|Institutional Source||Beutler Lab|
|Gene Name||homeobox C6|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R1978 (G1)|
|Chromosomal Location||102998257-103011881 bp(+) (GRCm38)|
|Type of Mutation||critical splice donor site (2 bp from exon)|
|DNA Base Change (assembly)||T to C at 103010007 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000001711 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000001709] [ENSMUST00000001711]|
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the homeobox family, members of which encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC6, is one of several HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Alternatively spliced transcript variants encoding different isoforms have been identified for HOXC6. Transcript variant two includes the shared exon, and transcript variant one includes only gene-specific exons. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this gene display a transformation of thoracic vertebra 2 to a form similar to that of T1. Mammary glands do not develop normally resulting in poor lactation and poor survival of pups. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Hoxc6||
(F):5'- ACCAGGAGAAAGACATGCTC -3'
(R):5'- GGCCTAACTAGACTTTGGGG -3'
(F):5'- GACATGCTCTCAAACTGCAG -3'
(R):5'- GAGCCCTCCAATCCGTCAG -3'