Incidental Mutation 'R1973:Olfr919'
ID221264
Institutional Source Beutler Lab
Gene Symbol Olfr919
Ensembl Gene ENSMUSG00000056961
Gene Nameolfactory receptor 919
SynonymsMOR171-23, GA_x6K02T2PVTD-32400678-32399743
MMRRC Submission 039986-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.066) question?
Stock #R1973 (G1)
Quality Score225
Status Not validated
Chromosome9
Chromosomal Location38696804-38703673 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 38697868 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 170 (V170A)
Ref Sequence ENSEMBL: ENSMUSP00000071372 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071425] [ENSMUST00000215612] [ENSMUST00000217508]
Predicted Effect probably damaging
Transcript: ENSMUST00000071425
AA Change: V170A

PolyPhen 2 Score 0.961 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000071372
Gene: ENSMUSG00000056961
AA Change: V170A

DomainStartEndE-ValueType
Pfam:7tm_4 35 312 9.8e-50 PFAM
Pfam:7tm_1 45 294 9e-21 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000215612
AA Change: V166A

PolyPhen 2 Score 0.927 (Sensitivity: 0.81; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000217508
AA Change: V166A

PolyPhen 2 Score 0.927 (Sensitivity: 0.81; Specificity: 0.94)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.7%
  • 20x: 93.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1b A C 5: 8,812,746 I143L probably benign Het
Acp7 T A 7: 28,607,989 D481V probably damaging Het
AI597479 T A 1: 43,111,126 I132K probably benign Het
Anxa13 T C 15: 58,356,181 noncoding transcript Het
Brca1 A T 11: 101,526,403 C302S probably benign Het
Brd8 T A 18: 34,608,013 D420V probably damaging Het
Cacna1g A T 11: 94,459,777 V414E possibly damaging Het
Ccdc142 T A 6: 83,102,563 C294S probably benign Het
Cdh7 G A 1: 110,061,132 V255I probably benign Het
Chat C T 14: 32,424,191 V342I probably benign Het
Chd6 A G 2: 160,966,387 S1636P probably damaging Het
Clec4a1 A G 6: 122,924,834 probably null Het
Col6a3 A T 1: 90,804,175 I1452N probably damaging Het
Dennd2c T C 3: 103,131,698 V54A probably benign Het
Dnah1 C T 14: 31,265,391 W3550* probably null Het
Dscr3 T C 16: 94,501,546 N267S probably damaging Het
Efl1 T C 7: 82,762,877 S825P probably damaging Het
Fam189a1 A T 7: 64,775,768 I192N possibly damaging Het
Faxc G A 4: 21,993,405 E350K probably benign Het
Frem2 T A 3: 53,652,232 Y1618F probably benign Het
Fubp3 A G 2: 31,603,286 T6A probably benign Het
Gm5814 A T 17: 47,410,549 M63L probably benign Het
Gpr149 T C 3: 62,530,795 K647R probably benign Het
Iqgap3 T A 3: 88,083,928 probably null Het
Kcnh3 T C 15: 99,229,400 V359A probably damaging Het
Kit G A 5: 75,615,442 A295T probably damaging Het
Krt77 G T 15: 101,861,244 A397E probably damaging Het
Mis18bp1 G C 12: 65,149,076 S638* probably null Het
Neurl4 C T 11: 69,909,292 P1091S probably benign Het
Nod2 A T 8: 88,652,873 M8L probably damaging Het
Nos1 A G 5: 117,936,426 T1046A possibly damaging Het
Nsfl1c G T 2: 151,505,414 S202I probably damaging Het
Nuak2 A T 1: 132,330,602 H257L probably damaging Het
Nwd1 T C 8: 72,704,962 V1195A possibly damaging Het
Olfr243 T A 7: 103,716,597 M1K probably null Het
Olfr370 T C 8: 83,541,792 V216A probably benign Het
Olfr693 T C 7: 106,678,219 D89G probably benign Het
Olfr889 T A 9: 38,116,567 M257K possibly damaging Het
Pclo G T 5: 14,676,059 probably null Het
Pnpla7 A G 2: 25,016,617 D664G probably damaging Het
Prl8a1 G A 13: 27,576,934 T105I probably benign Het
Ptger1 C A 8: 83,669,454 T380K probably benign Het
Ptk7 G A 17: 46,586,807 Q282* probably null Het
Ptpn18 G T 1: 34,463,109 D45Y probably damaging Het
Rab11fip3 T C 17: 26,024,391 D589G probably damaging Het
Rara A G 11: 98,971,670 N299S possibly damaging Het
Rpl13a T A 7: 45,125,995 K368* probably null Het
Rslcan18 T C 13: 67,108,023 probably benign Het
Rtel1 A G 2: 181,351,626 Y731C probably benign Het
Sec16a A T 2: 26,426,489 S1666R probably damaging Het
Sis A G 3: 72,921,004 F1217S probably damaging Het
Slc10a7 T A 8: 78,697,333 probably null Het
Slc22a7 A G 17: 46,437,090 V214A probably damaging Het
Slc26a8 T C 17: 28,663,605 I249V probably benign Het
Slc38a4 T C 15: 96,999,597 K446E probably benign Het
Sned1 G A 1: 93,265,073 G361S probably damaging Het
Spef2 T G 15: 9,663,066 *876C probably null Het
Spink11 A G 18: 44,196,138 C14R unknown Het
Stk4 C T 2: 164,100,528 T360M probably benign Het
Tnfaip3 T C 10: 19,004,504 N605S probably damaging Het
Trpc1 A G 9: 95,723,255 M283T probably benign Het
Ttn A G 2: 76,714,362 S32799P probably damaging Het
Ttn A G 2: 76,720,099 I31613T probably damaging Het
Ugt1a10 A T 1: 88,056,047 Y189F probably damaging Het
Usp32 G T 11: 85,103,931 L52I probably benign Het
Usp33 A G 3: 152,360,286 T68A possibly damaging Het
Vmn1r7 A G 6: 57,025,026 F83S probably benign Het
Vmn2r5 C T 3: 64,504,221 E309K probably damaging Het
Wdr43 A G 17: 71,640,240 N364D probably benign Het
Zdbf2 C A 1: 63,309,701 P2413Q unknown Het
Other mutations in Olfr919
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01510:Olfr919 APN 9 38697905 missense probably benign 0.00
IGL02515:Olfr919 APN 9 38697791 missense probably benign 0.39
IGL02745:Olfr919 APN 9 38698198 missense probably damaging 0.99
H8562:Olfr919 UTSW 9 38697910 missense probably damaging 1.00
R1960:Olfr919 UTSW 9 38698204 missense probably benign 0.28
R3119:Olfr919 UTSW 9 38697659 nonsense probably null
R4543:Olfr919 UTSW 9 38697545 missense possibly damaging 0.93
R4752:Olfr919 UTSW 9 38697970 missense probably damaging 0.99
R5474:Olfr919 UTSW 9 38698313 missense possibly damaging 0.69
R5532:Olfr919 UTSW 9 38697647 missense probably damaging 1.00
R5635:Olfr919 UTSW 9 38698159 missense possibly damaging 0.64
R5940:Olfr919 UTSW 9 38697711 nonsense probably null
R6820:Olfr919 UTSW 9 38697475 missense possibly damaging 0.88
R7164:Olfr919 UTSW 9 38698219 missense possibly damaging 0.95
R7337:Olfr919 UTSW 9 38697865 missense probably benign 0.12
R7806:Olfr919 UTSW 9 38698271 missense probably benign 0.39
Z1176:Olfr919 UTSW 9 38697928 missense possibly damaging 0.76
Predicted Primers PCR Primer
(F):5'- AGCTACATGTGCTGAAGGC -3'
(R):5'- TATCTGAGTGTCACATGTTGGC -3'

Sequencing Primer
(F):5'- CTGAAGGCTTTGAATCTGCC -3'
(R):5'- CACATGTTGGCTGCAATGGC -3'
Posted On2014-08-25