Incidental Mutation 'R2027:Dido1'
| ID |
220746 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dido1
|
| Ensembl Gene |
ENSMUSG00000038914 |
| Gene Name |
death inducer-obliterator 1 |
| Synonyms |
D130048F08Rik, Datf1, 6720461J16Rik, dido, DIO-1, C130092D22Rik |
| MMRRC Submission |
040035-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.960)
|
| Stock # |
R2027 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
180299757-180351792 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
A to T
at 180330974 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Stop codon
at position 158
(L158*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000119689
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000087517]
[ENSMUST00000103055]
[ENSMUST00000103056]
[ENSMUST00000103057]
[ENSMUST00000130986]
|
| AlphaFold |
Q8C9B9 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000087517
AA Change: L158*
|
| SMART Domains |
Protein: ENSMUSP00000084794
Gene: ENSMUSG00000038914
AA Change: L158*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
134 |
155 |
N/A |
INTRINSIC |
|
PHD
|
267 |
317 |
1.19e-11 |
SMART |
|
low complexity region
|
430 |
446 |
N/A |
INTRINSIC |
|
TFS2M
|
669 |
770 |
1.16e-45 |
SMART |
|
low complexity region
|
937 |
962 |
N/A |
INTRINSIC |
|
low complexity region
|
1023 |
1037 |
N/A |
INTRINSIC |
|
Pfam:SPOC
|
1052 |
1158 |
1e-22 |
PFAM |
|
low complexity region
|
1253 |
1267 |
N/A |
INTRINSIC |
|
low complexity region
|
1279 |
1308 |
N/A |
INTRINSIC |
|
low complexity region
|
1372 |
1391 |
N/A |
INTRINSIC |
|
coiled coil region
|
1458 |
1502 |
N/A |
INTRINSIC |
|
low complexity region
|
1649 |
1680 |
N/A |
INTRINSIC |
|
low complexity region
|
1748 |
1766 |
N/A |
INTRINSIC |
|
low complexity region
|
1780 |
1792 |
N/A |
INTRINSIC |
|
low complexity region
|
1804 |
1815 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
1816 |
1852 |
3.9e-5 |
PROSPERO |
|
internal_repeat_1
|
1819 |
1859 |
6.92e-7 |
PROSPERO |
|
internal_repeat_2
|
1926 |
1964 |
3.9e-5 |
PROSPERO |
|
internal_repeat_1
|
1940 |
1982 |
6.92e-7 |
PROSPERO |
|
low complexity region
|
2025 |
2045 |
N/A |
INTRINSIC |
|
low complexity region
|
2123 |
2160 |
N/A |
INTRINSIC |
|
low complexity region
|
2163 |
2177 |
N/A |
INTRINSIC |
|
low complexity region
|
2182 |
2239 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000103054
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000103055
AA Change: L158*
|
| SMART Domains |
Protein: ENSMUSP00000099344
Gene: ENSMUSG00000038914
AA Change: L158*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
134 |
155 |
N/A |
INTRINSIC |
|
PHD
|
267 |
317 |
1.19e-11 |
SMART |
|
low complexity region
|
430 |
446 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000103056
AA Change: L158*
|
| SMART Domains |
Protein: ENSMUSP00000099345
Gene: ENSMUSG00000038914
AA Change: L158*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
134 |
155 |
N/A |
INTRINSIC |
|
PHD
|
267 |
317 |
1.19e-11 |
SMART |
|
low complexity region
|
430 |
446 |
N/A |
INTRINSIC |
|
TFS2M
|
669 |
770 |
1.16e-45 |
SMART |
|
low complexity region
|
937 |
962 |
N/A |
INTRINSIC |
|
low complexity region
|
1023 |
1037 |
N/A |
INTRINSIC |
|
Pfam:SPOC
|
1052 |
1158 |
4.7e-23 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000103057
AA Change: L158*
|
| SMART Domains |
Protein: ENSMUSP00000099346
Gene: ENSMUSG00000038914
AA Change: L158*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
134 |
155 |
N/A |
INTRINSIC |
|
PHD
|
267 |
317 |
1.19e-11 |
SMART |
|
low complexity region
|
430 |
446 |
N/A |
INTRINSIC |
|
TFS2M
|
669 |
770 |
1.16e-45 |
SMART |
|
low complexity region
|
937 |
962 |
N/A |
INTRINSIC |
|
low complexity region
|
1023 |
1037 |
N/A |
INTRINSIC |
|
Pfam:SPOC
|
1052 |
1158 |
4.7e-23 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000130986
AA Change: L158*
|
| SMART Domains |
Protein: ENSMUSP00000119689
Gene: ENSMUSG00000038914
AA Change: L158*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
134 |
155 |
N/A |
INTRINSIC |
|
PHD
|
267 |
317 |
1.19e-11 |
SMART |
|
low complexity region
|
430 |
446 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.9712 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.1%
- 20x: 94.7%
|
| Validation Efficiency |
100% (70/70) |
| MGI Phenotype |
FUNCTION: This gene encodes a transcription factor involved in apoptosis. The encoded protein functions in cell cycle progression and plays a role in chromosomal stability. This protein regulates the self-renewal of embryonic stem cells. Disruption of this gene in mice causes symptoms similar to myelodysplastic/myeloproliferative diseases in humans. Mice lacking this gene show severely reduced fertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit severely reduced fertility; about one-half develop a transplantable disease characterized by anomalies in spleen, bone marrow, and peripheral blood and including anemia and various symptoms typical of myeloid dysplasia or myeloid proliferation. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(245) : Targeted, knock-out(1) Gene trapped(244) |
| Other mutations in this stock |
Total: 70 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A4gnt |
T |
C |
9: 99,502,254 (GRCm39) |
V138A |
possibly damaging |
Het |
| Aatk |
A |
G |
11: 119,900,143 (GRCm39) |
S1291P |
probably damaging |
Het |
| Adgrv1 |
C |
T |
13: 81,743,301 (GRCm39) |
V67M |
probably damaging |
Het |
| Apoa4 |
G |
A |
9: 46,154,298 (GRCm39) |
V300M |
probably damaging |
Het |
| Bcl2a1d |
A |
T |
9: 88,613,438 (GRCm39) |
V112E |
possibly damaging |
Het |
| Bltp1 |
T |
A |
3: 37,102,110 (GRCm39) |
|
probably benign |
Het |
| Cabp2 |
T |
A |
19: 4,137,126 (GRCm39) |
M166K |
probably damaging |
Het |
| Camsap1 |
A |
G |
2: 25,828,538 (GRCm39) |
V1062A |
possibly damaging |
Het |
| Cap1 |
T |
G |
4: 122,756,686 (GRCm39) |
|
probably benign |
Het |
| Caprin2 |
A |
G |
6: 148,779,385 (GRCm39) |
Y141H |
probably damaging |
Het |
| Card11 |
T |
C |
5: 140,892,522 (GRCm39) |
Y181C |
probably damaging |
Het |
| Ccdc107 |
T |
C |
4: 43,495,874 (GRCm39) |
V259A |
probably benign |
Het |
| Ccn4 |
A |
G |
15: 66,789,258 (GRCm39) |
E248G |
possibly damaging |
Het |
| Chd9 |
A |
G |
8: 91,634,619 (GRCm39) |
|
probably benign |
Het |
| Cibar1 |
T |
A |
4: 12,171,216 (GRCm39) |
D79V |
probably damaging |
Het |
| Col12a1 |
T |
C |
9: 79,553,075 (GRCm39) |
|
probably null |
Het |
| Cuzd1 |
T |
C |
7: 130,921,820 (GRCm39) |
T61A |
possibly damaging |
Het |
| Dbp |
C |
A |
7: 45,357,700 (GRCm39) |
D89E |
probably benign |
Het |
| Dhps |
A |
T |
8: 85,799,240 (GRCm39) |
N140Y |
probably damaging |
Het |
| Dnah9 |
T |
G |
11: 65,846,164 (GRCm39) |
N2958T |
probably benign |
Het |
| Dpp8 |
T |
A |
9: 64,986,056 (GRCm39) |
Y849N |
probably damaging |
Het |
| Dsg2 |
A |
G |
18: 20,716,061 (GRCm39) |
|
probably benign |
Het |
| Efemp1 |
A |
T |
11: 28,864,696 (GRCm39) |
Y250F |
possibly damaging |
Het |
| Faxc |
T |
C |
4: 21,958,439 (GRCm39) |
|
probably benign |
Het |
| Frem3 |
G |
T |
8: 81,421,966 (GRCm39) |
C2122F |
possibly damaging |
Het |
| Gan |
T |
C |
8: 117,914,238 (GRCm39) |
|
probably null |
Het |
| Gnl1 |
A |
G |
17: 36,293,850 (GRCm39) |
N274D |
probably benign |
Het |
| Hook3 |
T |
C |
8: 26,528,126 (GRCm39) |
E588G |
probably damaging |
Het |
| Itpr1 |
C |
A |
6: 108,363,814 (GRCm39) |
S812Y |
possibly damaging |
Het |
| Kbtbd3 |
C |
T |
9: 4,317,075 (GRCm39) |
|
probably benign |
Het |
| Macf1 |
C |
T |
4: 123,265,711 (GRCm39) |
A4821T |
probably damaging |
Het |
| Mepe |
T |
C |
5: 104,474,957 (GRCm39) |
S13P |
possibly damaging |
Het |
| Msantd5f6 |
A |
G |
4: 73,321,295 (GRCm39) |
I154T |
possibly damaging |
Het |
| Myh11 |
A |
G |
16: 14,050,532 (GRCm39) |
Y478H |
probably damaging |
Het |
| Myo7b |
A |
G |
18: 32,118,013 (GRCm39) |
V871A |
probably benign |
Het |
| Nckap1 |
A |
T |
2: 80,365,862 (GRCm39) |
M466K |
probably damaging |
Het |
| Nup155 |
A |
T |
15: 8,187,244 (GRCm39) |
H1391L |
probably damaging |
Het |
| Or4k6 |
A |
G |
14: 50,475,406 (GRCm39) |
I312T |
probably benign |
Het |
| Or52r1b |
A |
T |
7: 102,690,731 (GRCm39) |
H15L |
probably benign |
Het |
| Or5aq1b |
T |
A |
2: 86,901,897 (GRCm39) |
N194Y |
possibly damaging |
Het |
| Or5m13 |
A |
C |
2: 85,749,114 (GRCm39) |
S282R |
probably damaging |
Het |
| Or9k2 |
A |
G |
10: 129,998,604 (GRCm39) |
I197T |
probably benign |
Het |
| Or9s23 |
A |
T |
1: 92,501,489 (GRCm39) |
T199S |
probably damaging |
Het |
| Otof |
T |
C |
5: 30,578,358 (GRCm39) |
T97A |
probably benign |
Het |
| Peli2 |
G |
A |
14: 48,493,602 (GRCm39) |
E275K |
probably benign |
Het |
| Pik3c2a |
T |
C |
7: 115,950,057 (GRCm39) |
Y1320C |
probably damaging |
Het |
| Pkn1 |
A |
G |
8: 84,398,007 (GRCm39) |
V795A |
probably damaging |
Het |
| Pramel5 |
A |
G |
4: 143,998,274 (GRCm39) |
L323P |
probably damaging |
Het |
| Prr5 |
A |
T |
15: 84,585,580 (GRCm39) |
R183W |
probably damaging |
Het |
| Ptch1 |
T |
G |
13: 63,672,773 (GRCm39) |
E944A |
probably benign |
Het |
| Rabgef1 |
A |
G |
5: 130,237,620 (GRCm39) |
D231G |
possibly damaging |
Het |
| Rbp3 |
C |
T |
14: 33,677,975 (GRCm39) |
T641M |
probably damaging |
Het |
| Rc3h1 |
C |
T |
1: 160,782,507 (GRCm39) |
P662L |
probably benign |
Het |
| Rpl7a-ps5 |
G |
T |
17: 58,146,090 (GRCm39) |
Q47K |
probably benign |
Het |
| Sclt1 |
G |
A |
3: 41,685,323 (GRCm39) |
T45I |
probably benign |
Het |
| Slc22a17 |
A |
G |
14: 55,145,543 (GRCm39) |
I202T |
probably damaging |
Het |
| Slc25a13 |
A |
G |
6: 6,073,487 (GRCm39) |
L457S |
probably damaging |
Het |
| Slc44a3 |
T |
C |
3: 121,257,059 (GRCm39) |
|
probably benign |
Het |
| Slc7a9 |
G |
A |
7: 35,153,562 (GRCm39) |
V188M |
probably damaging |
Het |
| Spata31d1e |
A |
G |
13: 59,890,401 (GRCm39) |
M55T |
possibly damaging |
Het |
| Tmem161a |
T |
A |
8: 70,630,170 (GRCm39) |
F119I |
probably damaging |
Het |
| Tmem240 |
A |
G |
4: 155,819,892 (GRCm39) |
D32G |
possibly damaging |
Het |
| Tmtc4 |
T |
C |
14: 123,158,677 (GRCm39) |
N682S |
probably benign |
Het |
| Uqcrc1 |
G |
A |
9: 108,776,083 (GRCm39) |
V262M |
probably benign |
Het |
| Vmn1r87 |
G |
A |
7: 12,865,823 (GRCm39) |
R155C |
probably damaging |
Het |
| Vmn2r100 |
A |
T |
17: 19,742,334 (GRCm39) |
Q236L |
probably benign |
Het |
| Vmn2r97 |
T |
A |
17: 19,149,944 (GRCm39) |
I444N |
unknown |
Het |
| Yif1a |
A |
T |
19: 5,139,900 (GRCm39) |
H115L |
probably damaging |
Het |
| Zfp280b |
T |
C |
10: 75,874,328 (GRCm39) |
L69S |
probably damaging |
Het |
| Zfp579 |
C |
A |
7: 4,996,520 (GRCm39) |
E464* |
probably null |
Het |
|
| Other mutations in Dido1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00425:Dido1
|
APN |
2 |
180,325,782 (GRCm39) |
missense |
probably benign |
|
|
IGL00834:Dido1
|
APN |
2 |
180,331,319 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL01317:Dido1
|
APN |
2 |
180,313,550 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL01588:Dido1
|
APN |
2 |
180,330,668 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01834:Dido1
|
APN |
2 |
180,325,824 (GRCm39) |
splice site |
probably benign |
|
|
IGL02102:Dido1
|
APN |
2 |
180,304,040 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
IGL02556:Dido1
|
APN |
2 |
180,331,128 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL02756:Dido1
|
APN |
2 |
180,303,716 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02826:Dido1
|
APN |
2 |
180,325,751 (GRCm39) |
missense |
probably benign |
|
|
IGL02970:Dido1
|
APN |
2 |
180,331,208 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03110:Dido1
|
APN |
2 |
180,331,135 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03116:Dido1
|
APN |
2 |
180,312,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
3370:Dido1
|
UTSW |
2 |
180,313,335 (GRCm39) |
missense |
probably benign |
|
|
A4554:Dido1
|
UTSW |
2 |
180,317,164 (GRCm39) |
missense |
probably damaging |
1.00 |
|
H8441:Dido1
|
UTSW |
2 |
180,330,807 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0044:Dido1
|
UTSW |
2 |
180,303,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0044:Dido1
|
UTSW |
2 |
180,303,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0054:Dido1
|
UTSW |
2 |
180,303,267 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0054:Dido1
|
UTSW |
2 |
180,303,267 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0127:Dido1
|
UTSW |
2 |
180,313,617 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0620:Dido1
|
UTSW |
2 |
180,301,644 (GRCm39) |
missense |
probably benign |
0.26 |
|
R0734:Dido1
|
UTSW |
2 |
180,301,835 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1390:Dido1
|
UTSW |
2 |
180,326,917 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R1445:Dido1
|
UTSW |
2 |
180,313,263 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R1466:Dido1
|
UTSW |
2 |
180,304,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1466:Dido1
|
UTSW |
2 |
180,304,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1472:Dido1
|
UTSW |
2 |
180,302,513 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1538:Dido1
|
UTSW |
2 |
180,326,763 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R1584:Dido1
|
UTSW |
2 |
180,304,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2020:Dido1
|
UTSW |
2 |
180,301,378 (GRCm39) |
missense |
unknown |
|
|
R2025:Dido1
|
UTSW |
2 |
180,330,974 (GRCm39) |
nonsense |
probably null |
|
|
R2026:Dido1
|
UTSW |
2 |
180,330,974 (GRCm39) |
nonsense |
probably null |
|
|
R2089:Dido1
|
UTSW |
2 |
180,303,677 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2091:Dido1
|
UTSW |
2 |
180,303,677 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2091:Dido1
|
UTSW |
2 |
180,303,677 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2495:Dido1
|
UTSW |
2 |
180,331,181 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2931:Dido1
|
UTSW |
2 |
180,303,446 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3418:Dido1
|
UTSW |
2 |
180,302,728 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R3735:Dido1
|
UTSW |
2 |
180,325,829 (GRCm39) |
splice site |
probably benign |
|
|
R4523:Dido1
|
UTSW |
2 |
180,314,085 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4674:Dido1
|
UTSW |
2 |
180,329,352 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4729:Dido1
|
UTSW |
2 |
180,329,443 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4762:Dido1
|
UTSW |
2 |
180,331,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4786:Dido1
|
UTSW |
2 |
180,312,664 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4817:Dido1
|
UTSW |
2 |
180,303,209 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4892:Dido1
|
UTSW |
2 |
180,316,822 (GRCm39) |
nonsense |
probably null |
|
|
R4979:Dido1
|
UTSW |
2 |
180,302,606 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5510:Dido1
|
UTSW |
2 |
180,326,966 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5586:Dido1
|
UTSW |
2 |
180,301,445 (GRCm39) |
nonsense |
probably null |
|
|
R5672:Dido1
|
UTSW |
2 |
180,313,696 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5863:Dido1
|
UTSW |
2 |
180,303,566 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5943:Dido1
|
UTSW |
2 |
180,303,675 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5974:Dido1
|
UTSW |
2 |
180,313,290 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6123:Dido1
|
UTSW |
2 |
180,325,760 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6214:Dido1
|
UTSW |
2 |
180,303,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6215:Dido1
|
UTSW |
2 |
180,303,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6248:Dido1
|
UTSW |
2 |
180,302,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6285:Dido1
|
UTSW |
2 |
180,302,940 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6349:Dido1
|
UTSW |
2 |
180,302,494 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6437:Dido1
|
UTSW |
2 |
180,316,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6477:Dido1
|
UTSW |
2 |
180,302,274 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6836:Dido1
|
UTSW |
2 |
180,304,100 (GRCm39) |
missense |
probably benign |
0.16 |
|
R7055:Dido1
|
UTSW |
2 |
180,303,002 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7289:Dido1
|
UTSW |
2 |
180,301,424 (GRCm39) |
missense |
unknown |
|
|
R7304:Dido1
|
UTSW |
2 |
180,329,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7343:Dido1
|
UTSW |
2 |
180,316,914 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R7363:Dido1
|
UTSW |
2 |
180,304,310 (GRCm39) |
nonsense |
probably null |
|
|
R7429:Dido1
|
UTSW |
2 |
180,331,319 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R7594:Dido1
|
UTSW |
2 |
180,316,905 (GRCm39) |
missense |
probably benign |
|
|
R7629:Dido1
|
UTSW |
2 |
180,303,266 (GRCm39) |
missense |
probably benign |
|
|
R7899:Dido1
|
UTSW |
2 |
180,313,390 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7946:Dido1
|
UTSW |
2 |
180,303,501 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7951:Dido1
|
UTSW |
2 |
180,312,674 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8033:Dido1
|
UTSW |
2 |
180,316,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8069:Dido1
|
UTSW |
2 |
180,302,705 (GRCm39) |
missense |
probably benign |
|
|
R8331:Dido1
|
UTSW |
2 |
180,302,242 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8479:Dido1
|
UTSW |
2 |
180,315,022 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8936:Dido1
|
UTSW |
2 |
180,303,195 (GRCm39) |
missense |
probably benign |
|
|
R9089:Dido1
|
UTSW |
2 |
180,303,293 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9647:Dido1
|
UTSW |
2 |
180,315,068 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9648:Dido1
|
UTSW |
2 |
180,302,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9784:Dido1
|
UTSW |
2 |
180,325,354 (GRCm39) |
missense |
probably benign |
0.27 |
|
V1024:Dido1
|
UTSW |
2 |
180,330,807 (GRCm39) |
missense |
probably benign |
0.12 |
|
X0011:Dido1
|
UTSW |
2 |
180,302,627 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0019:Dido1
|
UTSW |
2 |
180,313,365 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCTGTCTCTGACTGGGACACTG -3'
(R):5'- TGAGCCCACATCTTCCACAG -3'
Sequencing Primer
(F):5'- ACACTGGTCCCTGACTAGC -3'
(R):5'- TTCCACAGTCACTGATGTGGAGAC -3'
|
| Posted On |
2014-08-25 |
Incidental Mutation