Mutagenetix > Incidental Mutation

Incidental Mutation 'R1977:Olfr167'

221914

Institutional Source

Beutler Lab

Gene Symbol

Olfr167

Ensembl Gene

ENSMUSG00000045341

Gene Name

olfactory receptor 167

Synonyms

MOR272-1, GA_x54KRFPKG5P-15963726-15962788

MMRRC Submission

039990-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.197) question?

Stock #

R1977 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

19509558-19522266 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 19514836 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Proline to Serine at position 267 (P267S)

Ref Sequence

ENSEMBL: ENSMUSP00000150102 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000054606] [ENSMUST00000214315]

AlphaFold

Q8VGJ5

Predicted Effect

probably damaging
Transcript: ENSMUST00000054606
AA Change: P267S

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000055344
Gene: ENSMUSG00000045341
AA Change: P267S

Domain	Start	End	E-Value	Type
Pfam:7tm_4	30	306	4.8e-46	PFAM
Pfam:7TM_GPCR_Srsx	33	295	1.2e-6	PFAM
Pfam:7tm_1	40	289	1.8e-26	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000214315
AA Change: P267S

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000217566

Meta Mutation Damage Score

0.5034

Coding Region Coverage

1x: 99.1%
3x: 98.4%
10x: 96.7%
20x: 93.8%

Validation Efficiency

99% (66/67)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 63 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acsf3	G	T	8: 122,781,533	C256F	probably damaging	Het
Adgra2	T	A	8: 27,115,761	V647D	possibly damaging	Het
AI593442	A	T	9: 52,678,192	S28R	probably damaging	Het
Akr1c21	G	C	13: 4,574,212	G22R	probably damaging	Het
Ampd3	T	C	7: 110,803,162	W458R	probably damaging	Het
Arhgap23	G	T	11: 97,451,447	R185L	possibly damaging	Het
Arhgap45	A	T	10: 80,020,818	I67F	probably damaging	Het
Asah1	A	G	8: 41,343,517		probably null	Het
Atl2	A	G	17: 79,852,590	Y56H	probably damaging	Het
Carf	A	T	1: 60,146,136	I447F	probably damaging	Het
Crmp1	A	G	5: 37,276,283	N162S	probably damaging	Het
Cyp2a5	A	G	7: 26,835,922	E103G	probably benign	Het
Cyp2c40	T	C	19: 39,778,041	D370G	probably damaging	Het
Dhrs2	T	A	14: 55,234,655	M1K	probably null	Het
Dnah17	T	C	11: 118,112,591	E810G	possibly damaging	Het
E2f5	T	A	3: 14,587,356	I84N	probably damaging	Het
Eif2ak4	A	T	2: 118,461,757	K1185*	probably null	Het
Eif4ebp1	T	A	8: 27,275,101	M115K	probably damaging	Het
Evi5	A	T	5: 107,799,139	L505*	probably null	Het
Fbxw25	T	A	9: 109,652,856	Y254F	possibly damaging	Het
Gm7964	T	A	7: 83,757,352	F439Y	possibly damaging	Het
Gps1	A	G	11: 120,785,826	T124A	probably damaging	Het
Hopx	T	C	5: 77,117,616		probably benign	Het
Hoxd3	A	G	2: 74,744,276	S89G	possibly damaging	Het
Hrc	A	T	7: 45,336,214	D263V	probably damaging	Het
Hs6st3	T	C	14: 119,138,476	I21T	probably benign	Het
Izumo4	A	G	10: 80,703,121	Y106C	probably damaging	Het
Lama2	A	T	10: 26,990,800		probably null	Het
Lcorl	A	C	5: 45,775,420	S123R	probably null	Het
Lgr4	A	T	2: 110,011,928	I729F	probably damaging	Het
Lonp1	T	C	17: 56,615,068	T771A	possibly damaging	Het
Matn3	T	A	12: 8,961,110		probably benign	Het
Mdc1	T	A	17: 35,850,930	S912T	probably benign	Het
Mgam	G	A	6: 40,664,880	V556I	probably benign	Het
Myom2	A	T	8: 15,085,263	I489F	possibly damaging	Het
Nfatc2	G	A	2: 168,504,459	T905I	possibly damaging	Het
Nme6	G	A	9: 109,835,341	R6Q	probably damaging	Het
Nr1h5	A	G	3: 102,947,817	S323P	probably damaging	Het
Nr4a3	C	A	4: 48,056,539	R364S	probably damaging	Het
Obox7	A	T	7: 14,664,398	D79V	probably damaging	Het
Olfr374	G	A	8: 72,109,854	G96D	probably benign	Het
Olfr435	T	A	6: 43,201,980	V112D	possibly damaging	Het
Pan2	T	C	10: 128,320,413	V1171A	probably damaging	Het
Parp8	T	A	13: 116,910,913	I208F	probably damaging	Het
Pdgfc	C	T	3: 81,209,245	T302I	probably damaging	Het
Pnpt1	A	G	11: 29,141,256	I337V	probably benign	Het
Polk	T	C	13: 96,489,228	E436G	probably damaging	Het
Pramel7	A	G	2: 87,491,121	V190A	probably benign	Het
Rplp2	T	C	7: 141,448,781		probably benign	Het
Sec23ip	T	A	7: 128,766,273	S670T	probably damaging	Het
Sgk2	A	G	2: 163,004,160	N207S	probably benign	Het
Sh2d2a	C	T	3: 87,851,816	Q242*	probably null	Het
Sh3pxd2b	A	C	11: 32,422,138	N435T	probably damaging	Het
Slc36a4	T	A	9: 15,734,210	V311D	probably damaging	Het
Stx17	G	A	4: 48,181,553	V241M	probably benign	Het
Taok3	A	T	5: 117,265,924	K721N	probably damaging	Het
Tbxas1	A	G	6: 38,948,641		probably benign	Het
Tmem87a	G	A	2: 120,374,504	A377V	probably benign	Het
Topaz1	C	T	9: 122,747,362	T6M	unknown	Het
Tspan8	A	G	10: 115,844,130	I217V	probably benign	Het
Vmn2r125	A	G	4: 156,354,591		probably null	Het
Vmn2r5	C	T	3: 64,504,221	E309K	probably damaging	Het
Wdr59	A	T	8: 111,458,638	C888S	probably benign	Het

Other mutations in Olfr167

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01535:Olfr167	APN	16	19515478	missense	probably benign	0.01
IGL02115:Olfr167	APN	16	19515103	missense	probably damaging	1.00
IGL02562:Olfr167	APN	16	19514964	missense	possibly damaging	0.74
BB008:Olfr167	UTSW	16	19515508	missense	possibly damaging	0.94
BB018:Olfr167	UTSW	16	19515508	missense	possibly damaging	0.94
R0366:Olfr167	UTSW	16	19514848	missense	probably benign	0.13
R0673:Olfr167	UTSW	16	19515396	missense	probably damaging	1.00
R1187:Olfr167	UTSW	16	19515046	missense	probably benign	0.01
R1237:Olfr167	UTSW	16	19515625	missense	probably benign	0.01
R1975:Olfr167	UTSW	16	19514836	missense	probably damaging	0.99
R1997:Olfr167	UTSW	16	19515042	missense	probably damaging	1.00
R2225:Olfr167	UTSW	16	19515246	missense	probably benign	0.05
R2226:Olfr167	UTSW	16	19515246	missense	probably benign	0.05
R4078:Olfr167	UTSW	16	19515232	missense	possibly damaging	0.76
R5019:Olfr167	UTSW	16	19515535	missense	probably damaging	0.99
R5071:Olfr167	UTSW	16	19515027	missense	probably benign	0.00
R5278:Olfr167	UTSW	16	19515378	nonsense	probably null
R5415:Olfr167	UTSW	16	19515246	missense	possibly damaging	0.94
R5744:Olfr167	UTSW	16	19515336	missense	probably benign	0.00
R5991:Olfr167	UTSW	16	19514757	missense	probably damaging	0.99
R6151:Olfr167	UTSW	16	19515531	missense	probably damaging	1.00
R6540:Olfr167	UTSW	16	19514821	missense	probably benign
R7014:Olfr167	UTSW	16	19515456	missense	probably benign	0.20
R7145:Olfr167	UTSW	16	19514899	missense	probably damaging	0.99
R7535:Olfr167	UTSW	16	19514794	missense	probably damaging	1.00
R7677:Olfr167	UTSW	16	19514928	missense	probably benign	0.42
R7715:Olfr167	UTSW	16	19514730	missense	probably benign	0.00
R7931:Olfr167	UTSW	16	19515508	missense	possibly damaging	0.94
R8137:Olfr167	UTSW	16	19515096	missense	possibly damaging	0.89
R8671:Olfr167	UTSW	16	19515054	missense	possibly damaging	0.63

Predicted Primers

PCR Primer
(F):5'- TGCATAAATTCTGGATTCACGG -3'
(R):5'- GCACAGACACATGGGTCTATGAG -3'

Sequencing Primer
(F):5'- CTGGATTCACGGAAGCAACTTGTC -3'
(R):5'- CACATGGGTCTATGAGTATACAGTG -3'

Posted On

2014-08-25