Incidental Mutation 'R0140:Or6c211'
ID 22267
Institutional Source Beutler Lab
Gene Symbol Or6c211
Ensembl Gene ENSMUSG00000058513
Gene Name olfactory receptor family 6 subfamily C member 211
Synonyms Olfr801, GA_x6K02T2PULF-11349138-11348182, MOR110-10
MMRRC Submission 038425-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R0140 (G1)
Quality Score 225
Status Validated (trace)
Chromosome 10
Chromosomal Location 129505430-129506386 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 129505557 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Asparagine at position 277 (T277N)
Ref Sequence ENSEMBL: ENSMUSP00000149555 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072063] [ENSMUST00000203424] [ENSMUST00000213294] [ENSMUST00000216067]
AlphaFold Q8VEU1
Predicted Effect probably damaging
Transcript: ENSMUST00000072063
AA Change: T277N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000071941
Gene: ENSMUSG00000058513
AA Change: T277N

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 1.2e-51 PFAM
Pfam:7tm_1 39 288 8.8e-25 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203321
Predicted Effect probably benign
Transcript: ENSMUST00000203424
SMART Domains Protein: ENSMUSP00000145011
Gene: ENSMUSG00000058513

DomainStartEndE-ValueType
Pfam:7tm_4 1 96 5.9e-18 PFAM
Pfam:7tm_1 2 96 1.3e-17 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213294
AA Change: T277N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000216067
AA Change: T277N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Meta Mutation Damage Score 0.3622 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 93.4%
Validation Efficiency 98% (79/81)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2010315B03Rik T C 9: 124,057,789 (GRCm39) probably benign Het
9330161L09Rik T C 12: 103,373,587 (GRCm39) probably benign Het
Abca2 T G 2: 25,328,097 (GRCm39) probably null Het
Adgrf3 T C 5: 30,401,379 (GRCm39) K13R probably benign Het
Arhgap15 C A 2: 44,212,779 (GRCm39) F416L probably damaging Het
Arhgef26 C G 3: 62,355,666 (GRCm39) T746R probably benign Het
Aspm C T 1: 139,408,379 (GRCm39) T2422I probably benign Het
Atp4a C G 7: 30,419,526 (GRCm39) R659G probably benign Het
AY358078 T A 14: 52,063,399 (GRCm39) D348E probably benign Het
Blnk A T 19: 40,928,668 (GRCm39) S285T probably damaging Het
Calr3 C T 8: 73,188,732 (GRCm39) probably benign Het
Camsap2 A T 1: 136,208,120 (GRCm39) V1124D probably benign Het
Ccdc40 G A 11: 119,155,125 (GRCm39) G1122S probably benign Het
Ccdc69 C A 11: 54,941,325 (GRCm39) C196F possibly damaging Het
Cdhr3 T G 12: 33,130,412 (GRCm39) N141T probably benign Het
Cdk4 T C 10: 126,900,214 (GRCm39) V37A probably damaging Het
Celsr2 C T 3: 108,305,249 (GRCm39) R2110K probably benign Het
Clcn7 A G 17: 25,372,728 (GRCm39) Y437C probably damaging Het
Col6a6 A G 9: 105,579,474 (GRCm39) F1917S probably damaging Het
Cps1 T G 1: 67,219,275 (GRCm39) S872A probably benign Het
Crebbp G T 16: 3,935,363 (GRCm39) T842N probably damaging Het
Dennd2d G A 3: 106,399,799 (GRCm39) V234I probably benign Het
Fam227b T C 2: 125,966,523 (GRCm39) M130V possibly damaging Het
Fbxw24 G T 9: 109,434,482 (GRCm39) L373I possibly damaging Het
Fubp3 T C 2: 31,498,196 (GRCm39) Y359H probably damaging Het
Gm19684 T C 17: 36,438,319 (GRCm39) probably benign Het
Hrnr C T 3: 93,238,800 (GRCm39) Q3013* probably null Het
Il12rb1 T C 8: 71,272,415 (GRCm39) probably benign Het
Lepr A T 4: 101,625,264 (GRCm39) D473V probably damaging Het
Myof A T 19: 37,940,004 (GRCm39) Y820* probably null Het
Nfil3 G A 13: 53,121,681 (GRCm39) Q408* probably null Het
Nolc1 G A 19: 46,069,817 (GRCm39) probably benign Het
Npbwr1 A C 1: 5,986,840 (GRCm39) Y225D probably damaging Het
Nrip3 T C 7: 109,361,022 (GRCm39) probably benign Het
Ntrk1 A C 3: 87,685,875 (GRCm39) L749R probably damaging Het
Or10ag53 A G 2: 87,082,969 (GRCm39) I229M probably damaging Het
Or2b11 A G 11: 59,461,804 (GRCm39) L254P probably damaging Het
Or4c126 T A 2: 89,824,463 (GRCm39) V242D probably damaging Het
Or52a24 A G 7: 103,381,349 (GRCm39) D72G probably damaging Het
Paox A T 7: 139,713,971 (GRCm39) T244S probably damaging Het
Pcdhb9 T A 18: 37,536,014 (GRCm39) D669E possibly damaging Het
Pggt1b A G 18: 46,391,150 (GRCm39) probably null Het
Phkg1 T A 5: 129,893,449 (GRCm39) I334F probably benign Het
Phtf1 A T 3: 103,894,876 (GRCm39) R208W probably null Het
Pnliprp2 A T 19: 58,754,795 (GRCm39) I280F probably benign Het
Pnma8a A G 7: 16,694,147 (GRCm39) M1V probably null Het
Prcp A G 7: 92,577,819 (GRCm39) T328A probably damaging Het
Pxdn A G 12: 30,032,753 (GRCm39) E179G probably benign Het
Racgap1 A T 15: 99,521,532 (GRCm39) N541K probably benign Het
Rnf103 T A 6: 71,486,315 (GRCm39) F315L possibly damaging Het
Septin2 A G 1: 93,429,361 (GRCm39) R237G probably damaging Het
Setd6 T A 8: 96,442,737 (GRCm39) L58Q probably damaging Het
Sipa1l1 G A 12: 82,442,974 (GRCm39) V755I probably damaging Het
Slc16a12 G T 19: 34,650,104 (GRCm39) probably benign Het
Slk G A 19: 47,610,774 (GRCm39) D815N probably damaging Het
Stx1a T C 5: 135,074,439 (GRCm39) probably benign Het
Tbc1d15 T A 10: 115,056,124 (GRCm39) I283F probably damaging Het
Tenm4 T C 7: 96,545,259 (GRCm39) I2425T possibly damaging Het
Tle1 G A 4: 72,038,422 (GRCm39) H702Y probably damaging Het
Tmc6 A G 11: 117,657,077 (GRCm39) probably benign Het
Tmem268 G A 4: 63,496,096 (GRCm39) R179H possibly damaging Het
Tmem9 A G 1: 135,961,900 (GRCm39) K165R probably damaging Het
Trpm6 A G 19: 18,796,558 (GRCm39) probably null Het
Tufm C T 7: 126,089,003 (GRCm39) P88S probably damaging Het
Ubqln1 A G 13: 58,341,103 (GRCm39) I216T probably damaging Het
Urad T G 5: 147,259,141 (GRCm39) M1L probably benign Het
Utp6 A G 11: 79,847,551 (GRCm39) probably benign Het
Vav2 C T 2: 27,163,688 (GRCm39) probably benign Het
Vmn2r55 G T 7: 12,402,104 (GRCm39) Q395K possibly damaging Het
Wwox T G 8: 115,433,027 (GRCm39) V231G probably damaging Het
Zfp646 T A 7: 127,482,678 (GRCm39) N1618K probably benign Het
Zzef1 G A 11: 72,790,377 (GRCm39) M2110I possibly damaging Het
Other mutations in Or6c211
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00948:Or6c211 APN 10 129,505,756 (GRCm39) missense probably damaging 1.00
IGL02400:Or6c211 APN 10 129,505,752 (GRCm39) missense probably damaging 0.99
IGL02721:Or6c211 APN 10 129,505,992 (GRCm39) missense probably benign 0.08
IGL03107:Or6c211 APN 10 129,505,809 (GRCm39) missense probably benign 0.00
R0114:Or6c211 UTSW 10 129,505,467 (GRCm39) missense probably benign
R0652:Or6c211 UTSW 10 129,506,248 (GRCm39) missense probably benign 0.08
R1375:Or6c211 UTSW 10 129,506,241 (GRCm39) missense probably null 0.97
R1449:Or6c211 UTSW 10 129,506,238 (GRCm39) missense probably damaging 0.99
R2026:Or6c211 UTSW 10 129,506,334 (GRCm39) missense probably damaging 1.00
R2241:Or6c211 UTSW 10 129,505,764 (GRCm39) missense probably damaging 1.00
R2516:Or6c211 UTSW 10 129,506,155 (GRCm39) missense probably damaging 1.00
R2869:Or6c211 UTSW 10 129,505,628 (GRCm39) nonsense probably null
R2869:Or6c211 UTSW 10 129,505,628 (GRCm39) nonsense probably null
R2870:Or6c211 UTSW 10 129,505,628 (GRCm39) nonsense probably null
R2870:Or6c211 UTSW 10 129,505,628 (GRCm39) nonsense probably null
R2873:Or6c211 UTSW 10 129,505,628 (GRCm39) nonsense probably null
R6562:Or6c211 UTSW 10 129,506,008 (GRCm39) missense probably damaging 1.00
R8362:Or6c211 UTSW 10 129,506,100 (GRCm39) missense possibly damaging 0.88
R8503:Or6c211 UTSW 10 129,505,512 (GRCm39) missense probably damaging 0.99
R8867:Or6c211 UTSW 10 129,505,628 (GRCm39) nonsense probably null
R9251:Or6c211 UTSW 10 129,505,980 (GRCm39) missense possibly damaging 0.61
Z1177:Or6c211 UTSW 10 129,505,663 (GRCm39) missense probably benign 0.39
Predicted Primers PCR Primer
(F):5'- CCTGAACCAACTATAGCATGAGAGACCT -3'
(R):5'- TCCTAAAGTTCCCTTCAGCTCAACAAAG -3'

Sequencing Primer
(F):5'- CCAGAAGAGATAATCCTCTCAATGTG -3'
(R):5'- CTTCAGCTCAACAAAGGAAAAAGG -3'
Posted On 2013-04-16