Incidental Mutation 'R0138:Zbtb26'
ID 22084
Institutional Source Beutler Lab
Gene Symbol Zbtb26
Ensembl Gene ENSMUSG00000050714
Gene Name zinc finger and BTB domain containing 26
Synonyms A630026F21Rik
MMRRC Submission 038423-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.365) question?
Stock # R0138 (G1)
Quality Score 225
Status Validated (trace)
Chromosome 2
Chromosomal Location 37322180-37333147 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 37326053 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 328 (M328L)
Ref Sequence ENSEMBL: ENSMUSP00000099850 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000067043] [ENSMUST00000102789] [ENSMUST00000112932]
AlphaFold Q8C8S0
Predicted Effect probably benign
Transcript: ENSMUST00000067043
AA Change: M317L

PolyPhen 2 Score 0.163 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000070071
Gene: ENSMUSG00000050714
AA Change: M317L

DomainStartEndE-ValueType
BTB 33 127 4.38e-12 SMART
low complexity region 169 179 N/A INTRINSIC
ZnF_C2H2 273 295 1.36e-2 SMART
ZnF_C2H2 298 320 1.4e-4 SMART
ZnF_C2H2 326 348 2.99e-4 SMART
ZnF_C2H2 354 377 2.09e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000102789
AA Change: M328L

PolyPhen 2 Score 0.163 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000099850
Gene: ENSMUSG00000050714
AA Change: M328L

DomainStartEndE-ValueType
BTB 44 138 4.38e-12 SMART
low complexity region 180 190 N/A INTRINSIC
ZnF_C2H2 284 306 1.36e-2 SMART
ZnF_C2H2 309 331 1.4e-4 SMART
ZnF_C2H2 337 359 2.99e-4 SMART
ZnF_C2H2 365 388 2.09e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000112932
SMART Domains Protein: ENSMUSP00000108554
Gene: ENSMUSG00000066798

DomainStartEndE-ValueType
BTB 33 127 2.67e-16 SMART
Blast:BTB 161 196 1e-5 BLAST
ZnF_C2H2 300 322 7.15e-2 SMART
ZnF_C2H2 325 347 1.58e-3 SMART
ZnF_C2H2 353 375 3.63e-3 SMART
ZnF_C2H2 381 404 8.81e-2 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203522
Meta Mutation Damage Score 0.0619 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.3%
  • 10x: 96.4%
  • 20x: 92.8%
Validation Efficiency 97% (76/78)
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca4 T A 3: 121,899,098 (GRCm39) N693K probably damaging Het
Adgrl3 T A 5: 81,841,454 (GRCm39) V845D probably damaging Het
Anxa8 T A 14: 33,819,896 (GRCm39) F269Y probably benign Het
Anxa8 T A 14: 33,819,897 (GRCm39) F295L possibly damaging Het
Aox4 C G 1: 58,268,025 (GRCm39) L202V probably damaging Het
Ap3s2 A G 7: 79,559,617 (GRCm39) V104A probably benign Het
Aqp3 G A 4: 41,094,843 (GRCm39) probably benign Het
Arhgef26 C T 3: 62,355,680 (GRCm39) H751Y probably benign Het
Asic4 A T 1: 75,446,331 (GRCm39) Q291L possibly damaging Het
Bap1 T C 14: 30,978,681 (GRCm39) Y31H probably damaging Het
Brf1 A T 12: 112,924,759 (GRCm39) V655D probably damaging Het
Cebpz A G 17: 79,238,820 (GRCm39) S663P probably benign Het
Ces2h A G 8: 105,744,693 (GRCm39) D357G probably benign Het
Cfap36 T C 11: 29,194,073 (GRCm39) T90A probably benign Het
Ciita A T 16: 10,330,134 (GRCm39) D803V probably damaging Het
Clnk C A 5: 38,931,951 (GRCm39) probably benign Het
Cyp46a1 A G 12: 108,317,470 (GRCm39) N158S probably damaging Het
Cyp4f13 A G 17: 33,160,080 (GRCm39) I98T possibly damaging Het
Def8 G A 8: 124,183,234 (GRCm39) A278T probably damaging Het
Dll3 T A 7: 28,000,746 (GRCm39) D103V possibly damaging Het
Dnai1 T A 4: 41,629,814 (GRCm39) M446K possibly damaging Het
Dppa4 A T 16: 48,111,425 (GRCm39) T85S probably benign Het
Eif4g1 A T 16: 20,494,095 (GRCm39) H57L probably damaging Het
Fmnl3 G C 15: 99,220,619 (GRCm39) probably benign Het
Fn1 T A 1: 71,663,269 (GRCm39) Q1073L possibly damaging Het
Foxp4 T C 17: 48,180,104 (GRCm39) D599G unknown Het
Frrs1 T C 3: 116,675,456 (GRCm39) V128A possibly damaging Het
Gcfc2 G A 6: 81,926,935 (GRCm39) D608N probably damaging Het
Gm1043 T C 5: 37,350,317 (GRCm39) probably benign Het
Gm5148 T C 3: 37,768,926 (GRCm39) E98G probably benign Het
Gpr141 T C 13: 19,936,428 (GRCm39) I116V probably benign Het
Hic1 T C 11: 75,058,169 (GRCm39) N240S probably damaging Het
Hpx G A 7: 105,241,445 (GRCm39) T322I probably damaging Het
Hs3st4 A T 7: 123,996,416 (GRCm39) M361L probably benign Het
Ifrd1 A G 12: 40,257,129 (GRCm39) probably benign Het
Ino80 G A 2: 119,213,441 (GRCm39) R1249C probably damaging Het
Klk1b21 T A 7: 43,755,319 (GRCm39) C173S probably damaging Het
Krt25 A T 11: 99,213,524 (GRCm39) V65E probably benign Het
Lrrc15 A T 16: 30,092,267 (GRCm39) D357E possibly damaging Het
Lrrd1 T A 5: 3,901,345 (GRCm39) V550E probably benign Het
Macf1 A G 4: 123,334,540 (GRCm39) Y1490H probably damaging Het
Macrod1 A G 19: 7,174,281 (GRCm39) probably benign Het
Mcm5 T A 8: 75,847,508 (GRCm39) V435D probably damaging Het
Mctp1 C T 13: 76,975,831 (GRCm39) R478C probably damaging Het
Med10 T C 13: 69,959,817 (GRCm39) probably benign Het
Mrpl4 T C 9: 20,919,888 (GRCm39) Y280H probably benign Het
Msrb3 T C 10: 120,687,892 (GRCm39) E61G probably damaging Het
Myo1c T C 11: 75,551,827 (GRCm39) Y337H possibly damaging Het
Myo7b T A 18: 32,143,204 (GRCm39) T165S probably damaging Het
Myrfl T A 10: 116,685,138 (GRCm39) R81W probably damaging Het
Neil1 T C 9: 57,051,030 (GRCm39) probably benign Het
Neto2 A G 8: 86,367,673 (GRCm39) I357T possibly damaging Het
Nfat5 C T 8: 108,065,707 (GRCm39) R156W probably damaging Het
Nkx6-3 T C 8: 23,643,607 (GRCm39) S3P probably benign Het
Or52h7 A T 7: 104,214,210 (GRCm39) I261L probably benign Het
Plce1 T C 19: 38,512,863 (GRCm39) I54T possibly damaging Het
Prex2 A T 1: 11,355,267 (GRCm39) probably benign Het
Psapl1 T A 5: 36,361,975 (GRCm39) V189E probably damaging Het
Ptdss2 T G 7: 140,735,232 (GRCm39) probably benign Het
Rnf213 T C 11: 119,307,322 (GRCm39) C661R probably benign Het
Rpap1 T C 2: 119,595,380 (GRCm39) probably null Het
Rrp1b A G 17: 32,279,426 (GRCm39) T696A probably benign Het
Sacm1l T A 9: 123,377,982 (GRCm39) H87Q probably benign Het
Serpinb11 T A 1: 107,305,260 (GRCm39) M212K probably damaging Het
Tbc1d22a C A 15: 86,183,885 (GRCm39) T248K probably damaging Het
Tcerg1 C T 18: 42,701,679 (GRCm39) probably benign Het
Tpst1 T A 5: 130,130,627 (GRCm39) H32Q probably damaging Het
Tsc2 A T 17: 24,818,600 (GRCm39) V1412E possibly damaging Het
Usp19 C A 9: 108,378,514 (GRCm39) P1326Q possibly damaging Het
Vmn1r235 T A 17: 21,482,596 (GRCm39) M307K probably damaging Het
Vmn2r58 T A 7: 41,487,048 (GRCm39) T616S probably damaging Het
Vps13a G A 19: 16,637,863 (GRCm39) T2406I possibly damaging Het
Zp2 A G 7: 119,736,423 (GRCm39) F340S probably damaging Het
Other mutations in Zbtb26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00579:Zbtb26 APN 2 37,326,454 (GRCm39) missense possibly damaging 0.82
IGL00899:Zbtb26 APN 2 37,326,270 (GRCm39) nonsense probably null
IGL01598:Zbtb26 APN 2 37,326,283 (GRCm39) missense probably damaging 1.00
IGL01940:Zbtb26 APN 2 37,325,987 (GRCm39) missense possibly damaging 0.93
IGL02152:Zbtb26 APN 2 37,326,703 (GRCm39) missense possibly damaging 0.95
IGL02867:Zbtb26 APN 2 37,326,261 (GRCm39) missense probably benign 0.00
IGL02889:Zbtb26 APN 2 37,326,261 (GRCm39) missense probably benign 0.00
IGL03081:Zbtb26 APN 2 37,326,612 (GRCm39) missense possibly damaging 0.67
R0328:Zbtb26 UTSW 2 37,326,807 (GRCm39) missense possibly damaging 0.81
R0927:Zbtb26 UTSW 2 37,326,337 (GRCm39) missense possibly damaging 0.91
R1671:Zbtb26 UTSW 2 37,326,377 (GRCm39) missense probably benign 0.00
R1813:Zbtb26 UTSW 2 37,326,347 (GRCm39) missense possibly damaging 0.68
R1896:Zbtb26 UTSW 2 37,326,347 (GRCm39) missense possibly damaging 0.68
R2128:Zbtb26 UTSW 2 37,326,563 (GRCm39) missense probably benign 0.00
R2374:Zbtb26 UTSW 2 37,326,497 (GRCm39) missense probably benign
R4050:Zbtb26 UTSW 2 37,327,000 (GRCm39) start codon destroyed probably null 0.46
R4631:Zbtb26 UTSW 2 37,326,968 (GRCm39) missense probably benign 0.00
R4940:Zbtb26 UTSW 2 37,326,781 (GRCm39) missense probably damaging 0.98
R5071:Zbtb26 UTSW 2 37,325,941 (GRCm39) missense probably benign 0.26
R6348:Zbtb26 UTSW 2 37,325,687 (GRCm39) missense probably benign 0.43
R6962:Zbtb26 UTSW 2 37,326,106 (GRCm39) missense possibly damaging 0.71
R6990:Zbtb26 UTSW 2 37,326,557 (GRCm39) missense probably benign 0.00
R7261:Zbtb26 UTSW 2 37,326,667 (GRCm39) missense possibly damaging 0.71
R7981:Zbtb26 UTSW 2 37,326,887 (GRCm39) missense possibly damaging 0.51
R8013:Zbtb26 UTSW 2 37,327,013 (GRCm39) critical splice acceptor site probably null
R8014:Zbtb26 UTSW 2 37,327,013 (GRCm39) critical splice acceptor site probably null
R8872:Zbtb26 UTSW 2 37,326,913 (GRCm39) missense probably damaging 0.99
R8876:Zbtb26 UTSW 2 37,326,896 (GRCm39) missense probably benign
R8905:Zbtb26 UTSW 2 37,326,927 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TGCATCCAGGACCTGTGTTGCATC -3'
(R):5'- ACAAAGGCTTACAGTGGCATCACC -3'

Sequencing Primer
(F):5'- GTCAAAATCCACTGTGAGGTC -3'
(R):5'- CAGTGCCCAAAGTGTACCAG -3'
Posted On 2013-04-12