Mutagenetix > Incidental Mutation

Incidental Mutation 'R2045:Dock2'

221854

Institutional Source

Beutler Lab

Gene Symbol

Dock2

Ensembl Gene

ENSMUSG00000020143

Gene Name

dedicator of cyto-kinesis 2

Synonyms

CED-5, MBC, Hch

MMRRC Submission

040052-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R2045 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

34226815-34783892 bp(-) (GRCm38)

Type of Mutation

splice site (4 bp from exon)

DNA Base Change (assembly)

T to C at 34294106 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000098916 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000093193] [ENSMUST00000093193] [ENSMUST00000101365] [ENSMUST00000101365]

AlphaFold

Q8C3J5

Predicted Effect

probably null
Transcript: ENSMUST00000093193

SMART Domains

Protein: ENSMUSP00000090884
Gene: ENSMUSG00000020143

Domain	Start	End	E-Value	Type
SH3	11	68	1.22e-11	SMART
Pfam:DOCK_N	71	414	2e-113	PFAM
Pfam:DOCK-C2	419	616	1e-60	PFAM
Pfam:DHR-2	1114	1614	6.3e-96	PFAM
low complexity region	1691	1706	N/A	INTRINSIC
low complexity region	1793	1800	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000093193

SMART Domains

Protein: ENSMUSP00000090884
Gene: ENSMUSG00000020143

Domain	Start	End	E-Value	Type
SH3	11	68	1.22e-11	SMART
Pfam:DOCK_N	71	414	2e-113	PFAM
Pfam:DOCK-C2	419	616	1e-60	PFAM
Pfam:DHR-2	1114	1614	6.3e-96	PFAM
low complexity region	1691	1706	N/A	INTRINSIC
low complexity region	1793	1800	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000101365

SMART Domains

Protein: ENSMUSP00000098916
Gene: ENSMUSG00000020143

Domain	Start	End	E-Value	Type
SH3	11	68	1.22e-11	SMART
Pfam:DOCK_N	71	414	1.4e-113	PFAM
Pfam:DOCK-C2	419	616	5.5e-61	PFAM
low complexity region	1163	1171	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000101365

SMART Domains

Protein: ENSMUSP00000098916
Gene: ENSMUSG00000020143

Domain	Start	End	E-Value	Type
SH3	11	68	1.22e-11	SMART
Pfam:DOCK_N	71	414	1.4e-113	PFAM
Pfam:DOCK-C2	419	616	5.5e-61	PFAM
low complexity region	1163	1171	N/A	INTRINSIC

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.0%
20x: 94.6%

Validation Efficiency

100% (74/74)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. [provided by RefSeq, Oct 2016]
PHENOTYPE: Homozygous mutants are defective in the migration of T and B lympohcytes in response to chemokines, and thus display immune defects such as lymphocytopenia, atrophy of lymphoid follicles and loss of marginal-zone B cells. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 74 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acta2	C	T	19: 34,243,399 (GRCm38)	G303E	probably damaging	Het
Adamts1	A	T	16: 85,795,976 (GRCm38)	Y515N	probably damaging	Het
Ankef1	T	C	2: 136,554,738 (GRCm38)	V695A	probably benign	Het
Ankrd63	C	A	2: 118,703,353 (GRCm38)		probably benign	Het
Asah2	A	T	19: 32,052,956 (GRCm38)	N105K	probably benign	Het
Atf2	A	C	2: 73,863,208 (GRCm38)	D3E	probably damaging	Het
Atp5f1	T	C	3: 105,943,874 (GRCm38)		probably benign	Het
Bag4	C	T	8: 25,769,488 (GRCm38)	A228T	probably benign	Het
Bms1	A	C	6: 118,392,627 (GRCm38)	L960W	probably damaging	Het
Cacna1c	A	G	6: 118,656,137 (GRCm38)	V977A	probably damaging	Het
Cadps2	A	G	6: 23,839,122 (GRCm38)	S6P	possibly damaging	Het
Capn8	A	G	1: 182,613,386 (GRCm38)	T462A	probably benign	Het
Cd226	T	C	18: 89,207,362 (GRCm38)	S128P	probably benign	Het
Cd33	G	T	7: 43,529,892 (GRCm38)	H278N	probably benign	Het
Cdh1	T	C	8: 106,666,182 (GRCm38)		probably benign	Het
Cfap54	T	C	10: 93,038,809 (GRCm38)		probably null	Het
Chit1	A	G	1: 134,151,144 (GRCm38)	I397M	probably benign	Het
Cic	C	A	7: 25,271,536 (GRCm38)	Q231K	possibly damaging	Het
Clca4b	A	G	3: 144,925,163 (GRCm38)	V312A	probably damaging	Het
Cngb1	T	A	8: 95,297,085 (GRCm38)		probably null	Het
Cyfip2	T	C	11: 46,249,789 (GRCm38)	I430V	probably benign	Het
Dnah12	A	G	14: 26,781,528 (GRCm38)	E1613G	probably null	Het
Dync2h1	A	T	9: 7,160,171 (GRCm38)	F646I	probably damaging	Het
Eef1b2	A	T	1: 63,179,487 (GRCm38)	K144*	probably null	Het
Erap1	T	C	13: 74,669,450 (GRCm38)	V137A	probably benign	Het
Fam196a	T	G	7: 134,918,430 (GRCm38)	K124Q	probably damaging	Het
Far1	A	T	7: 113,539,271 (GRCm38)		probably null	Het
Fbn2	A	T	18: 58,090,658 (GRCm38)	C807S	probably damaging	Het
Fgfr1	A	G	8: 25,558,215 (GRCm38)	K209R	probably benign	Het
Fpr-rs4	CAGGAA	CA	17: 18,022,334 (GRCm38)		probably null	Het
Frem2	A	T	3: 53,535,744 (GRCm38)	V2533D	probably damaging	Het
Hip1r	T	C	5: 124,000,731 (GRCm38)	M839T	probably benign	Het
Igfbp2	A	G	1: 72,852,151 (GRCm38)	S303G	probably benign	Het
Itga10	C	T	3: 96,651,738 (GRCm38)		probably benign	Het
Itgb3	T	G	11: 104,623,413 (GRCm38)	S27A	probably benign	Het
Kif21b	G	A	1: 136,160,313 (GRCm38)	D1015N	probably damaging	Het
Krt7	A	T	15: 101,423,484 (GRCm38)		probably null	Het
Krtdap	T	A	7: 30,790,585 (GRCm38)	F80L	probably benign	Het
Lcp1	A	T	14: 75,200,401 (GRCm38)	T84S	probably benign	Het
Lipi	G	A	16: 75,550,199 (GRCm38)	T444I	probably damaging	Het
Lrguk	A	T	6: 34,071,068 (GRCm38)	E316V	probably damaging	Het
Lypd1	G	A	1: 125,910,535 (GRCm38)		probably benign	Het
Med12l	A	T	3: 59,262,310 (GRCm38)	K1632*	probably null	Het
Mrgpra9	A	T	7: 47,235,835 (GRCm38)	M28K	probably benign	Het
Mylk	A	G	16: 34,953,653 (GRCm38)	K1291E	probably benign	Het
Nek4	T	A	14: 30,953,923 (GRCm38)	W72R	probably damaging	Het
Nudt8	T	C	19: 4,001,899 (GRCm38)	V170A	probably damaging	Het
Oosp3	T	A	19: 11,699,369 (GRCm38)	Y31N	probably benign	Het
Padi2	A	T	4: 140,937,930 (GRCm38)	R449W	probably damaging	Het
Pcf11	G	T	7: 92,661,879 (GRCm38)	N300K	probably damaging	Het
Pcsk5	T	C	19: 17,581,144 (GRCm38)	D633G	possibly damaging	Het
Phlpp2	T	A	8: 109,907,600 (GRCm38)	W271R	probably damaging	Het
Pikfyve	T	C	1: 65,253,353 (GRCm38)	V1276A	probably benign	Het
Pkhd1l1	A	T	15: 44,479,654 (GRCm38)	N176Y	probably damaging	Het
Pop5	T	G	5: 115,238,212 (GRCm38)	V33G	possibly damaging	Het
Prkag2	A	G	5: 24,947,582 (GRCm38)	F175L	possibly damaging	Het
Ptpn22	T	A	3: 103,874,021 (GRCm38)	D79E	possibly damaging	Het
Rab32	T	G	10: 10,550,833 (GRCm38)	D123A	probably damaging	Het
Rnpc3	T	C	3: 113,608,360 (GRCm38)	K513E	possibly damaging	Het
Senp1	A	T	15: 98,059,944 (GRCm38)	F358I	possibly damaging	Het
Sft2d2	A	G	1: 165,185,078 (GRCm38)	L83P	probably damaging	Het
Slc9c1	G	A	16: 45,580,250 (GRCm38)	R741H	probably damaging	Het
Smad4	A	T	18: 73,649,806 (GRCm38)	Y352*	probably null	Het
Tamm41	T	A	6: 115,016,095 (GRCm38)	Q232H	probably benign	Het
Tbx6	T	A	7: 126,782,883 (GRCm38)	L131Q	probably damaging	Het
Trappc10	T	C	10: 78,209,479 (GRCm38)		probably benign	Het
Trp53bp1	C	A	2: 121,204,483 (GRCm38)	A108S	probably benign	Het
Unc13b	G	A	4: 43,091,266 (GRCm38)	V31M	probably damaging	Het
Usp24	T	C	4: 106,400,980 (GRCm38)	M1525T	possibly damaging	Het
Vax2	G	A	6: 83,711,270 (GRCm38)		probably benign	Het
Vcan	T	A	13: 89,690,985 (GRCm38)	I2147L	probably benign	Het
Zbtb7a	C	A	10: 81,144,410 (GRCm38)	A146E	probably benign	Het
Zcchc6	T	C	13: 59,800,656 (GRCm38)	Y215C	probably damaging	Het
Zfp287	A	G	11: 62,727,569 (GRCm38)	L157P	probably damaging	Het

Other mutations in Dock2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00334:Dock2	APN	11	34,704,661 (GRCm38)	missense	probably damaging	1.00
IGL00469:Dock2	APN	11	34,229,603 (GRCm38)	splice site	probably benign
IGL01061:Dock2	APN	11	34,705,826 (GRCm38)	missense	probably damaging	1.00
IGL01319:Dock2	APN	11	34,698,790 (GRCm38)	missense	possibly damaging	0.61
IGL01451:Dock2	APN	11	34,310,390 (GRCm38)	missense	probably damaging	1.00
IGL01490:Dock2	APN	11	34,705,781 (GRCm38)	missense	probably damaging	0.97
IGL01601:Dock2	APN	11	34,239,528 (GRCm38)	critical splice donor site	probably null
IGL01800:Dock2	APN	11	34,756,273 (GRCm38)	missense	probably damaging	1.00
IGL01804:Dock2	APN	11	34,262,433 (GRCm38)	missense	probably benign	0.01
IGL01823:Dock2	APN	11	34,262,391 (GRCm38)	missense	probably damaging	1.00
IGL01829:Dock2	APN	11	34,705,841 (GRCm38)	missense	probably damaging	0.98
IGL01830:Dock2	APN	11	34,691,917 (GRCm38)	nonsense	probably null
IGL01835:Dock2	APN	11	34,310,435 (GRCm38)	missense	possibly damaging	0.51
IGL01845:Dock2	APN	11	34,708,865 (GRCm38)	missense	probably benign	0.02
IGL01953:Dock2	APN	11	34,732,356 (GRCm38)	missense	probably benign	0.28
IGL01989:Dock2	APN	11	34,268,053 (GRCm38)	missense	probably benign
IGL02081:Dock2	APN	11	34,254,355 (GRCm38)	missense	probably benign
IGL02105:Dock2	APN	11	34,714,525 (GRCm38)	missense	probably damaging	1.00
IGL02153:Dock2	APN	11	34,230,670 (GRCm38)	missense	probably benign	0.01
IGL02170:Dock2	APN	11	34,267,949 (GRCm38)	missense	probably damaging	1.00
IGL02344:Dock2	APN	11	34,731,510 (GRCm38)	missense	probably damaging	0.98
IGL02389:Dock2	APN	11	34,698,740 (GRCm38)	splice site	probably benign
IGL02409:Dock2	APN	11	34,501,204 (GRCm38)	missense	probably benign	0.00
IGL02472:Dock2	APN	11	34,249,801 (GRCm38)	missense	probably benign	0.00
IGL02625:Dock2	APN	11	34,501,168 (GRCm38)	critical splice donor site	probably null
IGL02929:Dock2	APN	11	34,268,048 (GRCm38)	missense	probably damaging	1.00
IGL02951:Dock2	APN	11	34,310,448 (GRCm38)	unclassified	probably benign
IGL02999:Dock2	APN	11	34,692,259 (GRCm38)	missense	probably damaging	0.99
IGL03165:Dock2	APN	11	34,687,533 (GRCm38)	missense	probably damaging	0.99
Arches	UTSW	11	34,689,760 (GRCm38)	missense	probably damaging	1.00
capitol_reef	UTSW	11	34,294,170 (GRCm38)	critical splice acceptor site	probably null
Croesus	UTSW	11	34,721,027 (GRCm38)	missense	probably damaging	1.00
denali	UTSW	11	34,229,472 (GRCm38)	critical splice donor site	probably null
dew	UTSW	11	34,248,636 (GRCm38)	nonsense	probably null
Dinghy	UTSW	11	34,262,460 (GRCm38)	missense	possibly damaging	0.70
Dry	UTSW	11	34,231,652 (GRCm38)	missense	possibly damaging	0.79
frazz	UTSW	11	34,248,572 (GRCm38)	critical splice donor site	probably benign
frizz	UTSW	11	34,258,184 (GRCm38)	splice site	probably benign
gildenstern	UTSW	11	34,732,339 (GRCm38)	critical splice donor site	probably null
godsgrace	UTSW	11	34,695,453 (GRCm38)	missense	probably damaging	1.00
Harborside	UTSW	11	34,262,445 (GRCm38)	missense	probably benign
Landing	UTSW	11	34,714,501 (GRCm38)	missense	possibly damaging	0.83
latest	UTSW	11	34,756,222 (GRCm38)	missense	probably damaging	1.00
Launch	UTSW	11	34,256,562 (GRCm38)	missense	probably damaging	1.00
liaoning	UTSW	11	34,708,793 (GRCm38)	missense	probably damaging	1.00
lucre	UTSW	11	34,704,609 (GRCm38)	frame shift	probably null
midas	UTSW	11	34,294,323 (GRCm38)	missense	probably damaging	0.99
muelle	UTSW	11	34,687,538 (GRCm38)	missense	probably damaging	1.00
narrowest	UTSW	11	34,282,652 (GRCm38)	missense	probably damaging	0.98
pier	UTSW	11	34,689,766 (GRCm38)	missense	probably damaging	1.00
Plank	UTSW	11	34,783,795 (GRCm38)	missense	possibly damaging	0.51
resplendent	UTSW	11	34,727,460 (GRCm38)	nonsense	probably null
riches	UTSW	11	34,688,452 (GRCm38)	critical splice donor site	probably null
skiff	UTSW	11	34,262,388 (GRCm38)	missense	probably null	0.80
Slip	UTSW	11	34,294,286 (GRCm38)	missense	probably benign	0.25
toothskin	UTSW	11	34,464,922 (GRCm38)	missense	probably damaging	1.00
Touch	UTSW	11	34,273,750 (GRCm38)	missense	possibly damaging	0.95
wassup	UTSW	11	34,503,413 (GRCm38)	missense	probably damaging	1.00
Wharf	UTSW	11	34,732,371 (GRCm38)	missense	possibly damaging	0.81
BB009:Dock2	UTSW	11	34,267,998 (GRCm38)	missense	probably benign	0.00
BB019:Dock2	UTSW	11	34,267,998 (GRCm38)	missense	probably benign	0.00
IGL03052:Dock2	UTSW	11	34,232,853 (GRCm38)	missense	probably benign	0.01
PIT4377001:Dock2	UTSW	11	34,721,008 (GRCm38)	missense	probably benign	0.02
R0006:Dock2	UTSW	11	34,312,453 (GRCm38)	unclassified	probably benign
R0012:Dock2	UTSW	11	34,783,795 (GRCm38)	missense	possibly damaging	0.51
R0063:Dock2	UTSW	11	34,756,284 (GRCm38)	critical splice acceptor site	probably null
R0063:Dock2	UTSW	11	34,756,284 (GRCm38)	critical splice acceptor site	probably null
R0116:Dock2	UTSW	11	34,688,565 (GRCm38)	intron	probably benign
R0149:Dock2	UTSW	11	34,438,327 (GRCm38)	missense	probably damaging	1.00
R0361:Dock2	UTSW	11	34,438,327 (GRCm38)	missense	probably damaging	1.00
R0462:Dock2	UTSW	11	34,268,052 (GRCm38)	missense	possibly damaging	0.74
R0471:Dock2	UTSW	11	34,688,553 (GRCm38)	missense	probably benign	0.30
R0538:Dock2	UTSW	11	34,704,718 (GRCm38)	splice site	probably benign
R0543:Dock2	UTSW	11	34,294,325 (GRCm38)	missense	probably damaging	1.00
R0660:Dock2	UTSW	11	34,248,621 (GRCm38)	missense	probably damaging	1.00
R0676:Dock2	UTSW	11	34,695,236 (GRCm38)	missense	probably damaging	0.99
R0722:Dock2	UTSW	11	34,464,970 (GRCm38)	splice site	probably benign
R0801:Dock2	UTSW	11	34,708,793 (GRCm38)	missense	probably damaging	1.00
R1110:Dock2	UTSW	11	34,256,535 (GRCm38)	missense	possibly damaging	0.78
R1171:Dock2	UTSW	11	34,695,241 (GRCm38)	missense	probably damaging	1.00
R1387:Dock2	UTSW	11	34,273,309 (GRCm38)	splice site	probably benign
R1445:Dock2	UTSW	11	34,239,705 (GRCm38)	missense	probably benign
R1494:Dock2	UTSW	11	34,282,761 (GRCm38)	nonsense	probably null
R1589:Dock2	UTSW	11	34,706,461 (GRCm38)	missense	probably damaging	0.99
R1597:Dock2	UTSW	11	34,704,647 (GRCm38)	missense	probably benign	0.00
R1629:Dock2	UTSW	11	34,262,480 (GRCm38)	splice site	probably null
R1749:Dock2	UTSW	11	34,232,767 (GRCm38)	critical splice donor site	probably null
R1888:Dock2	UTSW	11	34,707,342 (GRCm38)	missense	probably damaging	1.00
R1888:Dock2	UTSW	11	34,707,342 (GRCm38)	missense	probably damaging	1.00
R1899:Dock2	UTSW	11	34,294,286 (GRCm38)	missense	probably benign	0.25
R1924:Dock2	UTSW	11	34,464,934 (GRCm38)	missense	possibly damaging	0.69
R2031:Dock2	UTSW	11	34,727,470 (GRCm38)	splice site	probably benign
R2098:Dock2	UTSW	11	34,719,005 (GRCm38)	missense	probably damaging	0.99
R2098:Dock2	UTSW	11	34,266,279 (GRCm38)	missense	probably benign	0.16
R2129:Dock2	UTSW	11	34,727,415 (GRCm38)	missense	probably damaging	1.00
R2147:Dock2	UTSW	11	34,229,472 (GRCm38)	critical splice donor site	probably null
R2149:Dock2	UTSW	11	34,229,472 (GRCm38)	critical splice donor site	probably null
R2150:Dock2	UTSW	11	34,229,472 (GRCm38)	critical splice donor site	probably null
R2176:Dock2	UTSW	11	34,695,217 (GRCm38)	missense	probably benign	0.00
R2230:Dock2	UTSW	11	34,294,323 (GRCm38)	missense	probably damaging	0.99
R2508:Dock2	UTSW	11	34,312,485 (GRCm38)	missense	probably benign	0.04
R2875:Dock2	UTSW	11	34,718,885 (GRCm38)	missense	probably damaging	1.00
R2885:Dock2	UTSW	11	34,689,766 (GRCm38)	missense	probably damaging	1.00
R2910:Dock2	UTSW	11	34,232,910 (GRCm38)	splice site	probably benign
R3081:Dock2	UTSW	11	34,231,610 (GRCm38)	missense	probably benign
R3418:Dock2	UTSW	11	34,689,760 (GRCm38)	missense	probably damaging	1.00
R3552:Dock2	UTSW	11	34,720,960 (GRCm38)	missense	probably benign	0.22
R3731:Dock2	UTSW	11	34,708,895 (GRCm38)	missense	probably damaging	1.00
R3846:Dock2	UTSW	11	34,732,371 (GRCm38)	missense	possibly damaging	0.81
R4135:Dock2	UTSW	11	34,714,501 (GRCm38)	missense	possibly damaging	0.83
R4598:Dock2	UTSW	11	34,239,536 (GRCm38)	missense	probably damaging	1.00
R4599:Dock2	UTSW	11	34,239,536 (GRCm38)	missense	probably damaging	1.00
R4715:Dock2	UTSW	11	34,294,118 (GRCm38)	missense	probably damaging	1.00
R4722:Dock2	UTSW	11	34,695,471 (GRCm38)	missense	probably damaging	1.00
R4742:Dock2	UTSW	11	34,294,170 (GRCm38)	critical splice acceptor site	probably null
R4830:Dock2	UTSW	11	34,273,767 (GRCm38)	splice site	probably null
R4884:Dock2	UTSW	11	34,266,248 (GRCm38)	missense	probably damaging	1.00
R4990:Dock2	UTSW	11	34,695,251 (GRCm38)	missense	probably damaging	1.00
R5334:Dock2	UTSW	11	34,228,643 (GRCm38)	missense	probably benign	0.00
R5570:Dock2	UTSW	11	34,727,406 (GRCm38)	missense	probably damaging	1.00
R5602:Dock2	UTSW	11	34,254,391 (GRCm38)	missense	probably benign	0.16
R5681:Dock2	UTSW	11	34,249,836 (GRCm38)	missense	probably benign	0.06
R5809:Dock2	UTSW	11	34,262,445 (GRCm38)	missense	probably benign
R5860:Dock2	UTSW	11	34,256,562 (GRCm38)	missense	probably damaging	1.00
R6111:Dock2	UTSW	11	34,708,787 (GRCm38)	missense	probably damaging	0.99
R6155:Dock2	UTSW	11	34,294,123 (GRCm38)	missense	probably benign	0.06
R6156:Dock2	UTSW	11	34,247,789 (GRCm38)	missense	possibly damaging	0.51
R6173:Dock2	UTSW	11	34,262,388 (GRCm38)	missense	probably null	0.80
R6182:Dock2	UTSW	11	34,229,476 (GRCm38)	missense	probably damaging	0.97
R6188:Dock2	UTSW	11	34,503,396 (GRCm38)	missense	probably damaging	0.98
R6191:Dock2	UTSW	11	34,231,652 (GRCm38)	missense	possibly damaging	0.79
R6283:Dock2	UTSW	11	34,707,325 (GRCm38)	missense	probably damaging	0.99
R6395:Dock2	UTSW	11	34,232,874 (GRCm38)	missense	probably damaging	1.00
R6465:Dock2	UTSW	11	34,503,413 (GRCm38)	missense	probably damaging	1.00
R6500:Dock2	UTSW	11	34,362,822 (GRCm38)	missense	possibly damaging	0.76
R6561:Dock2	UTSW	11	34,687,538 (GRCm38)	missense	probably damaging	1.00
R6745:Dock2	UTSW	11	34,705,843 (GRCm38)	missense	probably damaging	1.00
R6745:Dock2	UTSW	11	34,705,842 (GRCm38)	missense	probably damaging	1.00
R6880:Dock2	UTSW	11	34,688,452 (GRCm38)	critical splice donor site	probably null
R6913:Dock2	UTSW	11	34,756,222 (GRCm38)	missense	probably damaging	1.00
R6997:Dock2	UTSW	11	34,464,922 (GRCm38)	missense	probably damaging	1.00
R7057:Dock2	UTSW	11	34,695,217 (GRCm38)	missense	probably benign	0.00
R7057:Dock2	UTSW	11	34,227,684 (GRCm38)	missense	probably benign	0.10
R7134:Dock2	UTSW	11	34,310,363 (GRCm38)	missense	probably benign	0.03
R7188:Dock2	UTSW	11	34,239,675 (GRCm38)	missense	possibly damaging	0.87
R7239:Dock2	UTSW	11	34,231,677 (GRCm38)	missense	probably benign	0.00
R7247:Dock2	UTSW	11	34,714,513 (GRCm38)	nonsense	probably null
R7250:Dock2	UTSW	11	34,695,293 (GRCm38)	missense	probably damaging	1.00
R7250:Dock2	UTSW	11	34,695,205 (GRCm38)	missense	probably benign	0.01
R7271:Dock2	UTSW	11	34,273,750 (GRCm38)	missense	possibly damaging	0.95
R7284:Dock2	UTSW	11	34,230,672 (GRCm38)	missense	probably benign	0.01
R7397:Dock2	UTSW	11	34,718,989 (GRCm38)	missense	probably benign	0.00
R7464:Dock2	UTSW	11	34,695,278 (GRCm38)	missense	probably damaging	0.99
R7512:Dock2	UTSW	11	34,312,542 (GRCm38)	missense	possibly damaging	0.95
R7556:Dock2	UTSW	11	34,720,951 (GRCm38)	missense	probably benign	0.43
R7663:Dock2	UTSW	11	34,721,027 (GRCm38)	missense	probably damaging	1.00
R7779:Dock2	UTSW	11	34,714,455 (GRCm38)	missense	probably benign	0.38
R7797:Dock2	UTSW	11	34,282,652 (GRCm38)	missense	probably damaging	0.98
R7855:Dock2	UTSW	11	34,273,698 (GRCm38)	missense	probably damaging	1.00
R7922:Dock2	UTSW	11	34,707,327 (GRCm38)	missense	probably benign	0.29
R7932:Dock2	UTSW	11	34,267,998 (GRCm38)	missense	probably benign	0.00
R8013:Dock2	UTSW	11	34,705,850 (GRCm38)	missense	probably damaging	0.96
R8192:Dock2	UTSW	11	34,732,339 (GRCm38)	critical splice donor site	probably null
R8244:Dock2	UTSW	11	34,695,453 (GRCm38)	missense	probably damaging	1.00
R8307:Dock2	UTSW	11	34,310,362 (GRCm38)	missense	possibly damaging	0.95
R8418:Dock2	UTSW	11	34,718,968 (GRCm38)	missense	probably benign	0.01
R8460:Dock2	UTSW	11	34,230,825 (GRCm38)	critical splice acceptor site	probably null
R8495:Dock2	UTSW	11	34,231,622 (GRCm38)	missense	probably benign	0.14
R8556:Dock2	UTSW	11	34,262,457 (GRCm38)	missense	possibly damaging	0.84
R8690:Dock2	UTSW	11	34,727,460 (GRCm38)	nonsense	probably null
R8743:Dock2	UTSW	11	34,273,252 (GRCm38)	nonsense	probably null
R8757:Dock2	UTSW	11	34,695,240 (GRCm38)	missense	probably benign	0.13
R8759:Dock2	UTSW	11	34,695,240 (GRCm38)	missense	probably benign	0.13
R8793:Dock2	UTSW	11	34,501,215 (GRCm38)	missense	probably benign	0.00
R8882:Dock2	UTSW	11	34,704,609 (GRCm38)	frame shift	probably null
R8885:Dock2	UTSW	11	34,310,396 (GRCm38)	missense	probably benign	0.01
R8943:Dock2	UTSW	11	34,708,819 (GRCm38)	missense	possibly damaging	0.63
R9171:Dock2	UTSW	11	34,698,843 (GRCm38)	missense	probably benign	0.12
R9182:Dock2	UTSW	11	34,310,398 (GRCm38)	missense	possibly damaging	0.51
R9203:Dock2	UTSW	11	34,731,539 (GRCm38)	missense	possibly damaging	0.92
R9310:Dock2	UTSW	11	34,294,139 (GRCm38)	missense	possibly damaging	0.71
R9388:Dock2	UTSW	11	34,262,460 (GRCm38)	missense	possibly damaging	0.70
R9490:Dock2	UTSW	11	34,698,755 (GRCm38)	missense	possibly damaging	0.90
R9568:Dock2	UTSW	11	34,708,811 (GRCm38)	missense	possibly damaging	0.83
R9593:Dock2	UTSW	11	34,228,607 (GRCm38)	missense	probably benign	0.34
R9694:Dock2	UTSW	11	34,268,054 (GRCm38)	missense	probably benign
R9697:Dock2	UTSW	11	34,254,417 (GRCm38)	missense	probably benign
R9753:Dock2	UTSW	11	34,273,673 (GRCm38)	missense	possibly damaging	0.68
R9783:Dock2	UTSW	11	34,258,128 (GRCm38)	missense	possibly damaging	0.83
X0017:Dock2	UTSW	11	34,266,271 (GRCm38)	missense	probably benign	0.08
X0018:Dock2	UTSW	11	34,232,833 (GRCm38)	missense	possibly damaging	0.65
X0058:Dock2	UTSW	11	34,256,564 (GRCm38)	missense	probably damaging	1.00
X0066:Dock2	UTSW	11	34,310,357 (GRCm38)	missense	possibly damaging	0.95
Z1088:Dock2	UTSW	11	34,692,382 (GRCm38)	missense	probably damaging	1.00
Z1088:Dock2	UTSW	11	34,438,300 (GRCm38)	missense	probably benign	0.14
Z1088:Dock2	UTSW	11	34,695,212 (GRCm38)	nonsense	probably null
Z1176:Dock2	UTSW	11	34,718,924 (GRCm38)	missense	probably benign	0.04
Z1177:Dock2	UTSW	11	34,312,553 (GRCm38)	missense	possibly damaging	0.68

Predicted Primers

PCR Primer
(F):5'- GGGATGCATGACAACAGTTC -3'
(R):5'- TCACTCAGGACTCTCTGCAG -3'

Sequencing Primer
(F):5'- GGATGCATGACAACAGTTCTCACAC -3'
(R):5'- TGGAGCAGTTCACACACG -3'

Posted On

2014-08-25