Incidental Mutation 'R0141:Vmn1r68'
ID 22315
Institutional Source Beutler Lab
Gene Symbol Vmn1r68
Ensembl Gene ENSMUSG00000047031
Gene Name vomeronasal 1 receptor 68
Synonyms Gm6898
MMRRC Submission 038426-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # R0141 (G1)
Quality Score 225
Status Validated (trace)
Chromosome 7
Chromosomal Location 10261137-10262096 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 10261252 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 282 (N282S)
Ref Sequence ENSEMBL: ENSMUSP00000050927 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058362]
AlphaFold E9Q0V3
Predicted Effect possibly damaging
Transcript: ENSMUST00000058362
AA Change: N282S

PolyPhen 2 Score 0.692 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000050927
Gene: ENSMUSG00000047031
AA Change: N282S

DomainStartEndE-ValueType
Pfam:V1R 49 306 2e-33 PFAM
Meta Mutation Damage Score 0.1975 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.0%
  • 10x: 95.5%
  • 20x: 89.9%
Validation Efficiency 88% (50/57)
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot12 A C 13: 91,919,947 (GRCm39) D294A probably benign Het
Adamts9 T C 6: 92,920,066 (GRCm39) D24G probably benign Het
Ahnak G A 19: 8,984,044 (GRCm39) G1776D probably damaging Het
Arfgef3 C A 10: 18,473,155 (GRCm39) C1636F probably damaging Het
AW551984 A G 9: 39,501,940 (GRCm39) L722P probably damaging Het
Ccndbp1 T A 2: 120,842,903 (GRCm39) M188K probably damaging Het
Col27a1 A T 4: 63,183,870 (GRCm39) probably null Het
Cpt1c A G 7: 44,616,095 (GRCm39) Y306H probably damaging Het
Cyp3a57 A G 5: 145,298,912 (GRCm39) I71V probably benign Het
Def8 G A 8: 124,183,234 (GRCm39) A278T probably damaging Het
Dmrt2 A T 19: 25,655,655 (GRCm39) Q418L possibly damaging Het
Ebf1 T C 11: 44,798,827 (GRCm39) L284S probably damaging Het
Fam131a G A 16: 20,517,738 (GRCm39) A15T probably benign Het
Fbxo17 A G 7: 28,432,916 (GRCm39) T146A possibly damaging Het
Fer1l6 A G 15: 58,430,251 (GRCm39) E226G probably damaging Het
Galnt18 A T 7: 111,198,238 (GRCm39) I174N probably damaging Het
Gm44501 T C 17: 40,889,744 (GRCm39) I86T probably benign Het
Gtsf1l T C 2: 162,929,246 (GRCm39) Q79R probably benign Het
Hapln4 T C 8: 70,540,930 (GRCm39) L321P probably damaging Het
Herc2 A G 7: 55,771,309 (GRCm39) T1024A probably benign Het
Hps5 A G 7: 46,438,605 (GRCm39) S43P probably damaging Het
Igsf10 A G 3: 59,238,253 (GRCm39) Y643H probably damaging Het
Lama4 G A 10: 38,968,274 (GRCm39) R1472H probably benign Het
Lhx9 A G 1: 138,767,744 (GRCm39) Y73H possibly damaging Het
Loxl1 T A 9: 58,219,415 (GRCm39) Q252L probably damaging Het
Lrrc37 A C 11: 103,504,512 (GRCm39) I2485M probably damaging Het
Nfat5 C T 8: 108,065,707 (GRCm39) R156W probably damaging Het
Nr3c2 T A 8: 77,635,037 (GRCm39) V46D probably damaging Het
Or11h4 T C 14: 50,973,840 (GRCm39) S260G possibly damaging Het
Or4k77 T A 2: 111,199,835 (GRCm39) I286N probably damaging Het
Or5i1 C G 2: 87,613,049 (GRCm39) P55R possibly damaging Het
Or5p63 A C 7: 107,811,210 (GRCm39) N175K possibly damaging Het
Or5p70 A T 7: 107,994,575 (GRCm39) N83Y probably benign Het
Osbp T C 19: 11,951,223 (GRCm39) V256A possibly damaging Het
Pclo A T 5: 14,841,936 (GRCm39) D4737V unknown Het
Pkdrej A G 15: 85,699,831 (GRCm39) I2035T probably damaging Het
Plek2 A G 12: 78,941,278 (GRCm39) S185P probably damaging Het
Pnpla6 G T 8: 3,582,117 (GRCm39) probably null Het
Pou3f2 T C 4: 22,487,210 (GRCm39) T308A possibly damaging Het
Pramel22 T C 4: 143,381,138 (GRCm39) Y295C probably benign Het
Pxmp4 A G 2: 154,434,215 (GRCm39) V82A probably damaging Het
Rnf6 A T 5: 146,148,645 (GRCm39) N135K possibly damaging Het
Rtl1 A G 12: 109,559,382 (GRCm39) V819A probably damaging Het
Scn1a C A 2: 66,119,406 (GRCm39) V1355L probably damaging Het
Scn2a T A 2: 65,542,160 (GRCm39) N754K probably benign Het
Serpina3b A T 12: 104,097,030 (GRCm39) N104Y probably damaging Het
Sh3rf2 T C 18: 42,289,122 (GRCm39) S648P probably benign Het
Slc17a6 G A 7: 51,318,815 (GRCm39) V486I probably benign Het
Spata31e2 A T 1: 26,722,863 (GRCm39) N772K probably benign Het
Syne2 T G 12: 75,988,072 (GRCm39) D1743E probably damaging Het
Tex14 T G 11: 87,383,857 (GRCm39) probably null Het
Tfb1m T C 17: 3,605,232 (GRCm39) D87G probably damaging Het
Tll2 C T 19: 41,086,351 (GRCm39) G609S probably damaging Het
Tsc22d2 A T 3: 58,324,577 (GRCm39) probably benign Het
Tsen2 A G 6: 115,545,790 (GRCm39) D360G probably damaging Het
Ugt2b37 G A 5: 87,388,842 (GRCm39) P457L probably damaging Het
Vmn2r58 G A 7: 41,511,309 (GRCm39) S498F probably benign Het
Zfp959 T C 17: 56,205,139 (GRCm39) I392T probably benign Het
Other mutations in Vmn1r68
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01892:Vmn1r68 APN 7 10,261,334 (GRCm39) missense possibly damaging 0.76
IGL02051:Vmn1r68 APN 7 10,261,948 (GRCm39) missense probably benign 0.00
IGL02112:Vmn1r68 APN 7 10,261,787 (GRCm39) missense probably damaging 0.96
IGL02619:Vmn1r68 APN 7 10,261,603 (GRCm39) missense probably benign 0.14
IGL03033:Vmn1r68 APN 7 10,262,074 (GRCm39) missense probably damaging 0.99
IGL03184:Vmn1r68 APN 7 10,261,799 (GRCm39) missense probably benign 0.16
PIT4354001:Vmn1r68 UTSW 7 10,261,958 (GRCm39) missense probably benign
R0359:Vmn1r68 UTSW 7 10,261,201 (GRCm39) missense probably damaging 1.00
R0634:Vmn1r68 UTSW 7 10,261,162 (GRCm39) missense probably benign 0.00
R1731:Vmn1r68 UTSW 7 10,261,802 (GRCm39) missense probably damaging 1.00
R2021:Vmn1r68 UTSW 7 10,261,918 (GRCm39) missense probably damaging 1.00
R2022:Vmn1r68 UTSW 7 10,261,918 (GRCm39) missense probably damaging 1.00
R2243:Vmn1r68 UTSW 7 10,262,089 (GRCm39) missense probably damaging 0.98
R2262:Vmn1r68 UTSW 7 10,261,372 (GRCm39) missense probably damaging 1.00
R3877:Vmn1r68 UTSW 7 10,261,408 (GRCm39) missense probably damaging 1.00
R4470:Vmn1r68 UTSW 7 10,261,275 (GRCm39) missense probably benign 0.23
R4843:Vmn1r68 UTSW 7 10,261,904 (GRCm39) missense probably benign 0.00
R5198:Vmn1r68 UTSW 7 10,261,723 (GRCm39) missense probably benign 0.00
R5835:Vmn1r68 UTSW 7 10,261,747 (GRCm39) missense possibly damaging 0.68
R5906:Vmn1r68 UTSW 7 10,261,550 (GRCm39) missense probably benign 0.02
R6015:Vmn1r68 UTSW 7 10,261,616 (GRCm39) missense probably benign 0.31
R7073:Vmn1r68 UTSW 7 10,261,778 (GRCm39) missense probably benign 0.00
R7614:Vmn1r68 UTSW 7 10,261,553 (GRCm39) missense probably benign 0.05
R7699:Vmn1r68 UTSW 7 10,261,559 (GRCm39) missense probably benign 0.15
R7700:Vmn1r68 UTSW 7 10,261,559 (GRCm39) missense probably benign 0.15
R7912:Vmn1r68 UTSW 7 10,261,237 (GRCm39) missense probably benign 0.01
R8166:Vmn1r68 UTSW 7 10,261,888 (GRCm39) missense probably benign 0.10
R8426:Vmn1r68 UTSW 7 10,261,382 (GRCm39) missense probably benign 0.02
R9466:Vmn1r68 UTSW 7 10,261,417 (GRCm39) missense probably damaging 1.00
R9466:Vmn1r68 UTSW 7 10,261,317 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CTGATTCTACCATCCAGCAAGCTCC -3'
(R):5'- TTCATGTTTCCAGCAGGAACTCCC -3'

Sequencing Primer
(F):5'- AGCAAGCTCCCATAATTGTTTCTG -3'
(R):5'- AACTCCCCTGAGTGGAGAG -3'
Posted On 2013-04-16