Incidental Mutation 'R1982:Slit2'
ID 219907
Institutional Source Beutler Lab
Gene Symbol Slit2
Ensembl Gene ENSMUSG00000031558
Gene Name slit guidance ligand 2
Synonyms E030015M03Rik, Drad-1, b2b1200.1Clo, Slil3, E130320P19Rik
MMRRC Submission 039994-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R1982 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 48140480-48465075 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 48407178 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 870 (V870M)
Ref Sequence ENSEMBL: ENSMUSP00000133912 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033967] [ENSMUST00000170109] [ENSMUST00000172493] [ENSMUST00000173107] [ENSMUST00000174421] [ENSMUST00000174313]
AlphaFold Q9R1B9
Predicted Effect silent
Transcript: ENSMUST00000033967
SMART Domains Protein: ENSMUSP00000033967
Gene: ENSMUSG00000031558

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
LRRNT 27 59 6.53e-9 SMART
LRR 53 77 1.41e2 SMART
LRR_TYP 78 101 1.79e-2 SMART
LRR 102 125 2.45e0 SMART
LRR 126 149 9.96e-1 SMART
LRR 154 173 1.29e2 SMART
LRR_TYP 174 197 2.05e-2 SMART
LRRCT 209 258 3.42e-9 SMART
LRRNT 272 304 4.55e-8 SMART
LRR 298 322 3e1 SMART
LRR_TYP 323 346 1.95e-3 SMART
LRR_TYP 347 370 2.24e-3 SMART
LRR 371 394 1.31e0 SMART
LRR 395 418 2.49e-1 SMART
LRRCT 430 479 1.88e-6 SMART
LRRNT 497 529 1.45e-6 SMART
LRR_TYP 549 572 1.38e-3 SMART
LRR 597 620 9.96e-1 SMART
LRR_TYP 621 644 2.71e-2 SMART
LRRCT 656 705 3.56e-7 SMART
LRRNT 718 750 3.69e-8 SMART
LRR 768 791 7.36e0 SMART
LRR_TYP 792 815 5.59e-4 SMART
LRR_TYP 816 839 7.9e-4 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000170109
AA Change: V878M

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000127615
Gene: ENSMUSG00000031558
AA Change: V878M

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
LRRNT 27 59 6.53e-9 SMART
LRR 53 77 1.41e2 SMART
LRR_TYP 78 101 1.79e-2 SMART
LRR 102 125 2.45e0 SMART
LRR 126 149 9.96e-1 SMART
LRR 154 173 1.29e2 SMART
LRR_TYP 174 197 2.05e-2 SMART
LRRCT 209 258 3.42e-9 SMART
LRRNT 272 304 4.55e-8 SMART
LRR 298 322 3e1 SMART
LRR_TYP 323 346 1.95e-3 SMART
LRR_TYP 347 370 2.24e-3 SMART
LRR 371 394 1.31e0 SMART
LRR 395 418 2.49e-1 SMART
LRRCT 430 479 1.88e-6 SMART
LRRNT 497 529 1.45e-6 SMART
LRR_TYP 549 572 1.38e-3 SMART
LRR 597 620 9.96e-1 SMART
LRR_TYP 621 644 2.71e-2 SMART
LRRCT 656 705 3.56e-7 SMART
LRRNT 718 750 3.69e-8 SMART
LRR 768 791 7.36e0 SMART
LRR_TYP 792 815 5.59e-4 SMART
LRR_TYP 816 839 7.9e-4 SMART
LRRCT 851 900 3.9e-13 SMART
EGF 913 947 3.73e-5 SMART
EGF 952 988 4.35e-6 SMART
EGF_CA 990 1026 2.21e-7 SMART
FOLN 993 1015 5.84e1 SMART
EGF 1031 1066 1.07e-5 SMART
EGF_CA 1068 1104 3.97e-9 SMART
FOLN 1116 1138 2.22e0 SMART
EGF 1116 1149 1.62e-5 SMART
LamG 1172 1308 4.82e-39 SMART
EGF 1327 1360 3.68e-4 SMART
EGF 1366 1399 3.88e-3 SMART
FOLN 1407 1429 3.34e0 SMART
EGF 1407 1440 4.46e-3 SMART
CT 1451 1520 4.23e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000172484
Predicted Effect probably damaging
Transcript: ENSMUST00000172493
AA Change: V118M

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000134655
Gene: ENSMUSG00000031558
AA Change: V118M

DomainStartEndE-ValueType
LRR 20 43 3.1e-2 SMART
LRR_TYP 44 67 2.4e-6 SMART
LRR_TYP 68 91 3.2e-6 SMART
LRRCT 103 152 1.8e-15 SMART
EGF 176 210 1.8e-7 SMART
EGF 215 251 2.1e-8 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000173107
AA Change: V866M

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000133840
Gene: ENSMUSG00000031558
AA Change: V866M

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
LRRNT 27 59 6.53e-9 SMART
LRR 53 77 1.41e2 SMART
LRR_TYP 78 101 1.79e-2 SMART
LRR 102 125 2.45e0 SMART
LRR 126 149 9.96e-1 SMART
LRR 154 173 1.29e2 SMART
LRR_TYP 174 197 2.05e-2 SMART
LRRCT 209 258 3.42e-9 SMART
LRRNT 272 304 4.55e-8 SMART
LRR 298 322 3e1 SMART
LRR_TYP 323 346 1.95e-3 SMART
LRR_TYP 347 370 2.24e-3 SMART
LRR 371 394 1.31e0 SMART
LRR 395 418 2.49e-1 SMART
LRRCT 430 479 1.88e-6 SMART
LRRNT 505 537 1.45e-6 SMART
LRR_TYP 557 580 1.38e-3 SMART
LRR 605 628 9.96e-1 SMART
LRR_TYP 629 652 2.71e-2 SMART
LRRCT 664 713 3.56e-7 SMART
LRRNT 726 758 3.69e-8 SMART
LRR 776 799 7.36e0 SMART
LRR_TYP 800 823 5.59e-4 SMART
LRR_TYP 824 847 7.9e-4 SMART
LRRCT 859 908 3.9e-13 SMART
EGF 921 955 3.73e-5 SMART
EGF 960 996 4.35e-6 SMART
EGF_CA 998 1034 2.21e-7 SMART
FOLN 1001 1023 5.84e1 SMART
EGF 1039 1074 1.07e-5 SMART
EGF_CA 1076 1112 3.97e-9 SMART
FOLN 1124 1146 2.22e0 SMART
EGF 1124 1157 1.62e-5 SMART
LamG 1180 1316 4.82e-39 SMART
EGF 1335 1368 3.68e-4 SMART
EGF 1374 1407 3.88e-3 SMART
FOLN 1415 1437 3.34e0 SMART
EGF 1415 1448 4.46e-3 SMART
CT 1459 1528 4.23e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000173671
Predicted Effect probably damaging
Transcript: ENSMUST00000174421
AA Change: V878M

PolyPhen 2 Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000134263
Gene: ENSMUSG00000031558
AA Change: V878M

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
LRRNT 27 59 6.53e-9 SMART
LRR 53 77 1.41e2 SMART
LRR_TYP 78 101 1.79e-2 SMART
LRR 102 125 2.45e0 SMART
LRR 126 149 9.96e-1 SMART
LRR 154 173 1.29e2 SMART
LRR_TYP 174 197 2.05e-2 SMART
LRRCT 209 258 3.42e-9 SMART
LRRNT 276 308 4.55e-8 SMART
LRR 302 326 3e1 SMART
LRR_TYP 327 350 1.95e-3 SMART
LRR_TYP 351 374 2.24e-3 SMART
LRR 375 398 1.31e0 SMART
LRR 399 422 2.49e-1 SMART
LRRCT 434 483 1.88e-6 SMART
LRRNT 509 541 1.45e-6 SMART
LRR_TYP 561 584 1.38e-3 SMART
LRR 609 632 9.96e-1 SMART
LRR_TYP 633 656 2.71e-2 SMART
LRRCT 668 717 3.56e-7 SMART
LRRNT 730 762 3.69e-8 SMART
LRR 780 803 7.36e0 SMART
LRR_TYP 804 827 5.59e-4 SMART
LRR_TYP 828 851 7.9e-4 SMART
LRRCT 863 912 3.9e-13 SMART
EGF 925 959 3.73e-5 SMART
EGF 964 1000 4.35e-6 SMART
EGF_CA 1002 1047 4.74e-7 SMART
FOLN 1005 1027 5.84e1 SMART
EGF 1052 1087 1.07e-5 SMART
EGF_CA 1089 1125 3.97e-9 SMART
FOLN 1137 1159 2.22e0 SMART
EGF 1137 1170 1.62e-5 SMART
LamG 1193 1329 4.82e-39 SMART
EGF 1348 1381 3.68e-4 SMART
EGF 1387 1420 3.88e-3 SMART
FOLN 1428 1450 3.34e0 SMART
EGF 1428 1461 4.46e-3 SMART
CT 1472 1541 4.23e-4 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000174313
AA Change: V870M

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000133912
Gene: ENSMUSG00000031558
AA Change: V870M

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
LRRNT 27 59 6.53e-9 SMART
LRR 53 77 1.41e2 SMART
LRR_TYP 78 101 1.79e-2 SMART
LRR 102 125 2.45e0 SMART
LRR 126 149 9.96e-1 SMART
LRR 154 173 1.29e2 SMART
LRR_TYP 174 197 2.05e-2 SMART
LRRCT 209 258 3.42e-9 SMART
LRRNT 276 308 4.55e-8 SMART
LRR 302 326 3e1 SMART
LRR_TYP 327 350 1.95e-3 SMART
LRR_TYP 351 374 2.24e-3 SMART
LRR 375 398 1.31e0 SMART
LRR 399 422 2.49e-1 SMART
LRRCT 434 483 1.88e-6 SMART
LRRNT 501 533 1.45e-6 SMART
LRR_TYP 553 576 1.38e-3 SMART
LRR 601 624 9.96e-1 SMART
LRR_TYP 625 648 2.71e-2 SMART
LRRCT 660 709 3.56e-7 SMART
LRRNT 722 754 3.69e-8 SMART
LRR 772 795 7.36e0 SMART
LRR_TYP 796 819 5.59e-4 SMART
LRR_TYP 820 843 7.9e-4 SMART
LRRCT 855 904 3.9e-13 SMART
EGF 917 951 3.73e-5 SMART
EGF 956 992 4.35e-6 SMART
EGF_CA 994 1030 2.21e-7 SMART
FOLN 997 1019 5.84e1 SMART
EGF 1035 1070 1.07e-5 SMART
EGF_CA 1072 1108 3.97e-9 SMART
FOLN 1120 1142 2.22e0 SMART
EGF 1120 1153 1.62e-5 SMART
LamG 1176 1312 4.82e-39 SMART
EGF 1331 1364 3.68e-4 SMART
EGF 1370 1403 3.88e-3 SMART
FOLN 1411 1433 3.34e0 SMART
EGF 1411 1444 4.46e-3 SMART
CT 1455 1524 4.23e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000199024
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.5%
Validation Efficiency
MGI Phenotype FUNCTION: The protein encoded by this gene is a member of the Slit family of secreted glycoproteins, which function as ligands for the Robo family of immunoglobulin receptors. Slit proteins play highly conserved roles in axon guidance and neuronal migration and may also have functions during other cell migration processes including leukocyte migration. In mammals, members of the slit family are characterized by an N-terminal signal peptide, four leucine-rich repeats, nine epidermal growth factor repeats, and a C-terminal cysteine knot. Mice deficient for this gene exhibit abnormal axonal projections in the embryonic forebrain and develop supernumerary uretic buds that maintain improper connections to the nephric duct. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
PHENOTYPE: Homozygous mutants display perinatal lethality, abnormal ureteric bud development, multiple fused kidneys, multiple ureters, and hydroureter. [provided by MGI curators]
Allele List at MGI

All alleles(4) : Targeted(4)

Other mutations in this stock
Total: 89 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aatk G T 11: 119,904,340 (GRCm39) P252Q probably damaging Het
Adamts4 T C 1: 171,086,503 (GRCm39) V765A probably benign Het
Agfg2 A T 5: 137,662,515 (GRCm39) V184E possibly damaging Het
Alas1 A T 9: 106,115,384 (GRCm39) I48N probably damaging Het
Anks1 T C 17: 28,204,095 (GRCm39) V181A probably damaging Het
Anxa8 A T 14: 33,818,527 (GRCm39) R261S probably damaging Het
Aqp4 T C 18: 15,526,608 (GRCm39) D291G probably damaging Het
Atrn A G 2: 130,812,142 (GRCm39) R696G probably benign Het
Barx2 A C 9: 31,824,308 (GRCm39) I27S probably damaging Het
Btnl1 A T 17: 34,598,725 (GRCm39) I114L possibly damaging Het
Casq1 C T 1: 172,043,097 (GRCm39) A200T probably damaging Het
Ccdc33 T A 9: 58,024,451 (GRCm39) E225D probably benign Het
Cd84 C A 1: 171,712,152 (GRCm39) probably null Het
Ceacam9 T G 7: 16,459,232 (GRCm39) L177R probably benign Het
Cenpi T A X: 133,218,782 (GRCm39) F161L possibly damaging Het
Cep63 T C 9: 102,480,079 (GRCm39) K251E probably damaging Het
Cetn3 A G 13: 81,932,816 (GRCm39) E25G probably damaging Het
Crybg3 T C 16: 59,364,488 (GRCm39) D2378G possibly damaging Het
Ddx19b T C 8: 111,735,975 (GRCm39) T357A possibly damaging Het
Dpep2 A C 8: 106,716,087 (GRCm39) Y266* probably null Het
Dqx1 G A 6: 83,035,558 (GRCm39) D24N probably damaging Het
Dsg4 A T 18: 20,604,269 (GRCm39) Y912F probably damaging Het
Fezf2 G T 14: 12,344,405 (GRCm38) P261T probably benign Het
Fmo1 T C 1: 162,667,325 (GRCm39) I163M possibly damaging Het
Garin1a A G 6: 29,285,921 (GRCm39) T69A probably benign Het
Gatad2a G A 8: 70,365,782 (GRCm39) R428* probably null Het
Gfpt1 T A 6: 87,031,612 (GRCm39) F85I possibly damaging Het
Gimap7 A T 6: 48,701,175 (GRCm39) I254F possibly damaging Het
Glcci1 T C 6: 8,592,980 (GRCm39) S261P probably damaging Het
Glis3 A T 19: 28,508,674 (GRCm39) F437I probably damaging Het
Glp1r C A 17: 31,144,601 (GRCm39) S258* probably null Het
Gpt2 C T 8: 86,242,832 (GRCm39) A288V possibly damaging Het
Grin2c G T 11: 115,151,731 (GRCm39) S76R possibly damaging Het
Guf1 T A 5: 69,724,569 (GRCm39) Y447* probably null Het
H2-T9 T A 17: 36,439,614 (GRCm39) D122V probably damaging Het
Hectd1 A C 12: 51,832,624 (GRCm39) L916V probably damaging Het
Hnf4g A G 3: 3,703,268 (GRCm39) K96E probably damaging Het
Hsh2d G A 8: 72,954,304 (GRCm39) D229N probably benign Het
Ifi207 T G 1: 173,562,805 (GRCm39) M114L probably benign Het
Ifi35 A T 11: 101,349,112 (GRCm39) E252V probably damaging Het
Igsf9b G A 9: 27,233,535 (GRCm39) R345H possibly damaging Het
Itih3 T C 14: 30,645,540 (GRCm39) probably benign Het
Kcnh8 GAGACCAACGAGCAGCTGATGCTTCAGA GAGA 17: 53,032,934 (GRCm39) 74 probably benign Het
Kidins220 A T 12: 25,101,193 (GRCm39) M1252L probably benign Het
Kifap3 T A 1: 163,689,591 (GRCm39) L525* probably null Het
Limk2 A T 11: 3,305,461 (GRCm39) D35E probably benign Het
Lrrc37a G A 11: 103,389,792 (GRCm39) P1878S probably benign Het
Mansc4 T A 6: 146,977,173 (GRCm39) I148F probably benign Het
Mei1 A G 15: 81,987,513 (GRCm39) N859S probably benign Het
Mib1 A G 18: 10,812,064 (GRCm39) D987G probably damaging Het
Mroh8 A G 2: 157,113,895 (GRCm39) V132A possibly damaging Het
Npnt T C 3: 132,653,893 (GRCm39) I29M probably benign Het
Nrap T C 19: 56,372,537 (GRCm39) D138G probably damaging Het
Or10a3m A G 7: 108,312,902 (GRCm39) Y102C probably damaging Het
Or1e16 A T 11: 73,285,918 (GRCm39) I310N probably benign Het
Or2h1 T A 17: 37,404,700 (GRCm39) E22V probably damaging Het
Or6z7 T C 7: 6,483,931 (GRCm39) M75V probably benign Het
Osbpl5 A C 7: 143,295,408 (GRCm39) probably null Het
Pcna-ps2 T C 19: 9,261,047 (GRCm39) V102A possibly damaging Het
Pik3c2g T C 6: 139,599,546 (GRCm39) S221P probably damaging Het
Plppr3 A G 10: 79,702,259 (GRCm39) I271T probably damaging Het
Ppp4r3c1 A T X: 88,975,051 (GRCm39) V382E probably damaging Het
Pramel25 C A 4: 143,521,720 (GRCm39) H445Q probably benign Het
Prkar1b C T 5: 139,113,398 (GRCm39) A41T probably benign Het
Prkcsh A G 9: 21,924,164 (GRCm39) D458G probably damaging Het
Prr14 G T 7: 127,074,662 (GRCm39) R398L possibly damaging Het
Ptafr A G 4: 132,307,296 (GRCm39) R229G probably damaging Het
Rbp3 T C 14: 33,676,502 (GRCm39) F150S probably damaging Het
Rel C T 11: 23,692,761 (GRCm39) G424D probably benign Het
Rlf T C 4: 121,007,309 (GRCm39) Y557C probably damaging Het
Samt3 A C X: 85,090,740 (GRCm39) M211L probably benign Het
Selenop A T 15: 3,305,176 (GRCm39) I111F probably damaging Het
Slc2a2 G A 3: 28,771,590 (GRCm39) M173I probably benign Het
Slc43a1 G T 2: 84,687,233 (GRCm39) G361V possibly damaging Het
Ssxb10 A G X: 8,197,258 (GRCm39) D77G probably benign Het
Stk32b T A 5: 37,806,458 (GRCm39) I29F probably damaging Het
Stra6l T A 4: 45,867,237 (GRCm39) C161* probably null Het
Tecpr2 T A 12: 110,921,219 (GRCm39) M1264K probably benign Het
Tfap2c A T 2: 172,399,156 (GRCm39) I468F probably damaging Het
Ticam1 C T 17: 56,578,555 (GRCm39) R180H probably damaging Het
Tlr4 T A 4: 66,759,272 (GRCm39) N688K probably benign Het
Tmem35b A T 4: 127,019,846 (GRCm39) probably benign Het
Ugt2b34 T C 5: 87,054,172 (GRCm39) E203G probably damaging Het
Vegfa A C 17: 46,329,786 (GRCm39) *393G probably null Het
Vmn2r16 T C 5: 109,511,890 (GRCm39) V699A probably benign Het
Zfp324 T C 7: 12,705,145 (GRCm39) S445P probably damaging Het
Zfp982 T A 4: 147,597,049 (GRCm39) C135* probably null Het
Zfp990 A C 4: 145,263,439 (GRCm39) N146H probably damaging Het
Zfyve26 A G 12: 79,302,017 (GRCm39) Y431H possibly damaging Het
Other mutations in Slit2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00791:Slit2 APN 5 48,461,374 (GRCm39) missense possibly damaging 0.86
IGL00809:Slit2 APN 5 48,146,493 (GRCm39) missense possibly damaging 0.88
IGL00811:Slit2 APN 5 48,146,493 (GRCm39) missense possibly damaging 0.88
IGL00813:Slit2 APN 5 48,146,493 (GRCm39) missense possibly damaging 0.88
IGL00815:Slit2 APN 5 48,146,493 (GRCm39) missense possibly damaging 0.88
IGL00816:Slit2 APN 5 48,146,493 (GRCm39) missense possibly damaging 0.88
IGL00817:Slit2 APN 5 48,146,493 (GRCm39) missense possibly damaging 0.88
IGL00819:Slit2 APN 5 48,146,493 (GRCm39) missense possibly damaging 0.88
IGL00820:Slit2 APN 5 48,146,493 (GRCm39) missense possibly damaging 0.88
IGL00822:Slit2 APN 5 48,146,493 (GRCm39) missense possibly damaging 0.88
IGL01077:Slit2 APN 5 48,374,785 (GRCm39) splice site probably null
IGL01375:Slit2 APN 5 48,439,056 (GRCm39) splice site probably benign
IGL01481:Slit2 APN 5 48,460,273 (GRCm39) missense probably benign 0.05
IGL01934:Slit2 APN 5 48,395,747 (GRCm39) missense possibly damaging 0.93
IGL01992:Slit2 APN 5 48,395,759 (GRCm39) missense probably benign 0.01
IGL02315:Slit2 APN 5 48,145,213 (GRCm39) missense probably damaging 0.98
IGL02328:Slit2 APN 5 48,387,646 (GRCm39) missense probably damaging 1.00
IGL02366:Slit2 APN 5 48,461,410 (GRCm39) missense possibly damaging 0.53
IGL02526:Slit2 APN 5 48,461,565 (GRCm39) nonsense probably null
IGL02852:Slit2 APN 5 48,402,014 (GRCm39) missense probably damaging 1.00
IGL02887:Slit2 APN 5 48,374,816 (GRCm39) missense probably benign 0.44
IGL03123:Slit2 APN 5 48,368,681 (GRCm39) missense probably damaging 1.00
IGL03182:Slit2 APN 5 48,377,395 (GRCm39) missense possibly damaging 0.77
P0025:Slit2 UTSW 5 48,461,377 (GRCm39) missense probably damaging 0.96
R0032:Slit2 UTSW 5 48,414,198 (GRCm39) missense probably damaging 0.99
R0032:Slit2 UTSW 5 48,414,198 (GRCm39) missense probably damaging 0.99
R0055:Slit2 UTSW 5 48,439,068 (GRCm39) nonsense probably null
R0055:Slit2 UTSW 5 48,439,068 (GRCm39) nonsense probably null
R0267:Slit2 UTSW 5 48,339,673 (GRCm39) splice site probably benign
R0552:Slit2 UTSW 5 48,395,721 (GRCm39) missense probably damaging 1.00
R0610:Slit2 UTSW 5 48,433,016 (GRCm39) missense possibly damaging 0.77
R0883:Slit2 UTSW 5 48,402,915 (GRCm39) splice site probably benign
R1390:Slit2 UTSW 5 48,374,832 (GRCm39) missense probably benign 0.06
R1442:Slit2 UTSW 5 48,395,725 (GRCm39) missense probably damaging 0.96
R1453:Slit2 UTSW 5 48,414,393 (GRCm39) missense possibly damaging 0.88
R1508:Slit2 UTSW 5 48,349,591 (GRCm39) missense probably damaging 0.98
R1639:Slit2 UTSW 5 48,416,996 (GRCm39) missense probably damaging 1.00
R1705:Slit2 UTSW 5 48,346,814 (GRCm39) missense probably damaging 0.99
R1828:Slit2 UTSW 5 48,461,372 (GRCm39) missense probably damaging 1.00
R1897:Slit2 UTSW 5 48,395,765 (GRCm39) missense probably damaging 1.00
R1908:Slit2 UTSW 5 48,439,330 (GRCm39) missense probably damaging 1.00
R1919:Slit2 UTSW 5 48,348,358 (GRCm39) unclassified probably benign
R2013:Slit2 UTSW 5 48,459,832 (GRCm39) missense probably damaging 1.00
R2136:Slit2 UTSW 5 48,461,567 (GRCm39) missense probably benign 0.03
R2655:Slit2 UTSW 5 48,346,917 (GRCm39) missense possibly damaging 0.88
R3402:Slit2 UTSW 5 48,440,763 (GRCm39) missense probably damaging 0.98
R3724:Slit2 UTSW 5 48,414,225 (GRCm39) critical splice donor site probably null
R4176:Slit2 UTSW 5 48,394,586 (GRCm39) splice site probably null
R4306:Slit2 UTSW 5 48,460,125 (GRCm39) missense possibly damaging 0.83
R4397:Slit2 UTSW 5 48,377,423 (GRCm39) critical splice donor site probably null
R4525:Slit2 UTSW 5 48,407,215 (GRCm39) missense probably damaging 1.00
R4688:Slit2 UTSW 5 48,414,345 (GRCm39) splice site probably null
R5026:Slit2 UTSW 5 48,414,147 (GRCm39) missense probably damaging 0.99
R5138:Slit2 UTSW 5 48,439,309 (GRCm39) missense probably damaging 1.00
R5465:Slit2 UTSW 5 48,407,254 (GRCm39) missense probably damaging 1.00
R5471:Slit2 UTSW 5 48,346,897 (GRCm39) missense probably damaging 1.00
R5699:Slit2 UTSW 5 48,378,333 (GRCm39) critical splice donor site probably null
R5735:Slit2 UTSW 5 48,416,958 (GRCm39) missense probably damaging 1.00
R5834:Slit2 UTSW 5 48,416,989 (GRCm39) missense probably damaging 1.00
R5967:Slit2 UTSW 5 48,142,506 (GRCm39) missense probably damaging 0.99
R6150:Slit2 UTSW 5 48,461,516 (GRCm39) missense probably damaging 1.00
R6219:Slit2 UTSW 5 48,459,770 (GRCm39) missense possibly damaging 0.53
R6344:Slit2 UTSW 5 48,377,023 (GRCm39) missense probably benign 0.07
R6408:Slit2 UTSW 5 48,142,328 (GRCm39) unclassified probably benign
R6479:Slit2 UTSW 5 48,389,331 (GRCm39) missense probably damaging 1.00
R6526:Slit2 UTSW 5 48,461,509 (GRCm39) missense probably damaging 0.99
R6959:Slit2 UTSW 5 48,395,727 (GRCm39) missense possibly damaging 0.83
R7139:Slit2 UTSW 5 48,402,025 (GRCm39) missense probably benign 0.19
R7201:Slit2 UTSW 5 48,394,627 (GRCm39) missense probably null 0.85
R7472:Slit2 UTSW 5 48,414,180 (GRCm39) missense probably damaging 0.97
R7491:Slit2 UTSW 5 48,377,336 (GRCm39) missense probably benign 0.18
R7566:Slit2 UTSW 5 48,407,239 (GRCm39) missense probably damaging 0.99
R7622:Slit2 UTSW 5 48,142,547 (GRCm39) missense probably damaging 0.98
R7831:Slit2 UTSW 5 48,402,025 (GRCm39) missense probably benign 0.19
R7870:Slit2 UTSW 5 48,459,649 (GRCm39) missense probably damaging 0.99
R7899:Slit2 UTSW 5 48,404,527 (GRCm39) missense possibly damaging 0.89
R7969:Slit2 UTSW 5 48,461,378 (GRCm39) missense possibly damaging 0.47
R7984:Slit2 UTSW 5 48,333,465 (GRCm39) intron probably benign
R8021:Slit2 UTSW 5 48,459,834 (GRCm39) nonsense probably null
R8253:Slit2 UTSW 5 48,433,013 (GRCm39) missense probably benign 0.00
R8321:Slit2 UTSW 5 48,387,609 (GRCm39) missense probably damaging 1.00
R8426:Slit2 UTSW 5 48,382,105 (GRCm39) missense probably benign 0.00
R8513:Slit2 UTSW 5 48,382,050 (GRCm39) nonsense probably null
R8756:Slit2 UTSW 5 48,459,829 (GRCm39) nonsense probably null
R8796:Slit2 UTSW 5 48,460,190 (GRCm39) missense probably benign 0.01
R8799:Slit2 UTSW 5 48,461,524 (GRCm39) missense possibly damaging 0.73
R8947:Slit2 UTSW 5 48,407,140 (GRCm39) missense probably damaging 1.00
R9005:Slit2 UTSW 5 48,459,860 (GRCm39) missense possibly damaging 0.73
R9173:Slit2 UTSW 5 48,377,285 (GRCm39) missense probably damaging 0.98
R9310:Slit2 UTSW 5 48,349,568 (GRCm39) missense possibly damaging 0.59
R9365:Slit2 UTSW 5 48,461,534 (GRCm39) missense probably benign 0.04
Z1088:Slit2 UTSW 5 48,459,695 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GAAAGTAGAAATCTGCAGTTTCTCC -3'
(R):5'- AAGATACTGCCACATCTGCG -3'

Sequencing Primer
(F):5'- AGAAATCTGCAGTTTCTCCATTTTC -3'
(R):5'- CCACATCTGCGGTGATTAATG -3'
Posted On 2014-08-25