Incidental Mutation 'R2044:Gpr155'
ID 221574
Institutional Source Beutler Lab
Gene Symbol Gpr155
Ensembl Gene ENSMUSG00000041762
Gene Name G protein-coupled receptor 155
Synonyms DEPDC3, 1110017O10Rik, PGR22, F730029F15Rik
MMRRC Submission 040051-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2044 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 73171850-73216842 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 73203977 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 279 (L279P)
Ref Sequence ENSEMBL: ENSMUSP00000107675 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076463] [ENSMUST00000112043] [ENSMUST00000112044]
AlphaFold A2AWR3
Predicted Effect noncoding transcript
Transcript: ENSMUST00000048504
SMART Domains Protein: ENSMUSP00000037772
Gene: ENSMUSG00000041762

DomainStartEndE-ValueType
Pfam:Mem_trans 40 205 1.9e-16 PFAM
Pfam:Mem_trans 187 360 4.9e-12 PFAM
transmembrane domain 380 402 N/A INTRINSIC
transmembrane domain 415 432 N/A INTRINSIC
transmembrane domain 442 464 N/A INTRINSIC
transmembrane domain 477 499 N/A INTRINSIC
transmembrane domain 519 538 N/A INTRINSIC
transmembrane domain 657 679 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000076463
AA Change: L279P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000075788
Gene: ENSMUSG00000041762
AA Change: L279P

DomainStartEndE-ValueType
Pfam:Mem_trans 40 205 3.3e-15 PFAM
transmembrane domain 209 231 N/A INTRINSIC
transmembrane domain 241 260 N/A INTRINSIC
transmembrane domain 272 291 N/A INTRINSIC
transmembrane domain 311 330 N/A INTRINSIC
transmembrane domain 343 365 N/A INTRINSIC
transmembrane domain 380 402 N/A INTRINSIC
transmembrane domain 415 432 N/A INTRINSIC
transmembrane domain 442 464 N/A INTRINSIC
transmembrane domain 477 499 N/A INTRINSIC
transmembrane domain 519 538 N/A INTRINSIC
transmembrane domain 657 679 N/A INTRINSIC
transmembrane domain 689 711 N/A INTRINSIC
DEP 759 833 8.28e-12 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000112043
AA Change: L279P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000107674
Gene: ENSMUSG00000041762
AA Change: L279P

DomainStartEndE-ValueType
Pfam:Mem_trans 40 205 3.3e-15 PFAM
transmembrane domain 209 231 N/A INTRINSIC
transmembrane domain 241 260 N/A INTRINSIC
transmembrane domain 272 291 N/A INTRINSIC
transmembrane domain 311 330 N/A INTRINSIC
transmembrane domain 343 365 N/A INTRINSIC
transmembrane domain 380 402 N/A INTRINSIC
transmembrane domain 415 432 N/A INTRINSIC
transmembrane domain 442 464 N/A INTRINSIC
transmembrane domain 477 499 N/A INTRINSIC
transmembrane domain 519 538 N/A INTRINSIC
transmembrane domain 657 679 N/A INTRINSIC
transmembrane domain 689 711 N/A INTRINSIC
DEP 759 833 8.28e-12 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000112044
AA Change: L279P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000107675
Gene: ENSMUSG00000041762
AA Change: L279P

DomainStartEndE-ValueType
Pfam:Mem_trans 40 205 3.3e-15 PFAM
Pfam:Mem_trans 187 360 8.3e-11 PFAM
transmembrane domain 382 404 N/A INTRINSIC
transmembrane domain 414 436 N/A INTRINSIC
transmembrane domain 449 471 N/A INTRINSIC
transmembrane domain 491 510 N/A INTRINSIC
transmembrane domain 629 651 N/A INTRINSIC
transmembrane domain 661 683 N/A INTRINSIC
DEP 731 805 8.28e-12 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129184
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138573
Predicted Effect noncoding transcript
Transcript: ENSMUST00000184503
Meta Mutation Damage Score 0.7292 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 93.7%
Validation Efficiency 98% (92/94)
Allele List at MGI
Other mutations in this stock
Total: 92 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410137M14Rik G A 17: 37,288,986 (GRCm39) probably benign Het
Abhd15 A G 11: 77,409,164 (GRCm39) T293A probably benign Het
Aldh1l1 C T 6: 90,539,647 (GRCm39) P192L probably benign Het
Aldoart1 T G 4: 72,770,779 (GRCm39) I10L probably benign Het
Ankhd1 G A 18: 36,778,166 (GRCm39) G1653D probably benign Het
Ankk1 A C 9: 49,330,664 (GRCm39) probably null Het
Astn1 A G 1: 158,428,072 (GRCm39) T748A possibly damaging Het
Bmp7 C A 2: 172,781,708 (GRCm39) R52L possibly damaging Het
Ccdc33 G A 9: 57,938,395 (GRCm39) P859S possibly damaging Het
Ccny A G 18: 9,449,644 (GRCm39) S10P probably damaging Het
Cdc6 C A 11: 98,801,287 (GRCm39) F179L probably benign Het
Cdc7 T A 5: 107,130,998 (GRCm39) V491E probably benign Het
Cdh23 G T 10: 60,432,509 (GRCm39) S138R possibly damaging Het
Cenpc1 T C 5: 86,185,614 (GRCm39) H299R probably benign Het
Ciart A T 3: 95,786,013 (GRCm39) M354K probably benign Het
Clasrp G T 7: 19,320,640 (GRCm39) probably benign Het
Col4a3 G A 1: 82,674,040 (GRCm39) G1132E unknown Het
Crebbp G A 16: 3,902,687 (GRCm39) T2184I probably benign Het
Cyp2r1 A C 7: 114,149,640 (GRCm39) M458R probably damaging Het
Cyp7a1 C A 4: 6,275,492 (GRCm39) R27M probably null Het
Ddhd2 A G 8: 26,242,192 (GRCm39) F116L probably damaging Het
Dgkd G A 1: 87,855,413 (GRCm39) R685K probably benign Het
Dnah2 A G 11: 69,415,066 (GRCm39) S223P probably benign Het
Exph5 A T 9: 53,283,979 (GRCm39) R353S possibly damaging Het
F11 C A 8: 45,705,155 (GRCm39) V129F probably benign Het
F830045P16Rik A T 2: 129,301,317 (GRCm39) S454T possibly damaging Het
Fam124a T C 14: 62,824,656 (GRCm39) I50T probably damaging Het
Fam20c T C 5: 138,741,982 (GRCm39) probably null Het
Fam234b A G 6: 135,203,912 (GRCm39) T405A probably benign Het
Fbh1 C A 2: 11,767,781 (GRCm39) V356L possibly damaging Het
Flywch1 G A 17: 23,981,287 (GRCm39) Q132* probably null Het
Foxo6 T C 4: 120,144,166 (GRCm39) D95G probably benign Het
Ggt5 T C 10: 75,439,921 (GRCm39) F174S probably damaging Het
Gm7104 G A 12: 88,252,551 (GRCm39) noncoding transcript Het
H2-T23 A G 17: 36,343,083 (GRCm39) L98P probably damaging Het
H4c16 G C 6: 136,781,101 (GRCm39) R93G possibly damaging Het
Heatr5a A G 12: 52,002,186 (GRCm39) V250A probably benign Het
Heyl A T 4: 123,135,156 (GRCm39) I50F probably damaging Het
Ifitm10 A T 7: 141,909,771 (GRCm39) S179R probably damaging Het
Isg15 A T 4: 156,284,249 (GRCm39) I93N probably benign Het
Itga10 C T 3: 96,559,054 (GRCm39) probably benign Het
Itga10 G A 3: 96,565,006 (GRCm39) V985I probably benign Het
Kcnt2 T C 1: 140,302,892 (GRCm39) I144T probably benign Het
Klk1 A C 7: 43,878,458 (GRCm39) K104T possibly damaging Het
Lemd3 C A 10: 120,769,347 (GRCm39) R654L probably damaging Het
Lmod1 A T 1: 135,292,125 (GRCm39) M327L probably benign Het
Lonrf2 T C 1: 38,846,131 (GRCm39) E347G probably benign Het
Ltbp1 A G 17: 75,583,427 (GRCm39) Y409C probably damaging Het
Mecom A T 3: 30,034,741 (GRCm39) Y312N probably damaging Het
Mmut A G 17: 41,252,342 (GRCm39) T295A probably benign Het
Mrgprb3 C T 7: 48,293,482 (GRCm39) C23Y possibly damaging Het
Nadk C A 4: 155,669,898 (GRCm39) L194I probably damaging Het
Naxd A G 8: 11,559,510 (GRCm39) I182V probably benign Het
Nbeal1 T A 1: 60,358,846 (GRCm39) I1176K probably damaging Het
Nol4l C A 2: 153,371,441 (GRCm39) R81L possibly damaging Het
Odad3 T G 9: 21,903,154 (GRCm39) T419P possibly damaging Het
Or4k47 T A 2: 111,452,159 (GRCm39) R87W probably benign Het
Or8g36 A T 9: 39,422,674 (GRCm39) M114K probably damaging Het
Or9s15 G T 1: 92,524,691 (GRCm39) R150L probably benign Het
Pcdh18 A G 3: 49,709,389 (GRCm39) V642A probably benign Het
Pdzk1 G A 3: 96,763,164 (GRCm39) probably benign Het
Per3 C T 4: 151,118,395 (GRCm39) V233I probably benign Het
Pisd G A 5: 32,922,140 (GRCm39) P267S possibly damaging Het
Prm1 T A 16: 10,614,357 (GRCm39) probably benign Het
Ptprj A G 2: 90,293,439 (GRCm39) V548A probably damaging Het
Ranbp3 G A 17: 56,980,367 (GRCm39) probably benign Het
Raver2 T A 4: 100,960,009 (GRCm39) V163D probably damaging Het
Rbm14 A T 19: 4,853,905 (GRCm39) I159N possibly damaging Het
Rfx6 G A 10: 51,594,222 (GRCm39) V381I probably benign Het
Rhobtb1 T C 10: 69,108,693 (GRCm39) probably benign Het
Rpl28-ps4 T A 6: 117,190,856 (GRCm39) noncoding transcript Het
Rsph10b A G 5: 143,904,068 (GRCm39) probably null Het
Rspo4 A G 2: 151,715,013 (GRCm39) K217E unknown Het
Scgb2b27 G A 7: 33,712,710 (GRCm39) A44V possibly damaging Het
Sec14l2 G A 11: 4,061,435 (GRCm39) probably benign Het
Sec31b T C 19: 44,524,595 (GRCm39) N101D probably benign Het
Sema6a A T 18: 47,439,496 (GRCm39) C9* probably null Het
Septin5 A C 16: 18,441,762 (GRCm39) L331R probably benign Het
Slc16a11 C A 11: 70,106,477 (GRCm39) Y238* probably null Het
Slc25a12 T C 2: 71,142,892 (GRCm39) T210A probably benign Het
Slc35f1 A T 10: 52,965,443 (GRCm39) Y286F probably damaging Het
Szt2 A T 4: 118,233,645 (GRCm39) L2225* probably null Het
Thap12 T C 7: 98,365,827 (GRCm39) L665P probably damaging Het
Tpsb2 T A 17: 25,586,698 (GRCm39) W237R probably damaging Het
Tyk2 T C 9: 21,031,637 (GRCm39) D451G probably damaging Het
Ube2j1 T A 4: 33,049,696 (GRCm39) N231K probably benign Het
Vmn1r225 A T 17: 20,722,852 (GRCm39) T98S possibly damaging Het
Vmn1r87 A T 7: 12,865,748 (GRCm39) S180T probably benign Het
Vmn2r6 A G 3: 64,445,262 (GRCm39) V821A probably damaging Het
Zfp689 C A 7: 127,043,998 (GRCm39) G211C probably damaging Het
Zfp827 A G 8: 79,802,865 (GRCm39) D479G probably benign Het
Zfp995 A C 17: 22,099,575 (GRCm39) F220V probably damaging Het
Other mutations in Gpr155
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00731:Gpr155 APN 2 73,192,957 (GRCm39) missense probably damaging 1.00
IGL01432:Gpr155 APN 2 73,182,229 (GRCm39) missense possibly damaging 0.51
IGL01528:Gpr155 APN 2 73,192,767 (GRCm39) critical splice donor site probably null
IGL01718:Gpr155 APN 2 73,212,576 (GRCm39) missense probably benign
IGL01733:Gpr155 APN 2 73,183,956 (GRCm39) splice site probably null
IGL03342:Gpr155 APN 2 73,180,022 (GRCm39) missense probably damaging 1.00
PIT1430001:Gpr155 UTSW 2 73,200,482 (GRCm39) missense probably benign 0.08
PIT4810001:Gpr155 UTSW 2 73,178,607 (GRCm39) missense probably benign 0.08
R0226:Gpr155 UTSW 2 73,197,936 (GRCm39) missense probably benign 0.02
R0399:Gpr155 UTSW 2 73,200,346 (GRCm39) missense possibly damaging 0.91
R0445:Gpr155 UTSW 2 73,200,488 (GRCm39) splice site probably benign
R1570:Gpr155 UTSW 2 73,200,382 (GRCm39) missense possibly damaging 0.87
R1598:Gpr155 UTSW 2 73,200,434 (GRCm39) missense probably damaging 0.98
R1647:Gpr155 UTSW 2 73,194,508 (GRCm39) splice site probably null
R1648:Gpr155 UTSW 2 73,194,508 (GRCm39) splice site probably null
R1756:Gpr155 UTSW 2 73,197,921 (GRCm39) missense probably benign 0.00
R1760:Gpr155 UTSW 2 73,212,279 (GRCm39) missense probably damaging 1.00
R2033:Gpr155 UTSW 2 73,178,526 (GRCm39) missense probably benign 0.18
R2145:Gpr155 UTSW 2 73,187,002 (GRCm39) missense probably benign 0.01
R2172:Gpr155 UTSW 2 73,212,471 (GRCm39) missense probably benign 0.00
R2274:Gpr155 UTSW 2 73,178,479 (GRCm39) critical splice donor site probably null
R3878:Gpr155 UTSW 2 73,198,736 (GRCm39) nonsense probably null
R3924:Gpr155 UTSW 2 73,200,420 (GRCm39) missense probably damaging 1.00
R4910:Gpr155 UTSW 2 73,197,882 (GRCm39) nonsense probably null
R4950:Gpr155 UTSW 2 73,212,529 (GRCm39) missense probably benign
R5337:Gpr155 UTSW 2 73,178,592 (GRCm39) missense probably benign 0.32
R5830:Gpr155 UTSW 2 73,200,433 (GRCm39) missense possibly damaging 0.93
R5887:Gpr155 UTSW 2 73,174,062 (GRCm39) nonsense probably null
R5929:Gpr155 UTSW 2 73,204,011 (GRCm39) nonsense probably null
R6293:Gpr155 UTSW 2 73,204,341 (GRCm39) missense possibly damaging 0.47
R6553:Gpr155 UTSW 2 73,179,989 (GRCm39) missense probably damaging 1.00
R6585:Gpr155 UTSW 2 73,179,989 (GRCm39) missense probably damaging 1.00
R7003:Gpr155 UTSW 2 73,173,961 (GRCm39) missense probably damaging 0.99
R7353:Gpr155 UTSW 2 73,197,835 (GRCm39) nonsense probably null
R7506:Gpr155 UTSW 2 73,198,683 (GRCm39) missense probably damaging 0.97
R7631:Gpr155 UTSW 2 73,213,291 (GRCm39) intron probably benign
R7753:Gpr155 UTSW 2 73,212,550 (GRCm39) missense probably benign 0.27
R7810:Gpr155 UTSW 2 73,212,296 (GRCm39) missense probably damaging 0.99
R7813:Gpr155 UTSW 2 73,212,329 (GRCm39) nonsense probably null
R7815:Gpr155 UTSW 2 73,192,904 (GRCm39) missense probably benign
R7873:Gpr155 UTSW 2 73,173,934 (GRCm39) missense possibly damaging 0.51
R8506:Gpr155 UTSW 2 73,173,806 (GRCm39) missense probably damaging 0.99
R8680:Gpr155 UTSW 2 73,174,039 (GRCm39) missense probably damaging 0.99
R8856:Gpr155 UTSW 2 73,203,993 (GRCm39) missense probably benign 0.27
R8872:Gpr155 UTSW 2 73,197,936 (GRCm39) missense probably benign 0.02
R9116:Gpr155 UTSW 2 73,204,109 (GRCm39) missense possibly damaging 0.78
R9683:Gpr155 UTSW 2 73,192,780 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TTTACACAAAAGCTGAATGGGG -3'
(R):5'- TACGCGTGTTACAGAACCCG -3'

Sequencing Primer
(F):5'- CCTCTTCTGGAGTGTCTGAAAACAG -3'
(R):5'- ACAGAACCCGATAGTATTTATGGTC -3'
Posted On 2014-08-25