Incidental Mutation 'R2011:Siglec1'
| ID |
219623 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Siglec1
|
| Ensembl Gene |
ENSMUSG00000027322 |
| Gene Name |
sialic acid binding Ig-like lectin 1, sialoadhesin |
| Synonyms |
Sn, CD169, Siglec-1 |
| MMRRC Submission |
040020-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.076)
|
| Stock # |
R2011 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
130911140-130928685 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 130925277 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Asparagine
at position 395
(Y395N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000105856
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000028794]
[ENSMUST00000110226]
[ENSMUST00000110227]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000028794
AA Change: Y395N
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000028794
Gene: ENSMUSG00000027322
AA Change: Y395N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
IG
|
32 |
142 |
2.92e-5 |
SMART |
|
Pfam:C2-set_2
|
148 |
235 |
9.4e-18 |
PFAM |
|
IGc2
|
260 |
319 |
8.78e-9 |
SMART |
|
IGc2
|
344 |
404 |
4.07e-4 |
SMART |
|
IGc2
|
431 |
505 |
3.3e-4 |
SMART |
|
IGc2
|
529 |
589 |
5.75e-4 |
SMART |
|
IGc2
|
622 |
698 |
3.54e-4 |
SMART |
|
low complexity region
|
700 |
705 |
N/A |
INTRINSIC |
|
IG
|
716 |
795 |
3.35e-5 |
SMART |
|
IG
|
804 |
896 |
6.51e-3 |
SMART |
|
IGc2
|
909 |
969 |
4.13e-5 |
SMART |
|
IG_like
|
1001 |
1076 |
6.78e-2 |
SMART |
|
low complexity region
|
1077 |
1088 |
N/A |
INTRINSIC |
|
IG
|
1094 |
1171 |
4.32e-8 |
SMART |
|
IG_like
|
1185 |
1250 |
1.94e-2 |
SMART |
|
IG
|
1268 |
1345 |
1.36e-5 |
SMART |
|
IG_like
|
1354 |
1447 |
1.45e1 |
SMART |
|
IG_like
|
1365 |
1435 |
4.51e-2 |
SMART |
|
IG
|
1454 |
1534 |
4.56e-7 |
SMART |
|
IG_like
|
1549 |
1624 |
1.21e-1 |
SMART |
|
transmembrane domain
|
1647 |
1669 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110226
|
| SMART Domains |
Protein: ENSMUSP00000105855
Gene: ENSMUSG00000027322
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
IG
|
32 |
142 |
2.92e-5 |
SMART |
|
Pfam:C2-set_2
|
148 |
235 |
7.7e-18 |
PFAM |
|
IGc2
|
260 |
319 |
8.78e-9 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000110227
AA Change: Y395N
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000105856
Gene: ENSMUSG00000027322
AA Change: Y395N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
IG
|
32 |
142 |
2.92e-5 |
SMART |
|
Pfam:C2-set_2
|
148 |
235 |
7e-17 |
PFAM |
|
IGc2
|
260 |
319 |
8.78e-9 |
SMART |
|
IGc2
|
344 |
404 |
4.07e-4 |
SMART |
|
IGc2
|
431 |
505 |
3.3e-4 |
SMART |
|
IGc2
|
529 |
589 |
5.75e-4 |
SMART |
|
IGc2
|
622 |
698 |
3.54e-4 |
SMART |
|
low complexity region
|
700 |
705 |
N/A |
INTRINSIC |
|
IG
|
716 |
795 |
3.35e-5 |
SMART |
|
IG
|
804 |
896 |
6.51e-3 |
SMART |
|
IGc2
|
909 |
969 |
4.13e-5 |
SMART |
|
IG_like
|
1001 |
1076 |
6.78e-2 |
SMART |
|
low complexity region
|
1077 |
1088 |
N/A |
INTRINSIC |
|
IG
|
1094 |
1171 |
4.32e-8 |
SMART |
|
IG_like
|
1185 |
1250 |
1.94e-2 |
SMART |
|
IG
|
1268 |
1345 |
1.36e-5 |
SMART |
|
IG_like
|
1354 |
1447 |
1.45e1 |
SMART |
|
IG_like
|
1365 |
1435 |
4.51e-2 |
SMART |
|
IG
|
1454 |
1534 |
4.56e-7 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a disruption in this gene display subtle changes in B- and T-cell populations and decreased IgM levels. Mice homozygous for a knock-out or knock-in allele exhibit impaired phagocytosis of sialylated C. jejuni. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 107 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abhd6 |
A |
T |
14: 8,042,742 (GRCm38) |
T100S |
probably benign |
Het |
| Adam6a |
T |
C |
12: 113,508,998 (GRCm39) |
I457T |
probably benign |
Het |
| Aff3 |
T |
C |
1: 38,246,996 (GRCm39) |
N863S |
probably benign |
Het |
| Agk |
C |
A |
6: 40,353,168 (GRCm39) |
D177E |
probably benign |
Het |
| Alg9 |
C |
T |
9: 50,699,500 (GRCm39) |
A209V |
probably damaging |
Het |
| Arl6 |
A |
T |
16: 59,444,676 (GRCm39) |
I51K |
probably damaging |
Het |
| Bpi |
A |
T |
2: 158,103,272 (GRCm39) |
H89L |
probably damaging |
Het |
| C1qtnf1 |
T |
A |
11: 118,339,110 (GRCm39) |
F260Y |
probably benign |
Het |
| Cblc |
T |
A |
7: 19,518,747 (GRCm39) |
D452V |
probably benign |
Het |
| Ccar1 |
T |
C |
10: 62,612,473 (GRCm39) |
T231A |
probably benign |
Het |
| Ccdc112 |
A |
G |
18: 46,420,499 (GRCm39) |
L417P |
probably damaging |
Het |
| Ccdc34 |
G |
A |
2: 109,874,649 (GRCm39) |
R336Q |
possibly damaging |
Het |
| CK137956 |
A |
G |
4: 127,844,829 (GRCm39) |
S305P |
probably benign |
Het |
| Clip2 |
T |
C |
5: 134,531,969 (GRCm39) |
D612G |
probably damaging |
Het |
| Col28a1 |
T |
C |
6: 8,059,360 (GRCm39) |
T692A |
probably benign |
Het |
| Copg2 |
A |
T |
6: 30,793,676 (GRCm39) |
|
probably null |
Het |
| Ctnna2 |
T |
A |
6: 76,950,774 (GRCm39) |
I566F |
possibly damaging |
Het |
| Cux2 |
C |
T |
5: 121,999,389 (GRCm39) |
D1184N |
probably benign |
Het |
| Dclk3 |
A |
G |
9: 111,297,422 (GRCm39) |
E322G |
probably benign |
Het |
| Ddx41 |
A |
T |
13: 55,681,906 (GRCm39) |
|
probably null |
Het |
| Dnaaf2 |
G |
A |
12: 69,243,559 (GRCm39) |
P107S |
probably damaging |
Het |
| Eif2ak4 |
A |
G |
2: 118,261,428 (GRCm39) |
E578G |
probably damaging |
Het |
| Exd1 |
A |
G |
2: 119,359,144 (GRCm39) |
|
probably benign |
Het |
| Fat2 |
G |
A |
11: 55,173,583 (GRCm39) |
P2377S |
probably damaging |
Het |
| Fbxl18 |
T |
C |
5: 142,858,214 (GRCm39) |
T741A |
probably benign |
Het |
| Fgr |
C |
A |
4: 132,724,832 (GRCm39) |
A311E |
probably damaging |
Het |
| Fmo4 |
T |
C |
1: 162,626,458 (GRCm39) |
T363A |
probably damaging |
Het |
| Fsbp |
T |
C |
4: 11,584,006 (GRCm39) |
V235A |
probably benign |
Het |
| Gm1110 |
T |
A |
9: 26,805,554 (GRCm39) |
H366L |
probably benign |
Het |
| Gm43302 |
T |
C |
5: 105,438,846 (GRCm39) |
N14S |
probably damaging |
Het |
| Gm5422 |
A |
G |
10: 31,124,764 (GRCm39) |
|
noncoding transcript |
Het |
| Gm57858 |
A |
T |
3: 36,064,827 (GRCm39) |
C515* |
probably null |
Het |
| Gpr21 |
A |
G |
2: 37,407,547 (GRCm39) |
E31G |
probably damaging |
Het |
| Gucy1b2 |
G |
T |
14: 62,646,207 (GRCm39) |
N560K |
probably damaging |
Het |
| Hmcn1 |
T |
C |
1: 150,553,085 (GRCm39) |
Q2535R |
probably benign |
Het |
| Hnrnpm |
A |
T |
17: 33,883,598 (GRCm39) |
N264K |
probably damaging |
Het |
| Hyal6 |
A |
T |
6: 24,734,723 (GRCm39) |
I219L |
possibly damaging |
Het |
| Ifi211 |
A |
G |
1: 173,735,169 (GRCm39) |
S87P |
probably damaging |
Het |
| Il17rb |
A |
T |
14: 29,718,797 (GRCm39) |
C428* |
probably null |
Het |
| Iqca1 |
T |
C |
1: 89,973,348 (GRCm39) |
N808S |
probably benign |
Het |
| Kcnu1 |
A |
G |
8: 26,408,470 (GRCm39) |
I94V |
probably benign |
Het |
| Lrba |
A |
T |
3: 86,217,324 (GRCm39) |
E517V |
probably damaging |
Het |
| Mcidas |
A |
G |
13: 113,130,515 (GRCm39) |
E37G |
possibly damaging |
Het |
| Med23 |
T |
A |
10: 24,755,653 (GRCm39) |
F83L |
possibly damaging |
Het |
| Micu2 |
T |
C |
14: 58,191,590 (GRCm39) |
|
probably null |
Het |
| Mrgprx2 |
A |
T |
7: 48,132,282 (GRCm39) |
C179S |
probably damaging |
Het |
| Myo6 |
A |
G |
9: 80,215,004 (GRCm39) |
T1236A |
probably damaging |
Het |
| Myo7a |
A |
T |
7: 97,703,915 (GRCm39) |
V1946E |
possibly damaging |
Het |
| Nek10 |
A |
T |
14: 14,885,122 (GRCm38) |
Y695F |
probably damaging |
Het |
| Nr3c2 |
A |
T |
8: 77,636,422 (GRCm39) |
I508F |
possibly damaging |
Het |
| Or11g27 |
T |
C |
14: 50,771,141 (GRCm39) |
S91P |
probably damaging |
Het |
| Or14a260 |
A |
T |
7: 85,984,955 (GRCm39) |
Y216* |
probably null |
Het |
| Or2ag13 |
T |
C |
7: 106,472,634 (GRCm39) |
I273V |
probably benign |
Het |
| Or5w1b |
A |
T |
2: 87,476,233 (GRCm39) |
I78N |
probably damaging |
Het |
| Or8k23 |
A |
T |
2: 86,186,530 (GRCm39) |
H65Q |
possibly damaging |
Het |
| Or9s13 |
T |
C |
1: 92,548,471 (GRCm39) |
V281A |
probably benign |
Het |
| Oxct1 |
T |
C |
15: 4,183,243 (GRCm39) |
S485P |
probably benign |
Het |
| Oxt |
A |
G |
2: 130,418,572 (GRCm39) |
D61G |
probably damaging |
Het |
| P2ry10 |
A |
C |
X: 106,146,241 (GRCm39) |
I59L |
probably damaging |
Het |
| Parp11 |
A |
G |
6: 127,454,854 (GRCm39) |
N124S |
probably benign |
Het |
| Pcdh7 |
T |
A |
5: 57,876,971 (GRCm39) |
N175K |
probably damaging |
Het |
| Pdgfrb |
T |
A |
18: 61,194,566 (GRCm39) |
S114R |
probably benign |
Het |
| Pfdn5 |
A |
G |
15: 102,234,956 (GRCm39) |
N54S |
possibly damaging |
Het |
| Phc2 |
T |
A |
4: 128,617,378 (GRCm39) |
V468E |
probably benign |
Het |
| Piezo2 |
T |
C |
18: 63,192,815 (GRCm39) |
T1605A |
probably damaging |
Het |
| Pik3cb |
A |
T |
9: 98,987,632 (GRCm39) |
Y35* |
probably null |
Het |
| Piwil2 |
A |
T |
14: 70,664,083 (GRCm39) |
M22K |
probably damaging |
Het |
| Plag1 |
A |
G |
4: 3,904,889 (GRCm39) |
F101L |
probably damaging |
Het |
| Pomt2 |
A |
G |
12: 87,158,173 (GRCm39) |
L680P |
possibly damaging |
Het |
| Ppp1r36 |
A |
G |
12: 76,465,700 (GRCm39) |
|
probably null |
Het |
| Prkag2 |
C |
T |
5: 25,076,052 (GRCm39) |
|
probably null |
Het |
| Prkg1 |
T |
C |
19: 31,641,542 (GRCm39) |
D47G |
possibly damaging |
Het |
| Prl6a1 |
G |
A |
13: 27,499,352 (GRCm39) |
G45D |
probably benign |
Het |
| Rbm20 |
G |
A |
19: 53,847,859 (GRCm39) |
C1135Y |
probably damaging |
Het |
| Recql5 |
A |
T |
11: 115,787,923 (GRCm39) |
N465K |
probably benign |
Het |
| Rlig1 |
T |
G |
10: 100,419,820 (GRCm39) |
D58A |
probably damaging |
Het |
| Rtcb |
A |
T |
10: 85,777,797 (GRCm39) |
I459N |
probably damaging |
Het |
| Rtp3 |
A |
T |
9: 110,815,102 (GRCm39) |
|
probably benign |
Het |
| Rundc3b |
T |
A |
5: 8,562,409 (GRCm39) |
|
probably null |
Het |
| Scube3 |
A |
G |
17: 28,387,132 (GRCm39) |
T877A |
probably damaging |
Het |
| Sh2d4a |
A |
T |
8: 68,799,394 (GRCm39) |
Q421L |
probably benign |
Het |
| Slc6a1 |
G |
T |
6: 114,284,731 (GRCm39) |
G263V |
probably damaging |
Het |
| Slco1c1 |
T |
A |
6: 141,500,833 (GRCm39) |
F437L |
probably benign |
Het |
| Slco3a1 |
G |
A |
7: 73,996,419 (GRCm39) |
A329V |
probably benign |
Het |
| Spag9 |
T |
A |
11: 93,983,201 (GRCm39) |
L504* |
probably null |
Het |
| Spen |
A |
T |
4: 141,200,640 (GRCm39) |
N2662K |
probably damaging |
Het |
| Sptb |
G |
C |
12: 76,679,246 (GRCm39) |
R70G |
possibly damaging |
Het |
| Stk3 |
A |
G |
15: 35,072,644 (GRCm39) |
S136P |
probably damaging |
Het |
| Synj1 |
A |
T |
16: 90,735,584 (GRCm39) |
F1456L |
probably damaging |
Het |
| Tbx5 |
T |
C |
5: 119,979,971 (GRCm39) |
|
probably null |
Het |
| Tchh |
G |
A |
3: 93,354,268 (GRCm39) |
R1236Q |
unknown |
Het |
| Timd4 |
C |
A |
11: 46,710,857 (GRCm39) |
T253K |
possibly damaging |
Het |
| Tmc6 |
A |
G |
11: 117,660,232 (GRCm39) |
Y669H |
probably damaging |
Het |
| Tmem151a |
C |
T |
19: 5,132,966 (GRCm39) |
R80H |
probably benign |
Het |
| Tpgs1 |
T |
C |
10: 79,511,722 (GRCm39) |
L288P |
probably damaging |
Het |
| Trhde |
T |
C |
10: 114,334,698 (GRCm39) |
I659V |
probably benign |
Het |
| Trpm7 |
A |
T |
2: 126,665,917 (GRCm39) |
Y896* |
probably null |
Het |
| Ttc5 |
C |
A |
14: 51,019,007 (GRCm39) |
E37* |
probably null |
Het |
| Uvrag |
A |
G |
7: 98,589,096 (GRCm39) |
|
probably null |
Het |
| Vmn1r59 |
T |
A |
7: 5,457,283 (GRCm39) |
D159V |
probably damaging |
Het |
| Vmn2r78 |
G |
A |
7: 86,604,287 (GRCm39) |
V822M |
possibly damaging |
Het |
| Vnn1 |
C |
A |
10: 23,770,869 (GRCm39) |
Y32* |
probably null |
Het |
| Wrn |
A |
G |
8: 33,726,432 (GRCm39) |
V1380A |
probably benign |
Het |
| Zc3h14 |
A |
C |
12: 98,746,527 (GRCm39) |
S579R |
possibly damaging |
Het |
| Zfp277 |
G |
A |
12: 40,367,217 (GRCm39) |
Q480* |
probably null |
Het |
| Zfp456 |
G |
A |
13: 67,514,993 (GRCm39) |
Q238* |
probably null |
Het |
| Zranb3 |
T |
A |
1: 128,019,638 (GRCm39) |
T35S |
probably benign |
Het |
|
| Other mutations in Siglec1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00482:Siglec1
|
APN |
2 |
130,921,245 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01092:Siglec1
|
APN |
2 |
130,921,137 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01115:Siglec1
|
APN |
2 |
130,916,422 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01324:Siglec1
|
APN |
2 |
130,927,461 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01330:Siglec1
|
APN |
2 |
130,916,925 (GRCm39) |
nonsense |
probably null |
|
|
IGL01330:Siglec1
|
APN |
2 |
130,925,456 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01558:Siglec1
|
APN |
2 |
130,920,419 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01632:Siglec1
|
APN |
2 |
130,925,740 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01768:Siglec1
|
APN |
2 |
130,916,314 (GRCm39) |
missense |
probably benign |
|
|
IGL02399:Siglec1
|
APN |
2 |
130,913,098 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL02558:Siglec1
|
APN |
2 |
130,916,915 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL02794:Siglec1
|
APN |
2 |
130,917,889 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02839:Siglec1
|
APN |
2 |
130,926,852 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
aggressor
|
UTSW |
2 |
130,925,861 (GRCm39) |
nonsense |
probably null |
|
|
boris
|
UTSW |
2 |
130,921,297 (GRCm39) |
nonsense |
probably null |
|
|
espia
|
UTSW |
2 |
130,914,664 (GRCm39) |
missense |
probably damaging |
0.98 |
|
hoodlum
|
UTSW |
2 |
130,914,667 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
microfische
|
UTSW |
2 |
130,928,015 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
K3955:Siglec1
|
UTSW |
2 |
130,923,359 (GRCm39) |
missense |
probably benign |
0.00 |
|
P0038:Siglec1
|
UTSW |
2 |
130,923,359 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4576001:Siglec1
|
UTSW |
2 |
130,920,081 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4677001:Siglec1
|
UTSW |
2 |
130,914,677 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0003:Siglec1
|
UTSW |
2 |
130,916,980 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0048:Siglec1
|
UTSW |
2 |
130,915,317 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0048:Siglec1
|
UTSW |
2 |
130,915,317 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0243:Siglec1
|
UTSW |
2 |
130,927,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0276:Siglec1
|
UTSW |
2 |
130,925,861 (GRCm39) |
nonsense |
probably null |
|
|
R0379:Siglec1
|
UTSW |
2 |
130,916,445 (GRCm39) |
splice site |
probably benign |
|
|
R0464:Siglec1
|
UTSW |
2 |
130,921,279 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0507:Siglec1
|
UTSW |
2 |
130,916,445 (GRCm39) |
splice site |
probably benign |
|
|
R0560:Siglec1
|
UTSW |
2 |
130,912,266 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0620:Siglec1
|
UTSW |
2 |
130,916,188 (GRCm39) |
missense |
probably benign |
0.30 |
|
R0621:Siglec1
|
UTSW |
2 |
130,916,188 (GRCm39) |
missense |
probably benign |
0.30 |
|
R0853:Siglec1
|
UTSW |
2 |
130,926,942 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1079:Siglec1
|
UTSW |
2 |
130,921,297 (GRCm39) |
nonsense |
probably null |
|
|
R1169:Siglec1
|
UTSW |
2 |
130,916,747 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1205:Siglec1
|
UTSW |
2 |
130,922,384 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1293:Siglec1
|
UTSW |
2 |
130,915,451 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1470:Siglec1
|
UTSW |
2 |
130,912,307 (GRCm39) |
missense |
probably benign |
0.19 |
|
R1470:Siglec1
|
UTSW |
2 |
130,912,307 (GRCm39) |
missense |
probably benign |
0.19 |
|
R1533:Siglec1
|
UTSW |
2 |
130,918,078 (GRCm39) |
missense |
probably benign |
|
|
R1717:Siglec1
|
UTSW |
2 |
130,925,932 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1717:Siglec1
|
UTSW |
2 |
130,915,876 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1744:Siglec1
|
UTSW |
2 |
130,923,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1852:Siglec1
|
UTSW |
2 |
130,923,420 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1941:Siglec1
|
UTSW |
2 |
130,920,051 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2012:Siglec1
|
UTSW |
2 |
130,925,277 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2128:Siglec1
|
UTSW |
2 |
130,922,417 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2278:Siglec1
|
UTSW |
2 |
130,913,257 (GRCm39) |
missense |
probably benign |
0.28 |
|
R2403:Siglec1
|
UTSW |
2 |
130,916,395 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R2449:Siglec1
|
UTSW |
2 |
130,920,645 (GRCm39) |
missense |
probably benign |
0.44 |
|
R2885:Siglec1
|
UTSW |
2 |
130,914,667 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4213:Siglec1
|
UTSW |
2 |
130,916,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4274:Siglec1
|
UTSW |
2 |
130,927,734 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4679:Siglec1
|
UTSW |
2 |
130,915,331 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4715:Siglec1
|
UTSW |
2 |
130,916,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4782:Siglec1
|
UTSW |
2 |
130,917,843 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4896:Siglec1
|
UTSW |
2 |
130,911,789 (GRCm39) |
missense |
probably benign |
0.21 |
|
R4993:Siglec1
|
UTSW |
2 |
130,915,281 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5004:Siglec1
|
UTSW |
2 |
130,915,331 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R5004:Siglec1
|
UTSW |
2 |
130,911,789 (GRCm39) |
missense |
probably benign |
0.21 |
|
R5105:Siglec1
|
UTSW |
2 |
130,922,320 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R5137:Siglec1
|
UTSW |
2 |
130,923,264 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5153:Siglec1
|
UTSW |
2 |
130,927,497 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5311:Siglec1
|
UTSW |
2 |
130,921,236 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5600:Siglec1
|
UTSW |
2 |
130,927,503 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5682:Siglec1
|
UTSW |
2 |
130,925,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5732:Siglec1
|
UTSW |
2 |
130,916,188 (GRCm39) |
missense |
probably benign |
0.30 |
|
R5870:Siglec1
|
UTSW |
2 |
130,914,767 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5898:Siglec1
|
UTSW |
2 |
130,915,553 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5909:Siglec1
|
UTSW |
2 |
130,919,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6488:Siglec1
|
UTSW |
2 |
130,923,227 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6920:Siglec1
|
UTSW |
2 |
130,919,997 (GRCm39) |
nonsense |
probably null |
|
|
R7064:Siglec1
|
UTSW |
2 |
130,925,834 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7270:Siglec1
|
UTSW |
2 |
130,923,471 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7355:Siglec1
|
UTSW |
2 |
130,922,371 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7400:Siglec1
|
UTSW |
2 |
130,928,015 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R7470:Siglec1
|
UTSW |
2 |
130,917,744 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7568:Siglec1
|
UTSW |
2 |
130,914,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7781:Siglec1
|
UTSW |
2 |
130,923,258 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7853:Siglec1
|
UTSW |
2 |
130,923,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7999:Siglec1
|
UTSW |
2 |
130,913,083 (GRCm39) |
missense |
probably benign |
0.28 |
|
R8191:Siglec1
|
UTSW |
2 |
130,927,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8274:Siglec1
|
UTSW |
2 |
130,925,830 (GRCm39) |
missense |
probably benign |
|
|
R8345:Siglec1
|
UTSW |
2 |
130,920,498 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8670:Siglec1
|
UTSW |
2 |
130,923,387 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8814:Siglec1
|
UTSW |
2 |
130,914,664 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9102:Siglec1
|
UTSW |
2 |
130,915,389 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9311:Siglec1
|
UTSW |
2 |
130,916,013 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9416:Siglec1
|
UTSW |
2 |
130,925,390 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9462:Siglec1
|
UTSW |
2 |
130,916,404 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9521:Siglec1
|
UTSW |
2 |
130,915,246 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9683:Siglec1
|
UTSW |
2 |
130,921,236 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9799:Siglec1
|
UTSW |
2 |
130,915,941 (GRCm39) |
missense |
probably damaging |
0.99 |
|
X0024:Siglec1
|
UTSW |
2 |
130,922,411 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Siglec1
|
UTSW |
2 |
130,922,444 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
Z1176:Siglec1
|
UTSW |
2 |
130,920,665 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGAGCTGGGTATGCGTTCAG -3'
(R):5'- GGCTGAAGTCAAAATGAACCC -3'
Sequencing Primer
(F):5'- TGGCCACACCATCTACATCTGAG -3'
(R):5'- TGAAGTCAAAATGAACCCCGCAG -3'
|
| Posted On |
2014-08-25 |
Incidental Mutation