|Institutional Source||Beutler Lab|
|Gene Name||anoctamin 7|
|Synonyms||Tmem16g, NGEP-L, IPCA-5, NGEP, Pcanap5|
|Essential gene?||Non essential (E-score: 0.000)|
|Stock #||R2002 (G1)|
|Chromosomal Location||93373930-93404303 bp(+) (GRCm38)|
|Type of Mutation||unclassified|
|DNA Base Change (assembly)||T to C at 93400581 bp (GRCm38)|
|Amino Acid Change|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000058682] [ENSMUST00000186641]|
|Coding Region Coverage||
|Validation Efficiency||97% (72/74)|
|MGI Phenotype||FUNCTION: This gene encodes a member of the anoctamin family, which in mammals is comprised of 10 members. Anoctamin proteins are proposed to have eight transmembrane domains with both termini facing the cytoplasm and a C-terminal domain of unknown function. While some members have been characterized as calcium-activated chloride channels, this protein is reported to have little anion conductance activity. In humans, this protein is primarily found in prostate tissues and may serve as a target for prostate cancer immunotherapy. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Dec 2012]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Ano7||
(F):5'- AGCATCCAAGGTGCACGTTC -3'
(R):5'- TCCCTAATGCACAGCCTCAG -3'
(F):5'- AAGGTGCACGTTCTCTCAGACTAG -3'
(R):5'- GCTCCCAAGCCTCCCCAAG -3'