Incidental Mutation 'R2047:Zfp777'
ID 222092
Institutional Source Beutler Lab
Gene Symbol Zfp777
Ensembl Gene ENSMUSG00000071477
Gene Name zinc finger protein 777
Synonyms 2500002G23Rik
MMRRC Submission 040054-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.837) question?
Stock # R2047 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 48001122-48025845 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 48021280 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 114 (I114T)
Ref Sequence ENSEMBL: ENSMUSP00000117227 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095944] [ENSMUST00000114583] [ENSMUST00000125385] [ENSMUST00000147281]
AlphaFold B9EKF4
Predicted Effect probably benign
Transcript: ENSMUST00000095944
AA Change: I114T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000093637
Gene: ENSMUSG00000071477
AA Change: I114T

DomainStartEndE-ValueType
Pfam:DUF3669 177 256 4.3e-12 PFAM
KRAB 284 344 1.6e-29 SMART
low complexity region 422 433 N/A INTRINSIC
coiled coil region 454 477 N/A INTRINSIC
low complexity region 489 505 N/A INTRINSIC
low complexity region 520 532 N/A INTRINSIC
low complexity region 539 555 N/A INTRINSIC
ZnF_C2H2 557 579 1.2e-5 SMART
ZnF_C2H2 585 607 3.8e-5 SMART
ZnF_C2H2 646 668 1.1e-6 SMART
ZnF_C2H2 674 696 4.6e-6 SMART
ZnF_C2H2 704 726 3.2e-7 SMART
ZnF_C2H2 732 754 3.3e-6 SMART
ZnF_C2H2 760 782 8.4e-6 SMART
ZnF_C2H2 788 810 4.9e-5 SMART
ZnF_C2H2 816 838 1.1e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000114583
AA Change: I158T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000110230
Gene: ENSMUSG00000071477
AA Change: I158T

DomainStartEndE-ValueType
low complexity region 2 24 N/A INTRINSIC
Pfam:DUF3669 231 298 4.7e-12 PFAM
KRAB 328 388 3.96e-27 SMART
low complexity region 466 477 N/A INTRINSIC
coiled coil region 498 521 N/A INTRINSIC
low complexity region 533 549 N/A INTRINSIC
low complexity region 564 576 N/A INTRINSIC
low complexity region 583 599 N/A INTRINSIC
ZnF_C2H2 601 623 2.95e-3 SMART
ZnF_C2H2 629 651 8.94e-3 SMART
ZnF_C2H2 690 712 2.43e-4 SMART
ZnF_C2H2 718 740 1.12e-3 SMART
ZnF_C2H2 748 770 7.49e-5 SMART
ZnF_C2H2 776 798 7.9e-4 SMART
ZnF_C2H2 804 826 1.95e-3 SMART
ZnF_C2H2 832 854 1.18e-2 SMART
ZnF_C2H2 860 882 2.53e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000125385
Predicted Effect probably benign
Transcript: ENSMUST00000147281
AA Change: I114T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000148362
SMART Domains Protein: ENSMUSP00000116303
Gene: ENSMUSG00000071477

DomainStartEndE-ValueType
Pfam:DUF3669 40 107 6.1e-13 PFAM
KRAB 137 197 3.96e-27 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000175187
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203645
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.4%
Validation Efficiency 100% (57/57)
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933402N03Rik A G 7: 130,747,836 (GRCm39) F52S probably damaging Het
Acot12 T C 13: 91,931,122 (GRCm39) S457P probably damaging Het
Adcy5 G A 16: 35,110,478 (GRCm39) V882M possibly damaging Het
Ahnak A G 19: 8,991,664 (GRCm39) D4316G possibly damaging Het
Aldh1l2 G A 10: 83,342,607 (GRCm39) A401V probably damaging Het
Apol7e A G 15: 77,601,810 (GRCm39) H136R probably benign Het
Arl5a A G 2: 52,302,072 (GRCm39) probably null Het
Asns G T 6: 7,680,093 (GRCm39) A341E probably damaging Het
C7 A G 15: 5,075,143 (GRCm39) L183P probably damaging Het
Cacng2 C T 15: 78,003,037 (GRCm39) A19T probably damaging Het
Ccdc121rt2 A G 5: 112,598,575 (GRCm39) N374S probably benign Het
Ccr4 A G 9: 114,321,633 (GRCm39) F144S probably damaging Het
Ckap2 A G 8: 22,658,763 (GRCm39) V660A probably benign Het
Cramp1 A T 17: 25,222,189 (GRCm39) Y176* probably null Het
Dgki A G 6: 36,890,581 (GRCm39) S922P possibly damaging Het
Drd5 C T 5: 38,477,679 (GRCm39) S224L probably damaging Het
Ei24 T C 9: 36,691,459 (GRCm39) K341E probably benign Het
Eno2 A T 6: 124,744,659 (GRCm39) probably benign Het
Epb41l4a T C 18: 33,961,259 (GRCm39) N425S probably benign Het
F13b T G 1: 139,435,961 (GRCm39) C256G probably damaging Het
Gp6 A T 7: 4,376,270 (GRCm39) probably benign Het
H2-Q7 A T 17: 35,659,123 (GRCm39) R191S probably damaging Het
Ivns1abp T A 1: 151,227,382 (GRCm39) S63R possibly damaging Het
Kcnj16 A G 11: 110,915,946 (GRCm39) probably null Het
Lpcat4 T C 2: 112,075,142 (GRCm39) probably null Het
Lrrc14b T C 13: 74,511,561 (GRCm39) K173R probably benign Het
Maml3 C A 3: 51,597,866 (GRCm39) R939S probably damaging Het
Mrgpra2b C T 7: 47,113,908 (GRCm39) V249I probably benign Het
Mrpl46 T A 7: 78,431,312 (GRCm39) Y82F probably damaging Het
Mthfs T A 9: 89,097,356 (GRCm39) I71N probably damaging Het
Nectin4 T C 1: 171,212,720 (GRCm39) V351A possibly damaging Het
Npas3 T C 12: 54,115,612 (GRCm39) F827L probably damaging Het
Nrp1 G A 8: 129,224,577 (GRCm39) probably benign Het
Ocln C A 13: 100,671,632 (GRCm39) A242S probably damaging Het
Or10ad1c T A 15: 98,084,920 (GRCm39) T253S probably damaging Het
Or13g1 G A 7: 85,956,012 (GRCm39) T103I probably damaging Het
Or5d37 A T 2: 87,924,237 (GRCm39) N14K probably benign Het
Pappa T C 4: 65,149,378 (GRCm39) probably benign Het
Ptpn6 T C 6: 124,698,752 (GRCm39) T480A probably benign Het
Pycr1 A T 11: 120,532,512 (GRCm39) D168E possibly damaging Het
Rnf6 T C 5: 146,148,674 (GRCm39) T126A probably damaging Het
Slc25a39 G A 11: 102,296,657 (GRCm39) probably benign Het
Slc35f4 G T 14: 49,541,029 (GRCm39) probably benign Het
Sppl2a C T 2: 126,768,772 (GRCm39) A112T probably damaging Het
Sptbn1 A C 11: 30,088,360 (GRCm39) probably benign Het
Sqle T C 15: 59,197,907 (GRCm39) Y376H probably benign Het
Terb1 A T 8: 105,212,094 (GRCm39) Y296N probably damaging Het
Ttbk2 T C 2: 120,579,397 (GRCm39) H506R probably damaging Het
Ttn T C 2: 76,737,879 (GRCm39) D4220G probably benign Het
Tub A G 7: 108,625,939 (GRCm39) D230G probably benign Het
Ube2d3 T A 3: 135,170,967 (GRCm39) I137K probably benign Het
Vldlr G T 19: 27,212,238 (GRCm39) C84F probably damaging Het
Vmn1r54 A T 6: 90,246,970 (GRCm39) I295F probably damaging Het
Vmn2r56 A G 7: 12,466,918 (GRCm39) S39P probably damaging Het
Zfp358 A G 8: 3,545,934 (GRCm39) H172R probably damaging Het
Zfp619 T C 7: 39,187,062 (GRCm39) C1031R probably damaging Het
Other mutations in Zfp777
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01530:Zfp777 APN 6 48,020,918 (GRCm39) missense probably damaging 1.00
IGL01916:Zfp777 APN 6 48,002,276 (GRCm39) missense probably damaging 1.00
IGL01959:Zfp777 APN 6 48,021,275 (GRCm39) missense probably benign
IGL02167:Zfp777 APN 6 48,021,460 (GRCm39) missense probably damaging 0.98
IGL03150:Zfp777 APN 6 48,021,059 (GRCm39) missense probably damaging 1.00
R0238:Zfp777 UTSW 6 48,001,903 (GRCm39) missense probably damaging 0.99
R0238:Zfp777 UTSW 6 48,001,903 (GRCm39) missense probably damaging 0.99
R0372:Zfp777 UTSW 6 48,021,410 (GRCm39) missense possibly damaging 0.62
R0762:Zfp777 UTSW 6 48,006,294 (GRCm39) missense probably damaging 1.00
R1300:Zfp777 UTSW 6 48,002,704 (GRCm39) missense probably benign 0.43
R1727:Zfp777 UTSW 6 48,020,824 (GRCm39) missense probably damaging 0.99
R1906:Zfp777 UTSW 6 48,018,995 (GRCm39) missense probably damaging 0.99
R2097:Zfp777 UTSW 6 48,021,176 (GRCm39) missense probably benign 0.08
R2211:Zfp777 UTSW 6 48,020,819 (GRCm39) missense possibly damaging 0.79
R2898:Zfp777 UTSW 6 48,002,594 (GRCm39) missense probably damaging 0.97
R3123:Zfp777 UTSW 6 48,006,050 (GRCm39) unclassified probably benign
R3832:Zfp777 UTSW 6 48,021,149 (GRCm39) missense probably benign 0.00
R4019:Zfp777 UTSW 6 48,019,046 (GRCm39) missense probably damaging 1.00
R4077:Zfp777 UTSW 6 48,002,456 (GRCm39) missense probably benign
R4471:Zfp777 UTSW 6 48,019,041 (GRCm39) missense probably damaging 1.00
R5021:Zfp777 UTSW 6 48,019,061 (GRCm39) missense probably damaging 0.99
R5030:Zfp777 UTSW 6 48,014,601 (GRCm39) missense probably damaging 0.99
R5819:Zfp777 UTSW 6 48,014,522 (GRCm39) missense probably damaging 0.99
R6544:Zfp777 UTSW 6 48,021,419 (GRCm39) missense probably damaging 0.98
R6736:Zfp777 UTSW 6 48,001,790 (GRCm39) missense probably damaging 0.99
R6971:Zfp777 UTSW 6 48,001,625 (GRCm39) missense probably damaging 1.00
R7240:Zfp777 UTSW 6 48,021,383 (GRCm39) missense probably benign 0.00
R7258:Zfp777 UTSW 6 48,002,731 (GRCm39) missense probably damaging 0.99
R7586:Zfp777 UTSW 6 48,006,152 (GRCm39) missense probably benign 0.33
R7833:Zfp777 UTSW 6 48,002,072 (GRCm39) missense probably damaging 0.99
R7947:Zfp777 UTSW 6 48,001,645 (GRCm39) missense probably damaging 1.00
R8136:Zfp777 UTSW 6 48,021,559 (GRCm39) missense probably benign 0.25
R8151:Zfp777 UTSW 6 48,006,075 (GRCm39) nonsense probably null
R8348:Zfp777 UTSW 6 48,006,101 (GRCm39) missense probably damaging 0.99
R8448:Zfp777 UTSW 6 48,006,101 (GRCm39) missense probably damaging 0.99
R8942:Zfp777 UTSW 6 48,006,125 (GRCm39) missense probably benign 0.25
R8983:Zfp777 UTSW 6 48,006,158 (GRCm39) missense probably damaging 1.00
R9205:Zfp777 UTSW 6 48,002,521 (GRCm39) missense probably benign 0.07
R9397:Zfp777 UTSW 6 48,021,190 (GRCm39) missense probably benign 0.00
R9562:Zfp777 UTSW 6 48,021,580 (GRCm39) missense possibly damaging 0.84
R9565:Zfp777 UTSW 6 48,021,580 (GRCm39) missense possibly damaging 0.84
RF008:Zfp777 UTSW 6 48,018,982 (GRCm39) nonsense probably null
Z1177:Zfp777 UTSW 6 48,002,168 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTCTTTCTGGGCGGCAGAAG -3'
(R):5'- CCAAAAGAAGTTCCTCCTTTGTC -3'

Sequencing Primer
(F):5'- GAGGTATGGAAGGGAGTGTCC -3'
(R):5'- AAGGTGTCTTGCCCCAGACTG -3'
Posted On 2014-08-25