Incidental Mutation 'R0137:Lrp4'
| ID |
21999 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lrp4
|
| Ensembl Gene |
ENSMUSG00000027253 |
| Gene Name |
low density lipoprotein receptor-related protein 4 |
| Synonyms |
6430526J12Rik, Megf7, mdig |
| MMRRC Submission |
038422-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.781)
|
| Stock # |
R0137 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
(trace)
|
| Chromosome |
2 |
| Chromosomal Location |
91287856-91344124 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 91325327 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Proline
at position 1384
(L1384P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000028689
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000028689]
|
| AlphaFold |
Q8VI56 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000028689
AA Change: L1384P
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000028689
Gene: ENSMUSG00000027253
AA Change: L1384P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
LDLa
|
26 |
68 |
5.77e-10 |
SMART |
|
LDLa
|
70 |
107 |
4.05e-14 |
SMART |
|
LDLa
|
109 |
145 |
1.9e-10 |
SMART |
|
LDLa
|
147 |
184 |
1.51e-13 |
SMART |
|
LDLa
|
190 |
227 |
6.83e-12 |
SMART |
|
LDLa
|
230 |
267 |
2.45e-13 |
SMART |
|
LDLa
|
269 |
306 |
6.32e-16 |
SMART |
|
LDLa
|
311 |
351 |
3.24e-13 |
SMART |
|
EGF
|
357 |
394 |
1.4e0 |
SMART |
|
EGF_CA
|
395 |
434 |
1.05e-8 |
SMART |
|
LY
|
460 |
502 |
7.01e-10 |
SMART |
|
LY
|
503 |
545 |
4.41e-16 |
SMART |
|
LY
|
546 |
589 |
1.04e-12 |
SMART |
|
LY
|
590 |
632 |
5.07e-16 |
SMART |
|
LY
|
633 |
674 |
3.12e-7 |
SMART |
|
EGF
|
701 |
737 |
9.27e-1 |
SMART |
|
LY
|
765 |
807 |
7.29e-8 |
SMART |
|
LY
|
808 |
850 |
1.92e-16 |
SMART |
|
LY
|
851 |
894 |
3.05e-10 |
SMART |
|
LY
|
895 |
937 |
6.69e-16 |
SMART |
|
LY
|
938 |
979 |
8.71e-6 |
SMART |
|
EGF
|
1005 |
1044 |
1.64e-1 |
SMART |
|
LY
|
1073 |
1115 |
2.58e-8 |
SMART |
|
LY
|
1116 |
1158 |
1.57e-12 |
SMART |
|
LY
|
1159 |
1202 |
7.4e-9 |
SMART |
|
LY
|
1203 |
1245 |
9.39e-11 |
SMART |
|
LY
|
1246 |
1285 |
6.11e-1 |
SMART |
|
EGF
|
1312 |
1349 |
1.53e-1 |
SMART |
|
LY
|
1377 |
1419 |
4.42e-7 |
SMART |
|
LY
|
1420 |
1462 |
1.04e-12 |
SMART |
|
LY
|
1463 |
1506 |
2.11e-13 |
SMART |
|
LY
|
1507 |
1549 |
4.66e-15 |
SMART |
|
LY
|
1550 |
1590 |
2.02e-1 |
SMART |
|
EGF_like
|
1616 |
1649 |
5.79e1 |
SMART |
|
low complexity region
|
1674 |
1690 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1724 |
1746 |
N/A |
INTRINSIC |
|
low complexity region
|
1857 |
1870 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.7892 |
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.2%
- 10x: 96.1%
- 20x: 91.8%
|
| Validation Efficiency |
95% (94/99) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the low-density lipoprotein receptor-related protein family. The encoded protein may be a regulator of Wnt signaling. Mutations in this gene are associated with Cenani-Lenz syndrome. [provided by RefSeq, May 2010]
PHENOTYPE: Homozygous mutations of this gene cause polysyndactyly. Additional phenotypes may include growth retardation, abnormal incisor development, kidney agenesis, and neonatal lethality associated with respiratory failure. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 91 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 6430548M08Rik |
A |
T |
8: 120,878,115 (GRCm39) |
H190L |
possibly damaging |
Het |
| Adap1 |
A |
G |
5: 139,278,976 (GRCm39) |
|
probably benign |
Het |
| Adgra3 |
C |
T |
5: 50,121,182 (GRCm39) |
|
probably benign |
Het |
| Adgre5 |
A |
T |
8: 84,451,527 (GRCm39) |
V527E |
probably damaging |
Het |
| Anapc5 |
A |
T |
5: 122,938,695 (GRCm39) |
Y360N |
probably damaging |
Het |
| Angptl6 |
C |
A |
9: 20,789,683 (GRCm39) |
A70S |
probably benign |
Het |
| Ankdd1a |
C |
A |
9: 65,417,610 (GRCm39) |
K137N |
probably null |
Het |
| Ccdc170 |
T |
C |
10: 4,496,950 (GRCm39) |
|
probably benign |
Het |
| Ccdc51 |
A |
G |
9: 108,920,698 (GRCm39) |
E195G |
probably damaging |
Het |
| Cdc37 |
A |
T |
9: 21,053,426 (GRCm39) |
C204S |
possibly damaging |
Het |
| Cfap36 |
T |
C |
11: 29,172,431 (GRCm39) |
|
probably benign |
Het |
| Col6a2 |
C |
A |
10: 76,432,259 (GRCm39) |
G965C |
probably damaging |
Het |
| Csn1s2a |
G |
A |
5: 87,926,826 (GRCm39) |
S53N |
possibly damaging |
Het |
| Dab2ip |
T |
C |
2: 35,582,388 (GRCm39) |
|
probably null |
Het |
| Dhx58 |
A |
G |
11: 100,587,823 (GRCm39) |
V578A |
probably damaging |
Het |
| Diaph1 |
G |
T |
18: 38,024,902 (GRCm39) |
Q520K |
unknown |
Het |
| Eefsec |
C |
A |
6: 88,274,631 (GRCm39) |
K444N |
probably benign |
Het |
| Eftud2 |
A |
T |
11: 102,759,443 (GRCm39) |
H153Q |
possibly damaging |
Het |
| Eif5b |
T |
G |
1: 38,058,324 (GRCm39) |
S209A |
probably benign |
Het |
| Exosc2 |
T |
A |
2: 31,562,497 (GRCm39) |
Y46N |
probably damaging |
Het |
| F2 |
C |
T |
2: 91,456,075 (GRCm39) |
G562D |
probably damaging |
Het |
| Fgf23 |
G |
A |
6: 127,057,128 (GRCm39) |
G148D |
probably damaging |
Het |
| Fmnl3 |
G |
C |
15: 99,220,619 (GRCm39) |
|
probably benign |
Het |
| Fstl5 |
G |
A |
3: 76,614,786 (GRCm39) |
G179R |
probably damaging |
Het |
| Garre1 |
A |
T |
7: 33,938,644 (GRCm39) |
W246R |
probably damaging |
Het |
| Gart |
T |
A |
16: 91,422,282 (GRCm39) |
Q745L |
probably benign |
Het |
| Gmeb1 |
T |
A |
4: 131,959,419 (GRCm39) |
M212L |
probably benign |
Het |
| Gpaa1 |
T |
C |
15: 76,218,981 (GRCm39) |
Y548H |
probably damaging |
Het |
| Gpatch1 |
T |
C |
7: 34,986,667 (GRCm39) |
E763G |
probably damaging |
Het |
| Grm8 |
T |
A |
6: 27,762,389 (GRCm39) |
I279F |
probably damaging |
Het |
| Hcls1 |
T |
A |
16: 36,771,536 (GRCm39) |
H147Q |
probably damaging |
Het |
| Hpcal1 |
A |
C |
12: 17,836,389 (GRCm39) |
D73A |
probably damaging |
Het |
| Il22ra1 |
T |
C |
4: 135,478,317 (GRCm39) |
S463P |
probably benign |
Het |
| Itgbl1 |
G |
A |
14: 124,078,098 (GRCm39) |
|
probably null |
Het |
| Izumo3 |
G |
T |
4: 92,035,437 (GRCm39) |
|
probably benign |
Het |
| Kcna5 |
A |
T |
6: 126,510,346 (GRCm39) |
L594Q |
probably damaging |
Het |
| Kif13a |
A |
T |
13: 46,918,079 (GRCm39) |
D409E |
probably benign |
Het |
| Kif9 |
A |
T |
9: 110,314,106 (GRCm39) |
I39F |
probably damaging |
Het |
| Klri2 |
C |
T |
6: 129,709,171 (GRCm39) |
R227H |
possibly damaging |
Het |
| Lamc3 |
G |
A |
2: 31,798,628 (GRCm39) |
G445S |
probably damaging |
Het |
| Lctl |
A |
G |
9: 64,024,980 (GRCm39) |
|
probably benign |
Het |
| Mcm9 |
G |
A |
10: 53,439,526 (GRCm39) |
S549L |
possibly damaging |
Het |
| Ms4a15 |
G |
A |
19: 10,956,697 (GRCm39) |
|
probably benign |
Het |
| Mtor |
T |
C |
4: 148,555,081 (GRCm39) |
V901A |
possibly damaging |
Het |
| Nckap1l |
A |
T |
15: 103,390,391 (GRCm39) |
I721F |
probably benign |
Het |
| Nemp2 |
T |
C |
1: 52,684,588 (GRCm39) |
V298A |
probably benign |
Het |
| Npc1l1 |
T |
A |
11: 6,178,148 (GRCm39) |
K421* |
probably null |
Het |
| Npr1 |
C |
T |
3: 90,363,244 (GRCm39) |
V879M |
probably damaging |
Het |
| Odad4 |
A |
G |
11: 100,454,394 (GRCm39) |
E393G |
probably damaging |
Het |
| Or2ad1 |
A |
G |
13: 21,326,336 (GRCm39) |
V297A |
possibly damaging |
Het |
| Or51q1c |
A |
G |
7: 103,652,709 (GRCm39) |
T82A |
probably benign |
Het |
| Osgin1 |
A |
T |
8: 120,169,219 (GRCm39) |
I39F |
possibly damaging |
Het |
| Phip |
G |
C |
9: 82,809,244 (GRCm39) |
|
probably null |
Het |
| Pkdrej |
G |
T |
15: 85,705,768 (GRCm39) |
P56Q |
possibly damaging |
Het |
| Plcxd2 |
A |
G |
16: 45,800,889 (GRCm39) |
Y112H |
probably damaging |
Het |
| Plekha1 |
C |
T |
7: 130,499,176 (GRCm39) |
T155M |
probably damaging |
Het |
| Prkdc |
T |
C |
16: 15,558,196 (GRCm39) |
|
probably null |
Het |
| Prss1 |
A |
G |
6: 41,439,495 (GRCm39) |
H76R |
probably damaging |
Het |
| Psg23 |
T |
C |
7: 18,348,558 (GRCm39) |
D83G |
probably benign |
Het |
| Ptprd |
T |
A |
4: 76,055,140 (GRCm39) |
Q196L |
probably benign |
Het |
| Ranbp3l |
A |
T |
15: 9,063,067 (GRCm39) |
H292L |
probably damaging |
Het |
| Ranbp6 |
T |
C |
19: 29,787,097 (GRCm39) |
E1085G |
probably benign |
Het |
| Rccd1 |
A |
G |
7: 79,970,326 (GRCm39) |
V97A |
possibly damaging |
Het |
| Rchy1 |
T |
C |
5: 92,105,458 (GRCm39) |
S48G |
probably benign |
Het |
| Rnmt |
G |
A |
18: 68,446,771 (GRCm39) |
M265I |
probably benign |
Het |
| Robo3 |
A |
T |
9: 37,336,640 (GRCm39) |
M376K |
probably benign |
Het |
| Rrp12 |
T |
C |
19: 41,862,289 (GRCm39) |
D898G |
probably benign |
Het |
| Scg3 |
A |
T |
9: 75,570,462 (GRCm39) |
|
probably benign |
Het |
| Sec31b |
A |
T |
19: 44,522,821 (GRCm39) |
M57K |
probably damaging |
Het |
| Slc17a6 |
A |
C |
7: 51,315,892 (GRCm39) |
I387L |
probably benign |
Het |
| Speer4a1 |
T |
A |
5: 26,240,982 (GRCm39) |
Q170L |
possibly damaging |
Het |
| Srsf9 |
A |
G |
5: 115,470,260 (GRCm39) |
D146G |
possibly damaging |
Het |
| Ss18 |
A |
G |
18: 14,788,200 (GRCm39) |
M90T |
probably damaging |
Het |
| Syna |
A |
T |
5: 134,588,314 (GRCm39) |
F212I |
possibly damaging |
Het |
| Tex54 |
A |
G |
19: 8,718,221 (GRCm39) |
|
probably benign |
Het |
| Thsd1 |
A |
G |
8: 22,733,055 (GRCm39) |
H34R |
probably damaging |
Het |
| Tmem143 |
T |
C |
7: 45,547,086 (GRCm39) |
I84T |
probably benign |
Het |
| Trim50 |
T |
C |
5: 135,395,487 (GRCm39) |
V281A |
probably damaging |
Het |
| Trp53i11 |
C |
A |
2: 93,029,696 (GRCm39) |
|
probably benign |
Het |
| Ttll4 |
C |
T |
1: 74,718,851 (GRCm39) |
T234I |
possibly damaging |
Het |
| Ttyh1 |
A |
T |
7: 4,127,719 (GRCm39) |
I136F |
possibly damaging |
Het |
| Ube2f |
T |
C |
1: 91,189,976 (GRCm39) |
|
probably benign |
Het |
| Vcl |
T |
A |
14: 21,037,083 (GRCm39) |
L227* |
probably null |
Het |
| Vmn1r222 |
A |
C |
13: 23,416,974 (GRCm39) |
C80G |
probably damaging |
Het |
| Vps13b |
G |
T |
15: 35,926,365 (GRCm39) |
A3889S |
probably benign |
Het |
| Vps8 |
T |
C |
16: 21,323,136 (GRCm39) |
|
probably benign |
Het |
| Zbtb44 |
A |
G |
9: 30,978,006 (GRCm39) |
Y422C |
probably damaging |
Het |
| Zfp180 |
A |
G |
7: 23,805,158 (GRCm39) |
S526G |
possibly damaging |
Het |
| Zfp518a |
A |
C |
19: 40,904,310 (GRCm39) |
E1413A |
probably damaging |
Het |
| Zfp629 |
T |
A |
7: 127,210,858 (GRCm39) |
Y317F |
probably damaging |
Het |
| Zfp804b |
T |
C |
5: 6,820,534 (GRCm39) |
E843G |
probably benign |
Het |
|
| Other mutations in Lrp4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00225:Lrp4
|
APN |
2 |
91,325,371 (GRCm39) |
missense |
probably benign |
|
|
IGL00509:Lrp4
|
APN |
2 |
91,316,519 (GRCm39) |
splice site |
probably benign |
|
|
IGL01145:Lrp4
|
APN |
2 |
91,317,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01287:Lrp4
|
APN |
2 |
91,304,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01531:Lrp4
|
APN |
2 |
91,341,898 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01534:Lrp4
|
APN |
2 |
91,303,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01544:Lrp4
|
APN |
2 |
91,307,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01761:Lrp4
|
APN |
2 |
91,312,326 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01885:Lrp4
|
APN |
2 |
91,331,452 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01909:Lrp4
|
APN |
2 |
91,324,529 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL02111:Lrp4
|
APN |
2 |
91,336,404 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02385:Lrp4
|
APN |
2 |
91,305,065 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02403:Lrp4
|
APN |
2 |
91,338,927 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02431:Lrp4
|
APN |
2 |
91,306,982 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02452:Lrp4
|
APN |
2 |
91,304,347 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02798:Lrp4
|
APN |
2 |
91,307,055 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02828:Lrp4
|
APN |
2 |
91,305,639 (GRCm39) |
missense |
probably benign |
|
|
IGL02832:Lrp4
|
APN |
2 |
91,341,925 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02893:Lrp4
|
APN |
2 |
91,305,161 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
artiodactyl
|
UTSW |
2 |
91,325,339 (GRCm39) |
missense |
probably damaging |
0.99 |
|
bubalus
|
UTSW |
2 |
91,325,300 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
riverhorse
|
UTSW |
2 |
91,310,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
wallow
|
UTSW |
2 |
91,308,043 (GRCm39) |
missense |
probably benign |
0.09 |
|
F5770:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R0037:Lrp4
|
UTSW |
2 |
91,301,548 (GRCm39) |
missense |
probably benign |
0.22 |
|
R0037:Lrp4
|
UTSW |
2 |
91,301,548 (GRCm39) |
missense |
probably benign |
0.22 |
|
R0265:Lrp4
|
UTSW |
2 |
91,321,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0368:Lrp4
|
UTSW |
2 |
91,308,079 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0531:Lrp4
|
UTSW |
2 |
91,305,523 (GRCm39) |
splice site |
probably benign |
|
|
R0827:Lrp4
|
UTSW |
2 |
91,325,386 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1029:Lrp4
|
UTSW |
2 |
91,317,372 (GRCm39) |
splice site |
probably benign |
|
|
R1183:Lrp4
|
UTSW |
2 |
91,307,864 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1587:Lrp4
|
UTSW |
2 |
91,306,650 (GRCm39) |
missense |
probably benign |
0.26 |
|
R1693:Lrp4
|
UTSW |
2 |
91,322,698 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1747:Lrp4
|
UTSW |
2 |
91,322,966 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1863:Lrp4
|
UTSW |
2 |
91,328,708 (GRCm39) |
missense |
probably benign |
0.15 |
|
R1908:Lrp4
|
UTSW |
2 |
91,328,753 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1909:Lrp4
|
UTSW |
2 |
91,328,753 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1932:Lrp4
|
UTSW |
2 |
91,327,700 (GRCm39) |
nonsense |
probably null |
|
|
R1934:Lrp4
|
UTSW |
2 |
91,310,777 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2358:Lrp4
|
UTSW |
2 |
91,332,299 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2433:Lrp4
|
UTSW |
2 |
91,336,360 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2698:Lrp4
|
UTSW |
2 |
91,305,557 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2919:Lrp4
|
UTSW |
2 |
91,321,075 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3105:Lrp4
|
UTSW |
2 |
91,331,394 (GRCm39) |
missense |
probably benign |
|
|
R3709:Lrp4
|
UTSW |
2 |
91,320,811 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R3711:Lrp4
|
UTSW |
2 |
91,332,299 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3735:Lrp4
|
UTSW |
2 |
91,328,716 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3808:Lrp4
|
UTSW |
2 |
91,307,047 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3894:Lrp4
|
UTSW |
2 |
91,304,294 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3895:Lrp4
|
UTSW |
2 |
91,304,294 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4397:Lrp4
|
UTSW |
2 |
91,342,015 (GRCm39) |
missense |
probably benign |
0.20 |
|
R4741:Lrp4
|
UTSW |
2 |
91,341,912 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4948:Lrp4
|
UTSW |
2 |
91,316,231 (GRCm39) |
missense |
probably benign |
|
|
R5050:Lrp4
|
UTSW |
2 |
91,322,767 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5096:Lrp4
|
UTSW |
2 |
91,316,137 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R5110:Lrp4
|
UTSW |
2 |
91,327,417 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R5141:Lrp4
|
UTSW |
2 |
91,309,023 (GRCm39) |
splice site |
probably benign |
|
|
R5439:Lrp4
|
UTSW |
2 |
91,327,418 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5725:Lrp4
|
UTSW |
2 |
91,325,240 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5795:Lrp4
|
UTSW |
2 |
91,304,816 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5820:Lrp4
|
UTSW |
2 |
91,322,960 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5883:Lrp4
|
UTSW |
2 |
91,318,778 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5919:Lrp4
|
UTSW |
2 |
91,303,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5925:Lrp4
|
UTSW |
2 |
91,342,029 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6080:Lrp4
|
UTSW |
2 |
91,332,345 (GRCm39) |
missense |
probably benign |
|
|
R6189:Lrp4
|
UTSW |
2 |
91,305,579 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R6192:Lrp4
|
UTSW |
2 |
91,338,833 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6319:Lrp4
|
UTSW |
2 |
91,310,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6378:Lrp4
|
UTSW |
2 |
91,324,174 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6479:Lrp4
|
UTSW |
2 |
91,317,429 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6500:Lrp4
|
UTSW |
2 |
91,322,765 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6643:Lrp4
|
UTSW |
2 |
91,332,340 (GRCm39) |
missense |
probably benign |
|
|
R6657:Lrp4
|
UTSW |
2 |
91,322,398 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6696:Lrp4
|
UTSW |
2 |
91,327,690 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6714:Lrp4
|
UTSW |
2 |
91,306,710 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6734:Lrp4
|
UTSW |
2 |
91,316,242 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R6770:Lrp4
|
UTSW |
2 |
91,327,648 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6774:Lrp4
|
UTSW |
2 |
91,341,849 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6957:Lrp4
|
UTSW |
2 |
91,317,387 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6978:Lrp4
|
UTSW |
2 |
91,322,343 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7065:Lrp4
|
UTSW |
2 |
91,341,925 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7142:Lrp4
|
UTSW |
2 |
91,325,339 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7219:Lrp4
|
UTSW |
2 |
91,322,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7237:Lrp4
|
UTSW |
2 |
91,303,528 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7387:Lrp4
|
UTSW |
2 |
91,306,959 (GRCm39) |
missense |
probably benign |
|
|
R7585:Lrp4
|
UTSW |
2 |
91,322,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7835:Lrp4
|
UTSW |
2 |
91,325,387 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7872:Lrp4
|
UTSW |
2 |
91,321,061 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R7968:Lrp4
|
UTSW |
2 |
91,324,424 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R8222:Lrp4
|
UTSW |
2 |
91,305,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8338:Lrp4
|
UTSW |
2 |
91,322,713 (GRCm39) |
missense |
probably benign |
0.15 |
|
R8342:Lrp4
|
UTSW |
2 |
91,318,790 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8435:Lrp4
|
UTSW |
2 |
91,307,998 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8720:Lrp4
|
UTSW |
2 |
91,324,459 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8774:Lrp4
|
UTSW |
2 |
91,308,043 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8774-TAIL:Lrp4
|
UTSW |
2 |
91,308,043 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8792:Lrp4
|
UTSW |
2 |
91,325,300 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8913:Lrp4
|
UTSW |
2 |
91,331,785 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9017:Lrp4
|
UTSW |
2 |
91,324,397 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R9062:Lrp4
|
UTSW |
2 |
91,303,925 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9118:Lrp4
|
UTSW |
2 |
91,308,927 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9640:Lrp4
|
UTSW |
2 |
91,316,296 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9649:Lrp4
|
UTSW |
2 |
91,338,914 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9708:Lrp4
|
UTSW |
2 |
91,342,076 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9748:Lrp4
|
UTSW |
2 |
91,316,116 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9776:Lrp4
|
UTSW |
2 |
91,316,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
V7580:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
V7581:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
V7582:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
V7583:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
X0021:Lrp4
|
UTSW |
2 |
91,331,407 (GRCm39) |
missense |
probably benign |
0.16 |
|
| Predicted Primers |
PCR Primer
(F):5'- TAGCCTCTCAGGTTGGGTGTGAAC -3'
(R):5'- TCTAACTCCATGTCAAACGGCCAAG -3'
Sequencing Primer
(F):5'- GGTGTGAACACTCTAGCCTC -3'
(R):5'- AAGCCATCCAGTCCGCTTATTC -3'
|
| Posted On |
2013-04-12 |
Incidental Mutation