Mutagenetix > Incidental Mutation

Incidental Mutation 'R0137:Prkdc'

22066

Institutional Source

Beutler Lab

Gene Symbol

Prkdc

Ensembl Gene

ENSMUSG00000022672

Gene Name

protein kinase, DNA activated, catalytic polypeptide

Synonyms

slip, DOXNPH, DNA-PKcs, XRCC7, dxnph, DNA-PK, DNAPDcs

MMRRC Submission

038422-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.948) question?

Stock #

R0137 (G1)

Quality Score

225

Status

Validated (trace)

Chromosome

Chromosomal Location

15637866-15842235 bp(+) (GRCm38)

Type of Mutation

critical splice donor site (2 bp from exon)

DNA Base Change (assembly)

T to C at 15740332 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000023352 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000023352]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000023352

SMART Domains

Protein: ENSMUSP00000023352
Gene: ENSMUSG00000022672

Domain	Start	End	E-Value	Type
low complexity region	125	138	N/A	INTRINSIC
low complexity region	1253	1263	N/A	INTRINSIC
low complexity region	1508	1522	N/A	INTRINSIC
NUC194	1810	2206	2.37e-246	SMART
SCOP:d1gw5a_	2210	2493	5e-3	SMART
low complexity region	2669	2681	N/A	INTRINSIC
low complexity region	2841	2855	N/A	INTRINSIC
Pfam:FAT	3024	3470	8.2e-75	PFAM
PI3Kc	3749	4068	3.67e-86	SMART
FATC	4096	4128	1.57e-9	SMART

Meta Mutation Damage Score

0.9480

Coding Region Coverage

1x: 99.0%
3x: 98.2%
10x: 96.1%
20x: 91.8%

Validation Efficiency

95% (94/99)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010]
PHENOTYPE: Mutations at this locus effect genome stability, radiation sensitivity and DNA repair. Nonsense (scid) and null homozygotes have severe combined immunodeficiency. A BALB/c variant allele reduces enzyme activity and predisposes to breast cancer. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 91 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700092M07Rik	A	G	19: 8,740,857		probably benign	Het
4931406P16Rik	A	T	7: 34,239,219	W246R	probably damaging	Het
6430548M08Rik	A	T	8: 120,151,376	H190L	possibly damaging	Het
Adap1	A	G	5: 139,293,221		probably benign	Het
Adgra3	C	T	5: 49,963,840		probably benign	Het
Adgre5	A	T	8: 83,724,898	V527E	probably damaging	Het
Anapc5	A	T	5: 122,800,632	Y360N	probably damaging	Het
Angptl6	C	A	9: 20,878,387	A70S	probably benign	Het
Ankdd1a	C	A	9: 65,510,328	K137N	probably null	Het
Ccdc170	T	C	10: 4,546,950		probably benign	Het
Ccdc51	A	G	9: 109,091,630	E195G	probably damaging	Het
Cdc37	A	T	9: 21,142,130	C204S	possibly damaging	Het
Cfap36	T	C	11: 29,222,431		probably benign	Het
Col6a2	C	A	10: 76,596,425	G965C	probably damaging	Het
Csn1s2a	G	A	5: 87,778,967	S53N	possibly damaging	Het
Dab2ip	T	C	2: 35,692,376		probably null	Het
Dhx58	A	G	11: 100,696,997	V578A	probably damaging	Het
Diaph1	G	T	18: 37,891,849	Q520K	unknown	Het
Eefsec	C	A	6: 88,297,649	K444N	probably benign	Het
Eftud2	A	T	11: 102,868,617	H153Q	possibly damaging	Het
Eif5b	T	G	1: 38,019,243	S209A	probably benign	Het
Exosc2	T	A	2: 31,672,485	Y46N	probably damaging	Het
F2	C	T	2: 91,625,730	G562D	probably damaging	Het
Fgf23	G	A	6: 127,080,165	G148D	probably damaging	Het
Fmnl3	G	C	15: 99,322,738		probably benign	Het
Fstl5	G	A	3: 76,707,479	G179R	probably damaging	Het
Gart	T	A	16: 91,625,394	Q745L	probably benign	Het
Gmeb1	T	A	4: 132,232,108	M212L	probably benign	Het
Gpaa1	T	C	15: 76,334,781	Y548H	probably damaging	Het
Gpatch1	T	C	7: 35,287,242	E763G	probably damaging	Het
Grm8	T	A	6: 27,762,390	I279F	probably damaging	Het
Hcls1	T	A	16: 36,951,174	H147Q	probably damaging	Het
Hpcal1	A	C	12: 17,786,388	D73A	probably damaging	Het
Il22ra1	T	C	4: 135,751,006	S463P	probably benign	Het
Itgbl1	G	A	14: 123,840,686		probably null	Het
Izumo3	G	T	4: 92,147,200		probably benign	Het
Kcna5	A	T	6: 126,533,383	L594Q	probably damaging	Het
Kif13a	A	T	13: 46,764,603	D409E	probably benign	Het
Kif9	A	T	9: 110,485,038	I39F	probably damaging	Het
Klri2	C	T	6: 129,732,208	R227H	possibly damaging	Het
Lamc3	G	A	2: 31,908,616	G445S	probably damaging	Het
Lctl	A	G	9: 64,117,698		probably benign	Het
Lrp4	T	C	2: 91,494,982	L1384P	probably damaging	Het
Mcm9	G	A	10: 53,563,430	S549L	possibly damaging	Het
Ms4a15	G	A	19: 10,979,333		probably benign	Het
Mtor	T	C	4: 148,470,624	V901A	possibly damaging	Het
Nckap1l	A	T	15: 103,481,964	I721F	probably benign	Het
Nemp2	T	C	1: 52,645,429	V298A	probably benign	Het
Npc1l1	T	A	11: 6,228,148	K421*	probably null	Het
Npr1	C	T	3: 90,455,937	V879M	probably damaging	Het
Olfr1368	A	G	13: 21,142,166	V297A	possibly damaging	Het
Olfr638	A	G	7: 104,003,502	T82A	probably benign	Het
Osgin1	A	T	8: 119,442,480	I39F	possibly damaging	Het
Phip	G	C	9: 82,927,191		probably null	Het
Pkdrej	G	T	15: 85,821,567	P56Q	possibly damaging	Het
Plcxd2	A	G	16: 45,980,526	Y112H	probably damaging	Het
Plekha1	C	T	7: 130,897,446	T155M	probably damaging	Het
Prss1	A	G	6: 41,462,561	H76R	probably damaging	Het
Psg23	T	C	7: 18,614,633	D83G	probably benign	Het
Ptprd	T	A	4: 76,136,903	Q196L	probably benign	Het
Ranbp3l	A	T	15: 9,062,987	H292L	probably damaging	Het
Ranbp6	T	C	19: 29,809,697	E1085G	probably benign	Het
Rccd1	A	G	7: 80,320,578	V97A	possibly damaging	Het
Rchy1	T	C	5: 91,957,599	S48G	probably benign	Het
Rnmt	G	A	18: 68,313,700	M265I	probably benign	Het
Robo3	A	T	9: 37,425,344	M376K	probably benign	Het
Rrp12	T	C	19: 41,873,850	D898G	probably benign	Het
Scg3	A	T	9: 75,663,180		probably benign	Het
Sec31b	A	T	19: 44,534,382	M57K	probably damaging	Het
Slc17a6	A	C	7: 51,666,144	I387L	probably benign	Het
Speer4a	T	A	5: 26,035,984	Q170L	possibly damaging	Het
Srsf9	A	G	5: 115,332,201	D146G	possibly damaging	Het
Ss18	A	G	18: 14,655,143	M90T	probably damaging	Het
Syna	A	T	5: 134,559,460	F212I	possibly damaging	Het
Thsd1	A	G	8: 22,243,039	H34R	probably damaging	Het
Tmem143	T	C	7: 45,897,662	I84T	probably benign	Het
Trim50	T	C	5: 135,366,633	V281A	probably damaging	Het
Trp53i11	C	A	2: 93,199,351		probably benign	Het
Ttc25	A	G	11: 100,563,568	E393G	probably damaging	Het
Ttll4	C	T	1: 74,679,692	T234I	possibly damaging	Het
Ttyh1	A	T	7: 4,124,720	I136F	possibly damaging	Het
Ube2f	T	C	1: 91,262,254		probably benign	Het
Vcl	T	A	14: 20,987,015	L227*	probably null	Het
Vmn1r222	A	C	13: 23,232,804	C80G	probably damaging	Het
Vps13b	G	T	15: 35,926,219	A3889S	probably benign	Het
Vps8	T	C	16: 21,504,386		probably benign	Het
Zbtb44	A	G	9: 31,066,710	Y422C	probably damaging	Het
Zfp180	A	G	7: 24,105,733	S526G	possibly damaging	Het
Zfp518a	A	C	19: 40,915,866	E1413A	probably damaging	Het
Zfp629	T	A	7: 127,611,686	Y317F	probably damaging	Het
Zfp804b	T	C	5: 6,770,534	E843G	probably benign	Het

Other mutations in Prkdc

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00157:Prkdc	APN	16	15697226	missense	probably damaging	1.00
IGL00225:Prkdc	APN	16	15809644	missense	possibly damaging	0.64
IGL00481:Prkdc	APN	16	15790466	missense	probably benign	0.41
IGL00488:Prkdc	APN	16	15775847	splice site	probably null
IGL00489:Prkdc	APN	16	15799926	missense	possibly damaging	0.51
IGL00579:Prkdc	APN	16	15664239	missense	probably damaging	1.00
IGL00587:Prkdc	APN	16	15652358	splice site	probably benign
IGL00666:Prkdc	APN	16	15736835	missense	probably damaging	1.00
IGL00675:Prkdc	APN	16	15787158	missense	probably benign	0.05
IGL00708:Prkdc	APN	16	15779426	missense	probably damaging	0.97
IGL00725:Prkdc	APN	16	15816639	missense	probably benign	0.10
IGL00818:Prkdc	APN	16	15759754	missense	possibly damaging	0.92
IGL00917:Prkdc	APN	16	15739564	missense	probably damaging	0.98
IGL00990:Prkdc	APN	16	15702115	missense	probably benign	0.03
IGL01126:Prkdc	APN	16	15669321	missense	probably benign	0.01
IGL01141:Prkdc	APN	16	15726704	missense	probably damaging	0.99
IGL01306:Prkdc	APN	16	15667731	missense	possibly damaging	0.67
IGL01326:Prkdc	APN	16	15829692	missense	probably benign
IGL01335:Prkdc	APN	16	15816896	critical splice donor site	probably null
IGL01419:Prkdc	APN	16	15835166	missense	probably damaging	1.00
IGL01434:Prkdc	APN	16	15713587	missense	probably benign	0.00
IGL01554:Prkdc	APN	16	15652302	missense	probably benign	0.05
IGL01671:Prkdc	APN	16	15667745	missense	possibly damaging	0.90
IGL01871:Prkdc	APN	16	15783087	missense	probably benign	0.00
IGL01874:Prkdc	APN	16	15734994	missense	possibly damaging	0.89
IGL01930:Prkdc	APN	16	15698887	missense	probably damaging	1.00
IGL01984:Prkdc	APN	16	15708779	missense	probably benign
IGL02121:Prkdc	APN	16	15717184	missense	probably benign	0.18
IGL02152:Prkdc	APN	16	15669285	missense	probably benign	0.15
IGL02172:Prkdc	APN	16	15809759	missense	probably benign	0.10
IGL02336:Prkdc	APN	16	15785978	missense	possibly damaging	0.47
IGL02336:Prkdc	APN	16	15785979	missense	probably benign	0.01
IGL02393:Prkdc	APN	16	15816758	missense	probably benign	0.42
IGL02406:Prkdc	APN	16	15670535	missense	probably benign	0.00
IGL02500:Prkdc	APN	16	15714282	critical splice donor site	probably null
IGL02568:Prkdc	APN	16	15726542	missense	probably damaging	0.98
IGL02579:Prkdc	APN	16	15670601	missense	possibly damaging	0.83
IGL02652:Prkdc	APN	16	15783087	missense	probably benign	0.00
IGL02661:Prkdc	APN	16	15769825	missense	possibly damaging	0.92
IGL02685:Prkdc	APN	16	15836043	missense	possibly damaging	0.61
IGL02741:Prkdc	APN	16	15752726	splice site	probably benign
IGL02803:Prkdc	APN	16	15833666	splice site	probably benign
IGL02866:Prkdc	APN	16	15831327	missense	probably damaging	1.00
IGL02882:Prkdc	APN	16	15651519	nonsense	probably null
IGL02989:Prkdc	APN	16	15800016	missense	possibly damaging	0.67
IGL03053:Prkdc	APN	16	15834166	missense	probably benign	0.02
IGL03071:Prkdc	APN	16	15799984	missense	probably benign	0.01
IGL03091:Prkdc	APN	16	15705310	splice site	probably benign
IGL03100:Prkdc	APN	16	15713635	missense	probably benign	0.08
IGL03128:Prkdc	APN	16	15700744	splice site	probably benign
IGL03168:Prkdc	APN	16	15834166	missense	probably benign	0.02
IGL03204:Prkdc	APN	16	15769801	missense	probably benign	0.01
IGL03390:Prkdc	APN	16	15670626	nonsense	probably null
anhimid	UTSW	16	15725461	critical splice donor site	probably null
anhinga	UTSW	16	15708932	critical splice donor site	probably null
Bushtit	UTSW	16	15752764	missense	probably damaging	0.97
clover	UTSW	16	15702156	splice site	probably benign
crackle	UTSW	16	15786050	critical splice donor site	probably null
Daffy	UTSW	16	15829697	missense	possibly damaging	0.86
darter	UTSW	16	15773613	missense	possibly damaging	0.93
Elmer_fudd	UTSW	16	15808058	missense	probably benign	0.01
envenomation	UTSW	16	15835227	nonsense	probably null
hobgoblin	UTSW	16	15815986	missense	probably damaging	1.00
Incubus	UTSW	16	15672327	missense	probably damaging	1.00
liming	UTSW	16	15752829	nonsense	probably null
newt	UTSW	16	15727726	missense	probably benign	0.04
ornithorhynchus	UTSW	16	15816659	critical splice donor site	probably null
primitive	UTSW	16	15835158	frame shift	probably null
roadrunner	UTSW	16	15833887	missense	probably damaging	1.00
Schreier	UTSW	16	15670528	missense	probably benign	0.00
screamer	UTSW	16	15831282	nonsense	probably null
Screamer10	UTSW	16	15768025	missense	probably damaging	0.98
screamer2	UTSW	16	15652552	critical splice donor site	probably null
screamer3	UTSW	16	15740332	critical splice donor site	probably null
screamer4	UTSW	16	15783079	missense	probably benign	0.00
screamer5	UTSW	16	15687404	missense	probably benign
screamer6	UTSW	16	15759605	missense	probably damaging	1.00
screamer7	UTSW	16	15654817	splice site	probably null
Screamer8	UTSW	16	15719433	missense	probably benign	0.00
Screamer9	UTSW	16	15734922	missense	probably benign	0.01
Tweetie	UTSW	16	15717801	missense	probably damaging	1.00
updock	UTSW	16	15795094	missense	probably benign
ANU23:Prkdc	UTSW	16	15667731	missense	possibly damaging	0.67
R0008:Prkdc	UTSW	16	15708701	splice site	probably benign
R0018:Prkdc	UTSW	16	15726542	missense	probably benign	0.03
R0018:Prkdc	UTSW	16	15726542	missense	probably benign	0.03
R0069:Prkdc	UTSW	16	15726504	missense	probably benign	0.03
R0125:Prkdc	UTSW	16	15699007	missense	probably damaging	0.98
R0131:Prkdc	UTSW	16	15713653	missense	probably benign	0.09
R0131:Prkdc	UTSW	16	15713653	missense	probably benign	0.09
R0132:Prkdc	UTSW	16	15713653	missense	probably benign	0.09
R0334:Prkdc	UTSW	16	15736799	missense	probably benign	0.00
R0373:Prkdc	UTSW	16	15791927	missense	probably damaging	1.00
R0485:Prkdc	UTSW	16	15833740	missense	probably damaging	0.97
R0511:Prkdc	UTSW	16	15831282	nonsense	probably null
R0538:Prkdc	UTSW	16	15833788	missense	probably damaging	1.00
R0595:Prkdc	UTSW	16	15808088	missense	probably damaging	1.00
R0607:Prkdc	UTSW	16	15772057	missense	probably damaging	0.98
R0616:Prkdc	UTSW	16	15690407	missense	probably damaging	1.00
R0630:Prkdc	UTSW	16	15810801	missense	probably damaging	1.00
R0694:Prkdc	UTSW	16	15768637	missense	probably damaging	1.00
R0702:Prkdc	UTSW	16	15785971	missense	possibly damaging	0.95
R0965:Prkdc	UTSW	16	15829716	missense	probably benign
R1027:Prkdc	UTSW	16	15650712	missense	possibly damaging	0.80
R1029:Prkdc	UTSW	16	15654749	splice site	probably benign
R1033:Prkdc	UTSW	16	15767951	missense	probably damaging	1.00
R1067:Prkdc	UTSW	16	15752782	missense	probably damaging	0.99
R1116:Prkdc	UTSW	16	15783079	missense	probably benign	0.00
R1187:Prkdc	UTSW	16	15759746	missense	probably damaging	0.98
R1226:Prkdc	UTSW	16	15673997	missense	possibly damaging	0.80
R1279:Prkdc	UTSW	16	15690282	missense	probably damaging	1.00
R1304:Prkdc	UTSW	16	15759723	missense	probably damaging	0.99
R1314:Prkdc	UTSW	16	15664227	missense	possibly damaging	0.68
R1351:Prkdc	UTSW	16	15667700	missense	possibly damaging	0.62
R1509:Prkdc	UTSW	16	15731566	missense	probably damaging	1.00
R1512:Prkdc	UTSW	16	15687404	missense	probably benign
R1531:Prkdc	UTSW	16	15772106	missense	probably benign	0.01
R1579:Prkdc	UTSW	16	15675328	missense	probably benign	0.00
R1669:Prkdc	UTSW	16	15734058	missense	probably damaging	1.00
R1682:Prkdc	UTSW	16	15676989	missense	probably benign	0.19
R1713:Prkdc	UTSW	16	15795094	missense	probably benign
R1762:Prkdc	UTSW	16	15637961	missense	probably benign
R1789:Prkdc	UTSW	16	15739524	missense	probably damaging	1.00
R1822:Prkdc	UTSW	16	15759605	missense	probably damaging	1.00
R1848:Prkdc	UTSW	16	15808058	missense	probably benign	0.01
R1887:Prkdc	UTSW	16	15829635	missense	probably benign	0.00
R1891:Prkdc	UTSW	16	15725436	missense	probably benign	0.02
R1921:Prkdc	UTSW	16	15714215	missense	possibly damaging	0.80
R1922:Prkdc	UTSW	16	15714266	missense	probably benign	0.00
R1929:Prkdc	UTSW	16	15654817	splice site	probably null
R1939:Prkdc	UTSW	16	15835913	missense	possibly damaging	0.95
R2021:Prkdc	UTSW	16	15677009	missense	probably benign	0.00
R2033:Prkdc	UTSW	16	15687352	splice site	probably benign
R2056:Prkdc	UTSW	16	15727605	missense	probably benign	0.03
R2057:Prkdc	UTSW	16	15727605	missense	probably benign	0.03
R2058:Prkdc	UTSW	16	15727605	missense	probably benign	0.03
R2082:Prkdc	UTSW	16	15715963	missense	probably damaging	1.00
R2109:Prkdc	UTSW	16	15687390	missense	probably benign	0.01
R2124:Prkdc	UTSW	16	15719433	missense	probably benign	0.00
R2164:Prkdc	UTSW	16	15705207	missense	probably damaging	1.00
R2174:Prkdc	UTSW	16	15734922	missense	probably benign	0.01
R2191:Prkdc	UTSW	16	15698824	missense	probably damaging	1.00
R2270:Prkdc	UTSW	16	15654817	splice site	probably null
R2271:Prkdc	UTSW	16	15654817	splice site	probably null
R2272:Prkdc	UTSW	16	15654817	splice site	probably null
R2356:Prkdc	UTSW	16	15684204	missense	probably benign
R2852:Prkdc	UTSW	16	15652552	critical splice donor site	probably null
R3115:Prkdc	UTSW	16	15664358	missense	probably benign	0.01
R3116:Prkdc	UTSW	16	15664358	missense	probably benign	0.01
R3499:Prkdc	UTSW	16	15768025	missense	probably damaging	0.98
R3687:Prkdc	UTSW	16	15799967	missense	probably benign
R3834:Prkdc	UTSW	16	15791946	missense	probably damaging	1.00
R3835:Prkdc	UTSW	16	15791946	missense	probably damaging	1.00
R3961:Prkdc	UTSW	16	15829611	splice site	probably null
R4151:Prkdc	UTSW	16	15816773	missense	probably benign
R4233:Prkdc	UTSW	16	15835919	missense	probably benign	0.11
R4281:Prkdc	UTSW	16	15806099	splice site	probably null
R4296:Prkdc	UTSW	16	15737905	missense	probably damaging	0.99
R4344:Prkdc	UTSW	16	15768022	missense	probably damaging	0.98
R4424:Prkdc	UTSW	16	15773739	missense	probably damaging	0.98
R4424:Prkdc	UTSW	16	15836082	missense	probably damaging	1.00
R4497:Prkdc	UTSW	16	15700653	missense	probably benign	0.43
R4549:Prkdc	UTSW	16	15736870	missense	possibly damaging	0.89
R4594:Prkdc	UTSW	16	15767966	missense	possibly damaging	0.64
R4603:Prkdc	UTSW	16	15810824	missense	probably damaging	0.98
R4615:Prkdc	UTSW	16	15663074	missense	probably damaging	0.99
R4648:Prkdc	UTSW	16	15816774	missense	probably benign	0.05
R4662:Prkdc	UTSW	16	15734052	missense	probably damaging	1.00
R4680:Prkdc	UTSW	16	15772030	missense	probably benign	0.00
R4700:Prkdc	UTSW	16	15702112	missense	probably damaging	1.00
R4716:Prkdc	UTSW	16	15810837	missense	probably benign	0.32
R4720:Prkdc	UTSW	16	15667715	missense	probably benign
R4785:Prkdc	UTSW	16	15648976	missense	probably benign	0.21
R4822:Prkdc	UTSW	16	15650712	missense	possibly damaging	0.80
R4829:Prkdc	UTSW	16	15702075	missense	possibly damaging	0.80
R4981:Prkdc	UTSW	16	15678309	missense	probably damaging	1.00
R4989:Prkdc	UTSW	16	15673997	missense	possibly damaging	0.80
R5059:Prkdc	UTSW	16	15838018	missense	probably damaging	1.00
R5074:Prkdc	UTSW	16	15772048	missense	probably damaging	1.00
R5115:Prkdc	UTSW	16	15790580	missense	probably benign
R5151:Prkdc	UTSW	16	15716035	missense	probably damaging	1.00
R5165:Prkdc	UTSW	16	15678272	missense	probably damaging	1.00
R5215:Prkdc	UTSW	16	15772121	missense	possibly damaging	0.64
R5270:Prkdc	UTSW	16	15734955	missense	probably damaging	1.00
R5278:Prkdc	UTSW	16	15714974	missense	probably damaging	1.00
R5351:Prkdc	UTSW	16	15831312	missense	probably benign	0.03
R5416:Prkdc	UTSW	16	15805950	missense	probably damaging	1.00
R5418:Prkdc	UTSW	16	15795097	missense	probably benign	0.20
R5437:Prkdc	UTSW	16	15769875	missense	possibly damaging	0.46
R5452:Prkdc	UTSW	16	15768637	missense	possibly damaging	0.96
R5518:Prkdc	UTSW	16	15678308	missense	probably damaging	1.00
R5538:Prkdc	UTSW	16	15651469	missense	probably damaging	1.00
R5589:Prkdc	UTSW	16	15706791	missense	probably benign	0.02
R5618:Prkdc	UTSW	16	15809612	missense	probably damaging	1.00
R5640:Prkdc	UTSW	16	15829769	missense	possibly damaging	0.86
R5661:Prkdc	UTSW	16	15810770	missense	possibly damaging	0.81
R5771:Prkdc	UTSW	16	15664233	missense	probably damaging	1.00
R5772:Prkdc	UTSW	16	15779388	missense	possibly damaging	0.49
R5783:Prkdc	UTSW	16	15717801	missense	probably damaging	1.00
R5792:Prkdc	UTSW	16	15816752	missense	probably damaging	1.00
R5797:Prkdc	UTSW	16	15737834	nonsense	probably null
R5826:Prkdc	UTSW	16	15734098	missense	probably benign
R5883:Prkdc	UTSW	16	15715914	missense	probably benign
R5895:Prkdc	UTSW	16	15752829	nonsense	probably null
R5998:Prkdc	UTSW	16	15783157	missense	probably damaging	1.00
R6000:Prkdc	UTSW	16	15829697	missense	possibly damaging	0.86
R6120:Prkdc	UTSW	16	15739471	missense	probably benign	0.00
R6145:Prkdc	UTSW	16	15772073	missense	probably damaging	1.00
R6209:Prkdc	UTSW	16	15790592	missense	probably damaging	1.00
R6293:Prkdc	UTSW	16	15787155	missense	probably benign	0.00
R6321:Prkdc	UTSW	16	15714919	missense	probably benign
R6376:Prkdc	UTSW	16	15769885	missense	probably benign	0.06
R6387:Prkdc	UTSW	16	15698815	missense	probably benign	0.01
R6406:Prkdc	UTSW	16	15717801	missense	probably damaging	1.00
R6469:Prkdc	UTSW	16	15795075	missense	probably benign	0.10
R6486:Prkdc	UTSW	16	15752764	missense	probably damaging	0.97
R6665:Prkdc	UTSW	16	15786050	critical splice donor site	probably null
R6703:Prkdc	UTSW	16	15670528	missense	probably benign	0.00
R6774:Prkdc	UTSW	16	15725461	critical splice donor site	probably null
R6854:Prkdc	UTSW	16	15651538	missense	probably damaging	1.00
R6878:Prkdc	UTSW	16	15777072	missense	probably benign	0.31
R6882:Prkdc	UTSW	16	15783263	critical splice donor site	probably null
R6882:Prkdc	UTSW	16	15808156	missense	probably benign	0.33
R6949:Prkdc	UTSW	16	15799989	missense	probably benign
R6950:Prkdc	UTSW	16	15815986	missense	probably damaging	1.00
R7019:Prkdc	UTSW	16	15769966	missense	probably benign	0.00
R7064:Prkdc	UTSW	16	15790453	missense	probably benign	0.00
R7097:Prkdc	UTSW	16	15689343	missense	probably damaging	1.00
R7201:Prkdc	UTSW	16	15698803	missense	probably benign	0.12
R7235:Prkdc	UTSW	16	15714263	missense	probably benign
R7283:Prkdc	UTSW	16	15717764	missense	probably benign	0.00
R7401:Prkdc	UTSW	16	15648738	missense	probably damaging	1.00
R7525:Prkdc	UTSW	16	15672327	missense	probably damaging	1.00
R7647:Prkdc	UTSW	16	15737943	missense	probably damaging	1.00
R7679:Prkdc	UTSW	16	15831319	missense	probably damaging	1.00
R7803:Prkdc	UTSW	16	15806096	missense	probably null	0.05
R7858:Prkdc	UTSW	16	15689277	missense	probably benign	0.11
R7872:Prkdc	UTSW	16	15715006	missense	probably benign	0.05
R7896:Prkdc	UTSW	16	15708903	missense	probably damaging	0.97
R8032:Prkdc	UTSW	16	15779451	missense	probably benign	0.00
R8055:Prkdc	UTSW	16	15816885	missense	probably benign	0.09
R8153:Prkdc	UTSW	16	15664244	missense	probably damaging	1.00
R8281:Prkdc	UTSW	16	15705253	missense	probably damaging	1.00
R8302:Prkdc	UTSW	16	15836082	missense	probably damaging	1.00
R8322:Prkdc	UTSW	16	15714141	splice site	probably benign
R8401:Prkdc	UTSW	16	15773613	missense	possibly damaging	0.93
R8440:Prkdc	UTSW	16	15835158	frame shift	probably null
R8458:Prkdc	UTSW	16	15790676	critical splice donor site	probably null
R8472:Prkdc	UTSW	16	15651536	missense	probably damaging	1.00
R8478:Prkdc	UTSW	16	15648924	missense	probably benign	0.00
R8515:Prkdc	UTSW	16	15664368	missense	probably damaging	1.00
R8546:Prkdc	UTSW	16	15663035	missense	probably damaging	1.00
R8678:Prkdc	UTSW	16	15708932	critical splice donor site	probably null
R8739:Prkdc	UTSW	16	15808204	missense	probably benign	0.01
R8749:Prkdc	UTSW	16	15783165	missense	possibly damaging	0.85
R8836:Prkdc	UTSW	16	15727659	missense	probably damaging	1.00
R8904:Prkdc	UTSW	16	15727726	missense	probably benign	0.04
R8952:Prkdc	UTSW	16	15673760	intron	probably benign
R8971:Prkdc	UTSW	16	15675365	missense	probably null	0.99
R8974:Prkdc	UTSW	16	15799862	splice site	probably null
R9052:Prkdc	UTSW	16	15690296	missense	probably benign	0.05
R9069:Prkdc	UTSW	16	15835227	nonsense	probably null
R9200:Prkdc	UTSW	16	15705289	missense	probably damaging	1.00
R9235:Prkdc	UTSW	16	15833887	missense	probably damaging	1.00
R9278:Prkdc	UTSW	16	15816659	critical splice donor site	probably null
R9309:Prkdc	UTSW	16	15708928	nonsense	probably null
R9386:Prkdc	UTSW	16	15678272	missense	probably damaging	0.99
R9452:Prkdc	UTSW	16	15667601	missense	possibly damaging	0.90
R9500:Prkdc	UTSW	16	15839215	missense	possibly damaging	0.76
R9608:Prkdc	UTSW	16	15730470	missense	possibly damaging	0.96
R9608:Prkdc	UTSW	16	15730471	missense	probably damaging	1.00
R9636:Prkdc	UTSW	16	15730477	missense	probably benign	0.19
R9656:Prkdc	UTSW	16	15799954	missense	probably benign	0.00
R9674:Prkdc	UTSW	16	15715955	missense	probably damaging	0.98
R9760:Prkdc	UTSW	16	15839180	nonsense	probably null
X0023:Prkdc	UTSW	16	15740278	missense	probably benign
Z1176:Prkdc	UTSW	16	15687422	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- CCTGGAGCAAGCTGAAATTTTCAGAAC -3'
(R):5'- TCCAGATACATTTCCCCTTTCAAATGGC -3'

Sequencing Primer
(F):5'- CTTGGAAGTAGAAAAAAGCTGTGTTC -3'
(R):5'- CCCTTTCAAATGGCCTATAAATTCAG -3'

Posted On

2013-04-12