Incidental Mutation 'R2024:Meioc'
ID 220329
Institutional Source Beutler Lab
Gene Symbol Meioc
Ensembl Gene ENSMUSG00000051455
Gene Name meiosis specific with coiled-coil domain
Synonyms Gm1564, LOC380729, LOC268491
MMRRC Submission 040033-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.117) question?
Stock # R2024 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 102663716-102682237 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to T at 102675358 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Alanine to Valine at position 600 (A600V)
Ref Sequence ENSEMBL: ENSMUSP00000097947 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100378] [ENSMUST00000156590]
AlphaFold A2AG06
Predicted Effect probably benign
Transcript: ENSMUST00000100378
AA Change: A600V

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000097947
Gene: ENSMUSG00000051455
AA Change: A600V

DomainStartEndE-ValueType
low complexity region 526 537 N/A INTRINSIC
low complexity region 712 728 N/A INTRINSIC
Pfam:DUF4582 757 922 5.1e-89 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155813
Predicted Effect probably benign
Transcript: ENSMUST00000156590
SMART Domains Protein: ENSMUSP00000116246
Gene: ENSMUSG00000051455

DomainStartEndE-ValueType
low complexity region 470 481 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.1%
  • 20x: 90.8%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit infertility with small gonads, absent germ cells and arrested meiosis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arid2 A G 15: 96,361,799 (GRCm38) D280G probably damaging Het
Atosa A G 9: 75,010,390 (GRCm38) D757G probably damaging Het
Azi2 C T 9: 118,049,322 (GRCm38) R77* probably null Het
Chd8 T C 14: 52,231,493 (GRCm38) D556G probably benign Het
Cit T C 5: 115,947,924 (GRCm38) M849T probably damaging Het
Cit T C 5: 116,005,840 (GRCm38) S1923P probably damaging Het
Col17a1 T A 19: 47,650,746 (GRCm38) H1120L probably benign Het
Col6a5 G T 9: 105,936,994 (GRCm38) H606Q unknown Het
Dnajc2 A C 5: 21,776,790 (GRCm38) H45Q probably damaging Het
Dpp6 A G 5: 27,709,459 (GRCm38) D514G possibly damaging Het
Dync2h1 A G 9: 7,129,062 (GRCm38) S1818P probably damaging Het
Efemp1 A T 11: 28,914,696 (GRCm38) Y250F possibly damaging Het
Emc1 G A 4: 139,360,946 (GRCm38) E342K possibly damaging Het
Fam3c T C 6: 22,329,593 (GRCm38) D45G probably benign Het
Fchsd2 A C 7: 101,198,533 (GRCm38) D210A possibly damaging Het
Flg T A 3: 93,279,415 (GRCm38) M58K probably damaging Het
Gabra5 G A 7: 57,488,950 (GRCm38) R117C probably damaging Het
Gm6741 G A 17: 91,236,881 (GRCm38) S24N probably benign Het
Grin2a T C 16: 9,644,243 (GRCm38) D675G possibly damaging Het
Hectd4 T G 5: 121,281,918 (GRCm38) V642G possibly damaging Het
Herc6 C T 6: 57,583,332 (GRCm38) T119M probably benign Het
Hjurp GT GTT 1: 88,266,524 (GRCm38) probably null Het
Hmgcs2 T C 3: 98,299,214 (GRCm38) S371P probably damaging Het
Idua C T 5: 108,680,734 (GRCm38) A271V probably damaging Het
Inpp5d T A 1: 87,695,350 (GRCm38) C125* probably null Het
Krt14 C T 11: 100,207,218 (GRCm38) G80R unknown Het
Lama5 T C 2: 180,179,130 (GRCm38) Y3176C probably benign Het
Lce1k C T 3: 92,806,502 (GRCm38) C125Y unknown Het
Lig4 A T 8: 9,972,436 (GRCm38) L448Q probably damaging Het
Macf1 C T 4: 123,371,918 (GRCm38) A4821T probably damaging Het
Mepe T C 5: 104,327,091 (GRCm38) S13P possibly damaging Het
Mms22l A G 4: 24,588,365 (GRCm38) Y999C probably damaging Het
Ncbp3 T A 11: 73,053,520 (GRCm38) M116K possibly damaging Het
Ndufa10 A G 1: 92,439,892 (GRCm38) Y339H probably damaging Het
Nkx3-1 T C 14: 69,190,817 (GRCm38) I38T probably damaging Het
Nup155 A T 15: 8,157,760 (GRCm38) H1391L probably damaging Het
Or4k49 T A 2: 111,664,823 (GRCm38) M199K possibly damaging Het
Padi6 T G 4: 140,728,968 (GRCm38) I572L possibly damaging Het
Pdss2 A T 10: 43,393,875 (GRCm38) N238I possibly damaging Het
Pkd1l2 A G 8: 117,019,533 (GRCm38) V1906A probably benign Het
Pom121 T C 5: 135,381,550 (GRCm38) probably benign Het
Psmd9 T C 5: 123,241,862 (GRCm38) F115L probably damaging Het
Ptch1 T G 13: 63,524,959 (GRCm38) E944A probably benign Het
Rai1 T C 11: 60,185,589 (GRCm38) F160L probably damaging Het
Rhbdl2 A T 4: 123,826,872 (GRCm38) R234S probably damaging Het
Rnase2a T A 14: 51,255,788 (GRCm38) Y40F probably damaging Het
Setd2 T C 9: 110,549,133 (GRCm38) V672A possibly damaging Het
Sgpp2 A G 1: 78,417,220 (GRCm38) I287V probably benign Het
Sh3pxd2a T C 19: 47,267,264 (GRCm38) E1033G probably benign Het
Slc5a9 G A 4: 111,890,531 (GRCm38) T284I probably damaging Het
Slfn9 A G 11: 82,981,681 (GRCm38) L743P probably damaging Het
Smchd1 T A 17: 71,370,928 (GRCm38) N1473I probably benign Het
Stx1b A T 7: 127,815,403 (GRCm38) D16E probably benign Het
Tectb T C 19: 55,181,929 (GRCm38) F71L probably damaging Het
Tmem220 T C 11: 67,034,153 (GRCm38) I138T possibly damaging Het
Tmtc4 T C 14: 122,921,265 (GRCm38) N682S probably benign Het
Tnc A G 4: 63,964,621 (GRCm38) V1921A probably damaging Het
Ubn1 T G 16: 5,064,623 (GRCm38) L316W probably damaging Het
Vwa5a T C 9: 38,736,061 (GRCm38) S579P probably damaging Het
Xdh A G 17: 73,921,305 (GRCm38) L367P possibly damaging Het
Zfp280b T C 10: 76,038,494 (GRCm38) L69S probably damaging Het
Zfp990 A C 4: 145,537,404 (GRCm38) Y324S possibly damaging Het
Other mutations in Meioc
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01391:Meioc APN 11 102,674,287 (GRCm38) missense probably benign 0.33
IGL01952:Meioc APN 11 102,672,185 (GRCm38) missense possibly damaging 0.79
IGL02006:Meioc APN 11 102,674,266 (GRCm38) missense probably damaging 1.00
IGL02195:Meioc APN 11 102,674,857 (GRCm38) missense possibly damaging 0.91
IGL02339:Meioc APN 11 102,668,448 (GRCm38) missense probably benign 0.18
IGL02935:Meioc APN 11 102,672,191 (GRCm38) missense probably benign 0.06
IGL03294:Meioc APN 11 102,680,669 (GRCm38) missense probably damaging 1.00
PIT4519001:Meioc UTSW 11 102,679,957 (GRCm38) missense probably damaging 1.00
R0285:Meioc UTSW 11 102,672,191 (GRCm38) missense probably benign 0.06
R0964:Meioc UTSW 11 102,680,031 (GRCm38) missense probably damaging 1.00
R1074:Meioc UTSW 11 102,675,393 (GRCm38) missense probably damaging 1.00
R4012:Meioc UTSW 11 102,675,828 (GRCm38) missense probably damaging 0.99
R4429:Meioc UTSW 11 102,675,720 (GRCm38) missense probably damaging 1.00
R4491:Meioc UTSW 11 102,674,920 (GRCm38) missense possibly damaging 0.84
R4594:Meioc UTSW 11 102,674,166 (GRCm38) missense probably damaging 1.00
R4752:Meioc UTSW 11 102,674,433 (GRCm38) missense probably benign 0.00
R5301:Meioc UTSW 11 102,680,045 (GRCm38) missense probably damaging 1.00
R5352:Meioc UTSW 11 102,675,313 (GRCm38) missense probably benign 0.03
R5646:Meioc UTSW 11 102,675,257 (GRCm38) missense possibly damaging 0.94
R5958:Meioc UTSW 11 102,675,153 (GRCm38) missense probably benign 0.41
R5968:Meioc UTSW 11 102,675,831 (GRCm38) missense probably damaging 0.99
R6157:Meioc UTSW 11 102,668,401 (GRCm38) missense probably damaging 1.00
R6410:Meioc UTSW 11 102,675,034 (GRCm38) missense probably benign 0.00
R6644:Meioc UTSW 11 102,668,460 (GRCm38) critical splice donor site probably null
R7285:Meioc UTSW 11 102,666,342 (GRCm38) missense probably benign 0.00
R7440:Meioc UTSW 11 102,674,237 (GRCm38) missense possibly damaging 0.67
R7815:Meioc UTSW 11 102,675,588 (GRCm38) missense probably damaging 1.00
R7984:Meioc UTSW 11 102,674,606 (GRCm38) missense possibly damaging 0.94
R8009:Meioc UTSW 11 102,676,743 (GRCm38) missense probably damaging 1.00
R8078:Meioc UTSW 11 102,668,400 (GRCm38) nonsense probably null
R8195:Meioc UTSW 11 102,675,067 (GRCm38) nonsense probably null
R8429:Meioc UTSW 11 102,674,206 (GRCm38) missense probably benign 0.06
R8797:Meioc UTSW 11 102,676,860 (GRCm38) nonsense probably null
R8854:Meioc UTSW 11 102,675,763 (GRCm38) missense probably damaging 0.98
R8891:Meioc UTSW 11 102,668,420 (GRCm38) missense probably benign 0.43
R9081:Meioc UTSW 11 102,674,175 (GRCm38) missense probably benign 0.00
R9360:Meioc UTSW 11 102,674,953 (GRCm38) missense probably benign 0.13
R9539:Meioc UTSW 11 102,674,680 (GRCm38) missense probably damaging 0.99
R9549:Meioc UTSW 11 102,665,724 (GRCm38) intron probably benign
R9751:Meioc UTSW 11 102,675,593 (GRCm38) nonsense probably null
Z1177:Meioc UTSW 11 102,666,364 (GRCm38) frame shift probably null
Predicted Primers PCR Primer
(F):5'- GTATTGCCAAGAAAACCCTTCAGC -3'
(R):5'- AAAAGCATGAGGCCTGTGTG -3'

Sequencing Primer
(F):5'- CAAGAAAACCCTTCAGCATTTTCTAG -3'
(R):5'- AGGCCTGTGTGCGATTCAC -3'
Posted On 2014-08-25