A |
T |
6: 24,876,193 (GRCm39) |
Q22L |
possibly damaging |
Het |
| Itih1 |
A |
T |
14: 30,663,941 (GRCm39) |
V114E |
possibly damaging |
Het |
| Jak3 |
T |
A |
8: 72,134,179 (GRCm39) |
I427N |
probably damaging |
Het |
| Jcad |
T |
C |
18: 4,675,162 (GRCm39) |
S975P |
probably benign |
Het |
| Kcng4 |
A |
G |
8: 120,359,662 (GRCm39) |
V238A |
probably damaging |
Het |
| Klb |
A |
G |
5: 65,529,417 (GRCm39) |
D315G |
probably damaging |
Het |
| Klrh1 |
A |
T |
6: 129,752,798 (GRCm39) |
N2K |
possibly damaging |
Het |
| Krt5 |
T |
C |
15: 101,620,094 (GRCm39) |
N208D |
probably benign |
Het |
| Lrp8 |
G |
T |
4: 107,717,168 (GRCm39) |
G732V |
probably damaging |
Het |
| Lrrc38 |
A |
G |
4: 143,096,553 (GRCm39) |
D288G |
unknown |
Het |
| Lrrc4b |
GAGAAG |
GAG |
7: 44,111,654 (GRCm39) |
|
probably benign |
Het |
| Mas1 |
A |
G |
17: 13,060,923 (GRCm39) |
Y167H |
probably benign |
Het |
| Mcm8 |
A |
C |
2: 132,684,662 (GRCm39) |
I759L |
probably benign |
Het |
| Med13l |
G |
A |
5: 118,899,387 (GRCm39) |
D2148N |
probably damaging |
Het |
| Muc20 |
A |
T |
16: 32,614,612 (GRCm39) |
I255K |
probably benign |
Het |
| Myh1 |
A |
G |
11: 67,104,273 (GRCm39) |
N980S |
probably benign |
Het |
| Nap1l4 |
T |
A |
7: 143,088,024 (GRCm39) |
Q178L |
probably damaging |
Het |
| Ncapg |
T |
A |
5: 45,857,252 (GRCm39) |
L988Q |
probably damaging |
Het |
| Ncf2 |
A |
T |
1: 152,706,123 (GRCm39) |
H245L |
probably damaging |
Het |
| Neurl4 |
A |
G |
11: 69,794,036 (GRCm39) |
E164G |
possibly damaging |
Het |
| Nf1 |
G |
A |
11: 79,303,571 (GRCm39) |
R416H |
probably damaging |
Het |
| Obscn |
G |
A |
11: 59,026,535 (GRCm39) |
Q223* |
probably null |
Het |
| Or10q1 |
T |
A |
19: 13,727,417 (GRCm39) |
*316R |
probably null |
Het |
| Or2o1 |
T |
C |
11: 49,051,675 (GRCm39) |
I278T |
probably benign |
Het |
| Pcdhb16 |
T |
A |
18: 37,612,715 (GRCm39) |
N558K |
probably damaging |
Het |
| Pcnx2 |
A |
T |
8: 126,542,422 (GRCm39) |
M1253K |
possibly damaging |
Het |
| Pla2g4a |
A |
G |
1: 149,797,832 (GRCm39) |
V22A |
probably damaging |
Het |
| Plppr5 |
G |
A |
3: 117,419,555 (GRCm39) |
|
probably null |
Het |
| Pnpla2 |
T |
C |
7: 141,039,345 (GRCm39) |
S353P |
probably benign |
Het |
| Pom121 |
A |
T |
5: 135,420,608 (GRCm39) |
L271Q |
unknown |
Het |
| Prepl |
A |
T |
17: 85,395,979 (GRCm39) |
M1K |
probably null |
Het |
| Prr14l |
A |
G |
5: 33,001,813 (GRCm39) |
|
probably benign |
Het |
| Psmc3 |
C |
A |
2: 90,888,189 (GRCm39) |
P325T |
probably benign |
Het |
| Psme2b |
A |
G |
11: 48,836,896 (GRCm39) |
V17A |
probably damaging |
Het |
| Ptpro |
A |
G |
6: 137,393,863 (GRCm39) |
I23V |
probably benign |
Het |
| Rab31 |
A |
G |
17: 66,079,499 (GRCm39) |
|
probably null |
Het |
| Ranbp6 |
T |
A |
19: 29,789,900 (GRCm39) |
K151* |
probably null |
Het |
| Rbm12b1 |
A |
T |
4: 12,146,304 (GRCm39) |
I759L |
probably benign |
Het |
| Rgs5 |
T |
C |
1: 169,504,425 (GRCm39) |
I25T |
probably benign |
Het |
| Rnf213 |
T |
C |
11: 119,371,721 (GRCm39) |
V4842A |
probably damaging |
Het |
| Rtl9 |
A |
T |
X: 141,886,037 (GRCm39) |
I1150F |
probably damaging |
Het |
| Scn1a |
A |
T |
2: 66,158,769 (GRCm39) |
W384R |
probably damaging |
Het |
| Sema5a |
C |
T |
15: 32,681,765 (GRCm39) |
P948L |
probably damaging |
Het |
| Slc26a3 |
G |
A |
12: 31,515,777 (GRCm39) |
R559Q |
probably damaging |
Het |
| Slc29a3 |
A |
G |
10: 60,552,243 (GRCm39) |
V267A |
probably benign |
Het |
| Spata22 |
A |
G |
11: 73,221,953 (GRCm39) |
|
probably benign |
Het |
| Spata31e2 |
T |
A |
1: 26,722,454 (GRCm39) |
I909L |
probably benign |
Het |
| Sptbn2 |
G |
T |
19: 4,795,327 (GRCm39) |
R1595L |
probably benign |
Het |
| Tfdp1 |
T |
C |
8: 13,423,039 (GRCm39) |
S315P |
possibly damaging |
Het |
| Tle1 |
A |
T |
4: 72,038,463 (GRCm39) |
V688E |
probably damaging |
Het |
| Tmem129 |
A |
T |
5: 33,812,665 (GRCm39) |
|
probably null |
Het |
| Tmprss11a |
G |
A |
5: 86,579,702 (GRCm39) |
T91I |
probably benign |
Het |
| Tnfsf14 |
A |
G |
17: 57,497,807 (GRCm39) |
Y142H |
probably damaging |
Het |
| Tph1 |
T |
C |
7: 46,311,538 (GRCm39) |
D68G |
probably benign |
Het |
| Ttn |
A |
T |
2: 76,592,631 (GRCm39) |
S12507T |
probably damaging |
Het |
| Tubgcp2 |
T |
A |
7: 139,586,066 (GRCm39) |
M408L |
probably benign |
Het |
| Usp34 |
A |
T |
11: 23,314,503 (GRCm39) |
H815L |
probably benign |
Het |
| Usp6nl |
G |
A |
2: 6,446,330 (GRCm39) |
R746H |
probably benign |
Het |
| Utp20 |
A |
G |
10: 88,652,841 (GRCm39) |
S358P |
probably benign |
Het |
| Vmn2r118 |
G |
A |
17: 55,899,882 (GRCm39) |
T674I |
probably damaging |
Het |
| Vmn2r8 |
A |
T |
5: 108,950,249 (GRCm39) |
H199Q |
probably benign |
Het |
| Vmn2r9 |
A |
G |
5: 108,995,388 (GRCm39) |
V420A |
probably benign |
Het |
| Vmn2r99 |
A |
T |
17: 19,599,077 (GRCm39) |
T254S |
probably benign |
Het |
| Zbed5 |
A |
G |
5: 129,930,510 (GRCm39) |
H132R |
possibly damaging |
Het |
| Zfp568 |
A |
G |
7: 29,688,513 (GRCm39) |
E25G |
probably damaging |
Het |
| Zfp951 |
T |
A |
5: 104,964,866 (GRCm39) |
I67L |
possibly damaging |
Het |
|
| Other mutations in Lmo7 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00569:Lmo7
|
APN |
14 |
102,124,487 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00733:Lmo7
|
APN |
14 |
102,153,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00778:Lmo7
|
APN |
14 |
102,148,321 (GRCm39) |
splice site |
probably benign |
|
|
IGL01014:Lmo7
|
APN |
14 |
102,157,993 (GRCm39) |
splice site |
probably benign |
|
|
IGL01401:Lmo7
|
APN |
14 |
102,031,713 (GRCm39) |
nonsense |
probably null |
|
|
IGL01550:Lmo7
|
APN |
14 |
102,163,576 (GRCm39) |
utr 3 prime |
probably benign |
|
|
IGL01570:Lmo7
|
APN |
14 |
102,139,807 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01602:Lmo7
|
APN |
14 |
102,148,192 (GRCm39) |
splice site |
probably benign |
|
|
IGL01605:Lmo7
|
APN |
14 |
102,148,192 (GRCm39) |
splice site |
probably benign |
|
|
IGL02012:Lmo7
|
APN |
14 |
102,126,152 (GRCm39) |
intron |
probably benign |
|
|
IGL02145:Lmo7
|
APN |
14 |
102,139,659 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02236:Lmo7
|
APN |
14 |
102,163,524 (GRCm39) |
splice site |
probably benign |
|
|
IGL02318:Lmo7
|
APN |
14 |
102,137,502 (GRCm39) |
splice site |
probably benign |
|
|
IGL02345:Lmo7
|
APN |
14 |
102,124,909 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02498:Lmo7
|
APN |
14 |
102,044,918 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02583:Lmo7
|
APN |
14 |
102,171,360 (GRCm39) |
utr 3 prime |
probably benign |
|
|
IGL02670:Lmo7
|
APN |
14 |
102,118,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02694:Lmo7
|
APN |
14 |
102,124,606 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03026:Lmo7
|
APN |
14 |
102,166,769 (GRCm39) |
utr 3 prime |
probably benign |
|
|
IGL03062:Lmo7
|
APN |
14 |
102,149,515 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
IGL03068:Lmo7
|
APN |
14 |
102,112,928 (GRCm39) |
unclassified |
probably benign |
|
|
IGL03178:Lmo7
|
APN |
14 |
102,166,696 (GRCm39) |
nonsense |
probably null |
|
|
IGL03279:Lmo7
|
APN |
14 |
102,137,944 (GRCm39) |
missense |
probably benign |
0.30 |
|
PIT4458001:Lmo7
|
UTSW |
14 |
102,124,923 (GRCm39) |
nonsense |
probably null |
|
|
R0029:Lmo7
|
UTSW |
14 |
102,171,357 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R0112:Lmo7
|
UTSW |
14 |
102,124,629 (GRCm39) |
nonsense |
probably null |
|
|
R0345:Lmo7
|
UTSW |
14 |
102,114,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0372:Lmo7
|
UTSW |
14 |
102,155,489 (GRCm39) |
splice site |
probably benign |
|
|
R0393:Lmo7
|
UTSW |
14 |
102,137,892 (GRCm39) |
missense |
probably benign |
|
|
R0514:Lmo7
|
UTSW |
14 |
102,133,995 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0514:Lmo7
|
UTSW |
14 |
102,124,609 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0526:Lmo7
|
UTSW |
14 |
102,137,996 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0615:Lmo7
|
UTSW |
14 |
102,114,295 (GRCm39) |
nonsense |
probably null |
|
|
R0900:Lmo7
|
UTSW |
14 |
102,124,624 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0961:Lmo7
|
UTSW |
14 |
102,031,705 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0964:Lmo7
|
UTSW |
14 |
102,158,003 (GRCm39) |
splice site |
probably benign |
|
|
R1078:Lmo7
|
UTSW |
14 |
102,157,910 (GRCm39) |
splice site |
probably benign |
|
|
R1252:Lmo7
|
UTSW |
14 |
102,138,019 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1527:Lmo7
|
UTSW |
14 |
102,114,264 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1537:Lmo7
|
UTSW |
14 |
102,166,700 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R1565:Lmo7
|
UTSW |
14 |
102,124,957 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1637:Lmo7
|
UTSW |
14 |
102,118,268 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1943:Lmo7
|
UTSW |
14 |
102,139,738 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2002:Lmo7
|
UTSW |
14 |
102,124,497 (GRCm39) |
missense |
probably benign |
0.13 |
|
R2057:Lmo7
|
UTSW |
14 |
102,124,614 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2131:Lmo7
|
UTSW |
14 |
102,137,674 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2153:Lmo7
|
UTSW |
14 |
102,157,951 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R2257:Lmo7
|
UTSW |
14 |
102,137,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2355:Lmo7
|
UTSW |
14 |
102,126,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2356:Lmo7
|
UTSW |
14 |
102,124,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2898:Lmo7
|
UTSW |
14 |
102,114,350 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3847:Lmo7
|
UTSW |
14 |
102,159,531 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3848:Lmo7
|
UTSW |
14 |
102,159,531 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3849:Lmo7
|
UTSW |
14 |
102,159,531 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3916:Lmo7
|
UTSW |
14 |
102,166,778 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R4050:Lmo7
|
UTSW |
14 |
102,139,713 (GRCm39) |
nonsense |
probably null |
|
|
R4326:Lmo7
|
UTSW |
14 |
102,137,510 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4357:Lmo7
|
UTSW |
14 |
102,125,091 (GRCm39) |
missense |
probably null |
1.00 |
|
R4571:Lmo7
|
UTSW |
14 |
102,125,030 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4658:Lmo7
|
UTSW |
14 |
102,124,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4857:Lmo7
|
UTSW |
14 |
102,124,784 (GRCm39) |
splice site |
probably null |
|
|
R5006:Lmo7
|
UTSW |
14 |
102,163,673 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R5528:Lmo7
|
UTSW |
14 |
102,139,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5588:Lmo7
|
UTSW |
14 |
102,134,026 (GRCm39) |
splice site |
probably null |
|
|
R5643:Lmo7
|
UTSW |
14 |
102,166,772 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R5644:Lmo7
|
UTSW |
14 |
102,166,772 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R5650:Lmo7
|
UTSW |
14 |
102,136,110 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5737:Lmo7
|
UTSW |
14 |
102,124,672 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5832:Lmo7
|
UTSW |
14 |
102,121,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5966:Lmo7
|
UTSW |
14 |
102,137,938 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6026:Lmo7
|
UTSW |
14 |
102,118,426 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6072:Lmo7
|
UTSW |
14 |
102,166,772 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R6158:Lmo7
|
UTSW |
14 |
102,137,573 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6246:Lmo7
|
UTSW |
14 |
102,156,136 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6335:Lmo7
|
UTSW |
14 |
102,138,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6620:Lmo7
|
UTSW |
14 |
102,112,888 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6658:Lmo7
|
UTSW |
14 |
102,148,281 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6917:Lmo7
|
UTSW |
14 |
102,155,446 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7064:Lmo7
|
UTSW |
14 |
102,121,615 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7072:Lmo7
|
UTSW |
14 |
102,136,136 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7121:Lmo7
|
UTSW |
14 |
102,124,471 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7136:Lmo7
|
UTSW |
14 |
102,157,975 (GRCm39) |
missense |
unknown |
|
|
R7196:Lmo7
|
UTSW |
14 |
102,133,936 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R7228:Lmo7
|
UTSW |
14 |
102,133,971 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7337:Lmo7
|
UTSW |
14 |
102,121,640 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7341:Lmo7
|
UTSW |
14 |
102,122,948 (GRCm39) |
missense |
probably benign |
0.30 |
|
R7408:Lmo7
|
UTSW |
14 |
102,118,389 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7432:Lmo7
|
UTSW |
14 |
102,139,551 (GRCm39) |
missense |
probably benign |
0.42 |
|
R7470:Lmo7
|
UTSW |
14 |
102,138,040 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7506:Lmo7
|
UTSW |
14 |
102,157,045 (GRCm39) |
missense |
unknown |
|
|
R7559:Lmo7
|
UTSW |
14 |
102,124,662 (GRCm39) |
nonsense |
probably null |
|
|
R7565:Lmo7
|
UTSW |
14 |
102,122,737 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7788:Lmo7
|
UTSW |
14 |
102,136,012 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R8095:Lmo7
|
UTSW |
14 |
102,124,855 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8100:Lmo7
|
UTSW |
14 |
102,137,899 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8121:Lmo7
|
UTSW |
14 |
102,163,736 (GRCm39) |
missense |
unknown |
|
|
R8308:Lmo7
|
UTSW |
14 |
102,139,807 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8371:Lmo7
|
UTSW |
14 |
102,124,444 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8403:Lmo7
|
UTSW |
14 |
102,139,800 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8690:Lmo7
|
UTSW |
14 |
102,168,644 (GRCm39) |
missense |
unknown |
|
|
R8778:Lmo7
|
UTSW |
14 |
102,156,655 (GRCm39) |
missense |
probably benign |
0.24 |
|
R8778:Lmo7
|
UTSW |
14 |
102,149,503 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8822:Lmo7
|
UTSW |
14 |
102,121,610 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8849:Lmo7
|
UTSW |
14 |
102,163,543 (GRCm39) |
missense |
unknown |
|
|
R8923:Lmo7
|
UTSW |
14 |
102,137,679 (GRCm39) |
missense |
probably benign |
0.31 |
|
R9006:Lmo7
|
UTSW |
14 |
102,155,072 (GRCm39) |
small deletion |
probably benign |
|
|
R9135:Lmo7
|
UTSW |
14 |
102,118,297 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9154:Lmo7
|
UTSW |
14 |
102,122,743 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9178:Lmo7
|
UTSW |
14 |
102,044,906 (GRCm39) |
nonsense |
probably null |
|
|
R9375:Lmo7
|
UTSW |
14 |
102,136,123 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9428:Lmo7
|
UTSW |
14 |
102,155,076 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9488:Lmo7
|
UTSW |
14 |
102,122,783 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9493:Lmo7
|
UTSW |
14 |
102,137,907 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9594:Lmo7
|
UTSW |
14 |
102,156,136 (GRCm39) |
missense |
probably null |
0.98 |
|
R9674:Lmo7
|
UTSW |
14 |
102,078,340 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9736:Lmo7
|
UTSW |
14 |
102,157,929 (GRCm39) |
missense |
unknown |
|
|
X0066:Lmo7
|
UTSW |
14 |
102,124,897 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0067:Lmo7
|
UTSW |
14 |
102,124,369 (GRCm39) |
splice site |
probably null |
|
|
Z1176:Lmo7
|
UTSW |
14 |
102,156,717 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Lmo7
|
UTSW |
14 |
102,121,742 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Lmo7
|
UTSW |
14 |
102,166,664 (GRCm39) |
missense |
unknown |
|
|
Z1176:Lmo7
|
UTSW |
14 |
102,156,879 (GRCm39) |
missense |
unknown |
|
|
Z1177:Lmo7
|
UTSW |
14 |
102,135,993 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Lmo7
|
UTSW |
14 |
102,133,954 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCATAACTCTGTCGTAATGGCAC -3'
(R):5'- TGGTTCCTCGGAAGGCAAAG -3'
Sequencing Primer
(F):5'- ACATTTCTCTTTGCCCAGGGAATC -3'
(R):5'- TTCTGTGGACAGCAACGG -3'
|
| Posted On |
2014-08-25 |
Incidental Mutation