Mutagenetix > Incidental Mutations

Incidental Mutation 'R2048:Fpr-rs4'

222287

Institutional Source

Beutler Lab

Gene Symbol

Fpr-rs4

Ensembl Gene

ENSMUSG00000048062

Gene Name

formyl peptide receptor, related sequence 4

Synonyms

MMRRC Submission

040055-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.094) question?

Stock #

R2048 (G1)

Quality Score

217

Status

Validated

Chromosome

Chromosomal Location

18021733-18022704 bp(+) (GRCm38)

Type of Mutation

frame shift

DNA Base Change (assembly)

CAGGAA to CA at 18022334 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000093311 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095651]

Predicted Effect

probably null
Transcript: ENSMUST00000095651

SMART Domains

Protein: ENSMUSP00000093311
Gene: ENSMUSG00000048062

Domain	Start	End	E-Value	Type
Pfam:7tm_1	43	297	4.9e-35	PFAM

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.9%
20x: 94.2%

Validation Efficiency

98% (52/53)

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam10	A	G	9: 70,740,075	D19G	possibly damaging	Het
Adhfe1	A	G	1: 9,563,553	K342R	probably benign	Het
Adk	A	G	14: 21,318,176	N223S	probably damaging	Het
Aff4	A	G	11: 53,398,385	S454G	probably benign	Het
Ahnak	T	A	19: 9,007,056	N1901K	probably damaging	Het
Camsap1	T	C	2: 25,929,743	T1578A	probably benign	Het
Ccdc63	A	C	5: 122,130,287		probably null	Het
Ceacam1	G	T	7: 25,476,688	S27Y	probably benign	Het
Cit	T	C	5: 115,886,813		probably null	Het
Cntn4	A	G	6: 106,437,864		probably benign	Het
Cyp2d26	A	G	15: 82,792,727		probably benign	Het
Cyp3a13	A	T	5: 137,909,975	V204E	probably damaging	Het
Cyp51	G	A	5: 4,086,636		probably benign	Het
Epb41l4b	T	G	4: 57,142,866	E96D	probably benign	Het
Epg5	A	G	18: 78,023,987	E2221G	probably damaging	Het
Fam69a	T	C	5: 107,910,020	D179G	probably damaging	Het
Fbxo21	T	A	5: 118,008,104	N597K	probably damaging	Het
Fsip1	C	A	2: 118,241,716	E195D	probably damaging	Het
Gm10152	T	C	7: 144,763,312	F35L	unknown	Het
Gtpbp6	A	C	5: 110,107,065	V87G	probably damaging	Het
Hal	A	G	10: 93,491,140	T176A	probably damaging	Het
Il12rb2	G	T	6: 67,360,545	N117K	probably benign	Het
Kalrn	A	G	16: 34,252,310	V734A	probably benign	Het
Klf7	A	G	1: 64,078,754	V228A	possibly damaging	Het
Kng1	A	G	16: 23,058,604	Y54C	probably damaging	Het
Lpcat2	T	G	8: 92,869,843	N169K	possibly damaging	Het
Magohb	A	T	6: 131,289,422	S40R	probably damaging	Het
Mgam	A	G	6: 40,656,429	D186G	possibly damaging	Het
Mycbp2	A	G	14: 103,232,524		probably null	Het
Myh15	A	G	16: 49,155,565	D1332G	probably damaging	Het
Myh9	G	A	15: 77,771,132	T1208M	possibly damaging	Het
Ncor2	C	T	5: 125,084,932	R426H	unknown	Het
Nradd	T	C	9: 110,621,629	E160G	probably benign	Het
Olfr441	T	A	6: 43,116,378	M212K	probably benign	Het
Olfr819	G	A	10: 129,965,992	S230L	probably damaging	Het
Otog	A	T	7: 46,287,639	T1591S	probably damaging	Het
Oxsr1	A	G	9: 119,247,074	S389P	probably benign	Het
Pde3a	A	G	6: 141,489,006		probably benign	Het
Pi4k2b	A	T	5: 52,748,431	I105L	probably benign	Het
Pilrb1	T	C	5: 137,854,891	R217G	possibly damaging	Het
Poteg	A	T	8: 27,456,746	I159L	probably benign	Het
Ppargc1a	A	G	5: 51,548,516	F75S	probably damaging	Het
Ptk2b	T	G	14: 66,172,505	D466A	probably benign	Het
Ptpn21	A	G	12: 98,689,526	V394A	possibly damaging	Het
Rsf1	GCG	GCGACGGCGACG	7: 97,579,907		probably benign	Het
Shisa3	G	A	5: 67,611,308	E184K	possibly damaging	Het
Slc4a2	A	G	5: 24,431,559	H283R	probably damaging	Het
Slc9a3	A	G	13: 74,163,741	S603G	probably damaging	Het
Tas2r124	A	G	6: 132,754,895	I56V	possibly damaging	Het
Tbcd	G	T	11: 121,540,936	C470F	probably damaging	Het
Thsd1	A	G	8: 22,259,317	R674G	probably benign	Het
Zbtb11	T	A	16: 55,998,009	C599S	probably damaging	Het
Zfp541	A	G	7: 16,078,327	R302G	possibly damaging	Het

Other mutations in Fpr-rs4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00539:Fpr-rs4	APN	17	18021926	missense	probably damaging	1.00
IGL01064:Fpr-rs4	APN	17	18022517	missense	probably damaging	1.00
IGL01626:Fpr-rs4	APN	17	18022231	missense	probably damaging	0.97
IGL02544:Fpr-rs4	APN	17	18022211	missense	probably benign
IGL02837:Fpr-rs4	UTSW	17	18022251	missense	probably benign	0.00
R0179:Fpr-rs4	UTSW	17	18022027	nonsense	probably null
R0383:Fpr-rs4	UTSW	17	18022097	missense	probably damaging	1.00
R0686:Fpr-rs4	UTSW	17	18022351	missense	probably benign	0.05
R1551:Fpr-rs4	UTSW	17	18022327	missense	possibly damaging	0.89
R1956:Fpr-rs4	UTSW	17	18022256	missense	probably damaging	0.97
R2040:Fpr-rs4	UTSW	17	18022334	frame shift	probably null
R2041:Fpr-rs4	UTSW	17	18022334	frame shift	probably null
R2043:Fpr-rs4	UTSW	17	18022334	frame shift	probably null
R2045:Fpr-rs4	UTSW	17	18022334	frame shift	probably null
R2092:Fpr-rs4	UTSW	17	18022334	frame shift	probably null
R2093:Fpr-rs4	UTSW	17	18022334	frame shift	probably null
R2136:Fpr-rs4	UTSW	17	18022334	frame shift	probably null
R3624:Fpr-rs4	UTSW	17	18022334	frame shift	probably null
R4684:Fpr-rs4	UTSW	17	18022184	missense	probably damaging	1.00
R6076:Fpr-rs4	UTSW	17	18022055	missense	probably damaging	1.00
R6247:Fpr-rs4	UTSW	17	18022486	missense	probably benign	0.00
R6639:Fpr-rs4	UTSW	17	18022132	nonsense	probably null
R6757:Fpr-rs4	UTSW	17	18022132	nonsense	probably null
Z1088:Fpr-rs4	UTSW	17	18021919	missense	possibly damaging	0.85
Z1088:Fpr-rs4	UTSW	17	18022694	missense	probably benign	0.16

Predicted Primers

PCR Primer
(F):5'- CCAGAAAAGTGGTTCTTGGAGC -3'
(R):5'- AGCCAAGGTATTTGCTGGG -3'

Sequencing Primer
(F):5'- AGCTTGGATATTTGCTCTGCTGC -3'
(R):5'- CCAAGGTATTTGCTGGGTTAACCAAC -3'

Posted On

2014-08-25