Incidental Mutation 'R1971:Rttn'
| ID |
220993 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rttn
|
| Ensembl Gene |
ENSMUSG00000023066 |
| Gene Name |
rotatin |
| Synonyms |
C530033I08Rik, 4921538A15Rik |
| MMRRC Submission |
039984-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1971 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
18 |
| Chromosomal Location |
88989914-89149140 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 89108557 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Histidine
at position 1587
(R1587H)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000023828
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000023828]
|
| AlphaFold |
Q8R4Y8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000023828
AA Change: R1587H
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000023828
Gene: ENSMUSG00000023066
AA Change: R1587H
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:RTTN_N
|
16 |
112 |
1.2e-36 |
PFAM |
|
low complexity region
|
188 |
199 |
N/A |
INTRINSIC |
|
Blast:ARM
|
216 |
261 |
9e-18 |
BLAST |
|
low complexity region
|
302 |
319 |
N/A |
INTRINSIC |
|
low complexity region
|
335 |
341 |
N/A |
INTRINSIC |
|
SCOP:d1gw5a_
|
515 |
952 |
9e-3 |
SMART |
|
Blast:ARM
|
863 |
910 |
4e-8 |
BLAST |
|
low complexity region
|
972 |
985 |
N/A |
INTRINSIC |
|
low complexity region
|
1165 |
1176 |
N/A |
INTRINSIC |
|
low complexity region
|
1213 |
1222 |
N/A |
INTRINSIC |
|
low complexity region
|
1680 |
1698 |
N/A |
INTRINSIC |
|
low complexity region
|
1861 |
1879 |
N/A |
INTRINSIC |
|
Blast:ARM
|
2088 |
2129 |
1e-10 |
BLAST |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.9%
- 20x: 94.3%
|
| Validation Efficiency |
99% (115/116) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a large protein whose specific function is unknown. Absence of the orthologous protein in mouse results in embryonic lethality with deficient axial rotation, abnormal differentiation of the neural tube, and randomized looping of the heart tube during development. In human, mutations in this gene are associated with polymicrogyria with seizures. In human fibroblasts this protein localizes at the ciliary basal bodies. Given the intracellular localization of this protein and the phenotypic effects of mutations, this gene is suspected of playing a role in the maintenance of normal ciliary structure which in turn effects the developmental process of left-right organ specification, axial rotation, and perhaps notochord development. [provided by RefSeq, Jan 2013]
PHENOTYPE: Mice homozygous for an insertional mutation exhibit embryonic lethality and neurulation defects resulting in the arrest of gastrulation movements and abnormal left-right specification in the heart. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(15) : Targeted(2) Gene trapped(12) Transgenic(1)
|
| Other mutations in this stock |
Total: 113 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700001O22Rik |
A |
T |
2: 30,686,566 (GRCm39) |
I242N |
probably benign |
Het |
| 2510009E07Rik |
G |
T |
16: 21,472,048 (GRCm39) |
Y217* |
probably null |
Het |
| 4931429L15Rik |
C |
T |
9: 46,220,086 (GRCm39) |
V149M |
probably benign |
Het |
| Abcg8 |
G |
T |
17: 85,002,587 (GRCm39) |
|
probably benign |
Het |
| Acox1 |
A |
G |
11: 116,089,087 (GRCm39) |
F77S |
probably benign |
Het |
| Adgrb3 |
G |
T |
1: 25,586,525 (GRCm39) |
H389Q |
probably benign |
Het |
| Ak7 |
A |
G |
12: 105,692,504 (GRCm39) |
N186S |
probably damaging |
Het |
| Apobr |
A |
G |
7: 126,185,397 (GRCm39) |
T303A |
probably benign |
Het |
| Arnt |
C |
T |
3: 95,355,704 (GRCm39) |
S16L |
possibly damaging |
Het |
| Bcl9l |
T |
C |
9: 44,419,996 (GRCm39) |
|
probably null |
Het |
| Bco2 |
T |
C |
9: 50,457,284 (GRCm39) |
D86G |
probably damaging |
Het |
| Bmpr1b |
T |
A |
3: 141,563,333 (GRCm39) |
I204F |
probably damaging |
Het |
| Bpifb5 |
C |
A |
2: 154,072,264 (GRCm39) |
Q324K |
probably benign |
Het |
| Cacna2d2 |
G |
A |
9: 107,389,205 (GRCm39) |
V223I |
probably damaging |
Het |
| Capn3 |
A |
G |
2: 120,311,228 (GRCm39) |
D105G |
possibly damaging |
Het |
| Ccdc40 |
G |
T |
11: 119,153,901 (GRCm39) |
|
probably null |
Het |
| Ccdc83 |
T |
A |
7: 89,893,362 (GRCm39) |
S132C |
probably damaging |
Het |
| Ckap2l |
A |
G |
2: 129,127,342 (GRCm39) |
S279P |
possibly damaging |
Het |
| Cldn12 |
C |
A |
5: 5,558,137 (GRCm39) |
A97S |
probably benign |
Het |
| Clec2l |
T |
G |
6: 38,640,309 (GRCm39) |
S47A |
probably benign |
Het |
| Csnk1d |
C |
A |
11: 120,863,274 (GRCm39) |
R222M |
possibly damaging |
Het |
| Ctnna1 |
T |
A |
18: 35,287,580 (GRCm39) |
D96E |
probably benign |
Het |
| D630045J12Rik |
T |
C |
6: 38,145,078 (GRCm39) |
D1316G |
probably damaging |
Het |
| Ddx4 |
C |
T |
13: 112,736,547 (GRCm39) |
V608I |
probably damaging |
Het |
| Dmtf1 |
T |
C |
5: 9,198,989 (GRCm39) |
E48G |
probably benign |
Het |
| Dnah17 |
G |
C |
11: 117,995,361 (GRCm39) |
Q996E |
probably benign |
Het |
| Dnah9 |
G |
C |
11: 65,739,197 (GRCm39) |
N4180K |
probably damaging |
Het |
| Dpf3 |
T |
A |
12: 83,371,809 (GRCm39) |
|
probably null |
Het |
| Drd2 |
T |
C |
9: 49,318,359 (GRCm39) |
F434L |
probably damaging |
Het |
| En1 |
A |
G |
1: 120,534,742 (GRCm39) |
T344A |
unknown |
Het |
| Eri3 |
A |
G |
4: 117,421,964 (GRCm39) |
T81A |
probably benign |
Het |
| Fam20a |
T |
C |
11: 109,576,237 (GRCm39) |
Y174C |
probably damaging |
Het |
| Fam234a |
G |
C |
17: 26,435,629 (GRCm39) |
|
probably null |
Het |
| Fam76a |
A |
T |
4: 132,631,294 (GRCm39) |
I217N |
probably damaging |
Het |
| Fancm |
T |
A |
12: 65,148,466 (GRCm39) |
S694T |
probably benign |
Het |
| Fcgbpl1 |
C |
A |
7: 27,830,937 (GRCm39) |
A50E |
possibly damaging |
Het |
| Foxo3 |
A |
G |
10: 42,073,258 (GRCm39) |
S420P |
probably benign |
Het |
| Foxp4 |
C |
T |
17: 48,186,796 (GRCm39) |
R378Q |
unknown |
Het |
| Gm136 |
T |
G |
4: 34,755,986 (GRCm39) |
D9A |
probably benign |
Het |
| Gstt2 |
G |
T |
10: 75,668,499 (GRCm39) |
T116N |
probably benign |
Het |
| Hs3st6 |
A |
G |
17: 24,972,267 (GRCm39) |
T70A |
probably benign |
Het |
| Hspa14 |
A |
G |
2: 3,490,804 (GRCm39) |
V461A |
possibly damaging |
Het |
| Itih5 |
A |
T |
2: 10,243,379 (GRCm39) |
D372V |
probably damaging |
Het |
| Kcna2 |
A |
T |
3: 107,012,140 (GRCm39) |
R240S |
probably damaging |
Het |
| Kctd18 |
T |
C |
1: 58,006,779 (GRCm39) |
I24V |
probably benign |
Het |
| Lap3 |
T |
C |
5: 45,663,508 (GRCm39) |
|
probably benign |
Het |
| Lcp1 |
T |
C |
14: 75,437,946 (GRCm39) |
S119P |
probably damaging |
Het |
| Lig3 |
G |
C |
11: 82,686,544 (GRCm39) |
D642H |
probably benign |
Het |
| Lpin1 |
A |
T |
12: 16,630,724 (GRCm39) |
L58H |
probably damaging |
Het |
| Map4k5 |
G |
T |
12: 69,873,102 (GRCm39) |
P468Q |
possibly damaging |
Het |
| Med31 |
G |
A |
11: 72,106,244 (GRCm39) |
|
probably benign |
Het |
| Mki67 |
A |
T |
7: 135,315,688 (GRCm39) |
|
probably null |
Het |
| Mrc1 |
G |
A |
2: 14,249,103 (GRCm39) |
|
probably null |
Het |
| Msh3 |
A |
G |
13: 92,359,784 (GRCm39) |
I16T |
probably damaging |
Het |
| Msh3 |
T |
A |
13: 92,386,328 (GRCm39) |
|
probably benign |
Het |
| Mst1r |
A |
T |
9: 107,790,411 (GRCm39) |
I675F |
probably benign |
Het |
| Myb |
A |
C |
10: 21,016,555 (GRCm39) |
S652A |
probably benign |
Het |
| Myh2 |
G |
T |
11: 67,080,004 (GRCm39) |
S1099I |
possibly damaging |
Het |
| Myl6b |
A |
G |
10: 128,330,512 (GRCm39) |
V181A |
probably damaging |
Het |
| Myt1l |
A |
T |
12: 29,877,091 (GRCm39) |
K247N |
unknown |
Het |
| Nanos2 |
G |
T |
7: 18,721,629 (GRCm39) |
V34L |
probably benign |
Het |
| Nav1 |
T |
C |
1: 135,460,091 (GRCm39) |
T411A |
probably benign |
Het |
| Nedd9 |
T |
A |
13: 41,492,424 (GRCm39) |
I23F |
probably damaging |
Het |
| Nes |
G |
A |
3: 87,885,634 (GRCm39) |
V1254I |
possibly damaging |
Het |
| Nol6 |
A |
G |
4: 41,119,542 (GRCm39) |
F588S |
probably damaging |
Het |
| Numa1 |
C |
T |
7: 101,658,529 (GRCm39) |
A1605V |
probably damaging |
Het |
| Ofd1 |
T |
C |
X: 165,210,210 (GRCm39) |
Y205C |
probably benign |
Het |
| Olr1 |
T |
C |
6: 129,470,498 (GRCm39) |
E223G |
probably benign |
Het |
| Or1e30 |
T |
A |
11: 73,678,616 (GRCm39) |
M284K |
probably damaging |
Het |
| Or2ag12 |
T |
A |
7: 106,276,877 (GRCm39) |
N272I |
probably damaging |
Het |
| Or4c118 |
A |
T |
2: 88,975,078 (GRCm39) |
C96* |
probably null |
Het |
| Or51k2 |
A |
T |
7: 103,596,150 (GRCm39) |
I126F |
probably damaging |
Het |
| Or51l4 |
C |
T |
7: 103,404,527 (GRCm39) |
W88* |
probably null |
Het |
| Pate6 |
T |
A |
9: 35,700,309 (GRCm39) |
H92L |
probably benign |
Het |
| Pclo |
A |
G |
5: 14,763,487 (GRCm39) |
T3987A |
unknown |
Het |
| Pik3cg |
A |
T |
12: 32,242,152 (GRCm39) |
V986D |
probably damaging |
Het |
| Pitpnm1 |
T |
A |
19: 4,162,450 (GRCm39) |
D1093E |
probably damaging |
Het |
| Ppp1r12b |
T |
C |
1: 134,793,651 (GRCm39) |
D571G |
probably benign |
Het |
| Rfx1 |
A |
G |
8: 84,822,126 (GRCm39) |
E875G |
probably damaging |
Het |
| Rnf145 |
T |
A |
11: 44,439,642 (GRCm39) |
I146N |
probably damaging |
Het |
| Safb |
A |
G |
17: 56,912,821 (GRCm39) |
H883R |
probably benign |
Het |
| Sdhb |
A |
G |
4: 140,700,260 (GRCm39) |
D120G |
possibly damaging |
Het |
| Serpine3 |
A |
G |
14: 62,902,533 (GRCm39) |
N48S |
probably damaging |
Het |
| Sgms1 |
T |
A |
19: 32,137,357 (GRCm39) |
I70L |
probably benign |
Het |
| Slc1a7 |
G |
T |
4: 107,825,782 (GRCm39) |
D14Y |
probably benign |
Het |
| Smtnl2 |
C |
T |
11: 72,302,183 (GRCm39) |
A93T |
probably benign |
Het |
| Srpra |
T |
C |
9: 35,124,834 (GRCm39) |
|
probably null |
Het |
| Taf6l |
A |
G |
19: 8,752,866 (GRCm39) |
|
probably null |
Het |
| Tbc1d10b |
A |
T |
7: 126,807,036 (GRCm39) |
V167E |
probably benign |
Het |
| Tbc1d9 |
G |
A |
8: 83,976,139 (GRCm39) |
R566H |
probably damaging |
Het |
| Tenm3 |
A |
G |
8: 48,689,348 (GRCm39) |
Y2080H |
probably damaging |
Het |
| Tex14 |
A |
G |
11: 87,402,431 (GRCm39) |
N506S |
probably damaging |
Het |
| Thada |
G |
T |
17: 84,617,470 (GRCm39) |
P1349T |
probably damaging |
Het |
| Tjp1 |
G |
T |
7: 64,973,826 (GRCm39) |
T476K |
probably damaging |
Het |
| Tlr11 |
A |
T |
14: 50,598,691 (GRCm39) |
T226S |
probably benign |
Het |
| Tmem131 |
G |
A |
1: 36,843,680 (GRCm39) |
Q1394* |
probably null |
Het |
| Tmem161a |
C |
T |
8: 70,629,559 (GRCm39) |
R58W |
probably damaging |
Het |
| Tmem219 |
T |
C |
7: 126,496,422 (GRCm39) |
S13G |
probably benign |
Het |
| Trp53bp1 |
T |
C |
2: 121,035,517 (GRCm39) |
Y47C |
probably damaging |
Het |
| Ttn |
T |
A |
2: 76,731,922 (GRCm39) |
|
probably benign |
Het |
| Ush1g |
A |
G |
11: 115,209,280 (GRCm39) |
S305P |
probably damaging |
Het |
| Usp37 |
A |
T |
1: 74,479,127 (GRCm39) |
Y948* |
probably null |
Het |
| Vav1 |
A |
T |
17: 57,634,697 (GRCm39) |
Y805F |
probably damaging |
Het |
| Vmn1r59 |
A |
T |
7: 5,457,038 (GRCm39) |
Y241N |
probably damaging |
Het |
| Vmn2r2 |
T |
A |
3: 64,034,121 (GRCm39) |
Y467F |
probably damaging |
Het |
| Vps35l |
A |
C |
7: 118,374,557 (GRCm39) |
R352S |
probably damaging |
Het |
| Vps54 |
C |
A |
11: 21,242,051 (GRCm39) |
L389I |
probably damaging |
Het |
| Vwa8 |
G |
T |
14: 79,162,694 (GRCm39) |
|
probably benign |
Het |
| Wdr19 |
G |
T |
5: 65,398,503 (GRCm39) |
|
probably benign |
Het |
| Wnt2b |
A |
T |
3: 104,861,933 (GRCm39) |
|
probably benign |
Het |
| Xirp2 |
A |
G |
2: 67,342,039 (GRCm39) |
R1427G |
possibly damaging |
Het |
| Ylpm1 |
T |
C |
12: 85,087,560 (GRCm39) |
S1115P |
probably damaging |
Het |
| Zfp946 |
T |
A |
17: 22,674,406 (GRCm39) |
C387S |
probably damaging |
Het |
|
| Other mutations in Rttn |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00595:Rttn
|
APN |
18 |
88,992,464 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00788:Rttn
|
APN |
18 |
88,990,633 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00929:Rttn
|
APN |
18 |
89,047,059 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01392:Rttn
|
APN |
18 |
89,013,737 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01395:Rttn
|
APN |
18 |
89,147,894 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL01701:Rttn
|
APN |
18 |
89,082,339 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02136:Rttn
|
APN |
18 |
89,064,252 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL02151:Rttn
|
APN |
18 |
89,038,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02165:Rttn
|
APN |
18 |
89,061,165 (GRCm39) |
missense |
probably benign |
|
|
IGL02228:Rttn
|
APN |
18 |
89,060,355 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02276:Rttn
|
APN |
18 |
89,066,578 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02612:Rttn
|
APN |
18 |
88,991,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02645:Rttn
|
APN |
18 |
89,128,810 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL02716:Rttn
|
APN |
18 |
89,066,541 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
IGL02820:Rttn
|
APN |
18 |
89,047,122 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02961:Rttn
|
APN |
18 |
89,071,697 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02973:Rttn
|
APN |
18 |
88,990,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03027:Rttn
|
APN |
18 |
88,997,814 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03082:Rttn
|
APN |
18 |
89,002,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03121:Rttn
|
APN |
18 |
88,993,875 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03135:Rttn
|
APN |
18 |
89,033,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03328:Rttn
|
APN |
18 |
89,061,152 (GRCm39) |
missense |
probably benign |
0.19 |
|
Fascisti
|
UTSW |
18 |
89,027,584 (GRCm39) |
splice site |
probably benign |
|
|
marcher
|
UTSW |
18 |
89,056,070 (GRCm39) |
missense |
probably damaging |
0.99 |
|
militaristi
|
UTSW |
18 |
89,029,040 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Thoughtless
|
UTSW |
18 |
89,032,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
twister
|
UTSW |
18 |
89,064,286 (GRCm39) |
critical splice donor site |
probably null |
|
|
Vermiculus
|
UTSW |
18 |
89,108,557 (GRCm39) |
missense |
probably benign |
|
|
R0062:Rttn
|
UTSW |
18 |
89,029,090 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0062:Rttn
|
UTSW |
18 |
89,029,090 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0310:Rttn
|
UTSW |
18 |
89,027,584 (GRCm39) |
splice site |
probably benign |
|
|
R0330:Rttn
|
UTSW |
18 |
89,004,204 (GRCm39) |
splice site |
probably null |
|
|
R0363:Rttn
|
UTSW |
18 |
89,029,079 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0485:Rttn
|
UTSW |
18 |
89,108,543 (GRCm39) |
splice site |
probably benign |
|
|
R0590:Rttn
|
UTSW |
18 |
88,997,759 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0601:Rttn
|
UTSW |
18 |
89,061,090 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0604:Rttn
|
UTSW |
18 |
88,995,882 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0631:Rttn
|
UTSW |
18 |
89,007,670 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0882:Rttn
|
UTSW |
18 |
88,991,813 (GRCm39) |
nonsense |
probably null |
|
|
R0885:Rttn
|
UTSW |
18 |
89,001,934 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0900:Rttn
|
UTSW |
18 |
89,119,815 (GRCm39) |
missense |
probably benign |
0.13 |
|
R1077:Rttn
|
UTSW |
18 |
89,082,373 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1444:Rttn
|
UTSW |
18 |
89,060,991 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1460:Rttn
|
UTSW |
18 |
89,127,481 (GRCm39) |
splice site |
probably benign |
|
|
R1517:Rttn
|
UTSW |
18 |
89,131,474 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1630:Rttn
|
UTSW |
18 |
89,061,078 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1632:Rttn
|
UTSW |
18 |
89,027,460 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1722:Rttn
|
UTSW |
18 |
88,991,655 (GRCm39) |
missense |
probably benign |
0.34 |
|
R1755:Rttn
|
UTSW |
18 |
89,027,441 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1881:Rttn
|
UTSW |
18 |
89,033,336 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2035:Rttn
|
UTSW |
18 |
89,038,340 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2109:Rttn
|
UTSW |
18 |
89,004,197 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R2191:Rttn
|
UTSW |
18 |
89,113,772 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2201:Rttn
|
UTSW |
18 |
89,029,067 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R2266:Rttn
|
UTSW |
18 |
89,082,295 (GRCm39) |
missense |
probably benign |
0.05 |
|
R3014:Rttn
|
UTSW |
18 |
89,032,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3052:Rttn
|
UTSW |
18 |
89,033,370 (GRCm39) |
splice site |
probably benign |
|
|
R3427:Rttn
|
UTSW |
18 |
89,113,775 (GRCm39) |
splice site |
probably null |
|
|
R3431:Rttn
|
UTSW |
18 |
89,113,695 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3786:Rttn
|
UTSW |
18 |
89,056,018 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3803:Rttn
|
UTSW |
18 |
88,995,831 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3980:Rttn
|
UTSW |
18 |
89,035,399 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4035:Rttn
|
UTSW |
18 |
89,013,777 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4170:Rttn
|
UTSW |
18 |
88,993,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4223:Rttn
|
UTSW |
18 |
89,113,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4273:Rttn
|
UTSW |
18 |
89,110,020 (GRCm39) |
missense |
probably benign |
|
|
R4517:Rttn
|
UTSW |
18 |
89,047,097 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4674:Rttn
|
UTSW |
18 |
89,029,135 (GRCm39) |
splice site |
probably null |
|
|
R4837:Rttn
|
UTSW |
18 |
89,108,539 (GRCm39) |
splice site |
probably null |
|
|
R4869:Rttn
|
UTSW |
18 |
89,061,138 (GRCm39) |
nonsense |
probably null |
|
|
R4881:Rttn
|
UTSW |
18 |
89,119,809 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4959:Rttn
|
UTSW |
18 |
89,060,292 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4973:Rttn
|
UTSW |
18 |
89,060,292 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4975:Rttn
|
UTSW |
18 |
89,082,209 (GRCm39) |
splice site |
probably null |
|
|
R5166:Rttn
|
UTSW |
18 |
89,031,218 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R5243:Rttn
|
UTSW |
18 |
89,126,187 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R5594:Rttn
|
UTSW |
18 |
89,108,560 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5654:Rttn
|
UTSW |
18 |
89,066,556 (GRCm39) |
missense |
probably benign |
|
|
R5794:Rttn
|
UTSW |
18 |
89,013,693 (GRCm39) |
missense |
probably benign |
0.18 |
|
R5799:Rttn
|
UTSW |
18 |
89,056,070 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5955:Rttn
|
UTSW |
18 |
89,139,133 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5963:Rttn
|
UTSW |
18 |
89,091,819 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5989:Rttn
|
UTSW |
18 |
88,991,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6004:Rttn
|
UTSW |
18 |
89,039,816 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6132:Rttn
|
UTSW |
18 |
89,133,770 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6430:Rttn
|
UTSW |
18 |
89,039,809 (GRCm39) |
missense |
probably null |
0.18 |
|
R6436:Rttn
|
UTSW |
18 |
89,128,853 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6681:Rttn
|
UTSW |
18 |
89,032,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6994:Rttn
|
UTSW |
18 |
89,047,023 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7049:Rttn
|
UTSW |
18 |
89,082,340 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7078:Rttn
|
UTSW |
18 |
89,027,546 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7083:Rttn
|
UTSW |
18 |
89,108,722 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7250:Rttn
|
UTSW |
18 |
89,007,647 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7402:Rttn
|
UTSW |
18 |
89,004,035 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7565:Rttn
|
UTSW |
18 |
89,078,603 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7588:Rttn
|
UTSW |
18 |
89,082,353 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8029:Rttn
|
UTSW |
18 |
89,108,598 (GRCm39) |
missense |
not run |
|
|
R8085:Rttn
|
UTSW |
18 |
89,071,672 (GRCm39) |
nonsense |
probably null |
|
|
R8113:Rttn
|
UTSW |
18 |
89,029,040 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8355:Rttn
|
UTSW |
18 |
89,047,016 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8531:Rttn
|
UTSW |
18 |
89,131,467 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8992:Rttn
|
UTSW |
18 |
88,995,832 (GRCm39) |
missense |
probably benign |
0.24 |
|
R9008:Rttn
|
UTSW |
18 |
89,027,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9139:Rttn
|
UTSW |
18 |
89,038,261 (GRCm39) |
missense |
probably benign |
0.30 |
|
R9210:Rttn
|
UTSW |
18 |
89,064,286 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9212:Rttn
|
UTSW |
18 |
89,064,286 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9286:Rttn
|
UTSW |
18 |
88,995,849 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9368:Rttn
|
UTSW |
18 |
89,078,576 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9632:Rttn
|
UTSW |
18 |
89,035,334 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R9710:Rttn
|
UTSW |
18 |
89,035,334 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
X0017:Rttn
|
UTSW |
18 |
89,131,526 (GRCm39) |
missense |
probably benign |
0.01 |
|
X0022:Rttn
|
UTSW |
18 |
88,991,791 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TGCACATGTACACGCACAGG -3'
(R):5'- CAGAGGAGTTCTATGAGATGAGCTTG -3'
Sequencing Primer
(F):5'- CGGTGTAAGATCAGTAAATCTCCC -3'
(R):5'- GTTGAAAAGCATTTGCAGCATCTC -3'
|
| Posted On |
2014-08-25 |
Incidental Mutation