Mutagenetix > Incidental Mutations

Incidental Mutation 'R1980:Olfr91'

222216

Institutional Source

Beutler Lab

Gene Symbol

Olfr91

Ensembl Gene

ENSMUSG00000095377

Gene Name

olfactory receptor 91

Synonyms

MOR256-20, GA_x6K02T2PSCP-1533927-1532989

MMRRC Submission

039992-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.087) question?

Stock #

R1980 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

37090618-37098278 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 37093403 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Proline at position 157 (Q157P)

Ref Sequence

ENSEMBL: ENSMUSP00000150298 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000087144] [ENSMUST00000207101] [ENSMUST00000215195] [ENSMUST00000216376] [ENSMUST00000216488] [ENSMUST00000217372] [ENSMUST00000217397]

AlphaFold

Q7TRL3

Predicted Effect

probably damaging
Transcript: ENSMUST00000087144
AA Change: Q157P

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000129446
Gene: ENSMUSG00000095377
AA Change: Q157P

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srv	23	304	4.8e-7	PFAM
Pfam:7tm_4	29	306	5.7e-50	PFAM
Pfam:7tm_1	39	288	2.3e-27	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000207101

Predicted Effect

probably benign
Transcript: ENSMUST00000215195

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000215502

Predicted Effect

probably damaging
Transcript: ENSMUST00000216376
AA Change: Q157P

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)

Predicted Effect

probably benign
Transcript: ENSMUST00000216488

Predicted Effect

probably damaging
Transcript: ENSMUST00000217372
AA Change: Q157P

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)

Predicted Effect

probably benign
Transcript: ENSMUST00000217397

Coding Region Coverage

1x: 99.1%
3x: 98.4%
10x: 96.8%
20x: 94.1%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 68 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930415L06Rik	A	T	X: 89,931,445	V382E	probably damaging	Het
A730017C20Rik	T	A	18: 59,075,667	M129K	probably damaging	Het
Acly	A	C	11: 100,495,876	I620S	possibly damaging	Het
Acot8	A	G	2: 164,795,044	F262S	probably damaging	Het
Adgb	C	T	10: 10,433,498	V246I	probably benign	Het
Akap9	T	A	5: 3,972,771	M1200K	probably damaging	Het
Alg11	T	A	8: 22,061,887	F16I	possibly damaging	Het
Apol7c	A	G	15: 77,526,044	V234A	probably benign	Het
Arhgap19	T	G	19: 41,788,345	I122L	possibly damaging	Het
Arhgef37	A	G	18: 61,508,696	S201P	probably damaging	Het
Asgr1	A	T	11: 70,054,946	D16V	probably damaging	Het
Camta2	A	T	11: 70,682,482	C227S	probably benign	Het
Cd22	A	T	7: 30,873,233	L317Q	probably damaging	Het
Cenpf	A	T	1: 189,653,915	I2056K	probably benign	Het
Cenpi	T	A	X: 134,318,033	F161L	possibly damaging	Het
Ciapin1	C	T	8: 94,832,533	V43I	probably benign	Het
Dach1	A	G	14: 97,831,341	L601P	probably damaging	Het
Ddx11	T	A	17: 66,148,739	L711Q	probably damaging	Het
Dsg1a	A	T	18: 20,338,650	N653I	probably damaging	Het
Fezf2	G	T	14: 12,344,405	P261T	probably benign	Het
Galnt5	T	C	2: 58,024,723		probably null	Het
Gemin5	A	G	11: 58,136,917	L935P	probably damaging	Het
Gm11273	T	G	13: 21,501,124	T99P	possibly damaging	Het
Gm9507	A	T	10: 77,811,685	C53*	probably null	Het
Irgm2	A	G	11: 58,220,076	I198V	probably damaging	Het
Kcnh8	GAGACCAACGAGCAGCTGATGCTTCAGA	GAGA	17: 52,725,906	74	probably benign	Het
Klf12	A	C	14: 100,149,726		probably null	Het
Lpp	C	T	16: 24,661,701	P73L	probably damaging	Het
Lrrc34	G	A	3: 30,642,741	H127Y	probably benign	Het
Lyar	T	C	5: 38,224,709	S12P	probably damaging	Het
Maml3	A	G	3: 52,104,052	I31T	unknown	Het
Mei1	A	G	15: 82,103,312	N859S	probably benign	Het
Mysm1	A	T	4: 94,952,213	N655K	probably benign	Het
Npnt	T	C	3: 132,948,132	I29M	probably benign	Het
Nrxn1	A	G	17: 91,088,318	W137R	probably benign	Het
Numb	C	T	12: 83,797,344		probably null	Het
Obsl1	A	G	1: 75,505,836	F130S	probably damaging	Het
Olfr1297	T	A	2: 111,621,241	I278F	probably benign	Het
Pbx4	T	C	8: 69,870,126	V294A	probably benign	Het
Pde4dip	A	C	3: 97,756,996	L524R	possibly damaging	Het
Plppr1	G	A	4: 49,337,655	A319T	probably benign	Het
Ppid	A	T	3: 79,593,618	I32F	probably damaging	Het
Prkcsh	A	G	9: 22,012,868	D458G	probably damaging	Het
Prr27	A	G	5: 87,843,402	E291G	probably benign	Het
Psme4	A	T	11: 30,832,615	K923N	possibly damaging	Het
Rab25	T	C	3: 88,543,458	T45A	probably damaging	Het
Rapgef1	C	T	2: 29,722,227	P630S	probably benign	Het
Rasa2	T	C	9: 96,570,768	D355G	probably damaging	Het
Rel	C	T	11: 23,742,761	G424D	probably benign	Het
Rtn4	A	T	11: 29,708,634	E929D	probably benign	Het
Samt3	A	C	X: 86,047,134	M211L	probably benign	Het
Slk	T	G	19: 47,611,989	I151S	probably damaging	Het
Spin1	T	A	13: 51,144,470	V175D	probably damaging	Het
Ssxb10	A	G	X: 8,331,019	D77G	probably benign	Het
Ticam1	C	T	17: 56,271,555	R180H	probably damaging	Het
Tmem151b	G	C	17: 45,545,461	P351R	possibly damaging	Het
Tmod1	A	C	4: 46,061,043	Y10S	probably damaging	Het
Tns2	C	T	15: 102,108,934	R281C	probably damaging	Het
Trpm1	T	C	7: 64,208,434	Y225H	possibly damaging	Het
Ttc17	T	C	2: 94,326,704	N411S	probably benign	Het
Tyro3	A	G	2: 119,808,817	D335G	probably benign	Het
Unc79	C	A	12: 103,011,279	Y180*	probably null	Het
Upp1	A	T	11: 9,134,872	D197V	possibly damaging	Het
Vmn1r226	T	A	17: 20,688,046	M180K	possibly damaging	Het
Vtn	T	A	11: 78,501,898	I434N	probably damaging	Het
Zfp329	T	A	7: 12,811,468	N43I	probably benign	Het
Zfp819	A	G	7: 43,616,461	T47A	probably benign	Het
Zyg11b	G	A	4: 108,265,930	T280I	probably damaging	Het

Other mutations in Olfr91

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00928:Olfr91	APN	17	37093332	missense	probably benign	0.00
IGL03352:Olfr91	APN	17	37093419	missense	probably benign	0.06
R0506:Olfr91	UTSW	17	37093311	missense	probably damaging	1.00
R1982:Olfr91	UTSW	17	37093808	missense	probably damaging	0.98
R4941:Olfr91	UTSW	17	37093592	missense	probably damaging	1.00
R5160:Olfr91	UTSW	17	37093724	missense	possibly damaging	0.83
R5795:Olfr91	UTSW	17	37093769	missense	probably damaging	1.00
R6484:Olfr91	UTSW	17	37093266	missense	probably benign
R6710:Olfr91	UTSW	17	37093746	missense	probably damaging	1.00
R6838:Olfr91	UTSW	17	37093166	nonsense	probably null
R8439:Olfr91	UTSW	17	37093772	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TGGCAATGGCTCCGTAAGAG -3'
(R):5'- AAAGACCATCAGCTTCCTGG -3'

Sequencing Primer
(F):5'- GCTCCGTAAGAGACAAGGATG -3'
(R):5'- ACCATCAGCTTCCTGGGATGC -3'

Posted On

2014-08-25