Incidental Mutation 'R2047:Zfp619'
ID 222103
Institutional Source Beutler Lab
Gene Symbol Zfp619
Ensembl Gene ENSMUSG00000068959
Gene Name zinc finger protein 619
Synonyms 3000002G13Rik
MMRRC Submission 040054-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # R2047 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 39167190-39189844 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 39187062 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Arginine at position 1031 (C1031R)
Ref Sequence ENSEMBL: ENSMUSP00000103650 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108015]
AlphaFold G3X9T2
Predicted Effect probably damaging
Transcript: ENSMUST00000108015
AA Change: C1031R

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000103650
Gene: ENSMUSG00000068959
AA Change: C1031R

DomainStartEndE-ValueType
KRAB 4 61 2.19e-20 SMART
ZnF_C2H2 218 240 2.91e-2 SMART
ZnF_C2H2 246 268 5.81e-2 SMART
ZnF_C2H2 274 296 3.16e-3 SMART
ZnF_C2H2 302 324 2.4e-3 SMART
ZnF_C2H2 330 352 2.95e-3 SMART
ZnF_C2H2 358 380 6.32e-3 SMART
ZnF_C2H2 386 408 8.47e-4 SMART
ZnF_C2H2 414 436 5.06e-2 SMART
ZnF_C2H2 442 464 1.58e-3 SMART
ZnF_C2H2 470 492 5.42e-2 SMART
ZnF_C2H2 526 548 2.09e-3 SMART
ZnF_C2H2 554 576 3.39e-3 SMART
ZnF_C2H2 582 604 1.56e-2 SMART
ZnF_C2H2 610 632 2.24e-3 SMART
ZnF_C2H2 638 660 4.72e-2 SMART
ZnF_C2H2 666 688 7.78e-3 SMART
ZnF_C2H2 694 716 5.9e-3 SMART
ZnF_C2H2 722 744 1.12e-3 SMART
ZnF_C2H2 748 770 6.42e-4 SMART
ZnF_C2H2 776 798 1.38e-3 SMART
ZnF_C2H2 804 826 9.44e-2 SMART
ZnF_C2H2 832 854 2.36e-2 SMART
ZnF_C2H2 860 882 8.94e-3 SMART
ZnF_C2H2 888 910 3.58e-2 SMART
ZnF_C2H2 916 938 6.42e-4 SMART
ZnF_C2H2 942 964 4.72e-2 SMART
ZnF_C2H2 970 992 2.3e-5 SMART
ZnF_C2H2 998 1020 8.34e-3 SMART
ZnF_C2H2 1026 1048 8.81e-2 SMART
ZnF_C2H2 1054 1076 1.69e-3 SMART
ZnF_C2H2 1082 1104 6.32e-3 SMART
ZnF_C2H2 1110 1132 1.47e-3 SMART
ZnF_C2H2 1138 1160 7.15e-2 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000191753
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.4%
Validation Efficiency 100% (57/57)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Zinc finger proteins (ZNFs), such as ZNF208, bind DNA and, through this binding, regulate gene transcription. Most ZNFs contain conserved C2H2 motifs and are classified as Kruppel-type zinc fingers. A conserved protein motif, termed the Kruppel-associated box (KRAB) domain, mediates protein-protein interactions (Eichler et al., 1998 [PubMed 9724325]). See ZNF91 (MIM 603971) for further information on ZNFs.[supplied by OMIM, Aug 2009]
Allele List at MGI

All alleles(5) : Gene trapped(5)

Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933402N03Rik A G 7: 130,747,836 (GRCm39) F52S probably damaging Het
Acot12 T C 13: 91,931,122 (GRCm39) S457P probably damaging Het
Adcy5 G A 16: 35,110,478 (GRCm39) V882M possibly damaging Het
Ahnak A G 19: 8,991,664 (GRCm39) D4316G possibly damaging Het
Aldh1l2 G A 10: 83,342,607 (GRCm39) A401V probably damaging Het
Apol7e A G 15: 77,601,810 (GRCm39) H136R probably benign Het
Arl5a A G 2: 52,302,072 (GRCm39) probably null Het
Asns G T 6: 7,680,093 (GRCm39) A341E probably damaging Het
C7 A G 15: 5,075,143 (GRCm39) L183P probably damaging Het
Cacng2 C T 15: 78,003,037 (GRCm39) A19T probably damaging Het
Ccdc121rt2 A G 5: 112,598,575 (GRCm39) N374S probably benign Het
Ccr4 A G 9: 114,321,633 (GRCm39) F144S probably damaging Het
Ckap2 A G 8: 22,658,763 (GRCm39) V660A probably benign Het
Cramp1 A T 17: 25,222,189 (GRCm39) Y176* probably null Het
Dgki A G 6: 36,890,581 (GRCm39) S922P possibly damaging Het
Drd5 C T 5: 38,477,679 (GRCm39) S224L probably damaging Het
Ei24 T C 9: 36,691,459 (GRCm39) K341E probably benign Het
Eno2 A T 6: 124,744,659 (GRCm39) probably benign Het
Epb41l4a T C 18: 33,961,259 (GRCm39) N425S probably benign Het
F13b T G 1: 139,435,961 (GRCm39) C256G probably damaging Het
Gp6 A T 7: 4,376,270 (GRCm39) probably benign Het
H2-Q7 A T 17: 35,659,123 (GRCm39) R191S probably damaging Het
Ivns1abp T A 1: 151,227,382 (GRCm39) S63R possibly damaging Het
Kcnj16 A G 11: 110,915,946 (GRCm39) probably null Het
Lpcat4 T C 2: 112,075,142 (GRCm39) probably null Het
Lrrc14b T C 13: 74,511,561 (GRCm39) K173R probably benign Het
Maml3 C A 3: 51,597,866 (GRCm39) R939S probably damaging Het
Mrgpra2b C T 7: 47,113,908 (GRCm39) V249I probably benign Het
Mrpl46 T A 7: 78,431,312 (GRCm39) Y82F probably damaging Het
Mthfs T A 9: 89,097,356 (GRCm39) I71N probably damaging Het
Nectin4 T C 1: 171,212,720 (GRCm39) V351A possibly damaging Het
Npas3 T C 12: 54,115,612 (GRCm39) F827L probably damaging Het
Nrp1 G A 8: 129,224,577 (GRCm39) probably benign Het
Ocln C A 13: 100,671,632 (GRCm39) A242S probably damaging Het
Or10ad1c T A 15: 98,084,920 (GRCm39) T253S probably damaging Het
Or13g1 G A 7: 85,956,012 (GRCm39) T103I probably damaging Het
Or5d37 A T 2: 87,924,237 (GRCm39) N14K probably benign Het
Pappa T C 4: 65,149,378 (GRCm39) probably benign Het
Ptpn6 T C 6: 124,698,752 (GRCm39) T480A probably benign Het
Pycr1 A T 11: 120,532,512 (GRCm39) D168E possibly damaging Het
Rnf6 T C 5: 146,148,674 (GRCm39) T126A probably damaging Het
Slc25a39 G A 11: 102,296,657 (GRCm39) probably benign Het
Slc35f4 G T 14: 49,541,029 (GRCm39) probably benign Het
Sppl2a C T 2: 126,768,772 (GRCm39) A112T probably damaging Het
Sptbn1 A C 11: 30,088,360 (GRCm39) probably benign Het
Sqle T C 15: 59,197,907 (GRCm39) Y376H probably benign Het
Terb1 A T 8: 105,212,094 (GRCm39) Y296N probably damaging Het
Ttbk2 T C 2: 120,579,397 (GRCm39) H506R probably damaging Het
Ttn T C 2: 76,737,879 (GRCm39) D4220G probably benign Het
Tub A G 7: 108,625,939 (GRCm39) D230G probably benign Het
Ube2d3 T A 3: 135,170,967 (GRCm39) I137K probably benign Het
Vldlr G T 19: 27,212,238 (GRCm39) C84F probably damaging Het
Vmn1r54 A T 6: 90,246,970 (GRCm39) I295F probably damaging Het
Vmn2r56 A G 7: 12,466,918 (GRCm39) S39P probably damaging Het
Zfp358 A G 8: 3,545,934 (GRCm39) H172R probably damaging Het
Zfp777 A G 6: 48,021,280 (GRCm39) I114T probably benign Het
Other mutations in Zfp619
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02157:Zfp619 APN 7 39,184,288 (GRCm39) missense probably damaging 1.00
IGL02221:Zfp619 APN 7 39,186,334 (GRCm39) missense probably benign 0.00
IGL02625:Zfp619 APN 7 39,183,609 (GRCm39) splice site probably benign
3-1:Zfp619 UTSW 7 39,186,189 (GRCm39) missense probably damaging 1.00
R0035:Zfp619 UTSW 7 39,186,706 (GRCm39) missense probably damaging 1.00
R0035:Zfp619 UTSW 7 39,186,706 (GRCm39) missense probably damaging 1.00
R0113:Zfp619 UTSW 7 39,187,183 (GRCm39) missense probably benign 0.01
R0377:Zfp619 UTSW 7 39,186,221 (GRCm39) nonsense probably null
R0614:Zfp619 UTSW 7 39,187,099 (GRCm39) missense possibly damaging 0.79
R0848:Zfp619 UTSW 7 39,185,983 (GRCm39) missense probably damaging 1.00
R1157:Zfp619 UTSW 7 39,186,282 (GRCm39) missense probably damaging 0.98
R2074:Zfp619 UTSW 7 39,184,185 (GRCm39) missense probably benign 0.00
R2419:Zfp619 UTSW 7 39,185,307 (GRCm39) missense possibly damaging 0.71
R2571:Zfp619 UTSW 7 39,186,595 (GRCm39) missense probably damaging 1.00
R2890:Zfp619 UTSW 7 39,184,393 (GRCm39) missense probably benign 0.00
R3814:Zfp619 UTSW 7 39,184,823 (GRCm39) missense probably benign 0.01
R4003:Zfp619 UTSW 7 39,186,730 (GRCm39) missense possibly damaging 0.91
R4059:Zfp619 UTSW 7 39,184,823 (GRCm39) missense probably benign 0.01
R4503:Zfp619 UTSW 7 39,186,280 (GRCm39) missense probably damaging 1.00
R4664:Zfp619 UTSW 7 39,183,559 (GRCm39) missense probably benign 0.00
R4696:Zfp619 UTSW 7 39,186,412 (GRCm39) missense probably benign 0.00
R4895:Zfp619 UTSW 7 39,187,396 (GRCm39) missense possibly damaging 0.68
R4975:Zfp619 UTSW 7 39,186,504 (GRCm39) missense possibly damaging 0.90
R4977:Zfp619 UTSW 7 39,186,811 (GRCm39) missense probably damaging 1.00
R5049:Zfp619 UTSW 7 39,184,938 (GRCm39) missense probably benign 0.02
R5240:Zfp619 UTSW 7 39,186,642 (GRCm39) missense possibly damaging 0.68
R5468:Zfp619 UTSW 7 39,185,152 (GRCm39) missense unknown
R5546:Zfp619 UTSW 7 39,184,577 (GRCm39) missense probably benign 0.01
R5572:Zfp619 UTSW 7 39,184,663 (GRCm39) missense probably benign 0.01
R6106:Zfp619 UTSW 7 39,184,558 (GRCm39) missense probably benign 0.01
R6329:Zfp619 UTSW 7 39,186,969 (GRCm39) missense probably damaging 1.00
R6354:Zfp619 UTSW 7 39,184,243 (GRCm39) missense probably benign 0.02
R6395:Zfp619 UTSW 7 39,186,454 (GRCm39) missense possibly damaging 0.91
R6490:Zfp619 UTSW 7 39,183,586 (GRCm39) missense probably benign 0.00
R6560:Zfp619 UTSW 7 39,186,954 (GRCm39) missense probably damaging 1.00
R6713:Zfp619 UTSW 7 39,187,322 (GRCm39) missense probably damaging 0.99
R7011:Zfp619 UTSW 7 39,187,186 (GRCm39) missense probably damaging 1.00
R7022:Zfp619 UTSW 7 39,184,387 (GRCm39) missense probably benign 0.00
R7046:Zfp619 UTSW 7 39,186,787 (GRCm39) missense possibly damaging 0.95
R7206:Zfp619 UTSW 7 39,184,824 (GRCm39) missense probably benign 0.00
R7780:Zfp619 UTSW 7 39,184,432 (GRCm39) missense possibly damaging 0.68
R7787:Zfp619 UTSW 7 39,186,226 (GRCm39) missense possibly damaging 0.91
R8001:Zfp619 UTSW 7 39,184,645 (GRCm39) missense probably benign 0.29
R8559:Zfp619 UTSW 7 39,186,559 (GRCm39) missense probably benign 0.31
R8775:Zfp619 UTSW 7 39,184,639 (GRCm39) missense possibly damaging 0.75
R8775-TAIL:Zfp619 UTSW 7 39,184,639 (GRCm39) missense possibly damaging 0.75
R9014:Zfp619 UTSW 7 39,187,246 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- TGCGGGTTACCTTCGAATTCA -3'
(R):5'- CAACAACAAACTTCAGCATTTGT -3'

Sequencing Primer
(F):5'- CCCTACGAATGTAAGCAATGTG -3'
(R):5'- GACAAGTAAAGGCTTTCCTGCAGTC -3'
Posted On 2014-08-25