Incidental Mutation 'R2027:Or9k2'
ID 220834
Institutional Source Beutler Lab
Gene Symbol Or9k2
Ensembl Gene ENSMUSG00000058084
Gene Name olfactory receptor family 9 subfamily K member 2
Synonyms GA_x6K02T2PULF-11834065-11833103, Olfr825, MOR210-1
MMRRC Submission 040035-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.370) question?
Stock # R2027 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 129998231-129999193 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 129998604 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 197 (I197T)
Ref Sequence ENSEMBL: ENSMUSP00000149981 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076814] [ENSMUST00000216530]
AlphaFold Q8VFU7
Predicted Effect probably benign
Transcript: ENSMUST00000076814
AA Change: I197T

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000076091
Gene: ENSMUSG00000058084
AA Change: I197T

DomainStartEndE-ValueType
Pfam:7tm_4 34 309 8.8e-54 PFAM
Pfam:7TM_GPCR_Srsx 38 251 9.6e-6 PFAM
Pfam:7tm_1 44 291 2e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216434
Predicted Effect probably benign
Transcript: ENSMUST00000216530
AA Change: I197T

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000218167
Meta Mutation Damage Score 0.2995 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.7%
Validation Efficiency 100% (70/70)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A4gnt T C 9: 99,502,254 (GRCm39) V138A possibly damaging Het
Aatk A G 11: 119,900,143 (GRCm39) S1291P probably damaging Het
Adgrv1 C T 13: 81,743,301 (GRCm39) V67M probably damaging Het
Apoa4 G A 9: 46,154,298 (GRCm39) V300M probably damaging Het
Bcl2a1d A T 9: 88,613,438 (GRCm39) V112E possibly damaging Het
Bltp1 T A 3: 37,102,110 (GRCm39) probably benign Het
Cabp2 T A 19: 4,137,126 (GRCm39) M166K probably damaging Het
Camsap1 A G 2: 25,828,538 (GRCm39) V1062A possibly damaging Het
Cap1 T G 4: 122,756,686 (GRCm39) probably benign Het
Caprin2 A G 6: 148,779,385 (GRCm39) Y141H probably damaging Het
Card11 T C 5: 140,892,522 (GRCm39) Y181C probably damaging Het
Ccdc107 T C 4: 43,495,874 (GRCm39) V259A probably benign Het
Ccn4 A G 15: 66,789,258 (GRCm39) E248G possibly damaging Het
Chd9 A G 8: 91,634,619 (GRCm39) probably benign Het
Cibar1 T A 4: 12,171,216 (GRCm39) D79V probably damaging Het
Col12a1 T C 9: 79,553,075 (GRCm39) probably null Het
Cuzd1 T C 7: 130,921,820 (GRCm39) T61A possibly damaging Het
Dbp C A 7: 45,357,700 (GRCm39) D89E probably benign Het
Dhps A T 8: 85,799,240 (GRCm39) N140Y probably damaging Het
Dido1 A T 2: 180,330,974 (GRCm39) L158* probably null Het
Dnah9 T G 11: 65,846,164 (GRCm39) N2958T probably benign Het
Dpp8 T A 9: 64,986,056 (GRCm39) Y849N probably damaging Het
Dsg2 A G 18: 20,716,061 (GRCm39) probably benign Het
Efemp1 A T 11: 28,864,696 (GRCm39) Y250F possibly damaging Het
Faxc T C 4: 21,958,439 (GRCm39) probably benign Het
Frem3 G T 8: 81,421,966 (GRCm39) C2122F possibly damaging Het
Gan T C 8: 117,914,238 (GRCm39) probably null Het
Gnl1 A G 17: 36,293,850 (GRCm39) N274D probably benign Het
Hook3 T C 8: 26,528,126 (GRCm39) E588G probably damaging Het
Itpr1 C A 6: 108,363,814 (GRCm39) S812Y possibly damaging Het
Kbtbd3 C T 9: 4,317,075 (GRCm39) probably benign Het
Macf1 C T 4: 123,265,711 (GRCm39) A4821T probably damaging Het
Mepe T C 5: 104,474,957 (GRCm39) S13P possibly damaging Het
Msantd5f6 A G 4: 73,321,295 (GRCm39) I154T possibly damaging Het
Myh11 A G 16: 14,050,532 (GRCm39) Y478H probably damaging Het
Myo7b A G 18: 32,118,013 (GRCm39) V871A probably benign Het
Nckap1 A T 2: 80,365,862 (GRCm39) M466K probably damaging Het
Nup155 A T 15: 8,187,244 (GRCm39) H1391L probably damaging Het
Or4k6 A G 14: 50,475,406 (GRCm39) I312T probably benign Het
Or52r1b A T 7: 102,690,731 (GRCm39) H15L probably benign Het
Or5aq1b T A 2: 86,901,897 (GRCm39) N194Y possibly damaging Het
Or5m13 A C 2: 85,749,114 (GRCm39) S282R probably damaging Het
Or9s23 A T 1: 92,501,489 (GRCm39) T199S probably damaging Het
Otof T C 5: 30,578,358 (GRCm39) T97A probably benign Het
Peli2 G A 14: 48,493,602 (GRCm39) E275K probably benign Het
Pik3c2a T C 7: 115,950,057 (GRCm39) Y1320C probably damaging Het
Pkn1 A G 8: 84,398,007 (GRCm39) V795A probably damaging Het
Pramel5 A G 4: 143,998,274 (GRCm39) L323P probably damaging Het
Prr5 A T 15: 84,585,580 (GRCm39) R183W probably damaging Het
Ptch1 T G 13: 63,672,773 (GRCm39) E944A probably benign Het
Rabgef1 A G 5: 130,237,620 (GRCm39) D231G possibly damaging Het
Rbp3 C T 14: 33,677,975 (GRCm39) T641M probably damaging Het
Rc3h1 C T 1: 160,782,507 (GRCm39) P662L probably benign Het
Rpl7a-ps5 G T 17: 58,146,090 (GRCm39) Q47K probably benign Het
Sclt1 G A 3: 41,685,323 (GRCm39) T45I probably benign Het
Slc22a17 A G 14: 55,145,543 (GRCm39) I202T probably damaging Het
Slc25a13 A G 6: 6,073,487 (GRCm39) L457S probably damaging Het
Slc44a3 T C 3: 121,257,059 (GRCm39) probably benign Het
Slc7a9 G A 7: 35,153,562 (GRCm39) V188M probably damaging Het
Spata31d1e A G 13: 59,890,401 (GRCm39) M55T possibly damaging Het
Tmem161a T A 8: 70,630,170 (GRCm39) F119I probably damaging Het
Tmem240 A G 4: 155,819,892 (GRCm39) D32G possibly damaging Het
Tmtc4 T C 14: 123,158,677 (GRCm39) N682S probably benign Het
Uqcrc1 G A 9: 108,776,083 (GRCm39) V262M probably benign Het
Vmn1r87 G A 7: 12,865,823 (GRCm39) R155C probably damaging Het
Vmn2r100 A T 17: 19,742,334 (GRCm39) Q236L probably benign Het
Vmn2r97 T A 17: 19,149,944 (GRCm39) I444N unknown Het
Yif1a A T 19: 5,139,900 (GRCm39) H115L probably damaging Het
Zfp280b T C 10: 75,874,328 (GRCm39) L69S probably damaging Het
Zfp579 C A 7: 4,996,520 (GRCm39) E464* probably null Het
Other mutations in Or9k2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03244:Or9k2 APN 10 129,998,269 (GRCm39) nonsense probably null
R1120:Or9k2 UTSW 10 129,998,406 (GRCm39) missense probably damaging 1.00
R1341:Or9k2 UTSW 10 129,999,185 (GRCm39) missense probably benign 0.00
R1754:Or9k2 UTSW 10 129,999,033 (GRCm39) missense probably benign 0.02
R2022:Or9k2 UTSW 10 129,999,049 (GRCm39) missense probably benign 0.00
R3838:Or9k2 UTSW 10 129,998,275 (GRCm39) nonsense probably null
R3842:Or9k2 UTSW 10 129,998,770 (GRCm39) missense probably benign 0.00
R4737:Or9k2 UTSW 10 129,998,707 (GRCm39) missense probably benign 0.01
R5166:Or9k2 UTSW 10 129,998,430 (GRCm39) missense possibly damaging 0.60
R5744:Or9k2 UTSW 10 129,998,661 (GRCm39) missense possibly damaging 0.92
R5899:Or9k2 UTSW 10 129,998,542 (GRCm39) missense probably benign 0.00
R7754:Or9k2 UTSW 10 129,998,698 (GRCm39) missense probably damaging 1.00
R8098:Or9k2 UTSW 10 129,998,916 (GRCm39) missense probably benign 0.32
R9393:Or9k2 UTSW 10 129,999,016 (GRCm39) missense probably benign 0.39
X0026:Or9k2 UTSW 10 129,998,600 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TCAGTTCAGGAAATCTGTCAGGG -3'
(R):5'- ATGTCCACACGTCTCTGCAC -3'

Sequencing Primer
(F):5'- ATCTGTCAGGGGTGAGATACATG -3'
(R):5'- GTCTCTGCACTCAGCTGGTG -3'
Posted On 2014-08-25