Incidental Mutation 'R1970:Pik3c2g'
| ID |
219690 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Pik3c2g
|
| Ensembl Gene |
ENSMUSG00000030228 |
| Gene Name |
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma |
| Synonyms |
|
| MMRRC Submission |
039983-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.087)
|
| Stock # |
R1970 (G1)
|
| Quality Score |
208 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
139587221-139969284 bp(+) (GRCm38) |
| Type of Mutation |
critical splice donor site (2 bp from exon) |
| DNA Base Change (assembly) |
T to A
at 139900386 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000151281
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000087657]
[ENSMUST00000087657]
[ENSMUST00000111868]
[ENSMUST00000218528]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably null
Transcript: ENSMUST00000087657
|
| SMART Domains |
Protein: ENSMUSP00000084939
Gene: ENSMUSG00000030228
| Domain | Start | End | E-Value | Type |
|---|
|
PI3Kc
|
125 |
387 |
2.11e-109 |
SMART |
|
PX
|
411 |
515 |
1.24e-21 |
SMART |
|
C2
|
550 |
647 |
1.34e-7 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000087657
|
| SMART Domains |
Protein: ENSMUSP00000084939
Gene: ENSMUSG00000030228
| Domain | Start | End | E-Value | Type |
|---|
|
PI3Kc
|
125 |
387 |
2.11e-109 |
SMART |
|
PX
|
411 |
515 |
1.24e-21 |
SMART |
|
C2
|
550 |
647 |
1.34e-7 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000111868
|
| SMART Domains |
Protein: ENSMUSP00000107499
Gene: ENSMUSG00000030228
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1e8xa2
|
1 |
83 |
4e-16 |
SMART |
|
PI3Ka
|
103 |
288 |
7.6e-29 |
SMART |
|
PI3Kc
|
375 |
637 |
2.11e-109 |
SMART |
|
PX
|
661 |
765 |
1.24e-21 |
SMART |
|
C2
|
800 |
897 |
1.34e-7 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000187448
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000189374
|
| SMART Domains |
Protein: ENSMUSP00000139763
Gene: ENSMUSG00000030228
| Domain | Start | End | E-Value | Type |
|---|
|
PI3Kc
|
125 |
387 |
2.11e-109 |
SMART |
|
PX
|
411 |
515 |
1.24e-21 |
SMART |
|
C2
|
550 |
647 |
1.34e-7 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000206646
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000218528
|
| Meta Mutation Damage Score |
0.9480 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 94.2%
|
| Validation Efficiency |
97% (121/125) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
PHENOTYPE: Mice homozygous for a knock-out allelel exhibit reduced liver glucogen accumulation, hyperlipidemia, adiposity and insulin resistance with age or after consumption of a high-fat diet. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 121 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca17 |
A |
T |
17: 24,307,575 (GRCm38) |
H578Q |
probably benign |
Het |
| Abcc12 |
A |
G |
8: 86,527,281 (GRCm38) |
I958T |
probably benign |
Het |
| Abcg5 |
AATCATTTG |
AG |
17: 84,673,602 (GRCm38) |
|
probably null |
Het |
| Acap2 |
A |
G |
16: 31,133,527 (GRCm38) |
|
probably null |
Het |
| Adgrb1 |
T |
C |
15: 74,539,877 (GRCm38) |
|
probably benign |
Het |
| Akap6 |
T |
A |
12: 52,938,475 (GRCm38) |
V897E |
probably damaging |
Het |
| Als2 |
A |
T |
1: 59,215,169 (GRCm38) |
L343Q |
probably benign |
Het |
| Arhgap5 |
A |
G |
12: 52,542,593 (GRCm38) |
I1275M |
probably damaging |
Het |
| Arnt |
C |
T |
3: 95,448,393 (GRCm38) |
S16L |
possibly damaging |
Het |
| Bglap3 |
C |
T |
3: 88,376,993 (GRCm38) |
|
probably benign |
Het |
| Blnk |
T |
C |
19: 40,940,165 (GRCm38) |
|
probably benign |
Het |
| C1qtnf4 |
T |
C |
2: 90,889,659 (GRCm38) |
M92T |
probably damaging |
Het |
| Ccdc177 |
G |
A |
12: 80,758,712 (GRCm38) |
R263C |
unknown |
Het |
| Ccdc83 |
T |
A |
7: 90,244,154 (GRCm38) |
S132C |
probably damaging |
Het |
| Cdc7 |
A |
G |
5: 106,973,074 (GRCm38) |
|
probably benign |
Het |
| Cgnl1 |
T |
A |
9: 71,725,535 (GRCm38) |
N178I |
probably benign |
Het |
| Col27a1 |
C |
T |
4: 63,273,117 (GRCm38) |
|
probably benign |
Het |
| Col5a1 |
A |
T |
2: 27,986,754 (GRCm38) |
M822L |
unknown |
Het |
| Coro7 |
T |
C |
16: 4,633,756 (GRCm38) |
I451V |
probably benign |
Het |
| Csmd3 |
T |
C |
15: 48,673,531 (GRCm38) |
T92A |
probably damaging |
Het |
| Ddc |
A |
G |
11: 11,815,292 (GRCm38) |
V460A |
possibly damaging |
Het |
| Ddx4 |
C |
T |
13: 112,600,013 (GRCm38) |
V608I |
probably damaging |
Het |
| Ddx60 |
A |
T |
8: 61,972,206 (GRCm38) |
H676L |
possibly damaging |
Het |
| Dmtf1 |
T |
C |
5: 9,148,989 (GRCm38) |
E48G |
probably benign |
Het |
| Dpf3 |
T |
A |
12: 83,325,035 (GRCm38) |
|
probably null |
Het |
| Dydc2 |
A |
G |
14: 41,061,903 (GRCm38) |
C88R |
probably benign |
Het |
| Elovl4 |
A |
G |
9: 83,780,719 (GRCm38) |
Y163H |
probably damaging |
Het |
| Enpp2 |
T |
C |
15: 54,882,982 (GRCm38) |
D296G |
probably damaging |
Het |
| Fam83h |
G |
T |
15: 76,006,570 (GRCm38) |
|
probably benign |
Het |
| Fbf1 |
T |
A |
11: 116,151,491 (GRCm38) |
Q511L |
possibly damaging |
Het |
| Fhdc1 |
A |
T |
3: 84,454,851 (GRCm38) |
L323Q |
probably damaging |
Het |
| Fmnl2 |
T |
A |
2: 53,105,576 (GRCm38) |
V437D |
possibly damaging |
Het |
| Foxo3 |
A |
G |
10: 42,197,262 (GRCm38) |
S420P |
probably benign |
Het |
| Foxp4 |
C |
T |
17: 47,875,871 (GRCm38) |
R378Q |
unknown |
Het |
| Garem2 |
G |
T |
5: 30,117,174 (GRCm38) |
G844* |
probably null |
Het |
| Glmp |
T |
C |
3: 88,327,870 (GRCm38) |
L269S |
probably damaging |
Het |
| Gm9915 |
T |
C |
1: 42,230,721 (GRCm38) |
|
noncoding transcript |
Het |
| Gnb4 |
A |
T |
3: 32,598,141 (GRCm38) |
D27E |
probably damaging |
Het |
| Gnb5 |
A |
G |
9: 75,344,650 (GRCm38) |
|
probably null |
Het |
| Gpr161 |
T |
G |
1: 165,306,358 (GRCm38) |
V63G |
probably damaging |
Het |
| Gsk3a |
T |
A |
7: 25,229,721 (GRCm38) |
|
probably benign |
Het |
| Hapln2 |
T |
C |
3: 88,024,120 (GRCm38) |
|
probably null |
Het |
| Incenp |
G |
T |
19: 9,885,487 (GRCm38) |
T401N |
unknown |
Het |
| Kalrn |
A |
G |
16: 33,977,524 (GRCm38) |
|
probably null |
Het |
| Kcnq3 |
A |
G |
15: 66,028,623 (GRCm38) |
|
probably null |
Het |
| Kif21b |
T |
C |
1: 136,171,156 (GRCm38) |
V1394A |
probably damaging |
Het |
| Klhl23 |
T |
C |
2: 69,833,686 (GRCm38) |
C460R |
probably damaging |
Het |
| L3mbtl1 |
G |
A |
2: 162,959,572 (GRCm38) |
A291T |
probably damaging |
Het |
| Lcp1 |
T |
C |
14: 75,200,506 (GRCm38) |
S119P |
probably damaging |
Het |
| Ldhc |
A |
G |
7: 46,869,751 (GRCm38) |
I133V |
probably benign |
Het |
| Lmntd2 |
G |
A |
7: 141,212,059 (GRCm38) |
|
probably benign |
Het |
| Lpl |
A |
T |
8: 68,896,802 (GRCm38) |
K327* |
probably null |
Het |
| Lrp1b |
T |
C |
2: 40,875,069 (GRCm38) |
D2801G |
probably damaging |
Het |
| Mppe1 |
C |
A |
18: 67,229,772 (GRCm38) |
A131S |
probably benign |
Het |
| Msh3 |
T |
A |
13: 92,249,820 (GRCm38) |
|
probably benign |
Het |
| Msh5 |
A |
G |
17: 35,033,600 (GRCm38) |
I377T |
probably damaging |
Het |
| Myo1e |
T |
C |
9: 70,368,773 (GRCm38) |
F757L |
probably benign |
Het |
| Myof |
A |
T |
19: 37,945,634 (GRCm38) |
D955E |
probably damaging |
Het |
| Nckap1 |
C |
T |
2: 80,517,942 (GRCm38) |
S889N |
probably benign |
Het |
| Ncor2 |
T |
C |
5: 125,038,918 (GRCm38) |
D858G |
probably damaging |
Het |
| Neb |
A |
T |
2: 52,263,905 (GRCm38) |
V2398D |
possibly damaging |
Het |
| Nefl |
C |
G |
14: 68,086,672 (GRCm38) |
T453R |
probably benign |
Het |
| Nf1 |
A |
G |
11: 79,553,961 (GRCm38) |
N371D |
probably benign |
Het |
| Nhsl3 |
A |
G |
4: 129,226,017 (GRCm38) |
|
probably benign |
Het |
| Nlrp4f |
T |
C |
13: 65,194,091 (GRCm38) |
Y580C |
probably damaging |
Het |
| Nme8 |
A |
C |
13: 19,652,322 (GRCm38) |
L228R |
probably damaging |
Het |
| Numa1 |
C |
T |
7: 102,009,322 (GRCm38) |
A1605V |
probably damaging |
Het |
| Ofd1 |
T |
C |
X: 166,427,214 (GRCm38) |
Y205C |
probably benign |
Het |
| Olfr1532-ps1 |
G |
A |
7: 106,914,246 (GRCm38) |
G16D |
probably damaging |
Het |
| Or2ag12 |
T |
A |
7: 106,677,670 (GRCm38) |
N272I |
probably damaging |
Het |
| Or4k77 |
C |
T |
2: 111,369,076 (GRCm38) |
S148L |
probably benign |
Het |
| Or8g55 |
T |
A |
9: 39,873,938 (GRCm38) |
I221N |
probably damaging |
Het |
| Or8k3 |
T |
A |
2: 86,228,252 (GRCm38) |
T240S |
probably damaging |
Het |
| Pclo |
A |
G |
5: 14,713,473 (GRCm38) |
T3987A |
unknown |
Het |
| Pdgfrb |
G |
A |
18: 61,066,494 (GRCm38) |
|
probably benign |
Het |
| Pdxk |
G |
A |
10: 78,441,154 (GRCm38) |
T270I |
probably damaging |
Het |
| Pex5 |
T |
C |
6: 124,414,405 (GRCm38) |
E10G |
probably damaging |
Het |
| Pkhd1 |
T |
A |
1: 20,381,523 (GRCm38) |
I2183F |
probably damaging |
Het |
| Plppr2 |
T |
C |
9: 21,941,126 (GRCm38) |
V102A |
probably damaging |
Het |
| Plxnd1 |
T |
C |
6: 115,962,517 (GRCm38) |
T1449A |
probably damaging |
Het |
| Pnkd |
T |
A |
1: 74,285,910 (GRCm38) |
|
probably null |
Het |
| Pom121l2 |
A |
G |
13: 21,983,472 (GRCm38) |
I638V |
probably damaging |
Het |
| Prag1 |
A |
G |
8: 36,129,160 (GRCm38) |
|
probably null |
Het |
| Ranbp10 |
A |
G |
8: 105,786,708 (GRCm38) |
F191L |
probably damaging |
Het |
| Rapgef1 |
T |
C |
2: 29,733,711 (GRCm38) |
L824P |
probably damaging |
Het |
| Rec8 |
T |
C |
14: 55,624,142 (GRCm38) |
L418P |
probably damaging |
Het |
| Rimbp2 |
T |
A |
5: 128,797,241 (GRCm38) |
N429Y |
probably damaging |
Het |
| Rpe65 |
C |
A |
3: 159,615,670 (GRCm38) |
T373K |
probably benign |
Het |
| Rpl35rt |
T |
G |
1: 156,366,447 (GRCm38) |
*124G |
probably null |
Het |
| Rrn3 |
T |
C |
16: 13,789,074 (GRCm38) |
S151P |
probably damaging |
Het |
| Scn7a |
A |
G |
2: 66,684,289 (GRCm38) |
V1047A |
possibly damaging |
Het |
| Scn9a |
G |
T |
2: 66,515,380 (GRCm38) |
P1123Q |
probably damaging |
Het |
| Secisbp2l |
T |
C |
2: 125,747,510 (GRCm38) |
D706G |
probably damaging |
Het |
| Serpina5 |
A |
T |
12: 104,103,857 (GRCm38) |
T338S |
probably benign |
Het |
| Sez6 |
G |
A |
11: 77,954,068 (GRCm38) |
|
probably null |
Het |
| Shisa4 |
C |
T |
1: 135,372,274 (GRCm38) |
G157D |
probably damaging |
Het |
| Slc1a7 |
G |
T |
4: 107,968,585 (GRCm38) |
D14Y |
probably benign |
Het |
| Slc25a11 |
A |
C |
11: 70,646,173 (GRCm38) |
L51V |
probably benign |
Het |
| Slit3 |
A |
G |
11: 35,630,841 (GRCm38) |
|
probably null |
Het |
| Spata13 |
G |
T |
14: 60,691,463 (GRCm38) |
G157W |
probably damaging |
Het |
| Spta1 |
T |
C |
1: 174,240,367 (GRCm38) |
V2120A |
possibly damaging |
Het |
| Srpra |
T |
C |
9: 35,213,538 (GRCm38) |
|
probably null |
Het |
| Syt6 |
A |
G |
3: 103,587,420 (GRCm38) |
I234V |
probably benign |
Het |
| Thada |
G |
T |
17: 84,310,042 (GRCm38) |
P1349T |
probably damaging |
Het |
| Tmem161a |
C |
T |
8: 70,176,909 (GRCm38) |
R58W |
probably damaging |
Het |
| Top3b |
A |
G |
16: 16,883,519 (GRCm38) |
I232V |
probably damaging |
Het |
| Tspan1 |
T |
A |
4: 116,163,629 (GRCm38) |
Q197L |
possibly damaging |
Het |
| Ttc28 |
A |
C |
5: 111,235,635 (GRCm38) |
Y1334S |
probably benign |
Het |
| Ubxn6 |
G |
T |
17: 56,073,077 (GRCm38) |
N28K |
possibly damaging |
Het |
| Uggt1 |
T |
C |
1: 36,151,781 (GRCm38) |
D1366G |
probably damaging |
Het |
| Ugp2 |
A |
G |
11: 21,328,942 (GRCm38) |
S415P |
probably damaging |
Het |
| Vcan |
A |
T |
13: 89,689,038 (GRCm38) |
S2796T |
probably damaging |
Het |
| Vipr2 |
T |
C |
12: 116,136,206 (GRCm38) |
V231A |
probably benign |
Het |
| Vmn1r176 |
T |
C |
7: 23,834,948 (GRCm38) |
N260S |
probably benign |
Het |
| Vmn1r59 |
A |
T |
7: 5,454,039 (GRCm38) |
Y241N |
probably damaging |
Het |
| Vmn2r67 |
A |
T |
7: 85,151,805 (GRCm38) |
Y308N |
probably benign |
Het |
| Vmn2r75 |
A |
T |
7: 86,148,262 (GRCm38) |
M781K |
probably damaging |
Het |
| Vwa3a |
A |
T |
7: 120,780,171 (GRCm38) |
I500F |
probably damaging |
Het |
| Zfp609 |
A |
G |
9: 65,795,277 (GRCm38) |
V31A |
probably damaging |
Het |
| Zfp689 |
G |
T |
7: 127,444,787 (GRCm38) |
Q224K |
probably damaging |
Het |
| Zfp81 |
A |
T |
17: 33,335,501 (GRCm38) |
L113H |
probably benign |
Het |
|
| Other mutations in Pik3c2g |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00159:Pik3c2g
|
APN |
6 |
139,896,125 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01355:Pik3c2g
|
APN |
6 |
139,852,857 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL01579:Pik3c2g
|
APN |
6 |
139,754,741 (GRCm38) |
nonsense |
probably null |
|
|
IGL01580:Pik3c2g
|
APN |
6 |
139,622,516 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01587:Pik3c2g
|
APN |
6 |
139,754,741 (GRCm38) |
nonsense |
probably null |
|
|
IGL01813:Pik3c2g
|
APN |
6 |
139,622,409 (GRCm38) |
missense |
possibly damaging |
0.55 |
|
IGL02218:Pik3c2g
|
APN |
6 |
139,860,355 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02479:Pik3c2g
|
APN |
6 |
139,918,004 (GRCm38) |
missense |
probably benign |
0.40 |
|
IGL02480:Pik3c2g
|
APN |
6 |
139,852,800 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02721:Pik3c2g
|
APN |
6 |
139,736,973 (GRCm38) |
missense |
probably benign |
0.15 |
|
IGL02967:Pik3c2g
|
APN |
6 |
139,967,828 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL03221:Pik3c2g
|
APN |
6 |
139,772,407 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
FR4304:Pik3c2g
|
UTSW |
6 |
139,635,656 (GRCm38) |
frame shift |
probably null |
|
|
FR4340:Pik3c2g
|
UTSW |
6 |
139,635,656 (GRCm38) |
frame shift |
probably null |
|
|
FR4976:Pik3c2g
|
UTSW |
6 |
139,635,654 (GRCm38) |
frame shift |
probably null |
|
|
IGL02837:Pik3c2g
|
UTSW |
6 |
139,626,564 (GRCm38) |
nonsense |
probably null |
|
|
PIT4531001:Pik3c2g
|
UTSW |
6 |
139,859,370 (GRCm38) |
missense |
|
|
|
R0002:Pik3c2g
|
UTSW |
6 |
139,768,745 (GRCm38) |
missense |
probably benign |
0.08 |
|
R0081:Pik3c2g
|
UTSW |
6 |
139,957,793 (GRCm38) |
missense |
probably benign |
0.05 |
|
R0098:Pik3c2g
|
UTSW |
6 |
139,662,443 (GRCm38) |
missense |
unknown |
|
|
R0719:Pik3c2g
|
UTSW |
6 |
139,629,725 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0740:Pik3c2g
|
UTSW |
6 |
139,633,793 (GRCm38) |
critical splice donor site |
probably null |
|
|
R0837:Pik3c2g
|
UTSW |
6 |
139,957,699 (GRCm38) |
splice site |
probably benign |
|
|
R0840:Pik3c2g
|
UTSW |
6 |
139,896,072 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1306:Pik3c2g
|
UTSW |
6 |
139,772,428 (GRCm38) |
missense |
probably benign |
|
|
R1501:Pik3c2g
|
UTSW |
6 |
139,844,070 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1591:Pik3c2g
|
UTSW |
6 |
139,748,178 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1666:Pik3c2g
|
UTSW |
6 |
139,635,636 (GRCm38) |
intron |
probably benign |
|
|
R1907:Pik3c2g
|
UTSW |
6 |
139,844,042 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1982:Pik3c2g
|
UTSW |
6 |
139,622,548 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2171:Pik3c2g
|
UTSW |
6 |
139,855,286 (GRCm38) |
nonsense |
probably null |
|
|
R2188:Pik3c2g
|
UTSW |
6 |
139,852,874 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3777:Pik3c2g
|
UTSW |
6 |
139,622,387 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3778:Pik3c2g
|
UTSW |
6 |
139,622,387 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3965:Pik3c2g
|
UTSW |
6 |
139,855,292 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R4076:Pik3c2g
|
UTSW |
6 |
139,852,863 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4078:Pik3c2g
|
UTSW |
6 |
139,635,610 (GRCm38) |
intron |
probably benign |
|
|
R4108:Pik3c2g
|
UTSW |
6 |
139,730,370 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4461:Pik3c2g
|
UTSW |
6 |
139,841,681 (GRCm38) |
intron |
probably benign |
|
|
R4474:Pik3c2g
|
UTSW |
6 |
139,633,751 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4509:Pik3c2g
|
UTSW |
6 |
139,720,006 (GRCm38) |
missense |
probably benign |
0.25 |
|
R4646:Pik3c2g
|
UTSW |
6 |
139,720,018 (GRCm38) |
missense |
probably benign |
0.05 |
|
R4732:Pik3c2g
|
UTSW |
6 |
139,935,985 (GRCm38) |
missense |
probably benign |
0.28 |
|
R4733:Pik3c2g
|
UTSW |
6 |
139,935,985 (GRCm38) |
missense |
probably benign |
0.28 |
|
R4854:Pik3c2g
|
UTSW |
6 |
139,768,779 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4928:Pik3c2g
|
UTSW |
6 |
139,967,802 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R4959:Pik3c2g
|
UTSW |
6 |
139,843,931 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R4973:Pik3c2g
|
UTSW |
6 |
139,843,931 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R5032:Pik3c2g
|
UTSW |
6 |
139,896,202 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5071:Pik3c2g
|
UTSW |
6 |
139,720,147 (GRCm38) |
missense |
probably null |
0.00 |
|
R5072:Pik3c2g
|
UTSW |
6 |
139,720,147 (GRCm38) |
missense |
probably null |
0.00 |
|
R5073:Pik3c2g
|
UTSW |
6 |
139,720,147 (GRCm38) |
missense |
probably null |
0.00 |
|
R5074:Pik3c2g
|
UTSW |
6 |
139,720,147 (GRCm38) |
missense |
probably null |
0.00 |
|
R5107:Pik3c2g
|
UTSW |
6 |
139,635,625 (GRCm38) |
intron |
probably benign |
|
|
R5186:Pik3c2g
|
UTSW |
6 |
139,622,018 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5253:Pik3c2g
|
UTSW |
6 |
139,896,257 (GRCm38) |
critical splice donor site |
probably null |
|
|
R5359:Pik3c2g
|
UTSW |
6 |
139,622,123 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5394:Pik3c2g
|
UTSW |
6 |
139,720,082 (GRCm38) |
missense |
probably benign |
|
|
R5417:Pik3c2g
|
UTSW |
6 |
139,736,943 (GRCm38) |
missense |
probably benign |
|
|
R5435:Pik3c2g
|
UTSW |
6 |
139,715,855 (GRCm38) |
splice site |
probably null |
|
|
R5580:Pik3c2g
|
UTSW |
6 |
139,626,533 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5664:Pik3c2g
|
UTSW |
6 |
139,737,007 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R5908:Pik3c2g
|
UTSW |
6 |
139,768,710 (GRCm38) |
missense |
|
|
|
R5914:Pik3c2g
|
UTSW |
6 |
139,622,479 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6046:Pik3c2g
|
UTSW |
6 |
139,896,792 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6046:Pik3c2g
|
UTSW |
6 |
139,622,139 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R6298:Pik3c2g
|
UTSW |
6 |
139,626,563 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6382:Pik3c2g
|
UTSW |
6 |
139,719,998 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R6480:Pik3c2g
|
UTSW |
6 |
139,730,469 (GRCm38) |
missense |
probably benign |
0.27 |
|
R6917:Pik3c2g
|
UTSW |
6 |
139,896,173 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6929:Pik3c2g
|
UTSW |
6 |
139,957,776 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R7022:Pik3c2g
|
UTSW |
6 |
139,622,063 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R7144:Pik3c2g
|
UTSW |
6 |
139,629,870 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7213:Pik3c2g
|
UTSW |
6 |
139,860,264 (GRCm38) |
missense |
|
|
|
R7215:Pik3c2g
|
UTSW |
6 |
139,754,863 (GRCm38) |
missense |
|
|
|
R7332:Pik3c2g
|
UTSW |
6 |
139,896,255 (GRCm38) |
missense |
|
|
|
R7357:Pik3c2g
|
UTSW |
6 |
139,633,793 (GRCm38) |
critical splice donor site |
probably null |
|
|
R7359:Pik3c2g
|
UTSW |
6 |
139,967,894 (GRCm38) |
missense |
unknown |
|
|
R7385:Pik3c2g
|
UTSW |
6 |
139,855,353 (GRCm38) |
missense |
|
|
|
R7455:Pik3c2g
|
UTSW |
6 |
139,967,917 (GRCm38) |
missense |
unknown |
|
|
R7651:Pik3c2g
|
UTSW |
6 |
139,622,072 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R7888:Pik3c2g
|
UTSW |
6 |
139,896,744 (GRCm38) |
missense |
|
|
|
R7923:Pik3c2g
|
UTSW |
6 |
139,633,793 (GRCm38) |
critical splice donor site |
probably null |
|
|
R7964:Pik3c2g
|
UTSW |
6 |
139,882,060 (GRCm38) |
missense |
|
|
|
R8005:Pik3c2g
|
UTSW |
6 |
139,622,069 (GRCm38) |
missense |
probably benign |
0.01 |
|
R8371:Pik3c2g
|
UTSW |
6 |
139,936,056 (GRCm38) |
missense |
unknown |
|
|
R8724:Pik3c2g
|
UTSW |
6 |
139,967,893 (GRCm38) |
missense |
unknown |
|
|
R8733:Pik3c2g
|
UTSW |
6 |
139,768,700 (GRCm38) |
nonsense |
probably null |
|
|
R8809:Pik3c2g
|
UTSW |
6 |
139,768,710 (GRCm38) |
missense |
|
|
|
R8888:Pik3c2g
|
UTSW |
6 |
139,730,366 (GRCm38) |
nonsense |
probably null |
|
|
R8931:Pik3c2g
|
UTSW |
6 |
139,875,367 (GRCm38) |
missense |
probably benign |
0.02 |
|
R9188:Pik3c2g
|
UTSW |
6 |
139,622,403 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R9336:Pik3c2g
|
UTSW |
6 |
139,875,435 (GRCm38) |
missense |
|
|
|
R9383:Pik3c2g
|
UTSW |
6 |
139,882,016 (GRCm38) |
nonsense |
probably null |
|
|
R9524:Pik3c2g
|
UTSW |
6 |
139,629,770 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9531:Pik3c2g
|
UTSW |
6 |
139,896,200 (GRCm38) |
missense |
|
|
|
R9630:Pik3c2g
|
UTSW |
6 |
139,622,239 (GRCm38) |
missense |
possibly damaging |
0.66 |
|
R9697:Pik3c2g
|
UTSW |
6 |
139,967,791 (GRCm38) |
missense |
unknown |
|
|
R9708:Pik3c2g
|
UTSW |
6 |
139,629,867 (GRCm38) |
missense |
probably benign |
|
|
R9717:Pik3c2g
|
UTSW |
6 |
139,896,184 (GRCm38) |
missense |
|
|
|
RF015:Pik3c2g
|
UTSW |
6 |
139,754,771 (GRCm38) |
missense |
|
|
|
RF032:Pik3c2g
|
UTSW |
6 |
139,635,658 (GRCm38) |
frame shift |
probably null |
|
|
X0024:Pik3c2g
|
UTSW |
6 |
139,860,258 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAGGTGACTTTGTTACCAGCC -3'
(R):5'- GTACAGTGGTGCACATCTAGGC -3'
Sequencing Primer
(F):5'- CTTTGTTACCAGCCAAAGGAG -3'
(R):5'- GTGCACATCTAGGCAATGTG -3'
|
| Posted On |
2014-08-25 |
Incidental Mutation