Incidental Mutation 'R1970:Ttc28'
| ID |
219681 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ttc28
|
| Ensembl Gene |
ENSMUSG00000033209 |
| Gene Name |
tetratricopeptide repeat domain 28 |
| Synonyms |
|
| MMRRC Submission |
039983-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1970 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
110879803-111289780 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to C
at 111235635 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Serine
at position 1334
(Y1334S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000136116
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000040111]
[ENSMUST00000156290]
|
| AlphaFold |
Q80XJ3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000040111
AA Change: Y1334S
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000136116
Gene: ENSMUSG00000033209
AA Change: Y1334S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
4 |
28 |
N/A |
INTRINSIC |
|
TPR
|
52 |
85 |
2.84e1 |
SMART |
|
TPR
|
86 |
119 |
5.03e-1 |
SMART |
|
TPR
|
120 |
153 |
2.11e-3 |
SMART |
|
TPR
|
268 |
301 |
8.51e0 |
SMART |
|
TPR
|
339 |
372 |
1.78e-1 |
SMART |
|
TPR
|
379 |
412 |
2.82e-4 |
SMART |
|
TPR
|
419 |
452 |
9.98e-5 |
SMART |
|
TPR
|
459 |
492 |
1.88e0 |
SMART |
|
TPR
|
499 |
532 |
1.11e1 |
SMART |
|
TPR
|
539 |
572 |
2.93e-2 |
SMART |
|
TPR
|
579 |
612 |
1.21e-3 |
SMART |
|
TPR
|
619 |
652 |
4.91e-4 |
SMART |
|
TPR
|
659 |
692 |
7.56e-5 |
SMART |
|
TPR
|
699 |
732 |
8.29e0 |
SMART |
|
TPR
|
739 |
772 |
1.63e0 |
SMART |
|
TPR
|
779 |
812 |
1.24e0 |
SMART |
|
TPR
|
819 |
852 |
7.98e-4 |
SMART |
|
TPR
|
859 |
892 |
8.74e0 |
SMART |
|
TPR
|
902 |
935 |
5.43e-6 |
SMART |
|
TPR
|
942 |
975 |
4.09e-1 |
SMART |
|
TPR
|
982 |
1015 |
9.98e-5 |
SMART |
|
TPR
|
1022 |
1055 |
7.12e-1 |
SMART |
|
TPR
|
1062 |
1095 |
5.69e0 |
SMART |
|
TPR
|
1102 |
1135 |
3.14e-2 |
SMART |
|
TPR
|
1142 |
1175 |
2.84e1 |
SMART |
|
low complexity region
|
1259 |
1277 |
N/A |
INTRINSIC |
|
Pfam:CHAT
|
1415 |
1738 |
7.3e-77 |
PFAM |
|
low complexity region
|
1972 |
1990 |
N/A |
INTRINSIC |
|
low complexity region
|
2014 |
2031 |
N/A |
INTRINSIC |
|
low complexity region
|
2033 |
2045 |
N/A |
INTRINSIC |
|
low complexity region
|
2155 |
2171 |
N/A |
INTRINSIC |
|
low complexity region
|
2283 |
2293 |
N/A |
INTRINSIC |
|
low complexity region
|
2327 |
2352 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000128584
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000129017
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000156290
AA Change: Y1303S
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000137609
Gene: ENSMUSG00000033209
AA Change: Y1303S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
4 |
28 |
N/A |
INTRINSIC |
|
TPR
|
52 |
85 |
2.84e1 |
SMART |
|
TPR
|
86 |
119 |
5.03e-1 |
SMART |
|
TPR
|
120 |
153 |
2.11e-3 |
SMART |
|
TPR
|
268 |
301 |
8.51e0 |
SMART |
|
TPR
|
308 |
341 |
1.78e-1 |
SMART |
|
TPR
|
348 |
381 |
2.82e-4 |
SMART |
|
TPR
|
388 |
421 |
9.98e-5 |
SMART |
|
TPR
|
428 |
461 |
1.88e0 |
SMART |
|
TPR
|
468 |
501 |
1.11e1 |
SMART |
|
TPR
|
508 |
541 |
2.93e-2 |
SMART |
|
TPR
|
548 |
581 |
1.21e-3 |
SMART |
|
TPR
|
588 |
621 |
4.91e-4 |
SMART |
|
TPR
|
628 |
661 |
7.56e-5 |
SMART |
|
TPR
|
668 |
701 |
8.29e0 |
SMART |
|
TPR
|
708 |
741 |
1.63e0 |
SMART |
|
TPR
|
748 |
781 |
1.24e0 |
SMART |
|
TPR
|
788 |
821 |
7.98e-4 |
SMART |
|
TPR
|
828 |
861 |
8.74e0 |
SMART |
|
TPR
|
871 |
904 |
5.43e-6 |
SMART |
|
TPR
|
911 |
944 |
4.09e-1 |
SMART |
|
TPR
|
951 |
984 |
9.98e-5 |
SMART |
|
TPR
|
991 |
1024 |
7.12e-1 |
SMART |
|
TPR
|
1031 |
1064 |
5.69e0 |
SMART |
|
TPR
|
1071 |
1104 |
3.14e-2 |
SMART |
|
TPR
|
1111 |
1144 |
2.84e1 |
SMART |
|
low complexity region
|
1228 |
1246 |
N/A |
INTRINSIC |
|
Pfam:CHAT
|
1384 |
1707 |
1.1e-76 |
PFAM |
|
low complexity region
|
1941 |
1959 |
N/A |
INTRINSIC |
|
low complexity region
|
1983 |
2000 |
N/A |
INTRINSIC |
|
low complexity region
|
2002 |
2014 |
N/A |
INTRINSIC |
|
low complexity region
|
2124 |
2140 |
N/A |
INTRINSIC |
|
low complexity region
|
2252 |
2262 |
N/A |
INTRINSIC |
|
low complexity region
|
2296 |
2321 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.1946 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 94.2%
|
| Validation Efficiency |
97% (121/125) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 121 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca17 |
A |
T |
17: 24,307,575 (GRCm38) |
H578Q |
probably benign |
Het |
| Abcc12 |
A |
G |
8: 86,527,281 (GRCm38) |
I958T |
probably benign |
Het |
| Abcg5 |
AATCATTTG |
AG |
17: 84,673,602 (GRCm38) |
|
probably null |
Het |
| Acap2 |
A |
G |
16: 31,133,527 (GRCm38) |
|
probably null |
Het |
| Adgrb1 |
T |
C |
15: 74,539,877 (GRCm38) |
|
probably benign |
Het |
| Akap6 |
T |
A |
12: 52,938,475 (GRCm38) |
V897E |
probably damaging |
Het |
| Als2 |
A |
T |
1: 59,215,169 (GRCm38) |
L343Q |
probably benign |
Het |
| Arhgap5 |
A |
G |
12: 52,542,593 (GRCm38) |
I1275M |
probably damaging |
Het |
| Arnt |
C |
T |
3: 95,448,393 (GRCm38) |
S16L |
possibly damaging |
Het |
| Bglap3 |
C |
T |
3: 88,376,993 (GRCm38) |
|
probably benign |
Het |
| Blnk |
T |
C |
19: 40,940,165 (GRCm38) |
|
probably benign |
Het |
| C1qtnf4 |
T |
C |
2: 90,889,659 (GRCm38) |
M92T |
probably damaging |
Het |
| C77080 |
A |
G |
4: 129,226,017 (GRCm38) |
|
probably benign |
Het |
| Ccdc177 |
G |
A |
12: 80,758,712 (GRCm38) |
R263C |
unknown |
Het |
| Ccdc83 |
T |
A |
7: 90,244,154 (GRCm38) |
S132C |
probably damaging |
Het |
| Cdc7 |
A |
G |
5: 106,973,074 (GRCm38) |
|
probably benign |
Het |
| Cgnl1 |
T |
A |
9: 71,725,535 (GRCm38) |
N178I |
probably benign |
Het |
| Col27a1 |
C |
T |
4: 63,273,117 (GRCm38) |
|
probably benign |
Het |
| Col5a1 |
A |
T |
2: 27,986,754 (GRCm38) |
M822L |
unknown |
Het |
| Coro7 |
T |
C |
16: 4,633,756 (GRCm38) |
I451V |
probably benign |
Het |
| Csmd3 |
T |
C |
15: 48,673,531 (GRCm38) |
T92A |
probably damaging |
Het |
| Ddc |
A |
G |
11: 11,815,292 (GRCm38) |
V460A |
possibly damaging |
Het |
| Ddx4 |
C |
T |
13: 112,600,013 (GRCm38) |
V608I |
probably damaging |
Het |
| Ddx60 |
A |
T |
8: 61,972,206 (GRCm38) |
H676L |
possibly damaging |
Het |
| Dmtf1 |
T |
C |
5: 9,148,989 (GRCm38) |
E48G |
probably benign |
Het |
| Dpf3 |
T |
A |
12: 83,325,035 (GRCm38) |
|
probably null |
Het |
| Dydc2 |
A |
G |
14: 41,061,903 (GRCm38) |
C88R |
probably benign |
Het |
| Elovl4 |
A |
G |
9: 83,780,719 (GRCm38) |
Y163H |
probably damaging |
Het |
| Enpp2 |
T |
C |
15: 54,882,982 (GRCm38) |
D296G |
probably damaging |
Het |
| Fam83h |
G |
T |
15: 76,006,570 (GRCm38) |
|
probably benign |
Het |
| Fbf1 |
T |
A |
11: 116,151,491 (GRCm38) |
Q511L |
possibly damaging |
Het |
| Fhdc1 |
A |
T |
3: 84,454,851 (GRCm38) |
L323Q |
probably damaging |
Het |
| Fmnl2 |
T |
A |
2: 53,105,576 (GRCm38) |
V437D |
possibly damaging |
Het |
| Foxo3 |
A |
G |
10: 42,197,262 (GRCm38) |
S420P |
probably benign |
Het |
| Foxp4 |
C |
T |
17: 47,875,871 (GRCm38) |
R378Q |
unknown |
Het |
| Garem2 |
G |
T |
5: 30,117,174 (GRCm38) |
G844* |
probably null |
Het |
| Glmp |
T |
C |
3: 88,327,870 (GRCm38) |
L269S |
probably damaging |
Het |
| Gm2000 |
T |
G |
1: 156,366,447 (GRCm38) |
*124G |
probably null |
Het |
| Gm9915 |
T |
C |
1: 42,230,721 (GRCm38) |
|
noncoding transcript |
Het |
| Gnb4 |
A |
T |
3: 32,598,141 (GRCm38) |
D27E |
probably damaging |
Het |
| Gnb5 |
A |
G |
9: 75,344,650 (GRCm38) |
|
probably null |
Het |
| Gpr161 |
T |
G |
1: 165,306,358 (GRCm38) |
V63G |
probably damaging |
Het |
| Gsk3a |
T |
A |
7: 25,229,721 (GRCm38) |
|
probably benign |
Het |
| Hapln2 |
T |
C |
3: 88,024,120 (GRCm38) |
|
probably null |
Het |
| Incenp |
G |
T |
19: 9,885,487 (GRCm38) |
T401N |
unknown |
Het |
| Kalrn |
A |
G |
16: 33,977,524 (GRCm38) |
|
probably null |
Het |
| Kcnq3 |
A |
G |
15: 66,028,623 (GRCm38) |
|
probably null |
Het |
| Kif21b |
T |
C |
1: 136,171,156 (GRCm38) |
V1394A |
probably damaging |
Het |
| Klhl23 |
T |
C |
2: 69,833,686 (GRCm38) |
C460R |
probably damaging |
Het |
| L3mbtl1 |
G |
A |
2: 162,959,572 (GRCm38) |
A291T |
probably damaging |
Het |
| Lcp1 |
T |
C |
14: 75,200,506 (GRCm38) |
S119P |
probably damaging |
Het |
| Ldhc |
A |
G |
7: 46,869,751 (GRCm38) |
I133V |
probably benign |
Het |
| Lmntd2 |
G |
A |
7: 141,212,059 (GRCm38) |
|
probably benign |
Het |
| Lpl |
A |
T |
8: 68,896,802 (GRCm38) |
K327* |
probably null |
Het |
| Lrp1b |
T |
C |
2: 40,875,069 (GRCm38) |
D2801G |
probably damaging |
Het |
| Mppe1 |
C |
A |
18: 67,229,772 (GRCm38) |
A131S |
probably benign |
Het |
| Msh3 |
T |
A |
13: 92,249,820 (GRCm38) |
|
probably benign |
Het |
| Msh5 |
A |
G |
17: 35,033,600 (GRCm38) |
I377T |
probably damaging |
Het |
| Myo1e |
T |
C |
9: 70,368,773 (GRCm38) |
F757L |
probably benign |
Het |
| Myof |
A |
T |
19: 37,945,634 (GRCm38) |
D955E |
probably damaging |
Het |
| Nckap1 |
C |
T |
2: 80,517,942 (GRCm38) |
S889N |
probably benign |
Het |
| Ncor2 |
T |
C |
5: 125,038,918 (GRCm38) |
D858G |
probably damaging |
Het |
| Neb |
A |
T |
2: 52,263,905 (GRCm38) |
V2398D |
possibly damaging |
Het |
| Nefl |
C |
G |
14: 68,086,672 (GRCm38) |
T453R |
probably benign |
Het |
| Nf1 |
A |
G |
11: 79,553,961 (GRCm38) |
N371D |
probably benign |
Het |
| Nlrp4f |
T |
C |
13: 65,194,091 (GRCm38) |
Y580C |
probably damaging |
Het |
| Nme8 |
A |
C |
13: 19,652,322 (GRCm38) |
L228R |
probably damaging |
Het |
| Numa1 |
C |
T |
7: 102,009,322 (GRCm38) |
A1605V |
probably damaging |
Het |
| Ofd1 |
T |
C |
X: 166,427,214 (GRCm38) |
Y205C |
probably benign |
Het |
| Olfr1047 |
T |
A |
2: 86,228,252 (GRCm38) |
T240S |
probably damaging |
Het |
| Olfr1283 |
C |
T |
2: 111,369,076 (GRCm38) |
S148L |
probably benign |
Het |
| Olfr1532-ps1 |
G |
A |
7: 106,914,246 (GRCm38) |
G16D |
probably damaging |
Het |
| Olfr693 |
T |
A |
7: 106,677,670 (GRCm38) |
N272I |
probably damaging |
Het |
| Olfr972 |
T |
A |
9: 39,873,938 (GRCm38) |
I221N |
probably damaging |
Het |
| Pclo |
A |
G |
5: 14,713,473 (GRCm38) |
T3987A |
unknown |
Het |
| Pdgfrb |
G |
A |
18: 61,066,494 (GRCm38) |
|
probably benign |
Het |
| Pdxk |
G |
A |
10: 78,441,154 (GRCm38) |
T270I |
probably damaging |
Het |
| Pex5 |
T |
C |
6: 124,414,405 (GRCm38) |
E10G |
probably damaging |
Het |
| Pik3c2g |
T |
A |
6: 139,900,386 (GRCm38) |
|
probably null |
Het |
| Pkhd1 |
T |
A |
1: 20,381,523 (GRCm38) |
I2183F |
probably damaging |
Het |
| Plppr2 |
T |
C |
9: 21,941,126 (GRCm38) |
V102A |
probably damaging |
Het |
| Plxnd1 |
T |
C |
6: 115,962,517 (GRCm38) |
T1449A |
probably damaging |
Het |
| Pnkd |
T |
A |
1: 74,285,910 (GRCm38) |
|
probably null |
Het |
| Pom121l2 |
A |
G |
13: 21,983,472 (GRCm38) |
I638V |
probably damaging |
Het |
| Prag1 |
A |
G |
8: 36,129,160 (GRCm38) |
|
probably null |
Het |
| Ranbp10 |
A |
G |
8: 105,786,708 (GRCm38) |
F191L |
probably damaging |
Het |
| Rapgef1 |
T |
C |
2: 29,733,711 (GRCm38) |
L824P |
probably damaging |
Het |
| Rec8 |
T |
C |
14: 55,624,142 (GRCm38) |
L418P |
probably damaging |
Het |
| Rimbp2 |
T |
A |
5: 128,797,241 (GRCm38) |
N429Y |
probably damaging |
Het |
| Rpe65 |
C |
A |
3: 159,615,670 (GRCm38) |
T373K |
probably benign |
Het |
| Rrn3 |
T |
C |
16: 13,789,074 (GRCm38) |
S151P |
probably damaging |
Het |
| Scn7a |
A |
G |
2: 66,684,289 (GRCm38) |
V1047A |
possibly damaging |
Het |
| Scn9a |
G |
T |
2: 66,515,380 (GRCm38) |
P1123Q |
probably damaging |
Het |
| Secisbp2l |
T |
C |
2: 125,747,510 (GRCm38) |
D706G |
probably damaging |
Het |
| Serpina5 |
A |
T |
12: 104,103,857 (GRCm38) |
T338S |
probably benign |
Het |
| Sez6 |
G |
A |
11: 77,954,068 (GRCm38) |
|
probably null |
Het |
| Shisa4 |
C |
T |
1: 135,372,274 (GRCm38) |
G157D |
probably damaging |
Het |
| Slc1a7 |
G |
T |
4: 107,968,585 (GRCm38) |
D14Y |
probably benign |
Het |
| Slc25a11 |
A |
C |
11: 70,646,173 (GRCm38) |
L51V |
probably benign |
Het |
| Slit3 |
A |
G |
11: 35,630,841 (GRCm38) |
|
probably null |
Het |
| Spata13 |
G |
T |
14: 60,691,463 (GRCm38) |
G157W |
probably damaging |
Het |
| Spta1 |
T |
C |
1: 174,240,367 (GRCm38) |
V2120A |
possibly damaging |
Het |
| Srpr |
T |
C |
9: 35,213,538 (GRCm38) |
|
probably null |
Het |
| Syt6 |
A |
G |
3: 103,587,420 (GRCm38) |
I234V |
probably benign |
Het |
| Thada |
G |
T |
17: 84,310,042 (GRCm38) |
P1349T |
probably damaging |
Het |
| Tmem161a |
C |
T |
8: 70,176,909 (GRCm38) |
R58W |
probably damaging |
Het |
| Top3b |
A |
G |
16: 16,883,519 (GRCm38) |
I232V |
probably damaging |
Het |
| Tspan1 |
T |
A |
4: 116,163,629 (GRCm38) |
Q197L |
possibly damaging |
Het |
| Ubxn6 |
G |
T |
17: 56,073,077 (GRCm38) |
N28K |
possibly damaging |
Het |
| Uggt1 |
T |
C |
1: 36,151,781 (GRCm38) |
D1366G |
probably damaging |
Het |
| Ugp2 |
A |
G |
11: 21,328,942 (GRCm38) |
S415P |
probably damaging |
Het |
| Vcan |
A |
T |
13: 89,689,038 (GRCm38) |
S2796T |
probably damaging |
Het |
| Vipr2 |
T |
C |
12: 116,136,206 (GRCm38) |
V231A |
probably benign |
Het |
| Vmn1r176 |
T |
C |
7: 23,834,948 (GRCm38) |
N260S |
probably benign |
Het |
| Vmn1r59 |
A |
T |
7: 5,454,039 (GRCm38) |
Y241N |
probably damaging |
Het |
| Vmn2r67 |
A |
T |
7: 85,151,805 (GRCm38) |
Y308N |
probably benign |
Het |
| Vmn2r75 |
A |
T |
7: 86,148,262 (GRCm38) |
M781K |
probably damaging |
Het |
| Vwa3a |
A |
T |
7: 120,780,171 (GRCm38) |
I500F |
probably damaging |
Het |
| Zfp609 |
A |
G |
9: 65,795,277 (GRCm38) |
V31A |
probably damaging |
Het |
| Zfp689 |
G |
T |
7: 127,444,787 (GRCm38) |
Q224K |
probably damaging |
Het |
| Zfp81 |
A |
T |
17: 33,335,501 (GRCm38) |
L113H |
probably benign |
Het |
|
| Other mutations in Ttc28 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00516:Ttc28
|
APN |
5 |
111,225,688 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00963:Ttc28
|
APN |
5 |
111,286,389 (GRCm38) |
nonsense |
probably null |
|
|
IGL00969:Ttc28
|
APN |
5 |
111,225,740 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01366:Ttc28
|
APN |
5 |
111,085,171 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL01528:Ttc28
|
APN |
5 |
111,101,960 (GRCm38) |
splice site |
probably benign |
|
|
IGL01558:Ttc28
|
APN |
5 |
111,283,962 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01973:Ttc28
|
APN |
5 |
111,224,235 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
IGL02040:Ttc28
|
APN |
5 |
110,892,936 (GRCm38) |
nonsense |
probably null |
|
|
IGL02432:Ttc28
|
APN |
5 |
111,223,235 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02531:Ttc28
|
APN |
5 |
111,225,850 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02819:Ttc28
|
APN |
5 |
111,266,583 (GRCm38) |
missense |
probably benign |
|
|
IGL02830:Ttc28
|
APN |
5 |
111,286,239 (GRCm38) |
missense |
probably benign |
0.10 |
|
IGL02893:Ttc28
|
APN |
5 |
111,285,385 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
IGL03387:Ttc28
|
APN |
5 |
111,233,342 (GRCm38) |
missense |
probably benign |
0.07 |
|
PIT4131001:Ttc28
|
UTSW |
5 |
110,892,853 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0142:Ttc28
|
UTSW |
5 |
111,277,457 (GRCm38) |
missense |
probably benign |
0.40 |
|
R0166:Ttc28
|
UTSW |
5 |
111,225,634 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0328:Ttc28
|
UTSW |
5 |
111,284,067 (GRCm38) |
splice site |
probably benign |
|
|
R0582:Ttc28
|
UTSW |
5 |
111,183,296 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0744:Ttc28
|
UTSW |
5 |
111,231,081 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0811:Ttc28
|
UTSW |
5 |
111,235,500 (GRCm38) |
missense |
probably benign |
0.24 |
|
R0812:Ttc28
|
UTSW |
5 |
111,235,500 (GRCm38) |
missense |
probably benign |
0.24 |
|
R0828:Ttc28
|
UTSW |
5 |
111,223,446 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0833:Ttc28
|
UTSW |
5 |
111,231,081 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1013:Ttc28
|
UTSW |
5 |
111,276,965 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1168:Ttc28
|
UTSW |
5 |
111,231,111 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1194:Ttc28
|
UTSW |
5 |
111,225,677 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1195:Ttc28
|
UTSW |
5 |
111,225,677 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1195:Ttc28
|
UTSW |
5 |
111,225,677 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1195:Ttc28
|
UTSW |
5 |
111,225,677 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1196:Ttc28
|
UTSW |
5 |
111,225,677 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1205:Ttc28
|
UTSW |
5 |
111,285,769 (GRCm38) |
missense |
probably benign |
0.04 |
|
R1386:Ttc28
|
UTSW |
5 |
111,225,677 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1467:Ttc28
|
UTSW |
5 |
111,285,388 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1467:Ttc28
|
UTSW |
5 |
111,285,388 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1537:Ttc28
|
UTSW |
5 |
111,285,318 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R1539:Ttc28
|
UTSW |
5 |
111,100,811 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
R1558:Ttc28
|
UTSW |
5 |
111,225,677 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1560:Ttc28
|
UTSW |
5 |
111,225,677 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1561:Ttc28
|
UTSW |
5 |
111,225,677 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1566:Ttc28
|
UTSW |
5 |
111,225,677 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1768:Ttc28
|
UTSW |
5 |
111,277,168 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
R1775:Ttc28
|
UTSW |
5 |
111,276,811 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1909:Ttc28
|
UTSW |
5 |
111,284,054 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1911:Ttc28
|
UTSW |
5 |
111,280,750 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R1990:Ttc28
|
UTSW |
5 |
111,276,322 (GRCm38) |
missense |
probably benign |
0.37 |
|
R1992:Ttc28
|
UTSW |
5 |
111,276,322 (GRCm38) |
missense |
probably benign |
0.37 |
|
R2066:Ttc28
|
UTSW |
5 |
111,225,933 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2112:Ttc28
|
UTSW |
5 |
111,276,273 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2158:Ttc28
|
UTSW |
5 |
111,177,617 (GRCm38) |
intron |
probably benign |
|
|
R2192:Ttc28
|
UTSW |
5 |
111,223,496 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2267:Ttc28
|
UTSW |
5 |
111,226,003 (GRCm38) |
missense |
possibly damaging |
0.75 |
|
R2384:Ttc28
|
UTSW |
5 |
111,276,208 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R2989:Ttc28
|
UTSW |
5 |
111,224,015 (GRCm38) |
missense |
probably benign |
0.29 |
|
R3881:Ttc28
|
UTSW |
5 |
111,183,240 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3919:Ttc28
|
UTSW |
5 |
111,285,379 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
R4455:Ttc28
|
UTSW |
5 |
111,224,058 (GRCm38) |
frame shift |
probably null |
|
|
R4456:Ttc28
|
UTSW |
5 |
111,224,058 (GRCm38) |
frame shift |
probably null |
|
|
R4522:Ttc28
|
UTSW |
5 |
111,280,172 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4548:Ttc28
|
UTSW |
5 |
111,271,224 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R4591:Ttc28
|
UTSW |
5 |
111,223,281 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4633:Ttc28
|
UTSW |
5 |
111,224,001 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4700:Ttc28
|
UTSW |
5 |
111,277,043 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4714:Ttc28
|
UTSW |
5 |
111,285,229 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R4790:Ttc28
|
UTSW |
5 |
111,224,217 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R4803:Ttc28
|
UTSW |
5 |
111,277,463 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R4840:Ttc28
|
UTSW |
5 |
111,286,081 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4969:Ttc28
|
UTSW |
5 |
111,276,255 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R5019:Ttc28
|
UTSW |
5 |
111,102,064 (GRCm38) |
missense |
possibly damaging |
0.47 |
|
R5130:Ttc28
|
UTSW |
5 |
110,892,856 (GRCm38) |
missense |
probably benign |
|
|
R5150:Ttc28
|
UTSW |
5 |
111,225,689 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5214:Ttc28
|
UTSW |
5 |
111,177,623 (GRCm38) |
intron |
probably benign |
|
|
R5254:Ttc28
|
UTSW |
5 |
111,271,238 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5518:Ttc28
|
UTSW |
5 |
111,225,928 (GRCm38) |
missense |
probably benign |
0.17 |
|
R5851:Ttc28
|
UTSW |
5 |
111,235,469 (GRCm38) |
splice site |
probably benign |
|
|
R5931:Ttc28
|
UTSW |
5 |
111,085,109 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
R6011:Ttc28
|
UTSW |
5 |
111,286,443 (GRCm38) |
missense |
probably benign |
|
|
R6176:Ttc28
|
UTSW |
5 |
111,223,985 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6221:Ttc28
|
UTSW |
5 |
111,271,248 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6398:Ttc28
|
UTSW |
5 |
111,276,276 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6717:Ttc28
|
UTSW |
5 |
111,285,436 (GRCm38) |
missense |
probably benign |
|
|
R6770:Ttc28
|
UTSW |
5 |
111,286,140 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6901:Ttc28
|
UTSW |
5 |
111,277,025 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R7038:Ttc28
|
UTSW |
5 |
111,266,579 (GRCm38) |
missense |
probably benign |
0.09 |
|
R7073:Ttc28
|
UTSW |
5 |
111,223,416 (GRCm38) |
missense |
possibly damaging |
0.96 |
|
R7101:Ttc28
|
UTSW |
5 |
111,085,092 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7135:Ttc28
|
UTSW |
5 |
111,280,007 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7350:Ttc28
|
UTSW |
5 |
111,226,037 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R7454:Ttc28
|
UTSW |
5 |
111,285,484 (GRCm38) |
missense |
probably benign |
0.19 |
|
R7461:Ttc28
|
UTSW |
5 |
111,224,129 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7596:Ttc28
|
UTSW |
5 |
111,280,124 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7613:Ttc28
|
UTSW |
5 |
111,224,129 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7625:Ttc28
|
UTSW |
5 |
111,285,219 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R7648:Ttc28
|
UTSW |
5 |
111,183,392 (GRCm38) |
missense |
possibly damaging |
0.52 |
|
R7735:Ttc28
|
UTSW |
5 |
111,266,678 (GRCm38) |
splice site |
probably null |
|
|
R8030:Ttc28
|
UTSW |
5 |
111,286,056 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
R8205:Ttc28
|
UTSW |
5 |
111,225,730 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R8246:Ttc28
|
UTSW |
5 |
111,233,341 (GRCm38) |
missense |
probably benign |
0.33 |
|
R8247:Ttc28
|
UTSW |
5 |
111,233,341 (GRCm38) |
missense |
probably benign |
0.33 |
|
R8269:Ttc28
|
UTSW |
5 |
111,277,459 (GRCm38) |
missense |
probably benign |
0.09 |
|
R8292:Ttc28
|
UTSW |
5 |
111,223,257 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8346:Ttc28
|
UTSW |
5 |
111,233,341 (GRCm38) |
missense |
probably benign |
0.33 |
|
R8356:Ttc28
|
UTSW |
5 |
111,233,341 (GRCm38) |
missense |
probably benign |
0.33 |
|
R8423:Ttc28
|
UTSW |
5 |
111,233,341 (GRCm38) |
missense |
probably benign |
0.33 |
|
R8424:Ttc28
|
UTSW |
5 |
111,233,341 (GRCm38) |
missense |
probably benign |
0.33 |
|
R8426:Ttc28
|
UTSW |
5 |
111,233,341 (GRCm38) |
missense |
probably benign |
0.33 |
|
R8441:Ttc28
|
UTSW |
5 |
111,177,641 (GRCm38) |
nonsense |
probably null |
|
|
R8494:Ttc28
|
UTSW |
5 |
111,235,640 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R8508:Ttc28
|
UTSW |
5 |
111,233,341 (GRCm38) |
missense |
probably benign |
0.33 |
|
R8510:Ttc28
|
UTSW |
5 |
111,233,341 (GRCm38) |
missense |
probably benign |
0.33 |
|
R8729:Ttc28
|
UTSW |
5 |
111,235,643 (GRCm38) |
critical splice donor site |
probably null |
|
|
R8845:Ttc28
|
UTSW |
5 |
111,224,175 (GRCm38) |
missense |
probably benign |
0.11 |
|
R9003:Ttc28
|
UTSW |
5 |
111,277,030 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9185:Ttc28
|
UTSW |
5 |
111,223,476 (GRCm38) |
missense |
probably benign |
0.03 |
|
R9187:Ttc28
|
UTSW |
5 |
111,102,036 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9245:Ttc28
|
UTSW |
5 |
111,177,659 (GRCm38) |
missense |
unknown |
|
|
R9251:Ttc28
|
UTSW |
5 |
110,892,832 (GRCm38) |
missense |
possibly damaging |
0.47 |
|
R9372:Ttc28
|
UTSW |
5 |
111,183,207 (GRCm38) |
missense |
probably benign |
0.25 |
|
R9466:Ttc28
|
UTSW |
5 |
111,183,029 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9563:Ttc28
|
UTSW |
5 |
111,223,226 (GRCm38) |
missense |
probably benign |
0.22 |
|
R9606:Ttc28
|
UTSW |
5 |
111,285,274 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9691:Ttc28
|
UTSW |
5 |
111,284,013 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9709:Ttc28
|
UTSW |
5 |
111,285,771 (GRCm38) |
missense |
probably damaging |
0.97 |
|
V8831:Ttc28
|
UTSW |
5 |
111,100,712 (GRCm38) |
missense |
probably benign |
0.11 |
|
Z1088:Ttc28
|
UTSW |
5 |
111,286,315 (GRCm38) |
missense |
probably benign |
0.00 |
|
Z1176:Ttc28
|
UTSW |
5 |
111,266,566 (GRCm38) |
missense |
possibly damaging |
0.59 |
|
Z1177:Ttc28
|
UTSW |
5 |
111,285,739 (GRCm38) |
missense |
probably benign |
0.10 |
|
Z1177:Ttc28
|
UTSW |
5 |
111,278,586 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTGCTACCCAACCATGTGTG -3'
(R):5'- CCAGCTCAGGGGATTGTAATG -3'
Sequencing Primer
(F):5'- AACCATGTGTGACCTTGCCATG -3'
(R):5'- CTCAGGGGATTGTAATGAAAGATG -3'
|
| Posted On |
2014-08-25 |
Incidental Mutation