|Institutional Source||Beutler Lab|
|Gene Name||insulin-like growth factor 2 mRNA binding protein 1|
|Synonyms||IMP-1, Zbp1, D030026A21Rik, D11Moh45, CRD-BP, D11Moh40e, Crdbp|
|Essential gene?||Possibly non essential (E-score: 0.273)|
|Stock #||R2025 (G1)|
|Chromosomal Location||95957163-96005940 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to G at 95974170 bp (GRCm38)|
|Amino Acid Change||Valine to Alanine at position 151 (V151A)|
|Ref Sequence||ENSEMBL: ENSMUSP00000013559 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000013559]|
AA Change: V151A
PolyPhen 2 Score 0.952 (Sensitivity: 0.79; Specificity: 0.95)
AA Change: V151A
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
PHENOTYPE: Homozygous mutation of this locus results in increased neonatal lethality, growth retardation, and impaired intestinal development. Males exhibit increased anxiety-like response and decreased exploratory behavior. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Igf2bp1||
(F):5'- CTCCTTGCCAATGATAGCGC -3'
(R):5'- ACGTTCCCTAGTGATGGAGGTG -3'
(F):5'- TGATAGCGCCTACATACTGCGTAG -3'
(R):5'- TAGGAGACAGATGGTTAGCTCCAC -3'